PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34737813-0	2021	Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells.	Hydrogen Peroxide	26-43	kelch-like ECH-associated protein 1	Mus musculus	110-115	
34229586-8	2021	Furthermore, overexpression of miR-141-3p ameliorated the cytotoxic effects of H2O2 on NP cells, which were abrogated by upregulating Keap1 and silencing Nrf2.	Hydrogen Peroxide	79-83	kelch-like ECH-associated protein 1	Mus musculus	134-139	
34628205-3	2021	Results showed that OS-LL11 could directly scavenge free radicals and sustain the viability of mouse keratinocytes challenged by ultraviolet B (UVB) irradiation or hydrogen peroxide (H2O2) by decreasing the levels of lipid peroxidation, malondialdehyde, and reactive oxygen species while increasing the level of catalase, Keap-1, HO-1, GCLM, and NQO1.	Hydrogen Peroxide	164-181	kelch-like ECH-associated protein 1	Mus musculus	322-328	
34628205-3	2021	Results showed that OS-LL11 could directly scavenge free radicals and sustain the viability of mouse keratinocytes challenged by ultraviolet B (UVB) irradiation or hydrogen peroxide (H2O2) by decreasing the levels of lipid peroxidation, malondialdehyde, and reactive oxygen species while increasing the level of catalase, Keap-1, HO-1, GCLM, and NQO1.	Hydrogen Peroxide	183-187	kelch-like ECH-associated protein 1	Mus musculus	322-328	
31315052-4	2019	Our analyses of multiple mutant mice lines, complemented by MEFs expressing a series of Keap1 mutants, reveal that Keap1 uses the cysteine residues redundantly to set up an elaborate fail-safe mechanism in which specific combinations of these four cysteine residues can form a disulfide bond to sense hydrogen peroxide.	Hydrogen Peroxide	301-318	kelch-like ECH-associated protein 1	Mus musculus	115-120	
35368107-6	2022	Furthermore, the trends of Nrf2, Keap1, p-ERK, p-JNK, p-p38, p-PI3K, and p-AKT levels in H2 O2 -induced RAW264.7 cells after AMP treatment were similar to the results in CCl4 -induced mice liver.	Hydrogen Peroxide	89-94	kelch-like ECH-associated protein 1	Mus musculus	33-38	
33197602-9	2021	Furthermore, overexpression of Keap1 and beta-cateninin in H2O2-treated NMVCs with recovered miR-200a elevated inflammation and apoptosis, respectively.	Hydrogen Peroxide	59-63	kelch-like ECH-associated protein 1	Mus musculus	31-36	
33197602-10	2021	CONCLUSION: The results showed that miR-200a expression was inhibited in murine cardiomyocytes due to H2O2 stress in MI cardiac tissues and overexpressed miR-200a could protect the cells from death by regulating the Keap1/Nrf2 and beta-catenin signal transduction pathways.	Hydrogen Peroxide	102-106	kelch-like ECH-associated protein 1	Mus musculus	216-221	
34226516-0	2021	A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts.	Hydrogen Peroxide	72-89	kelch-like ECH-associated protein 1	Mus musculus	8-13	
35605295-8	2022	In the MI cell model, low concentrations of DEX attenuated the H2O2-induced decreases in cell viability and antioxidative enzyme levels and activated the Keap1/Nrf2/HO-1 pathway.	Hydrogen Peroxide	63-67	kelch-like ECH-associated protein 1	Mus musculus	154-159	
33298178-10	2020	The autophagy/Keap1/Nrf2 signal in H2O2-treated BM-MSC/sh-Mst1 was also measured.	Hydrogen Peroxide	35-39	kelch-like ECH-associated protein 1	Mus musculus	14-19	
33197602-4	2021	METHODS: We observed down-regulation of miR-200a levels and up-regulation of Keap1 and beta-catenin levels in H2O2-treated newborn murine ventricular cardiomyocytes (NMVCs) and the infarcted heart tissues of MI mouse models, compared to the non-treated NMVCs and normal heart tissues of healthy mice.	Hydrogen Peroxide	110-114	kelch-like ECH-associated protein 1	Mus musculus	77-82	
33197602-8	2021	Moreover, miR-200a inhibited up-regulation of Keap1 and beta-catenin expression in H2O2-treated NMVCs by directly binding with the 3"-UTR regions of both Keap1 and beta-catenin.	Hydrogen Peroxide	83-87	kelch-like ECH-associated protein 1	Mus musculus	46-51	
33197602-8	2021	Moreover, miR-200a inhibited up-regulation of Keap1 and beta-catenin expression in H2O2-treated NMVCs by directly binding with the 3"-UTR regions of both Keap1 and beta-catenin.	Hydrogen Peroxide	83-87	kelch-like ECH-associated protein 1	Mus musculus	154-159	
29959995-4	2018	Our findings suggested that Ori exposure effectively alleviated H2O2-stimulated cytotoxicity, inhibited reactive oxygen species (ROS) generation, and glutathione (GSH) depletion, which were involved in induction of heme oxygenase-1 (HO-1) by enhancing the nuclear factor-erythroid 2-related factor 2 (Nrf2) translocation, decreasing the Keap1 protein expression, and increasing the antioxidant response element (ARE) activity.	Hydrogen Peroxide	64-68	kelch-like ECH-associated protein 1	Mus musculus	337-342	
29455993-4	2018	In addition, ORP treatment could improve survival capacity of H2O2-induced TM4 cells and its antioxidant mechanism in vitro also had been verified to activate Keap1-Nrf2/ARE signaling pathway.	Hydrogen Peroxide	62-66	kelch-like ECH-associated protein 1	Mus musculus	159-164	
29285281-7	2017	Meanwhile, Keap1 shRNA took over MIND4-17"s actions and protected OB-6 cells from H2O2.	Hydrogen Peroxide	82-86	kelch-like ECH-associated protein 1	Mus musculus	11-16