PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28442342-4 2017 In this study, we used primary hepatocytes to investigate the underlying mechanism of the protective effect of MsrA against APAP-induced hepatotoxicity. 4-amino-N-acetyl-N-methylaniline 124-128 methionine sulfoxide reductase A Homo sapiens 111-115 28442342-5 2017 MsrA gene-deleted (MsrA-/-) hepatocytes showed higher susceptibility to APAP-induced cytotoxicity than wild-type (MsrA+/+) cells, consistent with our previous in vivo results. 4-amino-N-acetyl-N-methylaniline 72-76 methionine sulfoxide reductase A Homo sapiens 0-4 28442342-5 2017 MsrA gene-deleted (MsrA-/-) hepatocytes showed higher susceptibility to APAP-induced cytotoxicity than wild-type (MsrA+/+) cells, consistent with our previous in vivo results. 4-amino-N-acetyl-N-methylaniline 72-76 methionine sulfoxide reductase A Homo sapiens 19-23 28442342-5 2017 MsrA gene-deleted (MsrA-/-) hepatocytes showed higher susceptibility to APAP-induced cytotoxicity than wild-type (MsrA+/+) cells, consistent with our previous in vivo results. 4-amino-N-acetyl-N-methylaniline 72-76 methionine sulfoxide reductase A Homo sapiens 19-23 28442342-7 2017 APAP treatment increased Nrf2 activation more profoundly in MsrA-/- than in MsrA+/+ hepatocytes. 4-amino-N-acetyl-N-methylaniline 0-4 methionine sulfoxide reductase A Homo sapiens 60-64 28442342-7 2017 APAP treatment increased Nrf2 activation more profoundly in MsrA-/- than in MsrA+/+ hepatocytes. 4-amino-N-acetyl-N-methylaniline 0-4 methionine sulfoxide reductase A Homo sapiens 76-80 28442342-9 2017 In addition, APAP treatment significantly increased TXNRD1 expression in MsrA-/- hepatocytes, while no significant change was observed in MsrA+/+ cells. 4-amino-N-acetyl-N-methylaniline 13-17 methionine sulfoxide reductase A Homo sapiens 73-77 28442342-10 2017 Overexpression of MsrA reduced APAP-induced cytotoxicity and TXNRD1 expression levels in APAP-treated MsrA-/- hepatocytes. 4-amino-N-acetyl-N-methylaniline 31-35 methionine sulfoxide reductase A Homo sapiens 18-22 28442342-10 2017 Overexpression of MsrA reduced APAP-induced cytotoxicity and TXNRD1 expression levels in APAP-treated MsrA-/- hepatocytes. 4-amino-N-acetyl-N-methylaniline 89-93 methionine sulfoxide reductase A Homo sapiens 18-22 28442342-10 2017 Overexpression of MsrA reduced APAP-induced cytotoxicity and TXNRD1 expression levels in APAP-treated MsrA-/- hepatocytes. 4-amino-N-acetyl-N-methylaniline 89-93 methionine sulfoxide reductase A Homo sapiens 102-106