PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35506157-5 2022 Moreover, GAA also suppressed H2O2 induced major matrix degrading proteases (MMP-3, MMP-13, ADAMTS4 and ADAMTS5) associated with NP degradation. Hydrogen Peroxide 30-34 ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens 104-111 26337541-7 2015 H2O2-senescent cells were found to possess a catabolic phenotype, mainly characterised by the up-regulation of extracellular matrix-degrading enzymes (MMP-1, -2, -9 and ADAMTS-5) and the down-regulation of their inhibitors (TIMPs), as well as of several proteoglycans, including aggrecan, the major component of the nucleus pulposus. Hydrogen Peroxide 0-4 ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens 169-177 29520849-5 2018 H19 could accelerate H2 O2 -induced degenerative changes by promoting cell senescence, increasing ADAMTS-5 and MMPs protein levels and Collagen I content, as well as suppressing NPC proliferation through activating Wnt/beta-catenin signaling. Hydrogen Peroxide 21-26 ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens 98-106