PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18275859-5	2008	We further show that Pten deletion is correlated with resistance to H2O2-induced expression of several antioxidants.	Hydrogen Peroxide	68-72	phosphatase and tensin homolog	Mus musculus	21-25	
19885556-6	2009	When NIH3T3 cells were treated with H2O2, oxidation of C106 of wt-DJ-1 occurred, accompanied by increased binding of wt-DJ-1 to PTEN, decreased PTEN activity and increased phosphorylation of AKT.	Hydrogen Peroxide	36-40	phosphatase and tensin homolog	Mus musculus	128-132	
19885556-6	2009	When NIH3T3 cells were treated with H2O2, oxidation of C106 of wt-DJ-1 occurred, accompanied by increased binding of wt-DJ-1 to PTEN, decreased PTEN activity and increased phosphorylation of AKT.	Hydrogen Peroxide	36-40	phosphatase and tensin homolog	Mus musculus	144-148	
18620044-5	2008	This compound inhibited LPS- and H(2)O(2)-induced increases in phosphatidylinositol 3-kinase (PI3K) activity, PTEN inactivation, NF-kappaB-inducing kinase (NIK), and Akt phosphorylation, which are all upstream of IKK activation, but did not affect the interaction between Toll-like receptor 4 and MyD88 and the activation of mitogen-activated protein kinases.	Hydrogen Peroxide	33-41	phosphatase and tensin homolog	Mus musculus	110-114	
18620044-8	2008	Our data suggest that H(2)O(2) modulates IKK-dependent NF-kappaB activation by promoting the redox-sensitive activation of the PI3K/PTEN/Akt and NIK/IKK pathways.	Hydrogen Peroxide	22-30	phosphatase and tensin homolog	Mus musculus	132-136	
18275859-4	2008	In these Pten-deleted MEFs, the basal levels of reactive oxygen species (ROS) were increased, and both the basal level and the ROS-induced oxidative damage of DNA were increased, as evidenced by increased levels of hydrogen peroxide (H2O2), superoxide anion, 8-hydroxy-2"-deoxyguanosine, and DNA double-strand breaks.	Hydrogen Peroxide	215-232	phosphatase and tensin homolog	Mus musculus	9-13	
18275859-4	2008	In these Pten-deleted MEFs, the basal levels of reactive oxygen species (ROS) were increased, and both the basal level and the ROS-induced oxidative damage of DNA were increased, as evidenced by increased levels of hydrogen peroxide (H2O2), superoxide anion, 8-hydroxy-2"-deoxyguanosine, and DNA double-strand breaks.	Hydrogen Peroxide	234-238	phosphatase and tensin homolog	Mus musculus	9-13	
19035120-7	2008	The phosphorylation level of Akt kinase was up-regulated and the antiproliferative effect of H2O2 decreased in PTEN-/- cells.	Hydrogen Peroxide	93-97	phosphatase and tensin homolog	Mus musculus	111-115	
19035120-8	2008	Furthermore, DNA damage was observed significantly severer in both the blank control and H2O2 treated groups than that in the PTEN+/+ cells.	Hydrogen Peroxide	89-93	phosphatase and tensin homolog	Mus musculus	126-130	
32650805-0	2020	MiR-708 inhibits MC3T3-E1 cells against H2O2-induced apoptosis through targeting PTEN.	Hydrogen Peroxide	40-44	phosphatase and tensin homolog	Mus musculus	81-85	
33993982-6	2021	Conversely, the upregulation of phosphatase and tensin homolog (PTEN) was observed in H2O2-treated NMVCs, and in infarcted hearts.	Hydrogen Peroxide	86-90	phosphatase and tensin homolog	Mus musculus	32-62	
33993982-6	2021	Conversely, the upregulation of phosphatase and tensin homolog (PTEN) was observed in H2O2-treated NMVCs, and in infarcted hearts.	Hydrogen Peroxide	86-90	phosphatase and tensin homolog	Mus musculus	64-68	
33993982-9	2021	Besides, miR-26a overexpression suppressed the upregulation of PTEN expression in H2O2-treated NMVCs by directly binding to PTEN 3"-UTR.	Hydrogen Peroxide	82-86	phosphatase and tensin homolog	Mus musculus	63-67	
33993982-9	2021	Besides, miR-26a overexpression suppressed the upregulation of PTEN expression in H2O2-treated NMVCs by directly binding to PTEN 3"-UTR.	Hydrogen Peroxide	82-86	phosphatase and tensin homolog	Mus musculus	124-128	
32650805-9	2020	Furthermore, we small interfering RNA of PTEN to identify the role of PTEN in H2O2-induced apoptosis of MC3T3-E1 cells.	Hydrogen Peroxide	78-82	phosphatase and tensin homolog	Mus musculus	41-45	
32650805-9	2020	Furthermore, we small interfering RNA of PTEN to identify the role of PTEN in H2O2-induced apoptosis of MC3T3-E1 cells.	Hydrogen Peroxide	78-82	phosphatase and tensin homolog	Mus musculus	70-74	
32650805-14	2020	CONCLUSIONS: miR-708 plays a protective role in H2O2-induced MC3T3-E1 osteoblasts apoptosis and its protective effect is proceeded by regulating ROS level and PTEN expression level.	Hydrogen Peroxide	48-52	phosphatase and tensin homolog	Mus musculus	159-163	
31351995-6	2019	Importantly, the moderate induction of H2O2 in livers dramatically improved the hepatic PI3K-C1/AKT signaling or dampened PI3K-C2gamma/AKT signaling through suppression of PTEN and PTP1B activities, thereby inhibiting the hepatic expression of HMGCR and SREBP2 for cholesterol synthesis.	Hydrogen Peroxide	39-43	phosphatase and tensin homolog	Mus musculus	172-176