PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29173042-0 2018 Antithrombin conformational modulation by D-myo-inositol 3,4,5,6-tetrakisphosphate (TMI), a novel scaffold for the development of antithrombotic agents. 4-tolyl isocyanate 84-87 serpin family C member 1 Homo sapiens 0-12 29173042-3 2018 Recently, a new compound, named TMI, was discovered in our group with nanomolar affinity to antithrombin, and shown to be able to induce a partial activation of antithrombin. 4-tolyl isocyanate 32-35 serpin family C member 1 Homo sapiens 92-104 29173042-3 2018 Recently, a new compound, named TMI, was discovered in our group with nanomolar affinity to antithrombin, and shown to be able to induce a partial activation of antithrombin. 4-tolyl isocyanate 32-35 serpin family C member 1 Homo sapiens 161-173 22742452-3 2012 We screened a large database in silico to find alternative molecules and predicted d-myo-inositol 3,4,5,6-tetrakisphosphate (TMI) to strongly interact with antithrombin. 4-tolyl isocyanate 125-128 serpin family C member 1 Homo sapiens 156-168 22742452-5 2012 Functional studies, fluorescence analysis, and citrullination experiments revealed that TMI induced a partial activation of antithrombin that facilitated the interaction with heparin and low affinity heparins. 4-tolyl isocyanate 88-91 serpin family C member 1 Homo sapiens 124-136 22742452-6 2012 TMI improved antithrombin inhibitory function of plasma from homozygous patients with antithrombin deficiency with a heparin binding defect and also in a model with endothelial cells. 4-tolyl isocyanate 0-3 serpin family C member 1 Homo sapiens 13-25 22742452-6 2012 TMI improved antithrombin inhibitory function of plasma from homozygous patients with antithrombin deficiency with a heparin binding defect and also in a model with endothelial cells. 4-tolyl isocyanate 0-3 serpin family C member 1 Homo sapiens 86-98