PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33672235-2	2021	Proteolysis is most prominent among the lymph-angiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo enzymatic removal of their C- and N-terminal propeptides before they can activate their receptors.	propeptides	178-189	vascular endothelial growth factor C	Homo sapiens	57-63	
9312130-7	1997	The VEGF-C gene structure is thus assembled from exons encoding propeptides and distinct cysteine-rich domains in addition to the VEGF homology domain, and it shows both similarities and distinct differences in comparison with other members of the VEGF/PDGF gene family.	propeptides	64-75	vascular endothelial growth factor C	Homo sapiens	4-10	
19443835-7	2009	Furthermore, receptor activation and arteriogenic activity were increased by an alanine substitution mutant of human VEGF-C (C137A) having an increased dimer stability and by a chimeric CAC growth factor that contained the VEGF receptor-binding domain flanked by VEGF-C propeptides, but only the latter promoted significantly more blood vessel perfusion when compared to the other growth factors studied.	propeptides	270-281	vascular endothelial growth factor C	Homo sapiens	117-123	
23344023-5	2012	The dimeric VEGF-C undergoes a series of proteolytic cleavage steps that increase the protein binding affinity to VEGFR-3; however, only complete processing, removing both the N- and C-terminal propeptides, yields mature VEGF-C that can bind to VEGFR-2.	propeptides	194-205	vascular endothelial growth factor C	Homo sapiens	12-18	
21148085-2	2011	VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding on proteolytic removal of the propeptides.	propeptides	97-108	vascular endothelial growth factor C	Homo sapiens	16-22	
21148085-2	2011	VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding on proteolytic removal of the propeptides.	propeptides	185-196	vascular endothelial growth factor C	Homo sapiens	16-22