PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32855694-0 2020 Hydrogen peroxide induces nucleus pulposus cell apoptosis by ATF4/CHOP signaling pathway. Hydrogen Peroxide 0-17 DNA damage inducible transcript 3 Homo sapiens 66-70 32855694-2 2020 The present study explored the activating transcription factor 4 (ATF4)/C/EBP homologous protein (CHOP) signaling pathway in the H2O2-induced nucleus pulposus (NP) cell apoptosis. Hydrogen Peroxide 129-133 DNA damage inducible transcript 3 Homo sapiens 98-102 32855694-10 2020 H2O2 induced NP cell apoptosis by upregulating expression of ATF4, CHOP and caspase-9. Hydrogen Peroxide 0-4 DNA damage inducible transcript 3 Homo sapiens 67-71 32855694-13 2020 In this study, we found H2O2 could promote NP cell apoptosis by activating the ATF4/CHOP signaling pathway resulting in the upregulation of caspase-9. Hydrogen Peroxide 24-28 DNA damage inducible transcript 3 Homo sapiens 84-88 32855694-14 2020 Interdict of ATF4, CHOP, or caspase-9 contributed to the reduction of apoptosis caused by H2O2. Hydrogen Peroxide 90-94 DNA damage inducible transcript 3 Homo sapiens 19-23 25220073-5 2014 L-carnitine suppress the endoplasmic reticulum dilation and activation of ER stress-associated proteins including glucose-regulated protein 78 (GRP78), CCAAT/enhancer-binding protein-homologous protein (CHOP), JNK, Bax and Bim induced by H2O2 or TM. Hydrogen Peroxide 238-242 DNA damage inducible transcript 3 Homo sapiens 152-201 30987565-14 2019 The expression of CHOP, PERK, IRE1 and ATF6 mRNA was significantly up-regulated in the presence of CCl4 or H2O2 (P < 0.05). Hydrogen Peroxide 107-111 DNA damage inducible transcript 3 Homo sapiens 18-22 27636901-6 2016 Induction of Chop/CHOP and p58IPK/P58IPK by oxidized LDL was mimicked by hydrogen peroxide and was blocked by co-treatment with the N-acetylcystein antioxidant. Hydrogen Peroxide 73-90 DNA damage inducible transcript 3 Homo sapiens 13-17 27636901-6 2016 Induction of Chop/CHOP and p58IPK/P58IPK by oxidized LDL was mimicked by hydrogen peroxide and was blocked by co-treatment with the N-acetylcystein antioxidant. Hydrogen Peroxide 73-90 DNA damage inducible transcript 3 Homo sapiens 18-22 32608212-7 2020 In addition, H2O2 and TM could increase the levels of PGE2, GRP78, CHOP, caspase-12, and reactive oxygen species (ROS), resulting in the degeneration of CHs. Hydrogen Peroxide 13-17 DNA damage inducible transcript 3 Homo sapiens 67-71 25220073-6 2014 In addition, H2O2-induced cell apoptosis and activation of ER stress can also be attenuated by antioxidant N-acetylcysteine (NAC), CHOP siRNA and the inhibitor of ER stress 4-phenylbutyric acid (4-PBA). Hydrogen Peroxide 13-17 DNA damage inducible transcript 3 Homo sapiens 131-135 25220073-8 2014 CHOP/Bim or JNK/Bim-dependent ER stress signaling pathways maybe related to the neuroprotective effects of L-carnitine against H2O2-induced apoptosis and oxidative injury. Hydrogen Peroxide 127-131 DNA damage inducible transcript 3 Homo sapiens 0-4 24068329-10 2014 H2O2 and MK886 both reduced the viability of HepG2 cells, increased oxidative stress and apoptosis, up-regulated the BiP and CHOP expression, and induced CHOP translocation from the cytoplasm to the nucleus. Hydrogen Peroxide 0-4 DNA damage inducible transcript 3 Homo sapiens 125-129 24068329-10 2014 H2O2 and MK886 both reduced the viability of HepG2 cells, increased oxidative stress and apoptosis, up-regulated the BiP and CHOP expression, and induced CHOP translocation from the cytoplasm to the nucleus. Hydrogen Peroxide 0-4 DNA damage inducible transcript 3 Homo sapiens 154-158 11145585-8 2001 This is the first evidence that the insulin-like growth factor I/phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway is required for gene regulation by amino acid deprivation and that this pathway is involved in the induction of CHOP by both amino acid deficiency and oxidative stress by hydrogen peroxide. Hydrogen Peroxide 304-321 DNA damage inducible transcript 3 Homo sapiens 245-249 22609744-5 2012 Moreover, these effects were eliminated by either the stable knockdown of CHOP or the pretreatment and then co-incubation with the specific H2O2 scavenger catalase. Hydrogen Peroxide 140-144 DNA damage inducible transcript 3 Homo sapiens 74-78 18631371-6 2008 Additionally, H(2)O(2) treatment induced upregulation of CHOP, GRP78 and several representative endoplasmic reticulum (ER) stress-responsive proteins, including heme oxygenase-1. Hydrogen Peroxide 14-22 DNA damage inducible transcript 3 Homo sapiens 57-61 16400006-4 2006 Superoxide anions and H(2)O(2) increased mRNA and protein expression of GAS5 (growth arrest-specific protein 5) and CHOP (C/EBP homology protein). Hydrogen Peroxide 22-30 DNA damage inducible transcript 3 Homo sapiens 116-120 16400006-4 2006 Superoxide anions and H(2)O(2) increased mRNA and protein expression of GAS5 (growth arrest-specific protein 5) and CHOP (C/EBP homology protein). Hydrogen Peroxide 22-30 DNA damage inducible transcript 3 Homo sapiens 122-144 15327748-0 2004 Hydrogen peroxide induces GADD153 in Jurkat cells through the protein kinase C-dependent pathway. Hydrogen Peroxide 0-17 DNA damage inducible transcript 3 Homo sapiens 26-33 15327748-3 2004 GADD153 mRNA expression was immediately enhanced following hydrogen peroxide exposure and was significantly inhibited by treatment with H-7, staurosporin, and Ro-31-8220. Hydrogen Peroxide 59-76 DNA damage inducible transcript 3 Homo sapiens 0-7 21875624-6 2011 Longer exposure (1-3h) to H(2)O(2) induced ER-mediated apoptosis, whereby CHOP expression increased, and enzymatic activity of calpain, caspase-7, -4, -12 and -9 also increased. Hydrogen Peroxide 26-34 DNA damage inducible transcript 3 Homo sapiens 74-78 17368854-6 2007 Importantly, we showed that, following H2O2 treatment, gadd153 gene reached higher levels of expression in replicon cells. Hydrogen Peroxide 39-43 DNA damage inducible transcript 3 Homo sapiens 55-62 17368854-8 2007 Treatment of replicon cells with a specific small interfering RNA, targeted to gadd153 gene, reduced basal expression of gadd153 and decreased cell death following H2O2. Hydrogen Peroxide 164-168 DNA damage inducible transcript 3 Homo sapiens 79-86 15327748-4 2004 In particular, rottlerin, a PKCdelta specific inhibitor, markedly attenuated hydrogen peroxide-induced GADD153 mRNA expression even at 1 microM. Hydrogen Peroxide 77-94 DNA damage inducible transcript 3 Homo sapiens 103-110 15327748-5 2004 Treatment with a potent PKC activator, phorbol-12-myristate-13-acetate (PMA), augmented GADD153 mRNA in Jurkat cells in the presence of hydrogen peroxide, although PMA alone induced GADD153 mRNA marginally. Hydrogen Peroxide 136-153 DNA damage inducible transcript 3 Homo sapiens 88-95 15327748-6 2004 Hydrogen peroxide significantly enhanced the AP-1 binding activity of the nuclear extract from Jurkat cells to the GADD153 AP-1 binding site. Hydrogen Peroxide 0-17 DNA damage inducible transcript 3 Homo sapiens 115-122 8670069-3 1996 Both commonalities and distinctions in the induction of GADD153 by H2O2 and the thiol-reactive compound arsenite were demonstrated. Hydrogen Peroxide 67-71 DNA damage inducible transcript 3 Homo sapiens 56-63 8670069-6 1996 Concordantly, GSH peroxidase overexpression in WI38 cells attenuated GADD153 mRNA induction by H2O2. Hydrogen Peroxide 95-99 DNA damage inducible transcript 3 Homo sapiens 69-76 8670069-4 1996 GADD153 mRNA induction by both H2O2 and arsenite was potentiated by GSH depletion, and completely inhibited by N-acetyl-cysteine. Hydrogen Peroxide 31-35 DNA damage inducible transcript 3 Homo sapiens 0-7 8670069-5 1996 o-Phenanthroline and mannitol blocked GADD153 induction by H2O2, indicating that iron-generated hydroxyl radical mediates this induction. Hydrogen Peroxide 59-63 DNA damage inducible transcript 3 Homo sapiens 38-45 34864562-0 2022 Protegrin-1 inhibits porcine ovarian granulosa cell apoptosis from H2O2-induced oxidative stress via the PERK/eIF2alpha/CHOP signaling pathway in vitro. Hydrogen Peroxide 67-71 DNA damage inducible transcript 3 Homo sapiens 120-124 34864562-8 2022 Using Western blot analysis, it was found that PG-1 decreased the phosphorylation of RNA-like endoplasmic reticulum kinase (PERK) and the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha) as well as the protein expression level of CCAAT enhancer-binding protein homologous protein (CHOP), all of which were increased by H2O2. Hydrogen Peroxide 330-334 DNA damage inducible transcript 3 Homo sapiens 241-290 34864562-8 2022 Using Western blot analysis, it was found that PG-1 decreased the phosphorylation of RNA-like endoplasmic reticulum kinase (PERK) and the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha) as well as the protein expression level of CCAAT enhancer-binding protein homologous protein (CHOP), all of which were increased by H2O2. Hydrogen Peroxide 330-334 DNA damage inducible transcript 3 Homo sapiens 292-296