PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30958073-2 2019 IDH1 and IDH2 are enzymes that are involved in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 51-69 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-4 34756979-5 2022 Metagenomics analysis revealed that FA introduction stimulated relative abundance genes in central pathway of tricarboxylic acid cycle such as ACO, IDH, OGDH, SCS, FUM, and MDH. Tricarboxylic Acids 110-128 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 148-151 34145795-1 2021 BACKGROUND: Isocitrate dehydrogenase (IDH) is an enzyme family involved in cell aerobic metabolism of tricarboxylic acid cycle. Tricarboxylic Acids 102-120 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 12-36 34145795-1 2021 BACKGROUND: Isocitrate dehydrogenase (IDH) is an enzyme family involved in cell aerobic metabolism of tricarboxylic acid cycle. Tricarboxylic Acids 102-120 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 38-41 32669607-4 2021 Mechanistically, coupling cell cycle with metabolism is largely achieved by timely destruction of IDH1/2, key TCA cycle enzymes, in a Skp2-dependent manner. Tricarboxylic Acids 110-113 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 98-104 30958073-2 2019 IDH1 and IDH2 are enzymes that are involved in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 71-74 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-4 31660152-1 2019 Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 129-147 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-24 31660152-1 2019 Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 149-152 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 26-29 31660152-1 2019 Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 129-147 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 26-29 31660152-1 2019 Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 149-152 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-24 31278288-5 2019 Gliomas with IDH mutation also showed decreased intermediates in the tricarboxylic acid cycle and pathways involved in the production of energy, amino acids, and nucleic acids. Tricarboxylic Acids 69-87 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 13-16 27097804-1 2016 PURPOSE: Inactivating mutations of isocitrate dehydrogenase (IDH) 1 and 2, mitochondrial enzymes participating in the Krebs tricarboxylic acid cycle play a role in the tumorigenesis of gliomas and also less frequently in acute myeloid leukemia and other malignancies. Tricarboxylic Acids 124-142 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 35-73 31086759-9 2019 Almost unique amongst intracellular bacteria, MAP"s variant isocitrate dehydrogenase 1 (IDH1) enzyme, a type 2-oxoglutarate ferredoxin oxidoreductase, can use a host cell"s cytosolic alpha-ketoglutarate in its own Krebs or tricarboxylic acid cycle. Tricarboxylic Acids 223-241 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 88-92 30596429-5 2019 Of note, tricarboxylic acid (TCA) cycle intermediates were in similar levels in both groups, with more pyruvate found entering the TCA cycle in IDH1 mutant glioma. Tricarboxylic Acids 131-134 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 144-148 29738972-1 2018 Isocitrate dehydrogenase (IDH) is one of the key enzymes in the tricarboxylic acid cycle, and IDH mutations have been associated with many cancers, including glioblastoma, sarcoma, acute myeloid leukemia, etc. Tricarboxylic Acids 64-82 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-24 29738972-1 2018 Isocitrate dehydrogenase (IDH) is one of the key enzymes in the tricarboxylic acid cycle, and IDH mutations have been associated with many cancers, including glioblastoma, sarcoma, acute myeloid leukemia, etc. Tricarboxylic Acids 64-82 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 26-29 27624942-1 2016 The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. Tricarboxylic Acids 57-75 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 131-137 27624942-1 2016 The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. Tricarboxylic Acids 77-80 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 131-137 30483760-1 2019 The mutation of isocitrate dehydrogenase (IDH)1 (R132H) and IDH2 (R172K) and the induction of hypoxia in various solid tumors results in alterations in metabolic profiles, including the production of the d- or l-forms of 2-hydroxyglutarate (2HG) from alpha-ketoglutarate in aerobic metabolism in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 300-318 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 42-47 30483760-1 2019 The mutation of isocitrate dehydrogenase (IDH)1 (R132H) and IDH2 (R172K) and the induction of hypoxia in various solid tumors results in alterations in metabolic profiles, including the production of the d- or l-forms of 2-hydroxyglutarate (2HG) from alpha-ketoglutarate in aerobic metabolism in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 320-323 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 42-47 30511933-11 2018 These data support the possibility of a functional tricarboxylic acid cycle that runs in reductive manner, as a probable mechanism of action of bevacizumab in IDH1 mutated gliomas and propose a new target pathway for effective treatment of malignant gliomas. Tricarboxylic Acids 51-69 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 159-163 29847930-1 2018 Isocitrate dehydrogenases 1 and 2 (IDH1/2) are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) in the tricarboxylic acid cycle. Tricarboxylic Acids 151-169 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 35-41 28711227-2 2017 Mutations in genes encoding enzymes involved in the tricarboxylic acid (TCA) cycle, such as the isocitrate dehydrogenases 1 and 2 (IDH1/2), are frequently encountered in astrocytomas and secondary glioblastomas, as well as in acute myeloid leukemias; however, the precise molecular mechanisms by which these mutations promote tumorigenesis remain to be fully characterized. Tricarboxylic Acids 52-70 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 131-137 28711227-2 2017 Mutations in genes encoding enzymes involved in the tricarboxylic acid (TCA) cycle, such as the isocitrate dehydrogenases 1 and 2 (IDH1/2), are frequently encountered in astrocytomas and secondary glioblastomas, as well as in acute myeloid leukemias; however, the precise molecular mechanisms by which these mutations promote tumorigenesis remain to be fully characterized. Tricarboxylic Acids 72-75 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 131-137 28498812-1 2017 Isocitrate dehydrogenase (IDH) plays an indispensable role in the tricarboxylic acid cycle, and IDH mutations are present in nearly 75% of glioma and 20% of acute myeloid leukemia. Tricarboxylic Acids 66-84 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-24 28498812-1 2017 Isocitrate dehydrogenase (IDH) plays an indispensable role in the tricarboxylic acid cycle, and IDH mutations are present in nearly 75% of glioma and 20% of acute myeloid leukemia. Tricarboxylic Acids 66-84 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 26-29 27624942-7 2016 Our results provide an additional molecular mechanism for the oncogenic activity of mutant IDH1/2 by revealing an unprecedented link between TCA cycle defects and positive modulation of mTOR function downstream of the canonical PI3K/AKT/TSC1-2 pathway. Tricarboxylic Acids 141-144 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 91-97 27528759-3 2016 In this review we discuss the consequences of dysfunction of three metabolic enzymes involved in or associated with the tricarboxylic acid (TCA) cycle: succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) focusing on the similarity between the phenotypes of cancers harbouring these mutations. Tricarboxylic Acids 120-138 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 237-240 27528759-3 2016 In this review we discuss the consequences of dysfunction of three metabolic enzymes involved in or associated with the tricarboxylic acid (TCA) cycle: succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) focusing on the similarity between the phenotypes of cancers harbouring these mutations. Tricarboxylic Acids 140-143 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 237-240 27355333-1 2016 Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 86-104 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-24 27355333-1 2016 Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 86-104 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 26-29 27355333-1 2016 Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 106-109 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-24 27355333-1 2016 Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 106-109 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 26-29 24295421-5 2013 Possibly, IDH mutations may also cause oncogenic effects through dysregulation of the tricarboxylic acid cycle, or by increasing susceptibility to oxidative stress. Tricarboxylic Acids 86-104 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 10-13 25956465-5 2015 As IDH1 and IDH2 represent key enzymes within the tricarboxylic acid (TCA) cycle, mutations have significant impact on intermediary metabolism. Tricarboxylic Acids 50-68 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 3-7 25956465-5 2015 As IDH1 and IDH2 represent key enzymes within the tricarboxylic acid (TCA) cycle, mutations have significant impact on intermediary metabolism. Tricarboxylic Acids 70-73 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 3-7 25576295-4 2015 PATIENTS AND METHODS: In this study, we genotyped 18 potentially functional SNPs in 7 genes belonging to 3 TCA cycle enzyme families (SDH, FH and IDH) using Sequenom iPLEX genotyping system in a cohort of 500 NSCLC patients. Tricarboxylic Acids 107-110 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 146-149 25355558-3 2014 However, the association between functional single nucleotide polymorphisms (SNPs) in one of TCA cycle key gene isocitrate dehydrogenase (IDH) and the overall survival of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE) has never been investigated. Tricarboxylic Acids 93-96 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 138-141 25980580-8 2015 Targeted metabolomics studies revealed that the ability of metformin to interfere with the anaplerotic entry of glutamine into the tricarboxylic acid cycle could explain the hypersensitivity of IDH1-mutant cells to biguanides. Tricarboxylic Acids 131-149 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 194-198 24755473-3 2014 We observed that under hypoxic conditions, IDH1-mutant cells exhibited increased oxidative tricarboxylic acid metabolism along with decreased reductive glutamine metabolism, but not IDH2-mutant cells. Tricarboxylic Acids 91-109 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 43-47 21289278-4 2011 Levels of amino acids, glutathione metabolites, choline derivatives, and tricarboxylic acid (TCA) cycle intermediates were altered in mutant IDH1- and IDH2-expressing cells. Tricarboxylic Acids 73-91 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 141-145 23795241-1 2013 Mutations in isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, have recently been found in ~75% glioma and ~20% acute myeloid leukemia. Tricarboxylic Acids 65-83 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 13-37 23795241-1 2013 Mutations in isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, have recently been found in ~75% glioma and ~20% acute myeloid leukemia. Tricarboxylic Acids 65-83 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 39-42 23232569-4 2013 Apart from epigenetic alterations, perturbations in the tricarboxylic acid cycle (depletion of intermediates) and activation of the intricately linked hypoxia signaling pathway are apparent in IDH mutated cells. Tricarboxylic Acids 56-74 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 193-196 22837861-5 2012 As a proof of principle, we focused on the TCA cycle, predicting that isocitrate dehydrogenase (IDH) activity would be altered in PAH, and then demonstrating increased IDH activity not only in cultured hPMVEC expressing mutant BMPR2 but also in the serum of PAH patients. Tricarboxylic Acids 43-46 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 96-99 24077277-2 2013 The IDH1 mutation induces down-regulation of tricarboxylic acid cycle intermediates and up-regulation of lipid metabolism. Tricarboxylic Acids 45-63 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 4-8 22385606-1 2012 Isocitrate dehydrogenase (IDH) encodes a nicotinamide adenine dinucleotide phosphate+-dependent enzyme for oxidative decarboxylation of isocitrate and has an essential role in the tricarboxylic acid cycle. Tricarboxylic Acids 180-198 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-24 22385606-1 2012 Isocitrate dehydrogenase (IDH) encodes a nicotinamide adenine dinucleotide phosphate+-dependent enzyme for oxidative decarboxylation of isocitrate and has an essential role in the tricarboxylic acid cycle. Tricarboxylic Acids 180-198 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 26-29 21289278-4 2011 Levels of amino acids, glutathione metabolites, choline derivatives, and tricarboxylic acid (TCA) cycle intermediates were altered in mutant IDH1- and IDH2-expressing cells. Tricarboxylic Acids 93-96 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 141-145