PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28341201-0	2017	The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a gammaH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D.	Hydrogen Peroxide	67-84	ataxia telangiectasia mutated	Mus musculus	4-7	
28341201-5	2017	Although KU-55933 inhibited the H2O2- and Dox-induced activation of ATM, it attenuated the toxin-induced phosphorylation of the proteins H2AX and p53 only in the latter model of cell damage.	Hydrogen Peroxide	32-36	ataxia telangiectasia mutated	Mus musculus	68-71	
28341201-6	2017	Moreover, the ATM inhibitor prevented the H2O2-evoked increases in calpain and cathepsin D activity and attenuated cell damage to a similar degree as inhibitors of calpain (MDL28170) and cathepsin D (pepstatin A).	Hydrogen Peroxide	42-46	ataxia telangiectasia mutated	Mus musculus	14-17	
28487983-0	2017	Role of ataxia-telangiectasia mutated in hydrogen peroxide preconditioning against oxidative stress in Neuro-2a cells.	Hydrogen Peroxide	41-58	ataxia telangiectasia mutated	Mus musculus	8-37	
28487983-4	2017	The aim of the present study was therefore to investigate whether ATM mediates H2O2 preconditioning.	Hydrogen Peroxide	79-83	ataxia telangiectasia mutated	Mus musculus	66-69	
28487983-6	2017	In addition, preconditioning with 100 microM H2O2 activated ATM and increased ATM mRNA and protein expression levels in N2a cells.	Hydrogen Peroxide	45-49	ataxia telangiectasia mutated	Mus musculus	60-63	
28487983-6	2017	In addition, preconditioning with 100 microM H2O2 activated ATM and increased ATM mRNA and protein expression levels in N2a cells.	Hydrogen Peroxide	45-49	ataxia telangiectasia mutated	Mus musculus	78-81	
28487983-7	2017	Furthermore, the protective effects induced by H2O2 preconditioning were attenuated by pretreatment with the ATM inhibitor, Ku55933, or ATM small interfering RNA.	Hydrogen Peroxide	47-51	ataxia telangiectasia mutated	Mus musculus	109-112	
28487983-7	2017	Furthermore, the protective effects induced by H2O2 preconditioning were attenuated by pretreatment with the ATM inhibitor, Ku55933, or ATM small interfering RNA.	Hydrogen Peroxide	47-51	ataxia telangiectasia mutated	Mus musculus	136-139	
24040138-0	2013	Zygotic G2/M cell cycle arrest induced by ATM/Chk1 activation and DNA repair in mouse embryos fertilized with hydrogen peroxide-treated epididymal mouse sperm.	Hydrogen Peroxide	110-127	ataxia telangiectasia mutated	Mus musculus	42-45	
28487983-8	2017	In conclusion, these findings suggested that ATM is involved in H2O2 preconditioning-mediated protection against oxidative stress-induced injury in N2a cells.	Hydrogen Peroxide	64-68	ataxia telangiectasia mutated	Mus musculus	45-48	
28487983-9	2017	To the best of our knowledge, the present study demonstrated, for the first time, that the ATM protein is a key mediator of H2O2 preconditioning.	Hydrogen Peroxide	124-128	ataxia telangiectasia mutated	Mus musculus	91-94	
16863997-5	2006	Here we also demonstrate that Atm(-/-) thymocytes exhibit increased levels of hydrogen peroxide, NF-E2-related factor (Nrf-2), peroxiredoxin-1, and intracellular glutathione relative to thymocytes from Atm(+/+) mice.	Hydrogen Peroxide	78-95	ataxia telangiectasia mutated	Mus musculus	30-33	
16863997-6	2006	Importantly, reduction of hydrogen peroxide by administration of the antioxidant N-acetylcysteine to Atm(-/-) mice attenuates the elevation of Nrf-2, c-Myc, and DNA synthesis in their thymocytes, suggesting that ATM may control c-Myc and DNA synthesis during postnatal thymocyte development by preventing accumulation of reactive oxygen species.	Hydrogen Peroxide	26-43	ataxia telangiectasia mutated	Mus musculus	101-104	
16863997-6	2006	Importantly, reduction of hydrogen peroxide by administration of the antioxidant N-acetylcysteine to Atm(-/-) mice attenuates the elevation of Nrf-2, c-Myc, and DNA synthesis in their thymocytes, suggesting that ATM may control c-Myc and DNA synthesis during postnatal thymocyte development by preventing accumulation of reactive oxygen species.	Hydrogen Peroxide	26-43	ataxia telangiectasia mutated	Mus musculus	212-215