PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22413812-13 2012 The H2O2 augmented IFNgamma induced IL-32 mRNA expression was suppressed by a JNK inhibitor, but not by MEK inhibitor, p38 inhibitor, and JAK inhibitor I. Hydrogen Peroxide 4-8 mitogen-activated protein kinase 8 Homo sapiens 78-81 21272161-7 2011 Activation of extracellular regulated kinases (ERK), p38, c-Jun N-terminal kinase (JNK) and Akt was observed after treatment of hydrogen peroxide. Hydrogen Peroxide 128-145 mitogen-activated protein kinase 8 Homo sapiens 58-81 21822690-8 2012 This decreased activation of JNK-1 in stressed, contact-inhibited cells did not appear to be dependent upon increased expression of MKP-1; however, over-expression of MKP-1 was sufficient to result in a slight decrease in H2O2-stimulated PARP cleavage. Hydrogen Peroxide 222-226 mitogen-activated protein kinase 8 Homo sapiens 29-34 21822690-9 2012 Increasing the antioxidant capacity of fibroblasts through NAC-treatment not only lessened H2O2-stimulated JNK-1 activation, but also did not influence the expression of MKP-1. Hydrogen Peroxide 91-95 mitogen-activated protein kinase 8 Homo sapiens 107-112 21272161-7 2011 Activation of extracellular regulated kinases (ERK), p38, c-Jun N-terminal kinase (JNK) and Akt was observed after treatment of hydrogen peroxide. Hydrogen Peroxide 128-145 mitogen-activated protein kinase 8 Homo sapiens 83-86 21272161-8 2011 SP600125, an inhibitor of JNK, reversed the RARalpha protein level reduced by hydrogen peroxide. Hydrogen Peroxide 78-95 mitogen-activated protein kinase 8 Homo sapiens 26-29 21241762-0 2011 Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells. Hydrogen Peroxide 25-42 mitogen-activated protein kinase 8 Homo sapiens 94-97 21237235-9 2011 Furthermore, LJ significantly attenuated the H(2)O(2)-induced phosphorylation of Akt, JNK, p38 MAPK, and ERK1/2. Hydrogen Peroxide 45-53 mitogen-activated protein kinase 8 Homo sapiens 86-89 21241762-8 2011 Furthermore, pretreatment with loganin significantly attenuated the H(2)O(2)-induced phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase 1/2 (ERK 1/2). Hydrogen Peroxide 68-76 mitogen-activated protein kinase 8 Homo sapiens 129-132 21145826-8 2011 Moreover, menadione or 2,3-dimethoxy-1,4-naphthoquinone, which generate intracellular superoxide anion or hydrogen peroxide, respectively, induced ERK1/2 and JNK1/2 activation and migration. Hydrogen Peroxide 106-123 mitogen-activated protein kinase 8 Homo sapiens 158-162 21241762-9 2011 These results suggest that the protective effects of loganin against H(2)O(2)-induced apoptosis may be due to a decrease in the Bcl-2/Bax ratio expression due to the inhibition of the phosphorylation of JNK, p38, and ERK 1/2 MAPKs. Hydrogen Peroxide 69-77 mitogen-activated protein kinase 8 Homo sapiens 203-206 20965163-5 2011 Mechanistically, honokiol suppressed H(2)O(2)-induced phosphorylation of ERK1/2, p38 mitogen-activated protein kinase (MAPK), JNK and Akt. Hydrogen Peroxide 37-45 mitogen-activated protein kinase 8 Homo sapiens 126-129 21264233-10 2011 GSPE also depressed H2O2-induced phosphorylation of the p38 and c-Jun N-terminal kinase (JNK) proteins of the MAPK family at various time points studied. Hydrogen Peroxide 20-24 mitogen-activated protein kinase 8 Homo sapiens 64-87 21264233-10 2011 GSPE also depressed H2O2-induced phosphorylation of the p38 and c-Jun N-terminal kinase (JNK) proteins of the MAPK family at various time points studied. Hydrogen Peroxide 20-24 mitogen-activated protein kinase 8 Homo sapiens 89-92 21814482-6 2011 Moreover, H2O2-triggered MMP-7 production was demonstrated via JNK/c-Jun and ERK/c-Fos activation in an activating protein 1 (AP-1)-dependent manner. Hydrogen Peroxide 10-14 mitogen-activated protein kinase 8 Homo sapiens 63-66 22146720-9 2011 Taken together, these results indicate that mangiferin attenuated H(2)O(2)-induced MMP-1 activation via inhibition of ERK and JNK pathway and AP-1. Hydrogen Peroxide 66-74 mitogen-activated protein kinase 8 Homo sapiens 126-129 21814482-7 2011 Taken together, these results suggest that DMA suppresses H2O2-induced cell invasion by inhibiting AP-1-mediated MMP-7 gene transcription via the JNK/c-Jun and ERK/c-Fos signaling pathways in SW620 human colon cancer cells. Hydrogen Peroxide 58-62 mitogen-activated protein kinase 8 Homo sapiens 146-149 22164242-0 2011 Crosstalk between JNK and SUMO signaling pathways: deSUMOylation is protective against H2O2-induced cell injury. Hydrogen Peroxide 87-91 mitogen-activated protein kinase 8 Homo sapiens 18-21 21747713-6 2011 Taken together, the protective effects of butin against H(2)O(2)-induced apoptosis were exerted via blockade of membrane potential depolarization, inhibition of the JNK pathway and mitochondria-involved caspase-dependent apoptotic pathway. Hydrogen Peroxide 56-64 mitogen-activated protein kinase 8 Homo sapiens 165-168 22164242-5 2011 Our data show that H(2)O(2) modulates JNK activation and induces cellular death in neuroblastoma SH-SY5Y cells. Hydrogen Peroxide 19-27 mitogen-activated protein kinase 8 Homo sapiens 38-41 22102892-4 2011 Treatment with high concentrations of H2O2 (25-50 microM) for 3 h reduced insulin-stimulated Akt phosphorylation, and increased the phosphorylation of both JNK and its substrate c-Jun. Hydrogen Peroxide 38-42 mitogen-activated protein kinase 8 Homo sapiens 156-159 20674765-6 2010 In COS-7 or HEK 293A cells treated with H(2)O(2), expression of PPEF2 abrogated sustained activation of p38 and one of the JNK p46 isoforms, and prevented ASK1-dependent caspase-3 cleavage and activation. Hydrogen Peroxide 40-48 mitogen-activated protein kinase 8 Homo sapiens 123-126 22102892-6 2011 Moreover, lower concentrations suppressed PTP1B activity, suggesting that JNK and phosphatases such as PTP1B may play roles in determining the thresholds for the diametrical effects of H2O2 on cellular insulin signaling. Hydrogen Peroxide 185-189 mitogen-activated protein kinase 8 Homo sapiens 74-77 21814482-0 2011 Dimerumic acid inhibits SW620 cell invasion by attenuating H2O2-mediated MMP-7 expression via JNK/C-Jun and ERK/C-Fos activation in an AP-1-dependent manner. Hydrogen Peroxide 59-63 mitogen-activated protein kinase 8 Homo sapiens 94-97 21814482-4 2011 Our results showed that increased MMP-7 expression due to H2O2 exposure was mediated by activation of mitogen-activated protein kinases (MAPKs) such as Jun N-terminal kinase (JNK), extracellular-regulated kinase (ERK), and p38 kinase. Hydrogen Peroxide 58-62 mitogen-activated protein kinase 8 Homo sapiens 152-173 21814482-4 2011 Our results showed that increased MMP-7 expression due to H2O2 exposure was mediated by activation of mitogen-activated protein kinases (MAPKs) such as Jun N-terminal kinase (JNK), extracellular-regulated kinase (ERK), and p38 kinase. Hydrogen Peroxide 58-62 mitogen-activated protein kinase 8 Homo sapiens 175-178 20806083-10 2010 Further studies showed that RES also inhibited H(2)O(2) induced p38 and JNK phosphorylation. Hydrogen Peroxide 47-55 mitogen-activated protein kinase 8 Homo sapiens 72-75 20665666-0 2010 Apoptosis of mesenchymal stem cells induced by hydrogen peroxide concerns both endoplasmic reticulum stress and mitochondrial death pathway through regulation of caspases, p38 and JNK. Hydrogen Peroxide 47-64 mitogen-activated protein kinase 8 Homo sapiens 180-183 20623534-7 2010 Cultures exposed to H(2)O(2) caused the activation of MAPKs (ERK1/2, JNK and p38-MAPK), whereas inhibition of MAPKs diminished cell swelling induced by 10 and 25 microM H(2)O(2). Hydrogen Peroxide 20-28 mitogen-activated protein kinase 8 Homo sapiens 69-72 20653470-0 2010 N-acetylcysteine protects alveolar epithelial cells from hydrogen peroxide-induced apoptosis through scavenging reactive oxygen species and suppressing c-Jun N-terminal kinase. Hydrogen Peroxide 57-74 mitogen-activated protein kinase 8 Homo sapiens 152-175 20653470-6 2010 SP600125, a specific inhibitor of JNK, can partially block H(2)O(2)-induced alveolar type II epithelial cells (ATII cells). Hydrogen Peroxide 59-67 mitogen-activated protein kinase 8 Homo sapiens 34-37 20653470-10 2010 Taken together, H(2)O(2) can induce primary ATII cells apoptosis and increase JNK phosphorylation. Hydrogen Peroxide 16-24 mitogen-activated protein kinase 8 Homo sapiens 78-81 19655415-6 2009 Moreover, magnolol attenuated the deactivation of ERK/MAPK (extracellular signal-regulated kinase/mitogen activated protein kinase) and the enhanced activation of p38, JNK (c-Jun N-terminal kinase) induced by H2O2. Hydrogen Peroxide 209-213 mitogen-activated protein kinase 8 Homo sapiens 168-171 19560504-5 2009 Since H(2)O(2) is the main source of the highly reactive hydroxyl radical in the brain, and FeCl(2) can stimulate oxidative stress, including the formation of the hydroxyl radical from H(2)O(2), in the present work we studied the effect of these two pro-oxidant molecules on the levels and processing of human APP by alpha-, beta- and gamma-secretase, and the role of the stress-activated kinase c-jun N-terminal kinase (JNK). Hydrogen Peroxide 185-193 mitogen-activated protein kinase 8 Homo sapiens 396-419 19560504-5 2009 Since H(2)O(2) is the main source of the highly reactive hydroxyl radical in the brain, and FeCl(2) can stimulate oxidative stress, including the formation of the hydroxyl radical from H(2)O(2), in the present work we studied the effect of these two pro-oxidant molecules on the levels and processing of human APP by alpha-, beta- and gamma-secretase, and the role of the stress-activated kinase c-jun N-terminal kinase (JNK). Hydrogen Peroxide 185-193 mitogen-activated protein kinase 8 Homo sapiens 421-424 19604147-3 2009 H2O2-induced JNK (c-Jun N-terminal kinase) activation was greatly enhanced in shMST3 cells (a cell line treated with short hairpin RNA against MST3). Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 13-16 19604147-3 2009 H2O2-induced JNK (c-Jun N-terminal kinase) activation was greatly enhanced in shMST3 cells (a cell line treated with short hairpin RNA against MST3). Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 18-41 19604147-4 2009 Suppression of JNK activity by the inhibitor SP600125 or by dominant-negative JNK2 re-sensitized cells to H2O2. Hydrogen Peroxide 106-110 mitogen-activated protein kinase 8 Homo sapiens 15-18 19604147-8 2009 Our results reveal that H2O2-induced MST3-mediated cell death involves suppressing both a JNK survival pathway and up-regulation of HO-1. Hydrogen Peroxide 24-28 mitogen-activated protein kinase 8 Homo sapiens 90-93 19223550-7 2009 These data show that JNK and ERK are two crucial players involved in H(2)O(2)-mediated increase in TRAIL sensitization of tumor cells upon exposure to LY30 and underscore a novel mode of action of this inactive analogue of LY29. Hydrogen Peroxide 69-77 mitogen-activated protein kinase 8 Homo sapiens 21-24 18845647-4 2009 By contrast, we show that H(2)O(2) exposure activates FOXO3a in thyrocytes with JNK (MAPK8)-mediated nuclear accumulation of FOXO3a and increased expression of the cell cycle arrest genes p27kip and GADD45A. Hydrogen Peroxide 26-34 mitogen-activated protein kinase 8 Homo sapiens 80-83 18845647-4 2009 By contrast, we show that H(2)O(2) exposure activates FOXO3a in thyrocytes with JNK (MAPK8)-mediated nuclear accumulation of FOXO3a and increased expression of the cell cycle arrest genes p27kip and GADD45A. Hydrogen Peroxide 26-34 mitogen-activated protein kinase 8 Homo sapiens 85-90 20716281-6 2010 The activation of the JNK pathway by HNE and endogenously generated H(2)O(2) illustrates these principles. Hydrogen Peroxide 68-76 mitogen-activated protein kinase 8 Homo sapiens 22-25 20637099-8 2010 H2O2 treatment was then shown to stimulate the activities of DNA-dependent protein kinase (DNA-PK) and c-jun N-terminal kinase (JNK). Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 103-126 20637099-8 2010 H2O2 treatment was then shown to stimulate the activities of DNA-dependent protein kinase (DNA-PK) and c-jun N-terminal kinase (JNK). Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 128-131 19937141-7 2009 However, the suppression of H(2)O(2)-induced oxidative stress by either JNK inhibitor or c-Jun specific antisense transfection was temporary in the cells exposed to glucose oxidase but not to a bolus H(2)O(2). Hydrogen Peroxide 28-36 mitogen-activated protein kinase 8 Homo sapiens 72-75 18681908-0 2009 SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. Hydrogen Peroxide 42-46 mitogen-activated protein kinase 8 Homo sapiens 92-95 19414004-3 2009 It was found that H(2)O(2)-induced apoptotic cell death in SH-SY5Y cells, which was revealed in DNA fragmentation, mitochondrial membrane potential depolarization, and activation of Akt, c-Jun N-terminal kinases (JNK) and caspase 3. Hydrogen Peroxide 18-26 mitogen-activated protein kinase 8 Homo sapiens 213-216 19414004-4 2009 Low doses of EGb761 (50-100 microg/ml) inhibited H(2)O(2)-induced cell apoptosis via inactivation of Akt, JNK and caspase 3 while high doses of EGb761 (250-500 microg/ml) enhanced H(2)O(2) toxicities via inactivation of Akt and enhancement of activation of JNK and caspase 3. Hydrogen Peroxide 49-57 mitogen-activated protein kinase 8 Homo sapiens 106-109 19655415-6 2009 Moreover, magnolol attenuated the deactivation of ERK/MAPK (extracellular signal-regulated kinase/mitogen activated protein kinase) and the enhanced activation of p38, JNK (c-Jun N-terminal kinase) induced by H2O2. Hydrogen Peroxide 209-213 mitogen-activated protein kinase 8 Homo sapiens 173-196 18681888-6 2008 Furthermore, both c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) were activated by treatment with H2O2, and the activation of both kinases was suppressed by overexpression of Hsp105alpha and Hsp105beta. Hydrogen Peroxide 133-137 mitogen-activated protein kinase 8 Homo sapiens 18-41 18692482-5 2008 In addition, stimulation of XIAP(-/-) MEF with hydrogen peroxide resulted in enhanced phosphorylation of JNK. Hydrogen Peroxide 47-64 mitogen-activated protein kinase 8 Homo sapiens 105-108 18974961-13 2008 These results indicate that H(2)O(2) acts as an inducer of IL-8 secretion via activation of ERK, p38, and JNK in PDL cells. Hydrogen Peroxide 28-36 mitogen-activated protein kinase 8 Homo sapiens 106-109 18997418-2 2008 Co-treatment with EGCG potentiated the cytotoxicity induced by benzyl isothiocyanate (BITC) and H(2)O(2), both being inhibited by ERK and JNK inhibitors. Hydrogen Peroxide 96-104 mitogen-activated protein kinase 8 Homo sapiens 138-141 18681888-6 2008 Furthermore, both c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) were activated by treatment with H2O2, and the activation of both kinases was suppressed by overexpression of Hsp105alpha and Hsp105beta. Hydrogen Peroxide 133-137 mitogen-activated protein kinase 8 Homo sapiens 43-46 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. Hydrogen Peroxide 298-302 mitogen-activated protein kinase 8 Homo sapiens 106-129 18603343-7 2008 Hydrogen peroxide provoked phosphorylation of extracellular regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK), and activation of nuclear factor-kappaB (NF-kappaB). Hydrogen Peroxide 0-17 mitogen-activated protein kinase 8 Homo sapiens 87-114 18603343-7 2008 Hydrogen peroxide provoked phosphorylation of extracellular regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK), and activation of nuclear factor-kappaB (NF-kappaB). Hydrogen Peroxide 0-17 mitogen-activated protein kinase 8 Homo sapiens 116-119 18603343-8 2008 On the contrary, eupatilin decreased H(2)O(2)-induced activation of ERK, JNK and NF-kappaB. Hydrogen Peroxide 37-45 mitogen-activated protein kinase 8 Homo sapiens 73-76 18603343-9 2008 In addition, treatment of specific inhibitors for ERK, JNK, and NF-kappaB attenuated H(2)O(2)-induced apoptosis. Hydrogen Peroxide 85-93 mitogen-activated protein kinase 8 Homo sapiens 55-58 18603343-11 2008 Taken together, we suggest that eupatilin inhibits H(2)O(2)-induced apoptosis through the inhibition ERK, JNK, and NF-kappaB. Hydrogen Peroxide 51-59 mitogen-activated protein kinase 8 Homo sapiens 106-109 17922126-7 2008 H(2)O(2)-induced phosphorylation of ERK and JNK was almost complete inhibited by more than 100-muM genistein. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 8 Homo sapiens 44-47 17922126-10 2008 H(2)O(2)-induced JNK phosphorylation and ERK phosphorylation were inhibited by staurosporine, protein kinase C (PKC) inhibitor. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 8 Homo sapiens 17-20 17922126-13 2008 Treatment with a non-thiol antioxidant agent, catalase, completely abrogated H(2)O(2)-induced JNK and ERK phosphorylation, but a thiol antioxidant, L: -cystein, had no effect on phosphorylation of them. Hydrogen Peroxide 77-85 mitogen-activated protein kinase 8 Homo sapiens 94-97 18436531-0 2008 Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 8 Homo sapiens 52-55 18501712-5 2008 In Prx-1 knockdown cells, ASK1, p38, and JNK were quickly activated, leading to apoptosis in response to H2O2. Hydrogen Peroxide 105-109 mitogen-activated protein kinase 8 Homo sapiens 41-44 18341430-6 2008 We observed that UV and H(2)O(2) induce JNK and its downstream component, c-Jun, activation in both a time- and dose-dependent manner. Hydrogen Peroxide 24-32 mitogen-activated protein kinase 8 Homo sapiens 40-43 18575770-0 2008 Minocycline protects melanocytes against H2O2-induced cell death via JNK and p38 MAPK pathways. Hydrogen Peroxide 41-45 mitogen-activated protein kinase 8 Homo sapiens 69-72 18575770-8 2008 Also, H2O2 treatment activates JNK and p38 MAPK, and executive caspase 3 in B10BR cells. Hydrogen Peroxide 6-10 mitogen-activated protein kinase 8 Homo sapiens 31-34 18575770-9 2008 Minocycline significantly inhibits H2O2-induced activation of JNK, p38 MAPK and caspase 3. Hydrogen Peroxide 35-39 mitogen-activated protein kinase 8 Homo sapiens 62-65 18385943-0 2008 The JNK/AP1/ATF2 pathway is involved in H2O2-induced acetylcholinesterase expression during apoptosis. Hydrogen Peroxide 40-44 mitogen-activated protein kinase 8 Homo sapiens 4-7 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 8 Homo sapiens 106-129 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 8 Homo sapiens 131-134 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 8 Homo sapiens 147-150 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. Hydrogen Peroxide 298-302 mitogen-activated protein kinase 8 Homo sapiens 131-134 18385943-2 2008 Overexpression of hemagglutinin (HA)-JNK increases H2O2-induced AChE expression and its promoter activity, whereas the dominant negative mutant form of JNK suppressed H2O2-induced AChE expression and promoter activity. Hydrogen Peroxide 51-55 mitogen-activated protein kinase 8 Homo sapiens 37-40 18385943-2 2008 Overexpression of hemagglutinin (HA)-JNK increases H2O2-induced AChE expression and its promoter activity, whereas the dominant negative mutant form of JNK suppressed H2O2-induced AChE expression and promoter activity. Hydrogen Peroxide 167-171 mitogen-activated protein kinase 8 Homo sapiens 152-155 18385943-5 2008 Taken together, our results strongly suggest that H2O2 induces AChE expression via the JNK/AP1/ ATF2 signaling pathway. Hydrogen Peroxide 50-54 mitogen-activated protein kinase 8 Homo sapiens 87-90 17218956-2 2007 Our previous study has illustrated that c-Jun-N-terminal kinase 1 (JNK1) is the main executor in hydrogen peroxide (H(2)O(2))-induced nonapoptotic cell death. Hydrogen Peroxide 116-125 mitogen-activated protein kinase 8 Homo sapiens 40-65 17960092-11 2007 In parallel, H2O2-induced the activation of ERK1/2, p38 and JNK in keratinocytes could be inhibited by ECG. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 8 Homo sapiens 60-63 18040775-7 2008 Further studies showed that Jun N-terminal kinase (JNK) may participate in the signaling pathway of H2O2-induced apoptosis by mediating the level of Mst3. Hydrogen Peroxide 100-104 mitogen-activated protein kinase 8 Homo sapiens 28-49 18040775-7 2008 Further studies showed that Jun N-terminal kinase (JNK) may participate in the signaling pathway of H2O2-induced apoptosis by mediating the level of Mst3. Hydrogen Peroxide 100-104 mitogen-activated protein kinase 8 Homo sapiens 51-54 17218956-2 2007 Our previous study has illustrated that c-Jun-N-terminal kinase 1 (JNK1) is the main executor in hydrogen peroxide (H(2)O(2))-induced nonapoptotic cell death. Hydrogen Peroxide 97-114 mitogen-activated protein kinase 8 Homo sapiens 40-65 17218956-2 2007 Our previous study has illustrated that c-Jun-N-terminal kinase 1 (JNK1) is the main executor in hydrogen peroxide (H(2)O(2))-induced nonapoptotic cell death. Hydrogen Peroxide 97-114 mitogen-activated protein kinase 8 Homo sapiens 67-71 17218956-2 2007 Our previous study has illustrated that c-Jun-N-terminal kinase 1 (JNK1) is the main executor in hydrogen peroxide (H(2)O(2))-induced nonapoptotic cell death. Hydrogen Peroxide 116-125 mitogen-activated protein kinase 8 Homo sapiens 67-71 17218956-9 2007 Taken together, data from our study reveal a novel underlying mechanism in H(2)O(2)-induced nonapoptotic cell death: JNK1 promotes a sustained PARP-1 activation via nuclear translocation, protein-protein interaction and PARP-1 phosphorylation. Hydrogen Peroxide 75-83 mitogen-activated protein kinase 8 Homo sapiens 117-121 16564553-9 2006 (+)-Catechin also inhibited UVB- and H2O2-induced JNK activation in keratinocytes. Hydrogen Peroxide 37-41 mitogen-activated protein kinase 8 Homo sapiens 50-53 17292858-4 2007 We found that JNK1 (wild type, WT) mediated H(2)O(2)-induced p21 protein up-regulation. Hydrogen Peroxide 44-52 mitogen-activated protein kinase 8 Homo sapiens 14-18 16815888-0 2006 Identification of a hydrogen peroxide-induced PP1-JNK1-Sp1 signaling pathway for gene regulation. Hydrogen Peroxide 20-37 mitogen-activated protein kinase 8 Homo sapiens 50-54 16815888-3 2006 Treatment of HAE cells with H(2)O(2) increases phosphorylation of Sp1 and activates JNK. Hydrogen Peroxide 28-36 mitogen-activated protein kinase 8 Homo sapiens 84-87 16815888-7 2006 Because H(2)O(2) inhibits Ser/Thr protein phosphatase-1 (PP1), we examined the role of PP1 in the regulation of JNK. Hydrogen Peroxide 8-16 mitogen-activated protein kinase 8 Homo sapiens 112-115 16927023-5 2006 Exposure to a lethal dose of H(2)O(2) elicited Bax translocation to the mitochondria and release of apoptosis-inducing factor (AIF) from the mitochondria, both of which were abolished by either JNK- or p38-specific inhibitors. Hydrogen Peroxide 29-37 mitogen-activated protein kinase 8 Homo sapiens 194-197 16927023-6 2006 Both H(2)O(2)-induced cell death and JNK/p38 phosphorylation were partially inhibited by C. difficile toxin B, inhibitor of Rho, Rac, and cdc42. Hydrogen Peroxide 5-13 mitogen-activated protein kinase 8 Homo sapiens 37-40 16927023-8 2006 This study is the first to demonstrate that H(2)O(2) induces a Rac1/JNK1/p38 signaling cascade, and that JNK and p38 activation is important for H(2)O(2)-induced apoptosis as well as AIF/Bax translocation of RPE cells. Hydrogen Peroxide 44-52 mitogen-activated protein kinase 8 Homo sapiens 68-72 16927023-8 2006 This study is the first to demonstrate that H(2)O(2) induces a Rac1/JNK1/p38 signaling cascade, and that JNK and p38 activation is important for H(2)O(2)-induced apoptosis as well as AIF/Bax translocation of RPE cells. Hydrogen Peroxide 44-52 mitogen-activated protein kinase 8 Homo sapiens 68-71 16927023-8 2006 This study is the first to demonstrate that H(2)O(2) induces a Rac1/JNK1/p38 signaling cascade, and that JNK and p38 activation is important for H(2)O(2)-induced apoptosis as well as AIF/Bax translocation of RPE cells. Hydrogen Peroxide 145-153 mitogen-activated protein kinase 8 Homo sapiens 68-72 16927023-8 2006 This study is the first to demonstrate that H(2)O(2) induces a Rac1/JNK1/p38 signaling cascade, and that JNK and p38 activation is important for H(2)O(2)-induced apoptosis as well as AIF/Bax translocation of RPE cells. Hydrogen Peroxide 145-153 mitogen-activated protein kinase 8 Homo sapiens 68-71 17308111-6 2007 Our results indicate that the mitogen-activated protein kinase kinase 4/c-Jun NH(2)-terminal kinase (MKK4/JNK) pathway was a link between BaP-induced H(2)O(2) production and NHE1 activation. Hydrogen Peroxide 150-158 mitogen-activated protein kinase 8 Homo sapiens 106-109 16836488-3 2006 Exposure of pre-confluent cells to stress conditions including IL-1beta (interleukin-1beta), H2O2 or UV irradiation resulted in marked increases in JNK activity as indicated by c-Jun phosphorylation. Hydrogen Peroxide 93-97 mitogen-activated protein kinase 8 Homo sapiens 148-151 16836488-8 2006 The role of GSTA1-1 in JNK suppression was more specifically revealed in Tet-Off-inducible MEF3T3-GSTA1-1 cells in which GSTA1 overexpression significantly reduced phosphorylation of c-Jun following exposure to IL-1beta, H2O2 and UV irradiation. Hydrogen Peroxide 221-225 mitogen-activated protein kinase 8 Homo sapiens 23-26 17065531-11 2006 In addition, dPGJ(2) significantly extended hydrogen peroxide-induced activation of JNK and p38, but not of Akt. Hydrogen Peroxide 44-61 mitogen-activated protein kinase 8 Homo sapiens 84-87 16125295-9 2005 But H2O2 induced a transient activation of p38 and c-Jun N-terminal kinase (JNK) without sustained activation and inhibitors of these kinses were not effective in preventing the cell death. Hydrogen Peroxide 4-8 mitogen-activated protein kinase 8 Homo sapiens 51-74 16569638-10 2006 Importantly, JNK signaling is largely responsible for the H2O2 sensitivity of the MMP-1 promoter, whereas ERK1/2 contributes to both its basal and H2O2 dependence. Hydrogen Peroxide 58-62 mitogen-activated protein kinase 8 Homo sapiens 13-16 16632120-9 2006 It was observed that H2O2-induced phosphorylation of ERK1/2, JNK, and p38 was decreased by these antioxidants. Hydrogen Peroxide 21-25 mitogen-activated protein kinase 8 Homo sapiens 61-64 16310883-0 2006 Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases. Hydrogen Peroxide 22-39 mitogen-activated protein kinase 8 Homo sapiens 104-107 16724983-6 2006 A total of 5.0 and 10 micromol/L hydrogen peroxide (H(2)O(2)) caused cell death in a dose-dependent manner after 24 h. On western blot analysis at 1 h with H(2)O(2), rapid phosphorylation of both ERK1/2 and c-Jun NH(2)-terminal kinase (JNK) was observed. Hydrogen Peroxide 33-50 mitogen-activated protein kinase 8 Homo sapiens 207-234 16724983-6 2006 A total of 5.0 and 10 micromol/L hydrogen peroxide (H(2)O(2)) caused cell death in a dose-dependent manner after 24 h. On western blot analysis at 1 h with H(2)O(2), rapid phosphorylation of both ERK1/2 and c-Jun NH(2)-terminal kinase (JNK) was observed. Hydrogen Peroxide 33-50 mitogen-activated protein kinase 8 Homo sapiens 236-239 16724983-10 2006 Furthermore, H(2)O(2)-induced phosphorylation of ERK and JNK was also reduced by VEGF (100 ng/mL). Hydrogen Peroxide 13-21 mitogen-activated protein kinase 8 Homo sapiens 57-60 16388335-5 2005 To address this question we used 7-11 passaged fibroblasts from HSP patients to measure the extent of DNA damage induced by H2O2 treatment and to evaluate the JNK phosphorylation level after hydrogen peroxide and serum stimuli. Hydrogen Peroxide 191-208 mitogen-activated protein kinase 8 Homo sapiens 159-162 16388335-7 2005 The present study demonstrates that HSP cells compared to controls are more sensitive to DNA damages induced by H2O2 treatment, and that JNK phosphorylation levels are increased in HSP fibroblasts compared to controls after hydrogen peroxide and serum stimuli. Hydrogen Peroxide 224-241 mitogen-activated protein kinase 8 Homo sapiens 137-140 16306192-7 2005 Inhibition of ERK and JNK decreased H2O2-induced apoptosis. Hydrogen Peroxide 36-40 mitogen-activated protein kinase 8 Homo sapiens 22-25 16125295-9 2005 But H2O2 induced a transient activation of p38 and c-Jun N-terminal kinase (JNK) without sustained activation and inhibitors of these kinses were not effective in preventing the cell death. Hydrogen Peroxide 4-8 mitogen-activated protein kinase 8 Homo sapiens 76-79 16000309-0 2005 Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 8 Homo sapiens 44-47 16105650-6 2005 Selective stimulation of the JNK pathway by lipofectamine-mediated delivery of recombinant JNK1 led to activation of c-Jun and decrease of extracellular H2O2, as well as apoptosis sensitization to CDDP in A2780/DDP cells. Hydrogen Peroxide 153-157 mitogen-activated protein kinase 8 Homo sapiens 29-32 16105650-6 2005 Selective stimulation of the JNK pathway by lipofectamine-mediated delivery of recombinant JNK1 led to activation of c-Jun and decrease of extracellular H2O2, as well as apoptosis sensitization to CDDP in A2780/DDP cells. Hydrogen Peroxide 153-157 mitogen-activated protein kinase 8 Homo sapiens 91-95 16105650-8 2005 The resistance to CDDP can be reversed through activating c-Jun and decreasing extracellular generation of H2O2 by pcDNA3(FLAG)-JNK1-wt transfection in A2780/DDP cells. Hydrogen Peroxide 107-111 mitogen-activated protein kinase 8 Homo sapiens 128-132 15958730-6 2005 Acute treatment with H(2)O(2) activated multiple signaling pathways, including the mitogen-activated protein kinases (MAPK) members (MAPK3/1-ERK2/1, MAPK8/9-JNK1/2, and MAPK11-p38(mapk)) and the c-src tyrosine kinase (CSK). Hydrogen Peroxide 21-29 mitogen-activated protein kinase 8 Homo sapiens 149-154 15958730-6 2005 Acute treatment with H(2)O(2) activated multiple signaling pathways, including the mitogen-activated protein kinases (MAPK) members (MAPK3/1-ERK2/1, MAPK8/9-JNK1/2, and MAPK11-p38(mapk)) and the c-src tyrosine kinase (CSK). Hydrogen Peroxide 21-29 mitogen-activated protein kinase 8 Homo sapiens 157-163 16356139-8 2005 Zinc deficiency-induced increases in cellular H(2)O(2) can trigger the activation of JNK and p38, leading to AP-1 activation, events that are not involved in zinc deficiency-induced apoptosis. Hydrogen Peroxide 46-54 mitogen-activated protein kinase 8 Homo sapiens 85-88 16000309-3 2005 Hydrogen peroxide (H2O2) increased apoptosis of endothelial cells through JNK activation, whereas Ang1 inhibited H2O2-induced apoptosis and concomitant JNK phosphorylation. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 8 Homo sapiens 74-77 16000309-3 2005 Hydrogen peroxide (H2O2) increased apoptosis of endothelial cells through JNK activation, whereas Ang1 inhibited H2O2-induced apoptosis and concomitant JNK phosphorylation. Hydrogen Peroxide 19-23 mitogen-activated protein kinase 8 Homo sapiens 74-77 16000309-3 2005 Hydrogen peroxide (H2O2) increased apoptosis of endothelial cells through JNK activation, whereas Ang1 inhibited H2O2-induced apoptosis and concomitant JNK phosphorylation. Hydrogen Peroxide 113-117 mitogen-activated protein kinase 8 Homo sapiens 152-155 16000309-4 2005 The inhibition of H2O2-induced JNK phosphorylation was reversed by inhibitors of phosphatidylinositol (PI) 3-kinase and dominant-negative Akt, and constitutively active-Akt attenuated JNK phosphorylation without Ang1. Hydrogen Peroxide 18-22 mitogen-activated protein kinase 8 Homo sapiens 31-34 16000309-4 2005 The inhibition of H2O2-induced JNK phosphorylation was reversed by inhibitors of phosphatidylinositol (PI) 3-kinase and dominant-negative Akt, and constitutively active-Akt attenuated JNK phosphorylation without Ang1. Hydrogen Peroxide 18-22 mitogen-activated protein kinase 8 Homo sapiens 184-187 16000309-6 2005 H2O2-induced phosphorylation of SAPK/Erk kinase (SEK1) at Thr261, which is an upstream regulator of JNK, was also attenuated by Ang1-dependent activation of the PI 3-kinase/Akt pathway. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 100-103 16000309-8 2005 These results demonstrated that Ang1 attenuates H2O2-induced SEK1/JNK phosphorylation through the PI 3-kinase/Akt pathway and inhibits the apoptosis of endothelial cells to oxidative stress. Hydrogen Peroxide 48-52 mitogen-activated protein kinase 8 Homo sapiens 66-69 15917192-4 2005 Therefore this study examines the role of hydrogen peroxide, both alone and in combination with lipopolysaccharide (LPS), in the regulation of activation of two key MAPK, p38 and JNK, regulation of phenotype, and regulation of apoptosis in human monocyte-derived DC. Hydrogen Peroxide 42-59 mitogen-activated protein kinase 8 Homo sapiens 179-182 16155405-7 2005 These cytoprotective doses of gamma-rays did not enhance cellular capacity to degrade H(2)O(2), but elevated cellular levels of p21(Cip/WAF1), a p53 target that can suppress H(2)O(2)-induced cell death by blocking JNK activation. Hydrogen Peroxide 174-182 mitogen-activated protein kinase 8 Homo sapiens 214-217 16155405-8 2005 Consistently, H(2)O(2)-induced JNK activation was dramatically suppressed in the pre-irradiated cells. Hydrogen Peroxide 14-22 mitogen-activated protein kinase 8 Homo sapiens 31-34 15940365-2 2005 In the HS-5 hBMSC, TNF-alpha and H2O2 increased intracellular ROS levels and induced cell apoptosis through activation of caspases, JNK and NF-kappaB. Hydrogen Peroxide 33-37 mitogen-activated protein kinase 8 Homo sapiens 132-135 15917192-6 2005 At higher concentrations, hydrogen peroxide activates both p38 and JNK. Hydrogen Peroxide 26-43 mitogen-activated protein kinase 8 Homo sapiens 67-70 15917192-8 2005 An upstream JNK inhibitor (CEP11004) and a competitive JNK inhibitor (SP600125) both partially protected the DC from the proapoptotic effects of hydrogen peroxide. Hydrogen Peroxide 145-162 mitogen-activated protein kinase 8 Homo sapiens 12-15 15917192-8 2005 An upstream JNK inhibitor (CEP11004) and a competitive JNK inhibitor (SP600125) both partially protected the DC from the proapoptotic effects of hydrogen peroxide. Hydrogen Peroxide 145-162 mitogen-activated protein kinase 8 Homo sapiens 55-58 15917192-9 2005 Unexpectedly, hydrogen peroxide and LPS synergize in inducing JNK activation and DC apoptosis. Hydrogen Peroxide 14-31 mitogen-activated protein kinase 8 Homo sapiens 62-65 15180991-2 2004 We found that inhibition of flavin- or heme-containing proteins eliminated H(2)O(2)-induced transactivation of the epidermal growth factor receptor and stimulation of its downstream targets, JNK and Akt. Hydrogen Peroxide 75-83 mitogen-activated protein kinase 8 Homo sapiens 191-194 15755722-0 2005 Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor. Hydrogen Peroxide 101-105 mitogen-activated protein kinase 8 Homo sapiens 76-79 15755722-1 2005 Although both tumor necrosis factor (TNF) and H2O2 induce activation of c-Jun N-terminal kinase (JNK) kinase cascades, it is not known whether they utilize distinct intracellular signaling pathways. Hydrogen Peroxide 46-50 mitogen-activated protein kinase 8 Homo sapiens 72-95 15755722-1 2005 Although both tumor necrosis factor (TNF) and H2O2 induce activation of c-Jun N-terminal kinase (JNK) kinase cascades, it is not known whether they utilize distinct intracellular signaling pathways. Hydrogen Peroxide 46-50 mitogen-activated protein kinase 8 Homo sapiens 97-100 15755722-2 2005 In this study, we first examined a variety of pharmacological inhibitors on TNF and H2O2-induced JNK activation. Hydrogen Peroxide 84-88 mitogen-activated protein kinase 8 Homo sapiens 97-100 15755722-5 2005 Consistently, H2O2, but not TNF, induced phosphorylation of PKD and translocation of PKD from endothelial cell membrane to cytoplasm where it associates with the JNK upstream activator, apoptosis signal-regulating kinase 1 (ASK1). Hydrogen Peroxide 14-18 mitogen-activated protein kinase 8 Homo sapiens 162-165 15755722-7 2005 Inhibition of PKD by Go6976 or by small interfering RNA of PKD blocked H2O2-induced ASK1-JNK activation and endothelial cell apoptosis. Hydrogen Peroxide 71-75 mitogen-activated protein kinase 8 Homo sapiens 89-92 15647999-8 2005 These observations were also confirmed by in vitro experiments, showing the ability of L-carnitine to reduce the JNK activation in normal PBMC exposed to different amounts of hydrogen peroxide. Hydrogen Peroxide 175-192 mitogen-activated protein kinase 8 Homo sapiens 113-116 15604272-11 2004 Whereas exogenous addition of H(2)O(2) was sufficient to activate JNK, reactive oxygen species scavengers were without effect on hypoxia-induced JNK or HIF-1 activation. Hydrogen Peroxide 30-38 mitogen-activated protein kinase 8 Homo sapiens 66-69 15538382-3 2004 Upon treatment of cells with H2O2, the small GTPase Ral is activated and this results in a JNK-dependent phosphorylation of FOXO4 on threonine 447 and threonine 451. Hydrogen Peroxide 29-33 mitogen-activated protein kinase 8 Homo sapiens 91-94 15538382-4 2004 This Ral-mediated, JNK-dependent phosphorylation is involved in the nuclear translocation and transcriptional activation of FOXO4 after H2O2 treatment. Hydrogen Peroxide 136-140 mitogen-activated protein kinase 8 Homo sapiens 19-22 15940365-14 2005 CONCLUSIONS: Our data show that TNF-alpha increases intracellular ROS in hBMSC and that TNF-alpha and H2O2 induce apoptosis in hBMSC through the activation of JNK and NF-kappaB. Hydrogen Peroxide 102-106 mitogen-activated protein kinase 8 Homo sapiens 159-162 15795422-11 2005 Western blot data revealed that H2O2 upregulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which was rapidly reversed by quercetin within 30 min; H2O2 activation of c-Jun was downregulated. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 8 Homo sapiens 68-91 15795422-11 2005 Western blot data revealed that H2O2 upregulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which was rapidly reversed by quercetin within 30 min; H2O2 activation of c-Jun was downregulated. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 8 Homo sapiens 93-96 15795422-11 2005 Western blot data revealed that H2O2 upregulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which was rapidly reversed by quercetin within 30 min; H2O2 activation of c-Jun was downregulated. Hydrogen Peroxide 202-206 mitogen-activated protein kinase 8 Homo sapiens 68-91 15795422-11 2005 Western blot data revealed that H2O2 upregulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which was rapidly reversed by quercetin within 30 min; H2O2 activation of c-Jun was downregulated. Hydrogen Peroxide 202-206 mitogen-activated protein kinase 8 Homo sapiens 93-96 15795422-12 2005 (-)Epigallocatechin gallate inhibited H2O2-induced phosphorylation of JNK and p38 MAPK after 60 min. Hydrogen Peroxide 38-42 mitogen-activated protein kinase 8 Homo sapiens 70-73 15550066-7 2004 RESULTS: IL-1beta, TNFalpha and H(2)O(2) stimulated the phosphorylation of ERK, p38 and JNK, while the total amounts of proteins of the respective MAPKs were virtually the same compared with those in the unstimulated controls. Hydrogen Peroxide 32-40 mitogen-activated protein kinase 8 Homo sapiens 88-91 15225802-4 2004 Furthermore, the neurotoxic effects of hydrogen peroxide was dependent on c-Jun N-terminal kinase (JNK)- and p38- mitogen-activated protein kinase (MAPK) activity. Hydrogen Peroxide 39-56 mitogen-activated protein kinase 8 Homo sapiens 74-104 15212948-11 2004 Both UV- and H(2)O(2)-induced JNK activities were inhibited by glutathione, suggesting that the redox status does play an important role in the activation of JNKs. Hydrogen Peroxide 13-21 mitogen-activated protein kinase 8 Homo sapiens 30-33 15212948-12 2004 Taken together, our findings suggest that JNK activation by UV and H(2)O(2) is mediated by distinct yet overlapping pathways and that K(+) channel activity and redox status are differentially required for UV- and H(2)O(2)-induced activation of JNKs. Hydrogen Peroxide 67-75 mitogen-activated protein kinase 8 Homo sapiens 42-45 15212948-12 2004 Taken together, our findings suggest that JNK activation by UV and H(2)O(2) is mediated by distinct yet overlapping pathways and that K(+) channel activity and redox status are differentially required for UV- and H(2)O(2)-induced activation of JNKs. Hydrogen Peroxide 213-221 mitogen-activated protein kinase 8 Homo sapiens 42-45 15020252-1 2004 Hydrogen peroxide (H(2)O(2)) induces apoptosis of mesangial cells via c-Jun N-terminal kinase (JNK)-activator protein-1 (AP-1) and extracellular signal-regulated kinase (ERK)-AP-1 pathways. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 8 Homo sapiens 95-98 15020252-1 2004 Hydrogen peroxide (H(2)O(2)) induces apoptosis of mesangial cells via c-Jun N-terminal kinase (JNK)-activator protein-1 (AP-1) and extracellular signal-regulated kinase (ERK)-AP-1 pathways. Hydrogen Peroxide 19-27 mitogen-activated protein kinase 8 Homo sapiens 95-98 12850239-9 2003 Taken together, these results suggest that Korean mistletoe lectin-II is a strong inducer of pro-oxidant generation such as H2O2, which mediates the JNK/SAPK activation, cytochrome c release, activation of caspase-9 and caspase 3-like protease, and PARP cleavage in human myeloleukemic U937 cells. Hydrogen Peroxide 124-128 mitogen-activated protein kinase 8 Homo sapiens 149-152 14757132-6 2004 Moreover, it was observed that H(2)O(2) significantly stimulated activation of mitogen-activated protein (MAP) kinases, i.e., p38 MAP kinase, c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK1/2). Hydrogen Peroxide 31-39 mitogen-activated protein kinase 8 Homo sapiens 142-165 14668614-10 2003 MEASUREMENTS AND MAIN RESULTS: The results showed that H2O2 induced ASK1 phosphorylation and concomitantly p38 MAPK and JNK phosphorylation as well as induced caspase-3 activation in pulmonary vascular endothelial cells. Hydrogen Peroxide 55-59 mitogen-activated protein kinase 8 Homo sapiens 120-123 14668614-13 2003 CONCLUSION: ASK1-p38 MAPK/JNK cascade regulates apoptosis of H2O2-stimulated human pulmonary vascular endothelial cells. Hydrogen Peroxide 61-65 mitogen-activated protein kinase 8 Homo sapiens 26-29 14757132-6 2004 Moreover, it was observed that H(2)O(2) significantly stimulated activation of mitogen-activated protein (MAP) kinases, i.e., p38 MAP kinase, c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK1/2). Hydrogen Peroxide 31-39 mitogen-activated protein kinase 8 Homo sapiens 167-170 14729104-8 2004 Furthermore, H(2)O(2)-mediated increases in ERK1/2 activation were sensitive to the MAPK kinase 1 (MEK1) inhibitor PD 98059 (2"-amino-3"-methoxyflavone), whereas JNK responses were blocked by the JNK inhibitor SP 600125 (anthra[1-9-cd]pyrazol-6(2H)-one). Hydrogen Peroxide 13-21 mitogen-activated protein kinase 8 Homo sapiens 162-165 14729104-8 2004 Furthermore, H(2)O(2)-mediated increases in ERK1/2 activation were sensitive to the MAPK kinase 1 (MEK1) inhibitor PD 98059 (2"-amino-3"-methoxyflavone), whereas JNK responses were blocked by the JNK inhibitor SP 600125 (anthra[1-9-cd]pyrazol-6(2H)-one). Hydrogen Peroxide 13-21 mitogen-activated protein kinase 8 Homo sapiens 196-199 14729104-12 2004 In conclusion, we have shown that H(2)O(2) stimulates robust increases in ERK1/2, JNK and PKB in undifferentiated and differentiated SH-SY5Y cells. Hydrogen Peroxide 34-42 mitogen-activated protein kinase 8 Homo sapiens 82-85 12899942-3 2003 TcR cross-linking of primary human T blasts and Jurkat human T cells rapidly activated the ERK, JNK, p38 and Akt kinases within minutes, and was temporally associated with TcR-stimulated production of hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 201-218 mitogen-activated protein kinase 8 Homo sapiens 96-99 12730670-8 2003 Moreover, we observed that treatment of cells with 2-Me or H(2)O(2) induced activation of the c-Jun N-terminal kinase (JNK). Hydrogen Peroxide 59-67 mitogen-activated protein kinase 8 Homo sapiens 94-117 12730670-8 2003 Moreover, we observed that treatment of cells with 2-Me or H(2)O(2) induced activation of the c-Jun N-terminal kinase (JNK). Hydrogen Peroxide 59-67 mitogen-activated protein kinase 8 Homo sapiens 119-122 12681294-0 2003 JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase. Hydrogen Peroxide 48-52 mitogen-activated protein kinase 8 Homo sapiens 0-4 12681294-0 2003 JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase. Hydrogen Peroxide 111-115 mitogen-activated protein kinase 8 Homo sapiens 0-4 12681294-3 2003 The growth-inhibitory effect of both high-level H(2)O(2) and H(2)O(2)-scavenging catalase treatments is accompanied by increased JNK1 activity. Hydrogen Peroxide 48-56 mitogen-activated protein kinase 8 Homo sapiens 129-133 12681294-3 2003 The growth-inhibitory effect of both high-level H(2)O(2) and H(2)O(2)-scavenging catalase treatments is accompanied by increased JNK1 activity. Hydrogen Peroxide 61-69 mitogen-activated protein kinase 8 Homo sapiens 129-133 12681294-9 2003 These results indicate that the JNK1 stress response contributes to growth inhibition by catalase treatment via inhibition of cellular H(2)O(2) production. Hydrogen Peroxide 135-143 mitogen-activated protein kinase 8 Homo sapiens 32-36 12374624-4 2002 Stimulation of Jurkat T cells with H(2)O(2) induces the phosphorylation of ERK, p38, and JNK members of MAPK family. Hydrogen Peroxide 35-43 mitogen-activated protein kinase 8 Homo sapiens 89-92 12427758-8 2003 Rottlerin, a specific inhibitor of PKC delta, significantly inhibited H(2)O(2)-induced activation of JNK1 in control cells, indicating that PKC delta is involved in the pathway. Hydrogen Peroxide 70-78 mitogen-activated protein kinase 8 Homo sapiens 101-105 12427758-9 2003 These findings suggest that the overexpression of GnT-III suppresses H(2)O(2)-induced activation of PKC delta-JNK1 pathway, resulting in inhibition of apoptosis. Hydrogen Peroxide 69-77 mitogen-activated protein kinase 8 Homo sapiens 110-114 12186877-9 2002 Furthermore, overexpression of MKP-1 inhibited H(2)O(2)-induced JNK phosphorylation and apoptosis. Hydrogen Peroxide 47-55 mitogen-activated protein kinase 8 Homo sapiens 64-67 12361705-10 2002 Furthermore we found that exogenous H2O2 could stimulate the proliferation of PKB-AS7721 cells transfected with antisense PKB cDNA, which was partly dependent on JNK activation, suggesting that H2O2 stimulated hepatoma cell proliferation via cross-talk between the PI3-K/PKB and the JNK signaling pathways. Hydrogen Peroxide 36-40 mitogen-activated protein kinase 8 Homo sapiens 162-165 12361705-10 2002 Furthermore we found that exogenous H2O2 could stimulate the proliferation of PKB-AS7721 cells transfected with antisense PKB cDNA, which was partly dependent on JNK activation, suggesting that H2O2 stimulated hepatoma cell proliferation via cross-talk between the PI3-K/PKB and the JNK signaling pathways. Hydrogen Peroxide 36-40 mitogen-activated protein kinase 8 Homo sapiens 283-286 12361705-10 2002 Furthermore we found that exogenous H2O2 could stimulate the proliferation of PKB-AS7721 cells transfected with antisense PKB cDNA, which was partly dependent on JNK activation, suggesting that H2O2 stimulated hepatoma cell proliferation via cross-talk between the PI3-K/PKB and the JNK signaling pathways. Hydrogen Peroxide 194-198 mitogen-activated protein kinase 8 Homo sapiens 162-165 12361705-10 2002 Furthermore we found that exogenous H2O2 could stimulate the proliferation of PKB-AS7721 cells transfected with antisense PKB cDNA, which was partly dependent on JNK activation, suggesting that H2O2 stimulated hepatoma cell proliferation via cross-talk between the PI3-K/PKB and the JNK signaling pathways. Hydrogen Peroxide 194-198 mitogen-activated protein kinase 8 Homo sapiens 283-286 12374624-8 2002 The Src-family kinase inhibitor, PP2, inhibited the H(2)O(2)-induced phosphorylation of ERK, p38, and JNK. Hydrogen Peroxide 52-60 mitogen-activated protein kinase 8 Homo sapiens 102-105 12374624-9 2002 The phospholipase C (PLC) inhibitor, U73122, or the protein kinase C (PKC) inhibitor, Ro-31-8425, blocked H(2)O(2)-induced ERK phosphorylation, whereas the same treatment did not inhibit p38 or JNK phosphorylation. Hydrogen Peroxide 106-114 mitogen-activated protein kinase 8 Homo sapiens 194-197 12374624-6 2002 Transfection of cells with wtSHP-1 decreased H(2)O(2)-induced ERK and JNK phosphorylation without affecting p38 phosphorylation. Hydrogen Peroxide 45-53 mitogen-activated protein kinase 8 Homo sapiens 70-73 12161102-6 2002 We further investigated the effect of green tea polyphenol on these protein kinases, and demonstrated that H(2)O(2)-induced phosphorylation of JNK and p38 but not p44/42 was inhibited by green tea polyphenol in A549 cells. Hydrogen Peroxide 107-115 mitogen-activated protein kinase 8 Homo sapiens 143-146 12161102-7 2002 We speculate that green tea polyphenol may inhibit H(2)O(2)-induced IL-8 production from A549 cells through inactivation of JNK and p38. Hydrogen Peroxide 51-59 mitogen-activated protein kinase 8 Homo sapiens 124-127 11278982-0 2001 c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation. Hydrogen Peroxide 38-55 mitogen-activated protein kinase 8 Homo sapiens 0-23 11790785-4 2002 In 293(PED) cells, decreased apoptosis induced by anisomycin and H(2)O(2) was also accompanied by block of JNK1/2 and p38 phosphorylations, respectively. Hydrogen Peroxide 65-73 mitogen-activated protein kinase 8 Homo sapiens 107-113 11790792-4 2002 Although hydrogen peroxide challenge resulted in JNK activation and cell death in cells transfected with vector control or beta-synuclein, alpha-synuclein-transfected cells were resistant to hydrogen peroxide, and JNK was not activated. Hydrogen Peroxide 9-26 mitogen-activated protein kinase 8 Homo sapiens 49-52 11796740-0 2002 Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca(2+) and PI3-kinase. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 8 Homo sapiens 66-69 11796740-4 2002 Higher concentrations of H(2)O(2) (1 mm) also stimulated a phosphorylation of JNK which was totally dependent on extracellular Ca(2+) but not PI3-K. H(2)O(2)-induced phosphorylation of ERK1/2, Akt/PKB or JNK were unaffected by the NMDA channel blocker MK801. Hydrogen Peroxide 25-33 mitogen-activated protein kinase 8 Homo sapiens 78-81 11796740-4 2002 Higher concentrations of H(2)O(2) (1 mm) also stimulated a phosphorylation of JNK which was totally dependent on extracellular Ca(2+) but not PI3-K. H(2)O(2)-induced phosphorylation of ERK1/2, Akt/PKB or JNK were unaffected by the NMDA channel blocker MK801. Hydrogen Peroxide 25-33 mitogen-activated protein kinase 8 Homo sapiens 204-207 11796740-4 2002 Higher concentrations of H(2)O(2) (1 mm) also stimulated a phosphorylation of JNK which was totally dependent on extracellular Ca(2+) but not PI3-K. H(2)O(2)-induced phosphorylation of ERK1/2, Akt/PKB or JNK were unaffected by the NMDA channel blocker MK801. Hydrogen Peroxide 149-157 mitogen-activated protein kinase 8 Homo sapiens 78-81 11796740-4 2002 Higher concentrations of H(2)O(2) (1 mm) also stimulated a phosphorylation of JNK which was totally dependent on extracellular Ca(2+) but not PI3-K. H(2)O(2)-induced phosphorylation of ERK1/2, Akt/PKB or JNK were unaffected by the NMDA channel blocker MK801. Hydrogen Peroxide 149-157 mitogen-activated protein kinase 8 Homo sapiens 204-207 11751424-5 2001 The cell death signaling JNK pathway elicited by H(2)O(2) is also inhibited by IL-6. Hydrogen Peroxide 49-57 mitogen-activated protein kinase 8 Homo sapiens 25-28 11695986-3 2001 They have peroxidase and isomerase activities, they can inhibit the Jun N-terminal kinase (thus protecting cells against H(2)O(2)-induced cell death), and they are able to bind non-catalytically a wide range of endogenous and exogenous ligands. Hydrogen Peroxide 121-129 mitogen-activated protein kinase 8 Homo sapiens 68-89 11601887-6 2001 Using the same in vitro system, when these cells were pretreated with EGCG or with the known antioxidant ascorbic acid (as positive control), H(2)O(2)-induced phosphorylation of ERK1/2, JNK, and p38 was found to be significantly inhibited. Hydrogen Peroxide 142-150 mitogen-activated protein kinase 8 Homo sapiens 186-189 11417847-10 2001 This inhibition of JNK1 in the system is involved in the protection of H2O2-induced apoptosis in H9C2 cardiomyoblasts. Hydrogen Peroxide 71-75 mitogen-activated protein kinase 8 Homo sapiens 19-23 11696540-10 2002 Increased HSP-27 expression in LLC-PK(1) cells results in reduced H(2)O(2)-induced phosphorylation of JNK1/2 and p38. Hydrogen Peroxide 66-74 mitogen-activated protein kinase 8 Homo sapiens 102-108 11709494-0 2002 Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways. Hydrogen Peroxide 20-37 mitogen-activated protein kinase 8 Homo sapiens 88-91 12403349-8 2002 JNK is activated by both exogenous and endogenously produced H2O2. Hydrogen Peroxide 61-65 mitogen-activated protein kinase 8 Homo sapiens 0-3 11278982-2 2001 Therefore, we exposed endothelial cells to hydrogen peroxide (H(2)O(2)) and observed rapid activation of JNK within 15 min that involved phosphorylation of JNK and c-Jun and induction of AP-1 DNA binding activity. Hydrogen Peroxide 43-60 mitogen-activated protein kinase 8 Homo sapiens 105-108 11278982-2 2001 Therefore, we exposed endothelial cells to hydrogen peroxide (H(2)O(2)) and observed rapid activation of JNK within 15 min that involved phosphorylation of JNK and c-Jun and induction of AP-1 DNA binding activity. Hydrogen Peroxide 43-60 mitogen-activated protein kinase 8 Homo sapiens 156-159 11278982-5 2001 Activation of JNK by H(2)O(2) was also inhibited by AG1478 and antisense oligonucleotides directed against the epidermal growth factor receptor (EGFR), implicating the EGFR in this process. Hydrogen Peroxide 21-29 mitogen-activated protein kinase 8 Homo sapiens 14-17 11313966-5 2001 The activation of JNK by PDTC, in the presence or absence of exogenous H(2)O(2), was dependent on its chelating ability to metal ions, most likely copper ions. Hydrogen Peroxide 71-79 mitogen-activated protein kinase 8 Homo sapiens 18-21 11278982-8 2001 These data indicate that H(2)O(2)-induced JNK activation in endothelial cells involves the EGFR through an Src-dependent pathway that is distinct from EGFR ligand activation. Hydrogen Peroxide 25-33 mitogen-activated protein kinase 8 Homo sapiens 42-45 11257445-3 2001 Consistent with these findings, we observed substantial nuclear translocation of JNK occurred in response to H2O2 but not TNFalpha. Hydrogen Peroxide 109-113 mitogen-activated protein kinase 8 Homo sapiens 81-84 11257445-4 2001 Using a phosphospecific anti-JNK antibody, we found that TNFalpha-stimulated JNK activity was associated principally with the cytosol while in response to H2O2, JNK activity was found within the nucleus. Hydrogen Peroxide 155-159 mitogen-activated protein kinase 8 Homo sapiens 29-32 10972672-6 2000 RESULTS: Mesangial cells exposed to H2O2 exhibited rapid phosphorylation of JNK, ERKs, and p38 MAP kinase. Hydrogen Peroxide 36-40 mitogen-activated protein kinase 8 Homo sapiens 76-79 11313966-0 2001 Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate. Hydrogen Peroxide 95-112 mitogen-activated protein kinase 8 Homo sapiens 23-46 11313966-0 2001 Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate. Hydrogen Peroxide 95-112 mitogen-activated protein kinase 8 Homo sapiens 48-51 11313966-0 2001 Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate. Hydrogen Peroxide 95-112 mitogen-activated protein kinase 8 Homo sapiens 88-91 11313966-3 2001 We found that the ability of hydrogen peroxide (H(2)O(2)) to induce JNK activation varied in different cell types. Hydrogen Peroxide 29-46 mitogen-activated protein kinase 8 Homo sapiens 68-71 11035067-5 2000 Lowering the intracellular GSH/GSH disulfide ratio by BCNU, HP, or NO resulted in all cases in the fulminant enhancement of Jun-N-terminal kinase and p38 mitogen-activated protein kinase but not extracellular signal-regulated kinase 1/2. Hydrogen Peroxide 60-62 mitogen-activated protein kinase 8 Homo sapiens 124-145 10972672-8 2000 Pretreatment with MAP kinase kinase inhibitor PD098059 or JNK-c-Jun/AP-1 inhibitor curcumin attenuated the H2O2-induced apoptosis. Hydrogen Peroxide 107-111 mitogen-activated protein kinase 8 Homo sapiens 58-61 10972672-10 2000 Consistently, transfection with dominant-negative mutants of ERK1 and ERK2 or a dominant-negative mutant of JNK inhibited H2O2-induced apoptosis. Hydrogen Peroxide 122-126 mitogen-activated protein kinase 8 Homo sapiens 108-111 10972672-13 2000 CONCLUSIONS: These results suggested that (1) activation of JNK and ERKs, but not p38 kinase, is required for the H2O2-induced apoptosis; and (2) suppression of the JNK-c-Jun/AP-1 pathway and the ERK-c-Fos/AP-1 pathway is involved in the anti-apoptotic effect of quercetin. Hydrogen Peroxide 114-118 mitogen-activated protein kinase 8 Homo sapiens 60-63 10972672-13 2000 CONCLUSIONS: These results suggested that (1) activation of JNK and ERKs, but not p38 kinase, is required for the H2O2-induced apoptosis; and (2) suppression of the JNK-c-Jun/AP-1 pathway and the ERK-c-Fos/AP-1 pathway is involved in the anti-apoptotic effect of quercetin. Hydrogen Peroxide 114-118 mitogen-activated protein kinase 8 Homo sapiens 165-168 11281730-0 2000 PD98059 attenuates hydrogen peroxide-induced cell death through inhibition of Jun N-Terminal Kinase in HT29 cells. Hydrogen Peroxide 19-36 mitogen-activated protein kinase 8 Homo sapiens 78-99 11281730-6 2000 This and UO126, another MEK inhibitor were ably to reproducibly inhibit p45-JNK activation induced by hydrogen peroxide. Hydrogen Peroxide 102-119 mitogen-activated protein kinase 8 Homo sapiens 76-79 11281730-9 2000 It is concluded that JNK mediates H(2)O(2)-induced cellular injury in the HT29 cell line, and additionally, we report for the first time that JNK activation can be inhibited by both PD98059 and UO126 at conventional doses used to inhibit MEK. Hydrogen Peroxide 34-42 mitogen-activated protein kinase 8 Homo sapiens 21-24 11281730-9 2000 It is concluded that JNK mediates H(2)O(2)-induced cellular injury in the HT29 cell line, and additionally, we report for the first time that JNK activation can be inhibited by both PD98059 and UO126 at conventional doses used to inhibit MEK. Hydrogen Peroxide 34-42 mitogen-activated protein kinase 8 Homo sapiens 142-145 10856288-3 2000 U937 human lymphoid cells treated with low dose (0.02 mm) H(2)O(2) rapidly caused p38 MAPK cascade activation detectable by phosphorylation of MKK3/6, p38 MAPK, activating transcription factor-2, and cAMP-responsive element-binding protein, leaving the JNK and NF-kappaB cascades unaffected. Hydrogen Peroxide 58-66 mitogen-activated protein kinase 8 Homo sapiens 253-256 10840014-11 2000 Furthermore, we found that JNK1 specific antisense oligonucleotide could suppress caspase-3 activity but not affect H(2)O(2) generation and could block apoptosis induced by high glucose. Hydrogen Peroxide 116-124 mitogen-activated protein kinase 8 Homo sapiens 27-31 9790925-2 1998 In this study we identify a selective and potent antisense oligonucleotide to RhoA (ISIS 17131) and investigate its effect on JNK activation induced by IL-1beta and H2O2 in A549 cells. Hydrogen Peroxide 165-169 mitogen-activated protein kinase 8 Homo sapiens 126-129 10464319-4 1999 The pro-oxidants sodium arsenite, cadmium chloride, and hydrogen peroxide activated JNK1 with slow kinetics, whereas UV-B potentiated the activity of JNK1 rapidly. Hydrogen Peroxide 56-73 mitogen-activated protein kinase 8 Homo sapiens 84-88 10400643-10 1999 Furthermore, t-RA inhibited H2O2-triggered activation of c-Jun N-terminal kinase (JNK), and dominant-negative inhibition of JNK attenuated the H2O2-induced apoptosis. Hydrogen Peroxide 28-32 mitogen-activated protein kinase 8 Homo sapiens 57-80 10400643-10 1999 Furthermore, t-RA inhibited H2O2-triggered activation of c-Jun N-terminal kinase (JNK), and dominant-negative inhibition of JNK attenuated the H2O2-induced apoptosis. Hydrogen Peroxide 28-32 mitogen-activated protein kinase 8 Homo sapiens 82-85 10400643-10 1999 Furthermore, t-RA inhibited H2O2-triggered activation of c-Jun N-terminal kinase (JNK), and dominant-negative inhibition of JNK attenuated the H2O2-induced apoptosis. Hydrogen Peroxide 143-147 mitogen-activated protein kinase 8 Homo sapiens 124-127 10593919-6 1999 In vitro kinase analyses revealed that 1 mM H(2)O(2) stimulated the activity of JNK by approximately 8-fold, MAPKAP-K2 (the downstream target of p38 MAP kinase) by approximately 12-fold and that of PKB by up to 34-fold. Hydrogen Peroxide 44-52 mitogen-activated protein kinase 8 Homo sapiens 80-83 9682214-0 1998 Bcl-2 regulates nonapoptotic signal transduction: inhibition of c-Jun N-terminal kinase (JNK) activation by IL-1 beta and hydrogen peroxide. Hydrogen Peroxide 122-139 mitogen-activated protein kinase 8 Homo sapiens 89-92 9790925-3 1998 The RhoA antisense oligonucleotide was able to inhibit JNK activation when A549 cells were stimulated by H2O2, but did not have any effect on IL-1beta induced JNK activation. Hydrogen Peroxide 105-109 mitogen-activated protein kinase 8 Homo sapiens 55-58 9790925-5 1998 Additionally, Wortmannin, a potent inhibitor of the PI 3-kinase and phospholipase A2 (PLA2), and AACOCF3, also a PLA2 inhibitor, were able to inhibit JNK activation induced by H2O2, but they had no effect on JNK activation when stimulated by IL-1beta. Hydrogen Peroxide 176-180 mitogen-activated protein kinase 8 Homo sapiens 150-153 9790925-5 1998 Additionally, Wortmannin, a potent inhibitor of the PI 3-kinase and phospholipase A2 (PLA2), and AACOCF3, also a PLA2 inhibitor, were able to inhibit JNK activation induced by H2O2, but they had no effect on JNK activation when stimulated by IL-1beta. Hydrogen Peroxide 176-180 mitogen-activated protein kinase 8 Homo sapiens 208-211 9790925-6 1998 These results suggest that, in A549, IL-1beta and H2O2 induce JNK activation by two independent pathways. Hydrogen Peroxide 50-54 mitogen-activated protein kinase 8 Homo sapiens 62-65 9657968-3 1998 Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. Hydrogen Peroxide 29-33 mitogen-activated protein kinase 8 Homo sapiens 273-281 9657968-7 1998 Because NF-kappaB activation by H2O2 is potentially related to both the ERK and JNK/SAPK signalling pathways, we examined the effects of inhibiting the activation of NF-kappaB; this interference had no effect on the cellular response to H2O2. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 8 Homo sapiens 80-83 9657968-10 1998 Bcl-2 acts independently and downstream of ERK and JNK/SAPK to enhance the survival of H2O2-treated cells. Hydrogen Peroxide 87-91 mitogen-activated protein kinase 8 Homo sapiens 51-59 9682214-5 1998 Treatment with nonlethal concentrations of H2O2, which resulted in the simultaneous stimulation of mitogen-activated protein kinase (MAPK) and JNK, demonstrated that bcl-2 appeared to alter the balance of activation of these two kinase cascades. Hydrogen Peroxide 43-47 mitogen-activated protein kinase 8 Homo sapiens 143-146 9119028-2 1997 Recently, H2O2 has been reported to stimulate the activity of the mitogen-activated protein kinases (MAPKs) ERK and JNK, and the expression of the proto-oncogenes c-fos and c-jun. Hydrogen Peroxide 10-14 mitogen-activated protein kinase 8 Homo sapiens 116-119 9119028-4 1997 The result was positive, a maximum of stimulation being reached with 200 microM H2O2 (0.3 pmol H2O2/cell) for both ERK and JNK. Hydrogen Peroxide 80-84 mitogen-activated protein kinase 8 Homo sapiens 123-126 9119028-4 1997 The result was positive, a maximum of stimulation being reached with 200 microM H2O2 (0.3 pmol H2O2/cell) for both ERK and JNK. Hydrogen Peroxide 95-99 mitogen-activated protein kinase 8 Homo sapiens 123-126 9119028-8 1997 Moreover, the stimulation by H2O2 of ERK and JNK was decreased by phospholipase A2 activity inhibitors. Hydrogen Peroxide 29-33 mitogen-activated protein kinase 8 Homo sapiens 45-48 9119028-13 1997 Furthermore, H2O2 likely induced the expression of CL100/PAC1/MKP-1, a dual specificity phosphatase which has been implicated in ERK and JNK inactivation in the nucleus. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 8 Homo sapiens 137-140 9119028-15 1997 These results strongly suggest an involvement of arachidonic acid and/or its metabolites in the stimulation of both ERK and JNK following the oxidative stress evoked by H2O2, which induced a cell cycle arrest probably independent of the stimulation of JNK. Hydrogen Peroxide 169-173 mitogen-activated protein kinase 8 Homo sapiens 124-127 9119028-15 1997 These results strongly suggest an involvement of arachidonic acid and/or its metabolites in the stimulation of both ERK and JNK following the oxidative stress evoked by H2O2, which induced a cell cycle arrest probably independent of the stimulation of JNK. Hydrogen Peroxide 169-173 mitogen-activated protein kinase 8 Homo sapiens 252-255 9090707-4 1997 The activation of JNK1 was enhanced when the cells were pretreated with prooxidant H2O2. Hydrogen Peroxide 83-87 mitogen-activated protein kinase 8 Homo sapiens 18-22 8674048-5 1996 Furthermore, activation of JNK1 by PEITC was inhibited by pro-oxidants hydrogen peroxide and diamide, although these two pro-oxidants by themselves had opposing effects on JNK1 activity. Hydrogen Peroxide 71-88 mitogen-activated protein kinase 8 Homo sapiens 27-31 35633887-11 2022 siPAGE4 plus H2O2 potentiated H2O2 effect via reducing the p-ERK1/2 level and increasing p-JNK1/2 level. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 8 Homo sapiens 91-97 34741589-7 2022 However, the inhibitory effect of tCQA on JNK and P38 levels activated by the JNK agonist anisomycin is not obvious; meanwhile, tCQA could inhibit the activation of JNK/P38 induced by H2 O2 , which suggests that tCQA might inhibit the JNK/P38 signaling pathway by reducing ROS. Hydrogen Peroxide 184-189 mitogen-activated protein kinase 8 Homo sapiens 165-168 34741589-7 2022 However, the inhibitory effect of tCQA on JNK and P38 levels activated by the JNK agonist anisomycin is not obvious; meanwhile, tCQA could inhibit the activation of JNK/P38 induced by H2 O2 , which suggests that tCQA might inhibit the JNK/P38 signaling pathway by reducing ROS. Hydrogen Peroxide 184-189 mitogen-activated protein kinase 8 Homo sapiens 235-238 34826531-6 2022 Meanwhile, Au NS exhibited enhanced ROS scavenging efficiency of hydrogen peroxides and superoxide, which was helpful to restrain the activity of peroxisome proliferators-activated receptors beta (PPARbeta) and c-Jun N-terminal kinase (JNK), thereby reducing HSCs proliferation to enhance HSCs inactivation efficacy. Hydrogen Peroxide 65-83 mitogen-activated protein kinase 8 Homo sapiens 211-234 34826531-6 2022 Meanwhile, Au NS exhibited enhanced ROS scavenging efficiency of hydrogen peroxides and superoxide, which was helpful to restrain the activity of peroxisome proliferators-activated receptors beta (PPARbeta) and c-Jun N-terminal kinase (JNK), thereby reducing HSCs proliferation to enhance HSCs inactivation efficacy. Hydrogen Peroxide 65-83 mitogen-activated protein kinase 8 Homo sapiens 236-239 34144191-4 2021 However, H2O2 also induces signaling through stress-activated kinases (SAPK, e.g., JNK and p38MAPK) that can activate p53. Hydrogen Peroxide 9-13 mitogen-activated protein kinase 8 Homo sapiens 83-86 8780897-6 1996 In contrast to UV irradiation, other forms of stress, such as H2O2 or heat shock were capable of inducing JNK activation in CS-B cells. Hydrogen Peroxide 62-66 mitogen-activated protein kinase 8 Homo sapiens 106-109 34203307-10 2021 Mechanistically, MT dramatically suppressed H2O2-induced Bcl-2 downregulation, Bax upregulation, apoptotic factor caspase-3 activation, Mitogen-activated protein kinase (MAPK) (JNK, ERK, and p38), and Nuclear factor-kappaB (NF-kappaB) activation, thereby preventing H2O2-induced neurotoxicity. Hydrogen Peroxide 44-48 mitogen-activated protein kinase 8 Homo sapiens 177-180 34165415-3 2022 MAM fights cancer progression by inducing apoptosis, necroptosis, and deregulating signaling pathways through H2O2-induced JNK/iNOS/NO and MAPK, ERK1/2 pathways, JNK activation, and the RIP1/RIP3 complex. Hydrogen Peroxide 110-114 mitogen-activated protein kinase 8 Homo sapiens 123-126 34165415-3 2022 MAM fights cancer progression by inducing apoptosis, necroptosis, and deregulating signaling pathways through H2O2-induced JNK/iNOS/NO and MAPK, ERK1/2 pathways, JNK activation, and the RIP1/RIP3 complex. Hydrogen Peroxide 110-114 mitogen-activated protein kinase 8 Homo sapiens 162-165 35633887-11 2022 siPAGE4 plus H2O2 potentiated H2O2 effect via reducing the p-ERK1/2 level and increasing p-JNK1/2 level. Hydrogen Peroxide 30-34 mitogen-activated protein kinase 8 Homo sapiens 91-97 33918172-13 2021 FMU200 reduced both early and late apoptotic cells, decreased ROS levels, restored mitochondrial membrane potential, and downregulated JNK phosphorylation after H2O2 exposure. Hydrogen Peroxide 161-165 mitogen-activated protein kinase 8 Homo sapiens 135-138 34211630-4 2021 We show that TPGS induces apoptosis in K562 cells through H2O2 signaling mechanism comprising the activation of a minimal molecular cascade: the kinase JNK>the transcription factor c-JUN>the activation of BCL-only BH3 proapoptotic protein PUMA>loss of mitochondrial membrane potential (DeltaPsi m)>activation of caspase-3>chromatin condensation>fragmentation of DNA. Hydrogen Peroxide 58-62 mitogen-activated protein kinase 8 Homo sapiens 152-155 35218032-6 2022 Furthermore, preincubation with Orz reduced H2 O2 -mediated the proapoptotic protein of Bak expression and the phosphorylation of ASK1, p38, JNK, and ERK, and increased the anti-apoptotic protein of Bcl-xl expression and anti-oxidative stress proteins of Nrf2 and HO-1 expression. Hydrogen Peroxide 44-49 mitogen-activated protein kinase 8 Homo sapiens 141-144 33880669-7 2021 Consequently, compared to TMPyP4 alone, TMPyP4 and H2O2 combined treatment upregulates the expression of BAX, cleaved caspase 3, and p-JNK and downregulates the expression of Bcl-2 in A549 and PANC cells. Hydrogen Peroxide 51-55 mitogen-activated protein kinase 8 Homo sapiens 135-138 33918172-15 2021 FMU200 protects neuroblastoma SH-SY5Y cells against 6-OHDA- and H2O2-induced apoptosis, which may result from suppressing the JNK pathways. Hydrogen Peroxide 64-68 mitogen-activated protein kinase 8 Homo sapiens 126-129 32821124-3 2020 Also, LanCL1 protects cells by inhibiting the JNK signaling pathway after H2O2 treatment. Hydrogen Peroxide 74-78 mitogen-activated protein kinase 8 Homo sapiens 46-49 33270331-7 2021 Furthermore, the UVB/H2 O2 -induced excessive production of reactive oxygen species, degradation of collagen, activation of MAPKs, including P38, ERK, and JNK, and premature senescence were remarkably attenuated by F-FEJS in dermal fibroblast cells. Hydrogen Peroxide 21-26 mitogen-activated protein kinase 8 Homo sapiens 155-158 33915898-6 2021 Western blotting detection indicated that H2O2 elicited hyperphosphorylation of PI3K/Akt, ERK1/2, JNK, p38 MAPK, and p65 NF-kappaB. Hydrogen Peroxide 42-46 mitogen-activated protein kinase 8 Homo sapiens 98-101 32678390-3 2020 The exposure of adipocytes to H2O2 (generated by glucose oxidase) resulted in an elevated level of ROS, a reduced content of GSH and an increase in JNK activation, concomitantly with a decrease in insulin-stimulated PI3K, Akt and p70S6K activation and cellular glucose uptake. Hydrogen Peroxide 30-34 mitogen-activated protein kinase 8 Homo sapiens 148-151 32502496-3 2020 In this study, we showed a strong interaction among SUMO-1-JNK-Tau proteins and their molecular targets in an in vitro model (SHSY5Y cell line) of oxidative stress in which a significant reduction of cell viability and an augmented cell death was induced by increased doses of H2O2. Hydrogen Peroxide 277-281 mitogen-activated protein kinase 8 Homo sapiens 59-62 32410998-0 2020 Paeoniflorin Resists H2O2-Induced Oxidative Stress in Melanocytes by JNK/Nrf2/HO-1 Pathway. Hydrogen Peroxide 21-25 mitogen-activated protein kinase 8 Homo sapiens 69-72 32552665-9 2020 Moreover, p-p-38, p-ERK, and p-JNK were up-regulated in H2O2-treated HLE-B3 cells, and overexpression of miR-182-5p reversed the effects of H2O2 on HLE-B3 cells. Hydrogen Peroxide 56-60 mitogen-activated protein kinase 8 Homo sapiens 31-34 32410998-6 2020 Taken together, our study firstly demonstrates that PF resists H2O2-induced oxidative stress in melanocytes probably by activating JNK/Nrf2/HO-1 signaling, suggesting a potential therapeutic application of PF on vitiligo. Hydrogen Peroxide 63-67 mitogen-activated protein kinase 8 Homo sapiens 131-134 30965208-6 2019 The current results showed that the cell viability loss, DNA fragmentation, morphological shrinkage, and nuclear condensation in H2O2-treated porcine GCs was correlated with enhanced activation of JNK. Hydrogen Peroxide 129-133 mitogen-activated protein kinase 8 Homo sapiens 197-200 32139669-7 2020 Moreover, we confirmed that the activation of MAPK signals (ERK1/2, p38, JNK) was required for the inflammatory response induced by O3 or H2O2 while only the phosphorylation of ERK pathway was diminished in the TRPC6-knockdown situation. Hydrogen Peroxide 138-142 mitogen-activated protein kinase 8 Homo sapiens 73-76 31430968-10 2019 Thus, the present study demonstrated that hispidin provides protection against H2O2-induced damage in ARPE-19 cells via activation of Nrf2 signaling and up-regulation of its downstream targets, including Phase II enzymes, which might be associated with the activation of the JNK pathway. Hydrogen Peroxide 79-83 mitogen-activated protein kinase 8 Homo sapiens 275-278 30965208-10 2019 Importantly, we found that p-PKCdelta acts as an upstream activator of JNK in H2O2-treated porcine GCs. Hydrogen Peroxide 78-82 mitogen-activated protein kinase 8 Homo sapiens 71-74 29753743-6 2018 We also found that the H2O2-induced JNK activation was attenuated in JLP KD cancer cells. Hydrogen Peroxide 23-27 mitogen-activated protein kinase 8 Homo sapiens 36-39 30791985-0 2019 JNK1/beta-catenin axis regulates H2O2-induced epithelial-to-mesenchymal transition in human lens epithelial cells. Hydrogen Peroxide 33-37 mitogen-activated protein kinase 8 Homo sapiens 0-4 30791985-5 2019 H2O2-induced EMT was accompanied by accumulation of phosphorylated JNK1. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 67-71 30791985-6 2019 In contrast, knockdown of JNK1 via siRNA reversed H2O2-induced EMT. Hydrogen Peroxide 50-54 mitogen-activated protein kinase 8 Homo sapiens 26-30 30791985-10 2019 In conclusion, our data suggest that JNK1 is essential for H2O2-induced EMT in hLECs via mediating the translocation of beta-catenin. Hydrogen Peroxide 59-63 mitogen-activated protein kinase 8 Homo sapiens 37-41 30839497-0 2019 Halofuginone protects HUVECs from H2O2-induced injury by modulating VEGF/JNK signaling pathway. Hydrogen Peroxide 34-38 mitogen-activated protein kinase 8 Homo sapiens 73-76 30839497-7 2019 In detail, it showed that H2O2 induced a transient activation of Mitogen-activated protein kinases members ERK1/2 and p38, whereas induced a sustained activation of c-Jun N-terminal kinase (JNK), which play dominant roles in triggering apoptosis. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 8 Homo sapiens 165-188 30839497-7 2019 In detail, it showed that H2O2 induced a transient activation of Mitogen-activated protein kinases members ERK1/2 and p38, whereas induced a sustained activation of c-Jun N-terminal kinase (JNK), which play dominant roles in triggering apoptosis. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 8 Homo sapiens 190-193 30839497-8 2019 Inhibition of JNK activation also inhibited H2O2-mediated apoptosis. Hydrogen Peroxide 44-48 mitogen-activated protein kinase 8 Homo sapiens 14-17 30662622-7 2018 Furthermore, H2O2-induced proliferation inhibition, apoptosis, and inflammation in HK-2 cells were ameliorated by NAC (N-acetyl cysteine, the ROS scavenger) and SP600125 (the JNK inhibitor). Hydrogen Peroxide 13-17 mitogen-activated protein kinase 8 Homo sapiens 175-178 29616751-8 2018 H2O2 activated the nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK) pathways and induced cell apoptosis, while the overexpression of miR-181a suppressed both pathways and decreased the rate of apoptosis. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 57-80 29458150-10 2018 Meanwhile, co-treatment with ROS scavenger N-acetyl-L-cysteine (NAC) or H2O2 consumer catalase-polyethylene glycol (PEG-catalase) inhibited parkin recruitment, alleviated autophagy formation, and mitigated JNK pathway related apoptosis. Hydrogen Peroxide 72-76 mitogen-activated protein kinase 8 Homo sapiens 206-209 29616751-8 2018 H2O2 activated the nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK) pathways and induced cell apoptosis, while the overexpression of miR-181a suppressed both pathways and decreased the rate of apoptosis. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 82-85 29616751-9 2018 CONCLUSIONS: In conclusion, this study indicated that miR-181a could improve the survival rate of TM cells after H2O2 treatment by blocking the NF-kappaB and JNK signaling pathways. Hydrogen Peroxide 113-117 mitogen-activated protein kinase 8 Homo sapiens 158-161 29363570-6 2018 On the other hand, blocking of autophagy and/or JNK also reduced the level of H2O2-induced GCs death, but failed to further restore GCs viability in the presence of melatonin. Hydrogen Peroxide 78-82 mitogen-activated protein kinase 8 Homo sapiens 48-51 29849919-6 2018 As well, in vitro study showed that p-CA also suppressed H2O2-induced phosphorylation of p-38, ERK, and JNK in HLE cells. Hydrogen Peroxide 57-61 mitogen-activated protein kinase 8 Homo sapiens 104-107 28751935-0 2017 Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding. Hydrogen Peroxide 82-99 mitogen-activated protein kinase 8 Homo sapiens 138-141 29531808-7 2018 Thapsigargin or hydrogen peroxide treatment activated multiple death signals including JNK, Bcl-2 family members, and caspases. Hydrogen Peroxide 16-33 mitogen-activated protein kinase 8 Homo sapiens 87-90 29207156-0 2018 MAPK inhibitors, particularly the JNK inhibitor, increase cell death effects in H2O2-treated lung cancer cells via increased superoxide anion and glutathione depletion. Hydrogen Peroxide 80-84 mitogen-activated protein kinase 8 Homo sapiens 34-37 29207156-5 2018 Among the MAPK inhibitors, a JNK inhibitor significantly augmented the loss of mitochondrial membrane potential (MMP; DeltaPsim) in H2O2-treated Calu-6 and A549 lung cancer cells. Hydrogen Peroxide 132-136 mitogen-activated protein kinase 8 Homo sapiens 29-32 29207156-6 2018 Intracellular ROS levels were significantly increased in the H2O2-treated cells at 1 and 24 h. Only the JNK inhibitor increased ROS levels in the H2O2-treated cells at 1 h and all MAPK inhibitors raised superoxide anion levels in these cells at 24 h. In addition, H2O2 induced GSH depletion in Calu-6 and A549 cells and the JNK inhibitor significantly enhanced GSH depletion in H2O2-treated cells. Hydrogen Peroxide 61-65 mitogen-activated protein kinase 8 Homo sapiens 104-107 29207156-6 2018 Intracellular ROS levels were significantly increased in the H2O2-treated cells at 1 and 24 h. Only the JNK inhibitor increased ROS levels in the H2O2-treated cells at 1 h and all MAPK inhibitors raised superoxide anion levels in these cells at 24 h. In addition, H2O2 induced GSH depletion in Calu-6 and A549 cells and the JNK inhibitor significantly enhanced GSH depletion in H2O2-treated cells. Hydrogen Peroxide 61-65 mitogen-activated protein kinase 8 Homo sapiens 324-327 29207156-6 2018 Intracellular ROS levels were significantly increased in the H2O2-treated cells at 1 and 24 h. Only the JNK inhibitor increased ROS levels in the H2O2-treated cells at 1 h and all MAPK inhibitors raised superoxide anion levels in these cells at 24 h. In addition, H2O2 induced GSH depletion in Calu-6 and A549 cells and the JNK inhibitor significantly enhanced GSH depletion in H2O2-treated cells. Hydrogen Peroxide 146-150 mitogen-activated protein kinase 8 Homo sapiens 104-107 29207156-6 2018 Intracellular ROS levels were significantly increased in the H2O2-treated cells at 1 and 24 h. Only the JNK inhibitor increased ROS levels in the H2O2-treated cells at 1 h and all MAPK inhibitors raised superoxide anion levels in these cells at 24 h. In addition, H2O2 induced GSH depletion in Calu-6 and A549 cells and the JNK inhibitor significantly enhanced GSH depletion in H2O2-treated cells. Hydrogen Peroxide 146-150 mitogen-activated protein kinase 8 Homo sapiens 104-107 29207156-6 2018 Intracellular ROS levels were significantly increased in the H2O2-treated cells at 1 and 24 h. Only the JNK inhibitor increased ROS levels in the H2O2-treated cells at 1 h and all MAPK inhibitors raised superoxide anion levels in these cells at 24 h. In addition, H2O2 induced GSH depletion in Calu-6 and A549 cells and the JNK inhibitor significantly enhanced GSH depletion in H2O2-treated cells. Hydrogen Peroxide 146-150 mitogen-activated protein kinase 8 Homo sapiens 104-107 29207156-9 2018 The enhanced effect of MAPK inhibitors, especially the JNK inhibitor, on cell death in H2O2-treated lung cancer cells was correlated with increased O2 - levels and GSH depletion. Hydrogen Peroxide 87-91 mitogen-activated protein kinase 8 Homo sapiens 55-58 29408825-6 2018 Furthermore, JNK (c-Jun N-terminal kinase), but not p38 and ERK (extracellular signal-regulated kinase), mediated PPARdelta-dependent inhibition of TSP-1 expression in VSMCs exposed to H2O2. Hydrogen Peroxide 185-189 mitogen-activated protein kinase 8 Homo sapiens 13-16 29408825-6 2018 Furthermore, JNK (c-Jun N-terminal kinase), but not p38 and ERK (extracellular signal-regulated kinase), mediated PPARdelta-dependent inhibition of TSP-1 expression in VSMCs exposed to H2O2. Hydrogen Peroxide 185-189 mitogen-activated protein kinase 8 Homo sapiens 18-41 27650197-7 2017 On the other hand, the increased phosphorylation of mitogen-activated protein kinase (MAPK) proteins (c-Jun N-terminal kinase [JNK], p38, and extracellular signal-regulated kinase [ERK]) by JDA-202 was suppressed by N-acetylcysteine (NAC) or catalase, a known reactive oxygen species (ROS) or H2O2 scavenger. Hydrogen Peroxide 293-297 mitogen-activated protein kinase 8 Homo sapiens 102-125 27650197-7 2017 On the other hand, the increased phosphorylation of mitogen-activated protein kinase (MAPK) proteins (c-Jun N-terminal kinase [JNK], p38, and extracellular signal-regulated kinase [ERK]) by JDA-202 was suppressed by N-acetylcysteine (NAC) or catalase, a known reactive oxygen species (ROS) or H2O2 scavenger. Hydrogen Peroxide 293-297 mitogen-activated protein kinase 8 Homo sapiens 127-130 27181592-7 2017 Moreover, the phosphorylated level of JNK increased markedly with the extension of H2O2 exposure time. Hydrogen Peroxide 83-87 mitogen-activated protein kinase 8 Homo sapiens 38-41 27181592-8 2017 Either attenuation of intracellular ROS with antioxidant NAC or inhibition of JNK phosphorylation with SP600125 or JNK siRNA could significantly prevent H2O2-induced parthanatos in glioma cells. Hydrogen Peroxide 153-157 mitogen-activated protein kinase 8 Homo sapiens 78-81 27181592-8 2017 Either attenuation of intracellular ROS with antioxidant NAC or inhibition of JNK phosphorylation with SP600125 or JNK siRNA could significantly prevent H2O2-induced parthanatos in glioma cells. Hydrogen Peroxide 153-157 mitogen-activated protein kinase 8 Homo sapiens 115-118 27357344-6 2017 In osteoblastic MC3T3-E1 and MG-63 cells, H2 O2 triggered p38, JNK, ERK and p66Shc phosphorylation, and cell apoptosis. Hydrogen Peroxide 42-47 mitogen-activated protein kinase 8 Homo sapiens 63-66 29027437-0 2017 [Rhaponticum uniflorum inhibits H2O2-induced apoptosis of liver cells via JNK and NF-kappaB pathways]. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 8 Homo sapiens 74-77 29027437-9 2017 unifloru had the inhibitory effect on apoptosis induced by H2O2in HepG2 cells, and the mechanism maybe associated with inhibiting JNK activation and NF-kappaB nuclear translocation. Hydrogen Peroxide 73-77 mitogen-activated protein kinase 8 Homo sapiens 144-147 28973972-3 2017 Mechanistically, ME exhibited protection from H2O2-induced neurotoxicity via caspase-3 inactivation, Bcl-2 downregulation, Bax upregulation, and MAPK activation (ERK 1/2, JNK 1/2, and p38 MAPK) in vitro. Hydrogen Peroxide 46-50 mitogen-activated protein kinase 8 Homo sapiens 171-178 27914828-9 2017 Further studies showed that OL also inhibited H2O2-induced P38 and JNK phosphorylation but enhanced ERK1/2 phosphorylation in a dose-dependent manner. Hydrogen Peroxide 46-50 mitogen-activated protein kinase 8 Homo sapiens 67-70 28751935-1 2017 Dysregulation of c-Jun N-terminal kinase (JNK) activation promoted DNA damage response bypass and tumorigenesis in our model of hydrogen peroxide-associated ulcerative colitis (UC) and in patients with quiescent UC (QUC), UC-related dysplasia, and UC-related carcinoma (UC-CRC), thereby adapting to oxidative stress. Hydrogen Peroxide 128-145 mitogen-activated protein kinase 8 Homo sapiens 17-40 28751935-1 2017 Dysregulation of c-Jun N-terminal kinase (JNK) activation promoted DNA damage response bypass and tumorigenesis in our model of hydrogen peroxide-associated ulcerative colitis (UC) and in patients with quiescent UC (QUC), UC-related dysplasia, and UC-related carcinoma (UC-CRC), thereby adapting to oxidative stress. Hydrogen Peroxide 128-145 mitogen-activated protein kinase 8 Homo sapiens 42-45 26789270-8 2016 Tbeta4 peptide inhibited the effects of H2O2 on the activation of ERK and JNK MAPK, and NF-kappaB in PDLCs. Hydrogen Peroxide 40-44 mitogen-activated protein kinase 8 Homo sapiens 74-77 27883020-7 2016 Meanwhile, JNK inhibitor prevents SIRT1 phosphorylation, leading to elevated SIRT1 protein levels even in the presence of H2O2. Hydrogen Peroxide 122-126 mitogen-activated protein kinase 8 Homo sapiens 11-14 27098861-7 2016 Cyanidin and delphinidin both showed inhibitory effects on the H2O2-induced increase in intracellular ROS formation and the activation of ERK1/2 and JNK. Hydrogen Peroxide 63-67 mitogen-activated protein kinase 8 Homo sapiens 149-152 26802903-0 2016 2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H2O2-dependent JNK activation in cancer cells. Hydrogen Peroxide 118-122 mitogen-activated protein kinase 8 Homo sapiens 133-136 26802903-4 2016 et Zucc, caused hydrogen peroxide (H2O2) dependent activation of JNK and induced the expression of inducible nitric oxide synthase (iNOS), thereby leading to nitric oxide (NO) generation in multiple cancer cells. Hydrogen Peroxide 16-33 mitogen-activated protein kinase 8 Homo sapiens 65-68 26802903-4 2016 et Zucc, caused hydrogen peroxide (H2O2) dependent activation of JNK and induced the expression of inducible nitric oxide synthase (iNOS), thereby leading to nitric oxide (NO) generation in multiple cancer cells. Hydrogen Peroxide 35-39 mitogen-activated protein kinase 8 Homo sapiens 65-68 26802903-8 2016 In summary, a natural product MAM induced NO-dependent multiple forms of cell death in cancer cells mediated by H2O2-dependent JNK activation in cancer cells. Hydrogen Peroxide 112-116 mitogen-activated protein kinase 8 Homo sapiens 127-130 26058460-7 2016 SelS silence aggravated hydrogen peroxide-induced oxidative stress and phosphorylation of p38 MAPK and c-Jun N-terminal kinase (JNK) in VSMCs. Hydrogen Peroxide 24-41 mitogen-activated protein kinase 8 Homo sapiens 103-126 26058460-7 2016 SelS silence aggravated hydrogen peroxide-induced oxidative stress and phosphorylation of p38 MAPK and c-Jun N-terminal kinase (JNK) in VSMCs. Hydrogen Peroxide 24-41 mitogen-activated protein kinase 8 Homo sapiens 128-131 26710786-3 2015 The mechanism of hydrogen peroxide apoptotic action includes launching signaling pathways that involve protein kinases PI3K, p38MAPK, JNK and ERK. Hydrogen Peroxide 17-34 mitogen-activated protein kinase 8 Homo sapiens 134-137 26456053-6 2015 Mechanistically, H2O2-induced cell death involves inhibition of pro-survival signaling proteins (Akt, Nrf2) and activation of pro-death signaling proteins (p38, JNK1). Hydrogen Peroxide 17-21 mitogen-activated protein kinase 8 Homo sapiens 161-165 26456053-7 2015 Overexpression of TRPV2 in H2O2-treated hepatoma cells aggravates the inhibition of Akt and Nrf2, while it enhances the activation of p38 and JNK1 at the early stage of cell death. Hydrogen Peroxide 27-31 mitogen-activated protein kinase 8 Homo sapiens 142-146 26535076-5 2015 H2O2-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 101-122 26535076-5 2015 H2O2-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 124-127 26495060-7 2015 Furthermore, propofol significantly ameliorated H2O2-induced phosphorylation of p38 MAPK, JNK, and Akt in HUVECs. Hydrogen Peroxide 48-52 mitogen-activated protein kinase 8 Homo sapiens 90-93 26495060-8 2015 CONCLUSIONS: Propofol can protect HUVECs against H2O2-induced apoptosis via a mechanism that may involve p38 MAPK, JNK, and Akt signaling pathways. Hydrogen Peroxide 49-53 mitogen-activated protein kinase 8 Homo sapiens 115-118 25615876-0 2015 Pretreatment with pPolyHb attenuates H2O2-induced endothelial cell injury through inhibition of JNK/p38 MAPK pathway by upregulation of heme oxygenase-1. Hydrogen Peroxide 37-41 mitogen-activated protein kinase 8 Homo sapiens 96-99 26234813-3 2015 The current study shows that H2O2 suppressed ERK1/2 activation and phosphorylation at specific concentrations and times in human umbilical vein endothelial cells but not in immortalized mouse aortic endothelial cells or human astrocytoma cell line CRT-MG. Phosphorylation of other MAPK family members (i.e., p38 and JNK) was not suppressed by H2O2. Hydrogen Peroxide 29-33 mitogen-activated protein kinase 8 Homo sapiens 316-319 25615876-3 2015 The results showed that the pretreatment augmented heme oxygenase-1 (HO-1) expression, and at the same time, decreased the phosphorylation of JNK/p38 mitogen-activated protein kinase (MAPK) and intracellular ROS generation in H2O2-treated HUVECs. Hydrogen Peroxide 226-230 mitogen-activated protein kinase 8 Homo sapiens 142-145 25874865-3 2015 We found that both JNK and AMPK were phosphorylated at their activation sites by TNF-alpha, Anisomycin, H2O2 and sorbitol. Hydrogen Peroxide 104-108 mitogen-activated protein kinase 8 Homo sapiens 19-22 25720812-4 2015 In addition, pretreatment with THF attenuated H2O2-induced rapid and significant phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinases (PI3K)/Akt. Hydrogen Peroxide 46-50 mitogen-activated protein kinase 8 Homo sapiens 100-123 25720812-4 2015 In addition, pretreatment with THF attenuated H2O2-induced rapid and significant phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinases (PI3K)/Akt. Hydrogen Peroxide 46-50 mitogen-activated protein kinase 8 Homo sapiens 125-128 24705900-10 2014 In conclusion, miR-92a overexpression inhibits H2O2-induced VSMC apoptosis by directly targeting the MKK4-JNK1 pathway. Hydrogen Peroxide 47-51 mitogen-activated protein kinase 8 Homo sapiens 106-110 25496033-11 2015 SOD3 knockdown abolished the inhibition of GW4064 on JNK phosphorylation induced by H2O2in HepG2 cells. Hydrogen Peroxide 84-88 mitogen-activated protein kinase 8 Homo sapiens 53-56 25997250-7 2015 Propofol also inhibited H2O2-induced p38 MAPK, JNK and Akt phosphorylation. Hydrogen Peroxide 24-28 mitogen-activated protein kinase 8 Homo sapiens 47-50 24820448-8 2014 H2O2 increased myocyte JNK activation by 237% and p38 activation by 60%, decreased myocyte viability by 38% and increased necrosis by 34% (all P < 0.01). Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 23-26 24820448-11 2014 Addition of JNK inhibitor SP600125 or p38 inhibitor SB203580 to myocytes plus H2O2 prevented H2O2 decrease in viability and increased hUCBC beneficial effects. Hydrogen Peroxide 93-97 mitogen-activated protein kinase 8 Homo sapiens 12-15 25351664-5 2015 At the protein level, 2PS reduced H2 O2 -induced phosphorylation of the ERK1/2 and JNK MAPKs, and increased Nrf2 expression. Hydrogen Peroxide 34-39 mitogen-activated protein kinase 8 Homo sapiens 83-86 25220073-8 2014 CHOP/Bim or JNK/Bim-dependent ER stress signaling pathways maybe related to the neuroprotective effects of L-carnitine against H2O2-induced apoptosis and oxidative injury. Hydrogen Peroxide 127-131 mitogen-activated protein kinase 8 Homo sapiens 12-15 25128742-6 2014 Immunofluorescence and Western blot analyses demonstrated that H2O2 treatment up-regulated SIRT1, phosphorylated-JNK (p-JNK), p-p38MAPK, and p-ERK expression. Hydrogen Peroxide 63-67 mitogen-activated protein kinase 8 Homo sapiens 113-116 25128742-6 2014 Immunofluorescence and Western blot analyses demonstrated that H2O2 treatment up-regulated SIRT1, phosphorylated-JNK (p-JNK), p-p38MAPK, and p-ERK expression. Hydrogen Peroxide 63-67 mitogen-activated protein kinase 8 Homo sapiens 120-123 24700514-7 2014 Taken together, our data suggest that EGCG is capable of potentiating photodynamic therapy responses, presumably through the intracellular oxidative stress-sensitive JNK/IFN-gamma pathway by exogenous hydrogen peroxide formation. Hydrogen Peroxide 201-218 mitogen-activated protein kinase 8 Homo sapiens 166-169 24906456-0 2014 Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus. Hydrogen Peroxide 64-81 mitogen-activated protein kinase 8 Homo sapiens 27-30 24802394-7 2014 These results suggest that, after 72 h of 250 muM H2O2 exposure, Akt, JNK, and GSK3beta intracellular kinase signaling pathways converge to regulate PDLC survival involving XIAP. Hydrogen Peroxide 50-54 mitogen-activated protein kinase 8 Homo sapiens 70-73 24582688-5 2014 Second, H2O2, the most important form of ROS in the cells in response to extracellular stress signals, can induce phosphorylation of the EZH2 protein and the activation of JNK, STAT3, and Akt. Hydrogen Peroxide 8-12 mitogen-activated protein kinase 8 Homo sapiens 172-175 24695490-0 2014 Opposing role of JNK-p38 kinase and ERK1/2 in hydrogen peroxide-induced oxidative damage of human trophoblast-like JEG-3 cells. Hydrogen Peroxide 46-63 mitogen-activated protein kinase 8 Homo sapiens 17-20 24712558-6 2014 RESULTS: Hydrogen peroxide induced apoptotic cell death in fibroblasts, accompanied by induction of phosphorylation of JNK and p38 and activation of caspase-3. Hydrogen Peroxide 9-26 mitogen-activated protein kinase 8 Homo sapiens 119-122 24695490-7 2014 The three MAPK subfamilies, ERK1/2, JNK and p38 kinase, were all activated under H2O2-induced oxidative stress. Hydrogen Peroxide 81-85 mitogen-activated protein kinase 8 Homo sapiens 36-39 24695490-8 2014 Blocking the activation of JNK and p38 kinase increased cell viability and decreased apoptosis induced by H2O2 with their respective inhibitors, SP600125 and SB203580. Hydrogen Peroxide 106-110 mitogen-activated protein kinase 8 Homo sapiens 27-30 24695490-10 2014 Taken together, these findings suggest that the mitochondria-dependent pathways and JNK-p38 kinase pathways are involved in H2O2-induced oxidative damage of human trophoblast-like JEG-3 cells, while ERK1/2 pathway may play an active role in cell survival following oxidant injury. Hydrogen Peroxide 124-128 mitogen-activated protein kinase 8 Homo sapiens 84-87 24118792-2 2013 Recently, we showed that H2 O2 activates DNA damage checkpoints in human colonic epithelial cells (HCEC) through c-Jun N-terminal Kinases (JNK) that induces p21(WAF1) . Hydrogen Peroxide 25-30 mitogen-activated protein kinase 8 Homo sapiens 113-137 24556843-9 2014 Moreover, activation of alpha7nAChR reduced H2O2-induced VPO-1 protein upregulation and JNK1/2 phosphorylation. Hydrogen Peroxide 44-48 mitogen-activated protein kinase 8 Homo sapiens 88-92 25431609-5 2014 In addition, H2O2 produced transcriptional changes in p53, JNK, p38 MAPK, AKT, BAX, and CDK4 that were inclined towards apoptosis, while GBR-extracts showed some transcriptional changes (upregulation of BAX and p53) that suggested an inclination for apoptosis although other changes (upregulation of antioxidant genes, AKT, JNK, and p38 MAPK) suggested that GBR-extracts favored survival of the HepG2 cells. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 8 Homo sapiens 324-327 25431609-5 2014 In addition, H2O2 produced transcriptional changes in p53, JNK, p38 MAPK, AKT, BAX, and CDK4 that were inclined towards apoptosis, while GBR-extracts showed some transcriptional changes (upregulation of BAX and p53) that suggested an inclination for apoptosis although other changes (upregulation of antioxidant genes, AKT, JNK, and p38 MAPK) suggested that GBR-extracts favored survival of the HepG2 cells. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 8 Homo sapiens 59-62 24118792-2 2013 Recently, we showed that H2 O2 activates DNA damage checkpoints in human colonic epithelial cells (HCEC) through c-Jun N-terminal Kinases (JNK) that induces p21(WAF1) . Hydrogen Peroxide 25-30 mitogen-activated protein kinase 8 Homo sapiens 139-142 24118792-4 2013 The latter observation raised the question of whether repeated H2 O2 exposures alter JNK activation, thereby promoting a direct passage of cells from G2/M arrest to driven cell cycle progression. Hydrogen Peroxide 63-68 mitogen-activated protein kinase 8 Homo sapiens 85-88 24118792-5 2013 Here, we report that increased proliferation of repeatedly H2 O2 -exposed HCEC cells (C-cell cultures) was associated with (i) increased phospho-p46 JNK, (ii) decreased total JNK and phospho-p54 JNK and (iii) p21(WAF1) down-regulation. Hydrogen Peroxide 59-64 mitogen-activated protein kinase 8 Homo sapiens 149-152 24118792-5 2013 Here, we report that increased proliferation of repeatedly H2 O2 -exposed HCEC cells (C-cell cultures) was associated with (i) increased phospho-p46 JNK, (ii) decreased total JNK and phospho-p54 JNK and (iii) p21(WAF1) down-regulation. Hydrogen Peroxide 59-64 mitogen-activated protein kinase 8 Homo sapiens 175-178 24118792-5 2013 Here, we report that increased proliferation of repeatedly H2 O2 -exposed HCEC cells (C-cell cultures) was associated with (i) increased phospho-p46 JNK, (ii) decreased total JNK and phospho-p54 JNK and (iii) p21(WAF1) down-regulation. Hydrogen Peroxide 59-64 mitogen-activated protein kinase 8 Homo sapiens 175-178 24118792-6 2013 Altered JNK activation and p21(WAF1) down-regulation were accompanied by defects in maintaining G2/M and mitotic spindle checkpoints through adaptation, as well as by apoptosis resistance following H2 O2 exposure. Hydrogen Peroxide 198-203 mitogen-activated protein kinase 8 Homo sapiens 8-11 23799549-2 2013 In the present study, the toxicological effect of hydrogen peroxide (H2O2) on HeLa cervical cancer cells was evaluated following treatment with MAPK inhibitors [MAP kinase or ERK kinase (MEK), c-Jun N-terminal kinase (JNK) or p38], N-acetyl cysteine (NAC) and propyl gallate (PG) (well-known antioxidants), or L-buthionine sulfoximine [BSO; an inhibitor of glutathione (GSH) synthesis]. Hydrogen Peroxide 50-67 mitogen-activated protein kinase 8 Homo sapiens 193-216 23811287-0 2013 Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells. Hydrogen Peroxide 18-35 mitogen-activated protein kinase 8 Homo sapiens 74-77 23811287-4 2013 We provided evidence that activated JNK was upstream effectors controlling both autophagy and apoptosis in response to elevated H2O2. Hydrogen Peroxide 128-132 mitogen-activated protein kinase 8 Homo sapiens 36-39 23811287-5 2013 Therefore, our findings demonstrate that calyxin Y serves multiple roles as a promising chemotherapeutic agent that induces H2O2-dependent autophagy and apoptosis via JNK activation. Hydrogen Peroxide 124-128 mitogen-activated protein kinase 8 Homo sapiens 167-170 23880762-7 2013 This increase in mitochondrial H2O2 specifically modulates MAPK signaling through the JNK/cJun pathway, whereas overexpressing Cu,Zn-SOD had no effect on any of these TCR-mediated signaling molecules. Hydrogen Peroxide 31-35 mitogen-activated protein kinase 8 Homo sapiens 86-89 23799549-2 2013 In the present study, the toxicological effect of hydrogen peroxide (H2O2) on HeLa cervical cancer cells was evaluated following treatment with MAPK inhibitors [MAP kinase or ERK kinase (MEK), c-Jun N-terminal kinase (JNK) or p38], N-acetyl cysteine (NAC) and propyl gallate (PG) (well-known antioxidants), or L-buthionine sulfoximine [BSO; an inhibitor of glutathione (GSH) synthesis]. Hydrogen Peroxide 69-73 mitogen-activated protein kinase 8 Homo sapiens 193-216 23417568-4 2013 In the current study, we scrutinized the effects of hydrogen peroxide and/or menadione (superoxide anion generator) on JNK/p38-MAPKs and JAK2-STAT3 pathways to elucidate the mechanism(s) by which each oxidant modulated the above-mentioned pathways leading to SK-N-MC cell death. Hydrogen Peroxide 52-69 mitogen-activated protein kinase 8 Homo sapiens 119-122 22757651-5 2012 The levels of p-JNK (Thr183/Tyr185) and cytochrome c in cytosol and BAX in heavy membrane (HM), respectively, were increased at 0.5 h and reached the peak at 12 h after stimulation with hydrogen peroxide. Hydrogen Peroxide 186-203 mitogen-activated protein kinase 8 Homo sapiens 16-19 23417568-6 2013 We also observed that menadione induced JNK-dependent p53 expression and apoptotic death in SK-N-MC cells while H2O2-induced JNK activation was p53 independent. Hydrogen Peroxide 112-116 mitogen-activated protein kinase 8 Homo sapiens 125-128 23742011-3 2013 A population of HCEC survived H2 O2 -induced oxidative stress via JNK-dependent cell cycle arrests. Hydrogen Peroxide 30-35 mitogen-activated protein kinase 8 Homo sapiens 66-69 23129185-6 2013 Further mechanistic study showed exposure of prostate cancer cells to H(2)O(2) resulted in increased phosphorylation of both JNK and c-Jun, and TAP siRNA effectively decreased H(2)O(2) -induced JNK and c-Jun phosphorylation. Hydrogen Peroxide 70-78 mitogen-activated protein kinase 8 Homo sapiens 125-128 23129185-6 2013 Further mechanistic study showed exposure of prostate cancer cells to H(2)O(2) resulted in increased phosphorylation of both JNK and c-Jun, and TAP siRNA effectively decreased H(2)O(2) -induced JNK and c-Jun phosphorylation. Hydrogen Peroxide 70-78 mitogen-activated protein kinase 8 Homo sapiens 194-197 23129185-6 2013 Further mechanistic study showed exposure of prostate cancer cells to H(2)O(2) resulted in increased phosphorylation of both JNK and c-Jun, and TAP siRNA effectively decreased H(2)O(2) -induced JNK and c-Jun phosphorylation. Hydrogen Peroxide 176-184 mitogen-activated protein kinase 8 Homo sapiens 125-128 23129185-6 2013 Further mechanistic study showed exposure of prostate cancer cells to H(2)O(2) resulted in increased phosphorylation of both JNK and c-Jun, and TAP siRNA effectively decreased H(2)O(2) -induced JNK and c-Jun phosphorylation. Hydrogen Peroxide 176-184 mitogen-activated protein kinase 8 Homo sapiens 194-197 23077074-10 2012 Exposure of CPCs to H(2)O(2) induced a 2-fold increase in cell apoptosis, mediated by activation of the c-Jun N-terminal protein kinase (JNK) pathway. Hydrogen Peroxide 20-28 mitogen-activated protein kinase 8 Homo sapiens 104-135 23077074-10 2012 Exposure of CPCs to H(2)O(2) induced a 2-fold increase in cell apoptosis, mediated by activation of the c-Jun N-terminal protein kinase (JNK) pathway. Hydrogen Peroxide 20-28 mitogen-activated protein kinase 8 Homo sapiens 137-140 23607503-4 2013 H2O2-induced ROS increased the phosphorylation of p38 MAPK and JNK; this was inhibited by DK pretreatment. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 63-66 23607503-5 2013 H2O2 treatment increased the phosphorylation of NF-kappaB, which was blocked by pretreatment with SB 203580, a p38 MAPK inhibitor, or SP 600125, a JNK inhibitor. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 8 Homo sapiens 147-150 22566145-0 2012 Phytosphingosine-1-phosphate represses the hydrogen peroxide-induced activation of c-Jun N-terminal kinase in human dermal fibroblasts through the phosphatidylinositol 3-kinase/Akt pathway. Hydrogen Peroxide 43-60 mitogen-activated protein kinase 8 Homo sapiens 85-106 22566145-6 2012 Interestingly, regulation of the JNK/Akt pathway by PhS1P attenuated H(2)O(2)-induced cell growth arrest. Hydrogen Peroxide 69-77 mitogen-activated protein kinase 8 Homo sapiens 33-36 22507555-7 2012 Melatonin blocked H(2) O(2) -induced phosphorylation of PI3K/Akt, p38, ERK, JNK, and MAPK, as well as activation of NF-kappaB, which was reversed by sirtinol and SIRT1 siRNA. Hydrogen Peroxide 18-27 mitogen-activated protein kinase 8 Homo sapiens 76-79 22683469-8 2012 We further demonstrated that the H(2)O(2)-induced increase in PLGF mRNA levels partially relies on p38 MAPK, JNK and ERK1/2 pathways. Hydrogen Peroxide 33-41 mitogen-activated protein kinase 8 Homo sapiens 109-112 22246135-6 2012 Our results demonstrated that flavonoid baicalein protected against H(2)O(2)-induced cell death by inhibition of JNK/ERK pathways activation and other key molecules in apoptotic pathways, including blockage of Bax and caspase-9 activation, induction of Bcl-2 expression and prevention of cell death. Hydrogen Peroxide 68-76 mitogen-activated protein kinase 8 Homo sapiens 113-116 22664326-5 2012 H(2)O(2) also induced epithelial to fibroblast-like morphological changes, together with upregulation of EMT biomarkers, and promoted phosphorylation of ERK1/2 and JNK in a time-dependent manner. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 8 Homo sapiens 164-167 22708121-10 2012 It also inhibited H2O2-induced phosphorylation of ERK, p38, and JNK. Hydrogen Peroxide 18-22 mitogen-activated protein kinase 8 Homo sapiens 64-67