PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31673852-0	2019	Production of 5-aminolevulinic acid from glutamate by overexpressing HemA1 and pgr7 from Arabidopsis thaliana in Escherichia coli.	5-amino levulinic acid	14-35	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	69-74	
21272955-3	2011	Induced inactivation of the HEMA1 gene encoding GluTR by RNAi expression in tobacco resulted in a reduced activity of Mg chelatase and Fe chelatase indicating a feed-forward regulatory mechanism that links ALA synthesis posttranslationally with late enzymes of tetrapyrrole biosynthesis (Hedtke et al., 2007).	5-amino levulinic acid	206-209	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	28-33	
21272955-6	2011	While constitutive AtHEMA1 overexpression in tobacco stimulates ALA synthesis by 50-90% during light-exposed growth of seedlings, no increase in heme and chlorophyll contents is observed.	5-amino levulinic acid	64-67	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	19-26	
31673852-2	2019	In this study, we introduced the HemA1 and pgr7 genes from the higher plant Arabidopsis thaliana into recombinant Escherichia coli to overproduce extracellular 5-aminolevulinic acid via the C5 pathway.	5-amino levulinic acid	160-181	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	33-38	
31673852-3	2019	In the E. coli BL21 (DE3) strain background, the ALA concentration of the strain expressing both HemA1 and pgr7 was the highest and reached 3080.62 mg/L.	5-amino levulinic acid	49-52	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	97-102	
31673852-7	2019	The recombinant E. coli Transetta GTR/GBP was able to produce 7642 mg/L ALA in modified minimal medium supplemented with 10 g/L glutamate and 15 g/L glucose after 48 h of fermentation at 22  C. The results provide persuading evidence for the efficient production of ALA from glucose and glutamate in E. coli expressing A. thaliana HemA1 and pgr7.	5-amino levulinic acid	72-75	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	331-336	
25706562-5	2015	In the pale-green leaves of the atl31/atl6, the expression of HEMA1, which encodes the key enzyme for 5-aminolevulinic acid synthesis, the rate-limiting step in chlorophyll biosynthesis, was markedly down-regulated.	5-amino levulinic acid	102-123	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	62-67	
25840087-5	2015	In addition, a mutation in either HEMA1 or GSA1, two other enzymes for 5-ALA synthesis, also suppressed ssadh fully and partially, respectively.	5-amino levulinic acid	71-76	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	34-39