PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18568953-7 2008 H(2)O(2) enhanced PZR tyrosine phosphorylation and PZR/SHP-2 interaction in ECs in a dose-and time-dependent manner. Hydrogen Peroxide 0-8 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 55-60 29408202-0 2018 Resolvin D1 blocks H2O2-mediated inhibitory crosstalk between SHP2 and PP2A and suppresses endothelial-monocyte interactions. Hydrogen Peroxide 19-23 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 62-66 12893640-3 2003 The recent demonstration that PECAM-1 tyrosine phosphorylation occurs in cells exposed to the reactive oxygen species hydrogen peroxide (H2O2) suggested that this form of oxidative stress may also support PECAM-1/SHP-2 complex formation. Hydrogen Peroxide 137-141 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 213-218 12893640-4 2003 In the present study, we show that PECAM-1 tyrosine phosphorylation in response to exposure of cells to H2O2 is reversible, involves a shift in the balance between kinase and phosphatase activities, and supports binding of SHP-2 and recruitment of this phosphatase to cell-cell borders. Hydrogen Peroxide 104-108 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 223-228 12893640-5 2003 We speculate, however, that the unique ability of H2O2 to reversibly oxidize the reactive site cysteine residues of protein tyrosine phosphatases may result in transient inactivation of the SHP-2 that is bound to PECAM-1 under these conditions. Hydrogen Peroxide 50-54 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 190-195 12893640-6 2003 Finally, we provide evidence that PECAM-1 tyrosine phosphorylation and SHP-2 binding in endothelial cells requires exposure to an "oxidative burst" of H2O2, but that exposure of these cells to sufficiently high concentrations of H2O2 for a sufficiently long period of time abrogates binding of SHP-2 to tyrosine-phosphorylated PECAM-1. Hydrogen Peroxide 151-155 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 71-76 12893640-6 2003 Finally, we provide evidence that PECAM-1 tyrosine phosphorylation and SHP-2 binding in endothelial cells requires exposure to an "oxidative burst" of H2O2, but that exposure of these cells to sufficiently high concentrations of H2O2 for a sufficiently long period of time abrogates binding of SHP-2 to tyrosine-phosphorylated PECAM-1. Hydrogen Peroxide 229-233 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 71-76 15556604-1 2004 Here, we examined whether catalase binds SHP2 and alters SHP2 susceptibility to H2O2. Hydrogen Peroxide 80-84 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 57-61 15556604-3 2004 Expression of active catalase nearly 15-fold over control levels in tet-off HeLa cells substantially increased the SHP2 binding, and the catalase-associated SHP2 displayed significantly high phosphatase activities with a H2O2-resistance compared to those with little catalase. Hydrogen Peroxide 221-225 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 157-161 15556604-5 2004 These results suggest that catalase-280pYIQV binds SHP2 via integrin-signaling to increase a H2O2-resistant SHP2 activity. Hydrogen Peroxide 93-97 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 51-55 15556604-5 2004 These results suggest that catalase-280pYIQV binds SHP2 via integrin-signaling to increase a H2O2-resistant SHP2 activity. Hydrogen Peroxide 93-97 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 108-112 10833515-7 2000 Further, stimulation of untransformed cells with H(2)O(2) or pervanadate increased tyrosine phosphorylation of each of the most prominent known substrates of BCR/ABL, including c-ABL, c-CBL, SHC, and SHP-2. Hydrogen Peroxide 49-57 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 200-205 29408202-3 2018 In addition, we found that H2O2-mediated SHP2 inhibition leads to tyrosine phosphorylation and inactivation of PP2A by LPS, which in turn, accounts for increased NFkappaB activation and ICAM1 and VCAM1 expression facilitating EC-monocyte interactions and all these LPS-mediated responses were reduced by RvD1. Hydrogen Peroxide 27-31 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 41-45 29408202-6 2018 Together, these observations suggest that RvD1 via activation of Gi-coupled ALX/FPR2 and GPR32 receptors blocks LPS-induced H2O2-mediated SHP2 and PP2A inactivation, NFkappaB activation, ICAM1 and VCAM1 expression and EC-monocyte interactions, which could be one of the several possible mechanisms underlying the anti-inflammatory actions of this specialized proresolving mediator. Hydrogen Peroxide 124-128 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 138-142 25672415-5 2015 Moreover, deletion of the N-SH2 domain of SHP-2 affected H2O2-mediated ERK phosphorylation and Src phosphorylation at Tyr 419 in primary astrocytes, suggesting that N-SH2 domain of SHP-2 is responsible for the binding of caveolin-1 and contributes to the regulation of Src phosphorylation and activation following ROS-induced oxidative stress in brain astrocytes. Hydrogen Peroxide 57-61 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 42-47 25672415-5 2015 Moreover, deletion of the N-SH2 domain of SHP-2 affected H2O2-mediated ERK phosphorylation and Src phosphorylation at Tyr 419 in primary astrocytes, suggesting that N-SH2 domain of SHP-2 is responsible for the binding of caveolin-1 and contributes to the regulation of Src phosphorylation and activation following ROS-induced oxidative stress in brain astrocytes. Hydrogen Peroxide 57-61 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 181-186 25325054-8 2014 Finally, equations were successfully tested with real data taken from published experiments that describe redox signaling mediated by the oxidation of two protein tyrosine phosphatases, PTP1B and SHP-2, which are two of the few H2O2-sensing proteins with known kinetic parameters. Hydrogen Peroxide 228-232 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 196-201 25325054-9 2014 Whereas for PTP1B estimated kinetic parameters fitted in general the present knowledge, for SHP-2 results obtained suggest that reactivity toward H2O2 as well as the rate of SHP-2 regeneration back to its reduced form are higher than previously thought. Hydrogen Peroxide 146-150 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 92-97 24632723-7 2014 Our results collectively indicate that SHP-2 alters Src kinase activity by interfering with the complex formation between CSK and phosphotyrosine caveolin-1 in the presence of H2O2, thus functions as a positive regulator in Src signaling under oxidative stress in brain astrocytes. Hydrogen Peroxide 176-180 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 39-44 18829466-10 2008 Overexpression of Shp-2 wt inhibited H2O2-induced export of TERT. Hydrogen Peroxide 37-41 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 18-23 24632723-0 2014 SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. Hydrogen Peroxide 102-106 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 0-5 24632723-2 2014 Here, we report the role of caveolin-1 and Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP-2) in H2O2-induced signaling pathway in brain astrocytes. Hydrogen Peroxide 118-122 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 108-113 24632723-3 2014 H2O2-mediated oxidative stress induced phosphorylation of caveolin-1 and association between p-caveolin-1 and SHP-2. Hydrogen Peroxide 0-4 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 110-115 24632723-5 2014 In the presence of CSK siRNA, binding between caveolin-1 and SHP-2 was enhanced by H2O2 treatment, which led to reduced Src phosphorylation at tyrosine (Tyr) 530 and enhanced Src phosphorylation at Tyr 419. Hydrogen Peroxide 83-87 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 61-66 24632723-6 2014 In contrast, siRNA targeting of SHP-2 facilitated H2O2-mediated interaction between caveolin-1 and CSK and enhanced Src phosphorylation at Tyr 530, leading to subsequent decrease in Src downstream signaling, such as focal adhesion kinase (FAK) and extracellular signal-related kinase (ERK). Hydrogen Peroxide 50-54 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 32-37 23582017-4 2013 Herein, we examined whether H2 O2 could induce MUC5AC transcription in a dose-dependent manner and activate tyrosine phosphatase (SHP)-2 in human airway epithelial cells. Hydrogen Peroxide 28-33 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 108-136 23582017-6 2013 RESULTS: H2 O2 induced MUC5AC transcription in a dose-dependent manner and dramatically activated SHP-2. Hydrogen Peroxide 9-14 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 98-103 23582017-7 2013 In addition, whereas wild-type SHP-2 completely inhibited H2 O2 -induced MUC5AC transcription, siRNA-SHP-2 restored it interestingly, suggesting that SHP-2 may act as a negative regulator for mucus overproduction and hypersecretion in the human respiratory tract. Hydrogen Peroxide 58-63 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 31-36 23582017-9 2013 CONCLUSION: We found that H2 O2 induced SHP-2 activation, which acted as a suppressor in H2 O2 signalling to regulate MUC5AC transcription in the airway. Hydrogen Peroxide 26-31 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 40-45 23582017-9 2013 CONCLUSION: We found that H2 O2 induced SHP-2 activation, which acted as a suppressor in H2 O2 signalling to regulate MUC5AC transcription in the airway. Hydrogen Peroxide 89-94 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 40-45 21918362-6 2011 To examine whether the H2O2-dependent phosphorylation of SHP-2 is mediated by caveolin-1, we used specific small interfering RNA (siRNA) to downregulate caveolin- 1 expression. Hydrogen Peroxide 23-27 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 57-62 21918362-7 2011 In the presence of caveolin-1 siRNA, the level of SHP-2 phosphorylation induced by H2O2 was significantly decreased, compared with in the presence of control siRNA. Hydrogen Peroxide 83-87 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 50-55 21918362-8 2011 Overexpression of caveolin- 1 effectively increased H2O2-induced SHP-2 phosphorylation in microglia. Hydrogen Peroxide 52-56 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 65-70