PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10452902-4 1999 Activation of these subunits occurs during late assembly stages through intramolecular precursor autolysis removing propeptides attached to Thr1, which then serves as N-terminal nucleophile in substrate hydrolysis. propeptides 116-127 homoserine kinase Saccharomyces cerevisiae S288C 140-144 10452902-12 1999 Thus, one role for the propeptides of active beta-type subunits might be to protect the mature subunits catalytic Thr1 alpha-amino group from acetylation. propeptides 23-34 homoserine kinase Saccharomyces cerevisiae S288C 114-118