PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24486724-3 2014 Using activated mouse splenic CD4 T cells we demonstrate that ICOS assists TCR-mediated signal transduction by potentiating the PI3K-AKT-mTOR signaling cascade that leads to hyper-phosphorylation of p70S6K and 4E-BP1, events that are known to augment cap-dependent mRNA translation. cap 251-254 inducible T cell co-stimulator Mus musculus 62-66