PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34169439-8	2021	At a lower total formoterol dose, the nanoparticle localization resulted in increased expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), the master regulator of MB, and increased electron transport chain proteins, markers of MB.	Formoterol Fumarate	17-27	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	100-167	
34169439-8	2021	At a lower total formoterol dose, the nanoparticle localization resulted in increased expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), the master regulator of MB, and increased electron transport chain proteins, markers of MB.	Formoterol Fumarate	17-27	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	169-179	
31841384-4	2020	In the present study, we showed that treatment of RPTCs with formoterol, LY344864, or riociguat, a sGC stimulator, induces MB through protein kinase G (PKG), a target of cGMP, and p38, an associated downstream target of PKG and a regulator of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) expression in RPTCs.	Formoterol Fumarate	61-71	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	243-310	
31841384-4	2020	In the present study, we showed that treatment of RPTCs with formoterol, LY344864, or riociguat, a sGC stimulator, induces MB through protein kinase G (PKG), a target of cGMP, and p38, an associated downstream target of PKG and a regulator of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) expression in RPTCs.	Formoterol Fumarate	61-71	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	312-322	
25292181-9	2014	Formoterol robustly activated the PGC-1alpha-4-IGF1-Akt-mTOR-rp-S6 pathway and increased p-FoxO3a as early as 8 hours and repressed myostatin at 16 hours.	Formoterol Fumarate	0-10	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	34-44	
31262488-11	2019	Furthermore, formoterol treatment reduced cellular apoptosis and increased the expression of the mitochondrial biogenesis marker PGC-1alpha and multiple electron transport chain proteins.	Formoterol Fumarate	13-23	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	129-139	
30280980-6	2019	Formoterol treatment attenuated this decrease in PGC-1alpha, indicating enhanced MB, and restored downstream mitochondrial protein expression to that of controls by 15 days.	Formoterol Fumarate	0-10	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	49-59	
22490378-8	2012	Mice exposed to formoterol for 24 or 72 h exhibited increases in kidney and heart mtDNA copy number, peroxisome proliferator-activated receptor gamma coactivator 1alpha, and multiple genes involved in the mitochondrial electron transport chain (F0 subunit 6 of transmembrane F-type ATP synthase, NADH dehydrogenase subunit 1, NADH dehydrogenase subunit 6, and NADH dehydrogenase [ubiquinone] 1beta subcomplex subunit 8).	Formoterol Fumarate	16-26	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	101-168