PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12963694-5	2003	Here, we report that the serine protease plasmin cleaved both propeptides from the VEGF homology domain of human VEGF-D and thereby generated a mature form exhibiting greatly enhanced binding and cross-linking of VEGFR-2 and VEGFR-3 in comparison to full-length material.	propeptides	62-73	vascular endothelial growth factor D	Homo sapiens	113-119	
33672235-2	2021	Proteolysis is most prominent among the lymph-angiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo enzymatic removal of their C- and N-terminal propeptides before they can activate their receptors.	propeptides	178-189	vascular endothelial growth factor D	Homo sapiens	68-74	
10785369-3	2000	VEGF-D consists of a central receptor-binding VEGF homology domain (VHD) and N-terminal and C-terminal propeptides that are cleaved from the VHD to generate a mature, bioactive form consisting of dimers of the VHD.	propeptides	103-114	vascular endothelial growth factor D	Homo sapiens	0-6	
21515745-3	2011	The propeptides can be cleaved from VEGF-D, enhancing affinity for VEGFR-2 and VEGFR-3 in vitro; however, the importance of this processing in cancer is unclear.	propeptides	4-15	vascular endothelial growth factor D	Homo sapiens	36-42	
21148085-2	2011	VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding on proteolytic removal of the propeptides.	propeptides	97-108	vascular endothelial growth factor D	Homo sapiens	27-33	
21148085-2	2011	VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding on proteolytic removal of the propeptides.	propeptides	185-196	vascular endothelial growth factor D	Homo sapiens	27-33	
24450584-3	2014	VEGF-D contains a central VEGF homology domain, which is the biologically active domain, with flanking N- and C-terminal propeptides.	propeptides	121-132	vascular endothelial growth factor D	Homo sapiens	0-6