PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16267404-5	2005	Application of exogenous H2O2 caused increased tyrosine phosphorylation and Grb2 binding to IRS-1 in SK-N-BE(2) cells, while exposure to an H2O2 scavenger (N-acetylcysteine) or to a phophatidylinositol-3 kinase inhibitor (wortmannin), and expression of a dominant negative Rac1, decreased the activation of ERK in insulin-stimulated PC12 cells.	Hydrogen Peroxide	25-29	Rac family small GTPase 1	Rattus norvegicus	273-277	
16354758-8	2006	Decreased Rac1 activity lowers intracellular H(2)O(2) levels, thus attenuating cell motility.	Hydrogen Peroxide	45-53	Rac family small GTPase 1	Rattus norvegicus	10-14	
35390465-4	2022	Here, we show that treatment with 6-OHDA, MPP+ or rotenone induced H2O2 generation by upregulating the levels of NOX2 and its regulatory proteins (p22phox, p40phox, p47phox, p67phox, and Rac1), leading to apoptotic cell death in PC12 cells and primary neurons.	Hydrogen Peroxide	67-71	Rac family small GTPase 1	Rattus norvegicus	187-191	
15475011-0	2004	Hydrogen peroxide mediates Rac1 activation of S6K1.	Hydrogen Peroxide	0-17	Rac family small GTPase 1	Rattus norvegicus	27-31	
15475011-6	2004	In contrast, Rat2 cells stably transfected with Rac1V12 produced high level of H2O2 in the absence of PDGF, comparable to that in the control cells stimulated with PDGF.	Hydrogen Peroxide	79-83	Rac family small GTPase 1	Rattus norvegicus	48-55	
15475011-7	2004	More importantly, elimination of H2O2 produced in Rat2 cells overexpressing Rac1V12 inhibited the Rac1V12 activation of S6K1, indicating the possible role of H2O2 as a mediator in the activation of S6K1 by Rac1.	Hydrogen Peroxide	33-37	Rac family small GTPase 1	Rattus norvegicus	76-83	
15475011-7	2004	More importantly, elimination of H2O2 produced in Rat2 cells overexpressing Rac1V12 inhibited the Rac1V12 activation of S6K1, indicating the possible role of H2O2 as a mediator in the activation of S6K1 by Rac1.	Hydrogen Peroxide	33-37	Rac family small GTPase 1	Rattus norvegicus	98-105	
15475011-7	2004	More importantly, elimination of H2O2 produced in Rat2 cells overexpressing Rac1V12 inhibited the Rac1V12 activation of S6K1, indicating the possible role of H2O2 as a mediator in the activation of S6K1 by Rac1.	Hydrogen Peroxide	33-37	Rac family small GTPase 1	Rattus norvegicus	76-80	
15475011-7	2004	More importantly, elimination of H2O2 produced in Rat2 cells overexpressing Rac1V12 inhibited the Rac1V12 activation of S6K1, indicating the possible role of H2O2 as a mediator in the activation of S6K1 by Rac1.	Hydrogen Peroxide	158-162	Rac family small GTPase 1	Rattus norvegicus	76-83	
15475011-7	2004	More importantly, elimination of H2O2 produced in Rat2 cells overexpressing Rac1V12 inhibited the Rac1V12 activation of S6K1, indicating the possible role of H2O2 as a mediator in the activation of S6K1 by Rac1.	Hydrogen Peroxide	158-162	Rac family small GTPase 1	Rattus norvegicus	98-105	
15475011-7	2004	More importantly, elimination of H2O2 produced in Rat2 cells overexpressing Rac1V12 inhibited the Rac1V12 activation of S6K1, indicating the possible role of H2O2 as a mediator in the activation of S6K1 by Rac1.	Hydrogen Peroxide	158-162	Rac family small GTPase 1	Rattus norvegicus	76-80	
15475011-9	2004	Taken together, these results suggest that H2O2 plays a pivotal role as a mediator in Rac1 activation of S6K1.	Hydrogen Peroxide	43-47	Rac family small GTPase 1	Rattus norvegicus	86-90	
15475011-2	2004	In this study, we investigated a possible role of H2O2 as a molecular linker in Rac1 activation of S6K1.	Hydrogen Peroxide	50-54	Rac family small GTPase 1	Rattus norvegicus	80-84	
15213258-8	2004	It was also shown that SMV, by inhibiting Rac1 activity, reversed Ang II-induced increase in intracellular H2O2 production, Akt activation, and p27 protein expression.	Hydrogen Peroxide	107-111	Rac family small GTPase 1	Rattus norvegicus	42-46