PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11462787-4 2001 The activation of apoptotic cascade by the oxidative stress and neurotoxins, such as activation of caspase 3 and DNA fragmentation, was also inhibited by pretreatment with rasagiline. rasagiline 172-182 caspase 3 Homo sapiens 99-108 17017568-3 2006 Rasagiline and propargylamine inhibited the cleavage and subsequent activation of pro-caspase-3 and poly ADP-ribose polymerase. rasagiline 0-10 caspase 3 Homo sapiens 82-95 14555244-5 2003 This pharmacological action of rasagiline is also associated with the prevention of the neurotoxin induced fall in mitochondrial membrane potential, opening of mitochondria permeability transition pore, activation of proteasome-ubiquitin complex, inhibition of cytochrome c release and prevention of caspase 3 activation, similar to the actions of cyclosporin A or Bcl-2 over expression in SH-SY5Y cells. rasagiline 31-41 caspase 3 Homo sapiens 300-309 10996018-6 2000 Rasagiline prevented the loss of DeltaPsim, the initial step to apoptosis, and also following caspase 3-activation and DNA fragmentation. rasagiline 0-10 caspase 3 Homo sapiens 94-103 23681678-5 2013 Rasagiline prevented release of cytochrome c (Cyt-c), and the following caspase 3 activation, ATP depletion and apoptosis, but did not inhibit the mitochondrial membrane potential collapse, in contrast to Bcl-2 overexpression. rasagiline 0-10 caspase 3 Homo sapiens 72-81