PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15247269-0	2004	Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization.	Hydrogen Peroxide	87-104	spermine oxidase	Mus musculus	13-32	
18381427-8	2008	In addition, treatment with MDL 72,527, an inhibitor of SMO, blocks the production of H(2)O(2) and increases the survival of Ker/ODC.	Hydrogen Peroxide	86-94	spermine oxidase	Mus musculus	56-59	
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Hydrogen Peroxide	148-156	spermine oxidase	Mus musculus	0-16	
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Hydrogen Peroxide	148-156	spermine oxidase	Mus musculus	18-21	
15247269-8	2004	Inhibition of PAO1 also significantly reduced H(2)O(2) generation, mitochondrial membrane depolarization, cytochrome c release, and caspase-3 activation.	Hydrogen Peroxide	46-54	spermine oxidase	Mus musculus	14-18	
15247269-11	2004	These studies demonstrate a new mechanism for pathogen-induced oxidative stress in macrophages in which activation of PAO1 leads to H(2)O(2) release and apoptosis by a mitochondrial-dependent cell death pathway, contributing to deficiencies in host defense in diseases such as H. pylori infection.	Hydrogen Peroxide	132-140	spermine oxidase	Mus musculus	118-122	
23840306-1	2013	Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal.	Hydrogen Peroxide	121-125	spermine oxidase	Mus musculus	0-16	
31197571-10	2020	This research points out the role of spermine oxidase, as a hydrogen peroxide producer, in the oxidative stress during epilepsy.	Hydrogen Peroxide	60-77	spermine oxidase	Mus musculus	37-53	
28043891-1	2017	Spermine oxidase oxidizes spermine to produce H2O2, spermidine, and 3-aminopropanal.	Hydrogen Peroxide	46-50	spermine oxidase	Mus musculus	0-16	
28043891-9	2017	Chronic H2O2 production induced by spermine oxidase overexpression leads to a cellular redox state imbalance in both tissues, although they show different redox adaptation.	Hydrogen Peroxide	8-12	spermine oxidase	Mus musculus	35-51