PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30424599-7	2019	In addition, catechins conferred their protective role by downregulating the proinflammation cytokines TGF-beta, tumor necrosis factor alpha, and interleukin 17.	Catechin	13-22	tumor necrosis factor	Rattus norvegicus	113-140	
32959859-4	2020	Pre-treatment of cells with EC and DHBA (5 muM) reverted the enhanced levels of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1), activated by high glucose and LPS.	Catechin	28-30	tumor necrosis factor	Rattus norvegicus	146-155	
21673994-9	2011	Supplementation with catechin ameliorated the alcohol-induced liver injury by downregulating the endotoxin-mediated activation of initial signalling molecule NF-kappaB and further going downstream the signalling cascade including tumor necrosis factor-alpha, nitric oxide and reactive oxygen species and by enhancing the antioxidant profile.	Catechin	21-29	tumor necrosis factor	Rattus norvegicus	230-257	
30373863-1	2018	OBJECTIVE: The aim of the present study was to explore the role of catechin on the expression of heat shock protein 27 (HSP27), nuclear factor-kappa beta (NF-kappaB) and inflammatory factors IL-1beta, IL-6 and TNF-alpha in streptozotocin (STZ)-induced diabetic retinopathy (DR) rats.	Catechin	67-75	tumor necrosis factor	Rattus norvegicus	210-219	
30373863-8	2018	Furthermore, IL-1beta, IL-6, and TNF-alpha levels were upregulated in the retinas of STZ-induced DR rats, but these changes were partially inhibited after treatment with catechin.	Catechin	170-178	tumor necrosis factor	Rattus norvegicus	33-42	
21239456-3	2012	Here, we demonstrate that catechin and quercetin have the potential to down-regulate the initial signalling molecule NF-kappaB which may further inhibit the downstream cascade including TNF-alpha and NO.	Catechin	26-34	tumor necrosis factor	Rattus norvegicus	186-195	
21763406-0	2011	Epicatechin attenuates doxorubicin-induced brain toxicity: critical role of TNF-alpha, iNOS and NF-kappaB.	Catechin	0-11	tumor necrosis factor	Rattus norvegicus	76-85	
21763406-3	2011	The present study proved that the use of epicatechin prior to DOX treatment significantly attenuated not only the increase in TNF-alpha, iNOS and NF-kappaB expressions but also the increase in TNF-alpha and total nitrite levels in brain tissue when compared with rats treated with DOX-only.	Catechin	41-52	tumor necrosis factor	Rattus norvegicus	126-135	
21763406-3	2011	The present study proved that the use of epicatechin prior to DOX treatment significantly attenuated not only the increase in TNF-alpha, iNOS and NF-kappaB expressions but also the increase in TNF-alpha and total nitrite levels in brain tissue when compared with rats treated with DOX-only.	Catechin	41-52	tumor necrosis factor	Rattus norvegicus	193-202	
21763406-4	2011	Thus, our study revealed that epicatechin can be used for the treatment of neuroinflammation and also for preventing the development of neurodegenerative disease during antineoplastic therapy because of its protective role in attenuation of neurotoxic pro-inflammatory mediators including TNF-alpha, NF-kappaB, and iNOS.	Catechin	30-41	tumor necrosis factor	Rattus norvegicus	289-298	
35337893-0	2022	Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1beta, TNF-alpha, NF-kappaB, IkappaKB, and p53 genes in male Wistar rats.	Catechin	27-35	tumor necrosis factor	Rattus norvegicus	149-158	
35337893-7	2022	While administration of catechin produced a more pronounced attenuating effect on IL-1beta, TNF-alpha, and p53 genes, the attenuating effect of quercetin (20mg/kg) was more pronounced on NF-kappaB and IkappaKB gene expressions when compared to the group administered with rotenone only.	Catechin	24-32	tumor necrosis factor	Rattus norvegicus	92-101