PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34751416-4 2022 The current study suggested that PD activates AKT/cAMP response element-binding protein (CREB) signaling and induces neuroglobin (Ngb) to protect neuronal cells from hydrogen peroxide (H2O2) in vitro. Hydrogen Peroxide 166-183 neuroglobin Mus musculus 117-128 34751416-4 2022 The current study suggested that PD activates AKT/cAMP response element-binding protein (CREB) signaling and induces neuroglobin (Ngb) to protect neuronal cells from hydrogen peroxide (H2O2) in vitro. Hydrogen Peroxide 166-183 neuroglobin Mus musculus 130-133 34751416-4 2022 The current study suggested that PD activates AKT/cAMP response element-binding protein (CREB) signaling and induces neuroglobin (Ngb) to protect neuronal cells from hydrogen peroxide (H2O2) in vitro. Hydrogen Peroxide 185-189 neuroglobin Mus musculus 117-128 34751416-4 2022 The current study suggested that PD activates AKT/cAMP response element-binding protein (CREB) signaling and induces neuroglobin (Ngb) to protect neuronal cells from hydrogen peroxide (H2O2) in vitro. Hydrogen Peroxide 185-189 neuroglobin Mus musculus 130-133 34751416-11 2022 The results indicated that PD protected neuronal cells from H2O2 by activating CREB/Ngb signaling in neuronal cells, indicating that PD has a neuroprotective effect against neurodegenerative diseases. Hydrogen Peroxide 60-64 neuroglobin Mus musculus 84-87 27787886-0 2017 Neuroglobin protects astroglial cells from hydrogen peroxide-induced oxidative stress and apoptotic cell death. Hydrogen Peroxide 43-60 neuroglobin Mus musculus 0-11 27787886-3 2017 Thus, the purpose of this study was to investigate the potential glioprotective effect of Ngb on hydrogen peroxide (H2 O2 )-induced oxidative stress and apoptosis in cultured mouse astrocytes. Hydrogen Peroxide 97-114 neuroglobin Mus musculus 90-93 27787886-3 2017 Thus, the purpose of this study was to investigate the potential glioprotective effect of Ngb on hydrogen peroxide (H2 O2 )-induced oxidative stress and apoptosis in cultured mouse astrocytes. Hydrogen Peroxide 116-121 neuroglobin Mus musculus 90-93 27787886-4 2017 Incubation of cells with subnanomolar concentrations of Ngb (10-14 -10-10 M) was found to prevent both H2 O2 -evoked reduction in surviving cells number and accumulation of reactive oxygen species in a concentration-dependent manner. Hydrogen Peroxide 104-109 neuroglobin Mus musculus 56-59 27787886-5 2017 Furthermore, Ngb treatment abolishes H2 O2 -induced increase in mitochondrial oxygen consumption rates. Hydrogen Peroxide 37-42 neuroglobin Mus musculus 13-16 27787886-6 2017 Concomitantly, Ngb treatment rescues H2 O2 -associated reduced expression of endogenous antioxidant enzymes (superoxide dismutases and catalase) and prevents the stimulation of the expression of pro-inflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2, and interleukin (IL) IL-6 and IL-33). Hydrogen Peroxide 37-42 neuroglobin Mus musculus 15-18 27787886-7 2017 Moreover, Ngb blocks the stimulation of Bax (pro-apoptotic) and the inhibition of Bcl-2 (anti-apoptotic) gene expression induced by H2 O2 , which in turn abolishes caspase 3 activation. Hydrogen Peroxide 132-137 neuroglobin Mus musculus 10-13 27787886-8 2017 The protective effect of Ngb upon H2 O2 induced activation of caspase 3 activity and cell death can be accounted for by activation of protein kinase A and mitogen-activated protein kinase transduction cascade. Hydrogen Peroxide 34-39 neuroglobin Mus musculus 25-28 27787886-9 2017 Finally, we demonstrate that Ngb increases Akt phosphorylation and prevents H2 O2 -provoked inhibition of ERK and Akt phosphorylation. Hydrogen Peroxide 76-81 neuroglobin Mus musculus 29-32 27787886-10 2017 Taken together, these data demonstrate for the first time that Ngb is a glioprotective agent that prevents H2 O2 -induced oxidative stress and apoptotic astroglial cell death. Hydrogen Peroxide 107-112 neuroglobin Mus musculus 63-66 19574997-9 2009 A WST-8 assay demonstrated that viability was significantly decreased in N2a/Ngb-siRNA cells and N2a cells transiently transfected with Ngb-siRNA plasmids compared with controls following hydrogen peroxide treatment. Hydrogen Peroxide 188-205 neuroglobin Mus musculus 136-139 19574997-10 2009 An LDH assay demonstrated a time-dependent increase in the death of Ngb-siRNA-transfected N2a cells following hydrogen peroxide treatment. Hydrogen Peroxide 110-127 neuroglobin Mus musculus 68-71 19574997-11 2009 Hoechst staining demonstrated that the quantity of apoptotic cells among N2a/Ngb-siRNA cells following hydrogen peroxide treatment significantly increased compared with controls. Hydrogen Peroxide 103-120 neuroglobin Mus musculus 77-80 19574997-13 2009 Transfection of 14-3-3gamma plasmids significantly enhanced the viability of N2a/Ngb-siRNA cells following hydrogen peroxide treatment compared with vector controls. Hydrogen Peroxide 107-124 neuroglobin Mus musculus 81-84 17286577-7 2007 In eyes, the negative correlation, after reoxygenation, between neuroglobin protein level and H(2)O(2) concentration is a first proof of a reactive oxygen species-scavenging function for neuroglobin. Hydrogen Peroxide 94-102 neuroglobin Mus musculus 64-75 17286577-7 2007 In eyes, the negative correlation, after reoxygenation, between neuroglobin protein level and H(2)O(2) concentration is a first proof of a reactive oxygen species-scavenging function for neuroglobin. Hydrogen Peroxide 94-102 neuroglobin Mus musculus 187-198