PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3985180-1 1985 A mitochondrial model of gluconeogenesis and the tricarboxylic acid cycle, where pyruvate is metabolized via pyruvate carboxylase and pyruvate dehydrogenase, and pyruvate kinase is examined. Tricarboxylic Acids 49-67 pyruvate carboxylase Homo sapiens 109-129 3828325-1 1987 13C NMR has been used to study the competition of pyruvate dehydrogenase with pyruvate carboxylase for entry of pyruvate into the tricarboxylic acid (TCA) cycle in perfused liver from streptozotocin-diabetic and normal donor rats. Tricarboxylic Acids 130-148 pyruvate carboxylase Homo sapiens 78-98 3828325-1 1987 13C NMR has been used to study the competition of pyruvate dehydrogenase with pyruvate carboxylase for entry of pyruvate into the tricarboxylic acid (TCA) cycle in perfused liver from streptozotocin-diabetic and normal donor rats. Tricarboxylic Acids 150-153 pyruvate carboxylase Homo sapiens 78-98 34057673-2 2021 Astrocytes synthesize glutamate de novo owing to the pyruvate entry to the citric/tricarboxylic acid cycle via pyruvate carboxylase, an astrocyte specific enzyme. Tricarboxylic Acids 82-100 pyruvate carboxylase Homo sapiens 111-131 412860-11 1977 This observation, coupled with the intermittent hypercholesterolemia and the increased tissue acetyl-CoA concentrations, suggests that pyruvate carboxylase is important in modulating the fractional distribution of intracellular acetyl-CoA between the tricarboxylic acid cycle, the beta-hydroxy-beta-methyl-glutaryl-CoA cycle (and the synthesis of cholesterol and ketone bodies), and fatty acid synthesis. Tricarboxylic Acids 251-269 pyruvate carboxylase Homo sapiens 135-155 4354325-10 1972 In particular, pyruvate carboxylase may be present in insect flight muscle for the provision of oxaloacetate to support the large increase in activity of the tricarboxylic acid cycle which occurs when an insect takes flight. Tricarboxylic Acids 158-176 pyruvate carboxylase Homo sapiens 15-35 30045381-1 2018 Pyruvate carboxylase (PC) is a biotin-containing enzyme that is responsible for the adenosine triphosphate-dependent carboxylation of pyruvate to oxaloacetate, a key intermediate in the tricarboxylic acid cycle. Tricarboxylic Acids 186-204 pyruvate carboxylase Homo sapiens 0-20 33860280-10 2021 Labeling in the TCA cycle indicated activity of pyruvate dehydrogenase (PDH) and pyruvate carboxylase (PC), with PDH predominating. Tricarboxylic Acids 16-19 pyruvate carboxylase Homo sapiens 81-101 32923630-4 2020 Unexpectedly, we identified a marked induction of pyruvate carboxylase (PCx) and other anaplerotic enzymes involved in replenishing tricarboxylic acid cycle intermediates. Tricarboxylic Acids 132-150 pyruvate carboxylase Homo sapiens 50-70 32923630-4 2020 Unexpectedly, we identified a marked induction of pyruvate carboxylase (PCx) and other anaplerotic enzymes involved in replenishing tricarboxylic acid cycle intermediates. Tricarboxylic Acids 132-150 pyruvate carboxylase Homo sapiens 72-75 33931119-1 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 159-177 pyruvate carboxylase Homo sapiens 0-20 33931119-1 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 159-177 pyruvate carboxylase Homo sapiens 22-24 33931119-1 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 179-182 pyruvate carboxylase Homo sapiens 0-20 33931119-1 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 179-182 pyruvate carboxylase Homo sapiens 22-24 32382484-5 2020 ZY-444 binds to cellular pyruvate carboxylase (PC), a key anaplerotic enzyme of the tricarboxylic acid cycle, and inactivates its catalytic activity. Tricarboxylic Acids 84-102 pyruvate carboxylase Homo sapiens 25-45 31167118-3 2019 (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress. Tricarboxylic Acids 134-152 pyruvate carboxylase Homo sapiens 17-37 30045381-1 2018 Pyruvate carboxylase (PC) is a biotin-containing enzyme that is responsible for the adenosine triphosphate-dependent carboxylation of pyruvate to oxaloacetate, a key intermediate in the tricarboxylic acid cycle. Tricarboxylic Acids 186-204 pyruvate carboxylase Homo sapiens 22-24 26070193-1 2015 Pyruvate carboxylase (PC) is an anaplerotic enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is crucial for replenishing tricarboxylic acid cycle intermediates when they are used for biosynthetic purposes. Tricarboxylic Acids 147-165 pyruvate carboxylase Homo sapiens 0-20 28271481-1 2017 Pyruvate carboxylase is a metabolic enzyme that fuels the tricarboxylic acid cycle with one of its intermediates and also participates in the first step of gluconeogenesis. Tricarboxylic Acids 58-76 pyruvate carboxylase Homo sapiens 0-20 26070193-1 2015 Pyruvate carboxylase (PC) is an anaplerotic enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is crucial for replenishing tricarboxylic acid cycle intermediates when they are used for biosynthetic purposes. Tricarboxylic Acids 147-165 pyruvate carboxylase Homo sapiens 22-24 28649521-1 2015 Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate. Tricarboxylic Acids 225-243 pyruvate carboxylase Homo sapiens 0-20 28649521-1 2015 Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate. Tricarboxylic Acids 225-243 pyruvate carboxylase Homo sapiens 22-24 28649521-1 2015 Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate. Tricarboxylic Acids 245-248 pyruvate carboxylase Homo sapiens 0-20 28649521-1 2015 Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate. Tricarboxylic Acids 245-248 pyruvate carboxylase Homo sapiens 22-24 16505973-2 2006 PC serves an anaplerotic role for the tricarboxylic acid cycle, when intermediates are removed for different biosynthetic purposes. Tricarboxylic Acids 38-56 pyruvate carboxylase Homo sapiens 0-2 21934355-2 2011 The first, pyruvate carboxylase (PC) replenishes oxaloacetate withdrawn from the tricarboxylic acid (TCA) cycle via the carboxylation of pyruvate to form oxaloacetate. Tricarboxylic Acids 81-99 pyruvate carboxylase Homo sapiens 11-31 21934355-2 2011 The first, pyruvate carboxylase (PC) replenishes oxaloacetate withdrawn from the tricarboxylic acid (TCA) cycle via the carboxylation of pyruvate to form oxaloacetate. Tricarboxylic Acids 101-104 pyruvate carboxylase Homo sapiens 11-31 11928941-9 2002 The acquired enzymatic injury resulting from the inhibition of mitochondrial carbonic anhydrase V that provides bicarbonate to pyruvate carboxylase can produce tricarboxylic acid cycle damage. Tricarboxylic Acids 160-178 pyruvate carboxylase Homo sapiens 127-147 8940619-2 1996 We developed a mathematical model of the tricarboxylic acid (TCA) cycle to determine the relative flux of molecules through the anaplerotic versus oxidative pathways and the relative pyruvate carboxylase versus pyruvate dehydrogenase activities. Tricarboxylic Acids 41-59 pyruvate carboxylase Homo sapiens 183-203 8940619-2 1996 We developed a mathematical model of the tricarboxylic acid (TCA) cycle to determine the relative flux of molecules through the anaplerotic versus oxidative pathways and the relative pyruvate carboxylase versus pyruvate dehydrogenase activities. Tricarboxylic Acids 61-64 pyruvate carboxylase Homo sapiens 183-203 7805591-3 1993 The key reason that an interaction with astrocytes is essential is that both pyruvate carboxylase, the major enzyme in the brain for net synthesis of tricarboxylic acid cycle intermediates, and glutamine synthetase, the enzyme forming glutamine from glutamate, are specifically located in astrocytes, but not in neurons. Tricarboxylic Acids 150-168 pyruvate carboxylase Homo sapiens 77-97 34931827-1 2022 Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production. Tricarboxylic Acids 148-166 pyruvate carboxylase Homo sapiens 101-121 34158007-1 2021 BACKGROUND: Pyruvate carboxylase (PC) is an important anaplerotic enzyme in the tricarboxylic acid cycle (TCA) in cancer cells. Tricarboxylic Acids 80-98 pyruvate carboxylase Homo sapiens 12-32