PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29914565-17 2018 By using inverse polymerase chain reaction (IPCR), we demonstrated that hydrogen peroxide (H2O2)-induced apoptosis in normal nasopharyngeal epithelial and NPC cells led to chromosomal breakages within the ABL BCR that contains a MAR/SAR. Hydrogen Peroxide 72-89 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 205-208 32792487-8 2020 Subsequently, Pyk2 acted as a scaffold for c-Abl phosphorylating the catalytic domain of NOX5 Tyr476/478 sites, which in turn upregulated hydrogen peroxide (H2O2) inside the Pyk2/NOX5 complex to oxidize and activate local Src. Hydrogen Peroxide 138-155 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 43-48 32792487-8 2020 Subsequently, Pyk2 acted as a scaffold for c-Abl phosphorylating the catalytic domain of NOX5 Tyr476/478 sites, which in turn upregulated hydrogen peroxide (H2O2) inside the Pyk2/NOX5 complex to oxidize and activate local Src. Hydrogen Peroxide 157-161 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 43-48 29914565-17 2018 By using inverse polymerase chain reaction (IPCR), we demonstrated that hydrogen peroxide (H2O2)-induced apoptosis in normal nasopharyngeal epithelial and NPC cells led to chromosomal breakages within the ABL BCR that contains a MAR/SAR. Hydrogen Peroxide 91-95 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 205-208 24012954-2 2013 Here, we investigated the changes of protein profile in H2O2-induced DNA damage/repair in BaF3-MIGR1 and BaF3-BCR/ABL cells through a proteomic strategy consisting of two-dimensional gel electrophoresis (2-DE) coupled with MALDI-TOF mass spectrometry. Hydrogen Peroxide 56-60 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 110-117 24464935-2 2014 We previously found that H2O2-induced death of astrocytes is mediated by cAbl in a metallothionein-3 (Mt3)-dependent manner. Hydrogen Peroxide 25-29 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 73-77 24464935-6 2014 STI571, an inhibitor of cAbl, blocked induction/activation of Mst1 and H2O2-induced cell death. Hydrogen Peroxide 71-75 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 24-28 24550450-5 2014 ADP treatment promoted the H2O2-dependent phosphorylation of c-Abl, a nonreceptor tyrosine kinase that modulates the actin cytoskeleton. Hydrogen Peroxide 27-31 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 61-66 24550450-7 2014 However, Rac1-dependent activation of AMP-activated protein kinase, the signaling phospholipid phosphatidylinositol-(4, 5)-bisphosphate, and the c-Abl-interacting protein CrkII are mediated by H2O2. Hydrogen Peroxide 193-197 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 145-150 26812110-0 2016 CR-LAAO antileukemic effect against Bcr-Abl(+) cells is mediated by apoptosis and hydrogen peroxide. Hydrogen Peroxide 82-99 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 36-43 24012954-6 2013 We also proved that Apg-2 inhibition aggravated H2O2 induced damage in BCR/ABL positive cells, and enhanced the sensitivity of BaF3-BCR/ABL(T315I) to STI571. Hydrogen Peroxide 48-52 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 71-78 18490454-9 2008 Our results show that c-Abl and Cdk5 cooperatively regulate maximal activation of p53, resulting in neuronal death in response to oxidative stress by hydrogen peroxide. Hydrogen Peroxide 150-167 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 22-27 22773836-12 2012 These studies establish a critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl. Hydrogen Peroxide 44-52 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 182-187 22291013-5 2012 Consistent with our previous overexpression studies, we found that H(2)O(2)-induced superoxide production by primary sperm cells was mediated by the non-receptor tyrosine kinase c-Abl. Hydrogen Peroxide 67-75 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 178-183 19153832-2 2009 Bcr-Abl kinase stimulates the production of H(2)O(2), which in turn activates Abl kinase. Hydrogen Peroxide 44-52 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 0-7 23723070-8 2013 Pretreatment with specific c-Abl inhibitor, imatinib mesylate, and knock down of c-Abl significantly decreased the caveolin-1 phosphorylation after H2O2 exposure and abolished the inhibitory effect of AICAR on the caveolin-1 phosphorylation. Hydrogen Peroxide 148-152 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 27-32 23723070-8 2013 Pretreatment with specific c-Abl inhibitor, imatinib mesylate, and knock down of c-Abl significantly decreased the caveolin-1 phosphorylation after H2O2 exposure and abolished the inhibitory effect of AICAR on the caveolin-1 phosphorylation. Hydrogen Peroxide 148-152 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 81-86 20043988-0 2010 Regulation of phagocyte NADPH oxidase by hydrogen peroxide through a Ca(2+)/c-Abl signaling pathway. Hydrogen Peroxide 41-58 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 76-81 20043988-7 2010 In conclusion, H(2)O(2) stimulates NOX2-mediated superoxide generation in neutrophils and K562/NOX2 cells via a signaling pathway involving Ca(2+) influx and c-Abl tyrosine kinase acting upstream of PKCdelta. Hydrogen Peroxide 15-23 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 158-163 18160052-8 2008 Furthermore, H(2)O(2)-induced NOX5 activity correlated with increased localization of c-Abl to the membrane fraction, and NOX5 proteins could be coimmunoprecipitated with GFP-Abl proteins. Hydrogen Peroxide 13-21 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 86-91 17112510-4 2007 The biological significance of the Shb/c-Abl interaction was presently tested in overexpression experiments and was found to promote hydrogen peroxide-induced cell death. Hydrogen Peroxide 133-150 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 39-44 17126298-2 2007 We found that c-Abl phosphorylated PKCdelta on tyrosine 311 in response to H2O2 and that this phosphorylation contributed to the apoptotic effect of H2O2. Hydrogen Peroxide 75-79 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 14-19 17126298-2 2007 We found that c-Abl phosphorylated PKCdelta on tyrosine 311 in response to H2O2 and that this phosphorylation contributed to the apoptotic effect of H2O2. Hydrogen Peroxide 149-153 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 14-19 17030193-0 2006 Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells. Hydrogen Peroxide 36-40 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 50-55 17626041-6 2007 c-Abl-dependent phosphorylation of CSB increased in cells treated with hydrogen peroxide and decreased in cells pre-treated with STI-571, a c-Abl-specific protein kinase inhibitor. Hydrogen Peroxide 71-88 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 0-5 17030193-9 2006 CONCLUSIONS: Our results showed that the induction of collagen expression by AcCHO in stellate cells is dependent on PPARgamma phosphorylation induced by a hydrogen peroxide-mediated activation of the profibrogenic c-Abl signaling pathway. Hydrogen Peroxide 156-173 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 215-220 12777400-3 2003 This work demonstrates that catalase, a major effector of the cellular defense against H2O2, interacts with c-Abl and Arg. Hydrogen Peroxide 87-91 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 108-113 15548364-3 2004 Using a p73-specific antibody, we confirmed that c-Abl is required for cisplatin-induced p73 upregulation, and further demonstrate that the p73 protein is upregulated by UV irradiation and other stress stimuli including sorbitol, hydrogen peroxide, nocodazol, and taxol. Hydrogen Peroxide 230-247 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 49-54 12527798-5 2003 Immunofluorescence microscopy and subcellular fractionation studies demonstrate that STI571 decreases H(2)O(2)-induced targeting of c-Abl to mitochondria in the two cell types by 59 to 85%. Hydrogen Peroxide 102-110 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 132-137 12777400-4 2003 The results show that H2O2 induced binding of c-Abl and Arg to catalase. Hydrogen Peroxide 22-26 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 46-51 12777400-6 2003 c-Abl and Arg phosphorylated catalase at Tyr231 and Tyr386 in vitro and in the response of cells to H2O2. Hydrogen Peroxide 100-104 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 0-5 12777400-7 2003 The functional significance of the interaction is supported by the demonstration that cells deficient in both c-Abl and Arg exhibit substantial increases in H2O2 levels. Hydrogen Peroxide 157-161 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 110-115 12777400-8 2003 In addition, c-abl-/- arg-/- cells exhibited a marked increase in H2O2-induced apoptosis compared with that found in the absence of either kinase. Hydrogen Peroxide 66-70 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 13-18 10833515-5 2000 To understand the significance of increased production of ROS, a model system was established in which hydrogen peroxide (H(2)O(2)) was added to untransformed cells to mimic the increase in ROS induced constitutively by BCR/ABL. Hydrogen Peroxide 103-120 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 220-227 10833515-7 2000 Further, stimulation of untransformed cells with H(2)O(2) or pervanadate increased tyrosine phosphorylation of each of the most prominent known substrates of BCR/ABL, including c-ABL, c-CBL, SHC, and SHP-2. Hydrogen Peroxide 49-57 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 158-165 10833515-7 2000 Further, stimulation of untransformed cells with H(2)O(2) or pervanadate increased tyrosine phosphorylation of each of the most prominent known substrates of BCR/ABL, including c-ABL, c-CBL, SHC, and SHP-2. Hydrogen Peroxide 49-57 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 177-182 10833515-9 2000 Further, treatment of MO7e cells with H(2)O(2) or pervanadate increased the tyrosine kinase activity of c-ABL. Hydrogen Peroxide 38-46 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 104-109 10770918-4 2000 The results also demonstrate that mitochondrial cytochrome c is released in the cellular response to H(2)O(2) and that this effect is mediated by a c-Abl-dependent mechanism. Hydrogen Peroxide 101-109 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 148-153 10770918-5 2000 In concert with these results, we show that H(2)O(2)-induced apoptosis is attenuated in c-Abl-deficient cells. Hydrogen Peroxide 44-52 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 88-93 10713049-2 2000 The present studies demonstrate that treatment of cells with hydrogen peroxide (H(2)O(2)) induces binding of the PKCdelta isoform and the c-Abl protein-tyrosine kinase. Hydrogen Peroxide 61-78 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 138-143 10713049-2 2000 The present studies demonstrate that treatment of cells with hydrogen peroxide (H(2)O(2)) induces binding of the PKCdelta isoform and the c-Abl protein-tyrosine kinase. Hydrogen Peroxide 80-88 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 138-143 10713049-5 2000 In cells, induction of c-Abl activity by H(2)O(2) is attenuated by the PKCdelta inhibitor, rottlerin, and by overexpression of the regulatory domain of PKCdelta. Hydrogen Peroxide 41-49 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 23-28 33181128-14 2021 Dual inhibition of SRC/ABL blocked activation of both pathways upon SHIP2 inhibition and H2O2 treatment. Hydrogen Peroxide 89-93 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 23-26