PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15316360-0 2004 Acute nephrotoxicity of tacrolimus and sirolimus in renal isografts: differential intragraft expression of transforming growth factor-beta1 and alpha-smooth muscle actin. Tacrolimus 24-34 transforming growth factor, beta 1 Rattus norvegicus 107-139 10566134-15 1999 FK 506 promotes axonal regeneration through binding to FKBP-12, thus activating GAP-43 (growth associated protein) and the TGF beta 1-pathway (transforming growth factor). Tacrolimus 0-6 transforming growth factor, beta 1 Rattus norvegicus 123-133 9762012-7 1998 TGF-beta did not alter basal GH release, but inhibited FK506-induced GH release. Tacrolimus 55-60 transforming growth factor, beta 1 Rattus norvegicus 0-8 9762012-10 1998 TGF-beta receptors might be involved in FK506-induced GH release as a separate pathway. Tacrolimus 40-45 transforming growth factor, beta 1 Rattus norvegicus 0-8 9422427-6 1997 FK506-treated kidneys had a progressive increase in the expression of TGF-beta1 and matrix proteins (biglycan, tenascin, fibronectin, and type I collagen). Tacrolimus 0-5 transforming growth factor, beta 1 Rattus norvegicus 70-79 7539555-9 1995 Cellular expression of IL-1 alpha, IL-2, IL-6, gamma-INF, FGF, and TGF-beta mRNA was suppressed with FK506 to below isograft levels, and clinical rejection was not observed with the doses, routes, and schedules used. Tacrolimus 101-106 transforming growth factor, beta 1 Rattus norvegicus 67-75 7518783-10 1994 Increased hepatic collagen and higher messenger RNA levels of transforming growth factor beta 1 and collagens I, III, and IV were found in the FK506-treated group. Tacrolimus 143-148 transforming growth factor, beta 1 Rattus norvegicus 62-95 33363168-0 2020 FK506 Induces the TGF-beta1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration. Tacrolimus 0-5 transforming growth factor, beta 1 Rattus norvegicus 18-27 33000210-0 2020 Effects of tacrolimus on the TGF-beta1/SMAD signaling pathway in paraquat-exposed rat alveolar type II epithelial cells. Tacrolimus 11-21 transforming growth factor, beta 1 Rattus norvegicus 29-38 33000210-8 2020 The expression levels of TGF-beta1, SMAD3 and CTGF, as well as their concentrations in the culture supernatant, were significantly downregulated in the tacrolimus group compared with the paraquat group. Tacrolimus 152-162 transforming growth factor, beta 1 Rattus norvegicus 25-34 33000210-10 2020 In conclusion, tacrolimus can reduce the levels of TGF-beta1, SMAD3 and CTGF, increase the level of SMAD7 in TGF-beta1 signaling pathway and protect the development of pulmonary fibrosis in paraquat exposed alveolar epithelial cells. Tacrolimus 15-25 transforming growth factor, beta 1 Rattus norvegicus 51-60 33000210-10 2020 In conclusion, tacrolimus can reduce the levels of TGF-beta1, SMAD3 and CTGF, increase the level of SMAD7 in TGF-beta1 signaling pathway and protect the development of pulmonary fibrosis in paraquat exposed alveolar epithelial cells. Tacrolimus 15-25 transforming growth factor, beta 1 Rattus norvegicus 109-118 30254425-8 2018 Additionally, the expression of IL-1beta, IL-6, monocyte chemotactic protein-1, macrophage inflammatory protein-1alpha and TGF-beta were significantly decreased by tacrolimus. Tacrolimus 164-174 transforming growth factor, beta 1 Rattus norvegicus 123-131 23220162-9 2013 The hydroxyproline content, the number of fibroblasts, the mRNA expression level of IL-2 and TGF-beta1 in 0.1mg/ml FK506 group were significantly less than those of 0.05 mg/ml FK506 group, 0.01 mg/ml FK506 group and control group. Tacrolimus 115-120 transforming growth factor, beta 1 Rattus norvegicus 93-102 22100870-1 2012 We previously demonstrated that the widely used immunosuppressive drugs cyclosporin A (CsA) and tacrolimus (FK506), independent of immunophilin binding, can activate profibrogenic transforming growth factor beta (TGFbeta)/Smad signaling cascades in rat renal mesangial cells (MC). Tacrolimus 96-106 transforming growth factor, beta 1 Rattus norvegicus 213-220 22100870-1 2012 We previously demonstrated that the widely used immunosuppressive drugs cyclosporin A (CsA) and tacrolimus (FK506), independent of immunophilin binding, can activate profibrogenic transforming growth factor beta (TGFbeta)/Smad signaling cascades in rat renal mesangial cells (MC). Tacrolimus 108-113 transforming growth factor, beta 1 Rattus norvegicus 213-220 21640200-8 2011 The expression of 1alpha (IV) collagen, p65, p-p65, OPN, alpha-SMA and TGF-beta1 protein in kidney was significantly increased in diabetic rats and reduced by FK506 treatment (p<0.05, 0.01). Tacrolimus 159-164 transforming growth factor, beta 1 Rattus norvegicus 71-80 21606250-1 2011 The immunosuppressive calcineurin inhibitors (CNIs) cyclosporine A (CsA) and tacrolimus are widely used in transplant organ recipients, but in the kidney allograft, they may cause tubulointerstitial as well as mesangial fibrosis, with TGF-beta believed to be a central inductor. Tacrolimus 77-87 transforming growth factor, beta 1 Rattus norvegicus 235-243 21606250-2 2011 In this study, we report that the cold-shock protein Y-box binding protein-1 (YB-1) is a TGF-beta independent downstream effector in CsA- as well as in tacrolimus- but not in rapamycin-mediated activation of rat mesangial cells (rMCs). Tacrolimus 152-162 transforming growth factor, beta 1 Rattus norvegicus 89-97 21358177-10 2011 Tacrolimus and cyclosporine increased fibronectin and TGF-beta expression and matrix deposition. Tacrolimus 0-10 transforming growth factor, beta 1 Rattus norvegicus 54-62 18684975-2 2008 Herein we demonstrate that the CNI cyclosporin A and tacrolimus (FK506), independent of TGFbeta synthesis, rapidly activate TGFbeta/Smad signaling in cultured mesangial cells and in whole kidney samples from CNI-treated rats. Tacrolimus 53-63 transforming growth factor, beta 1 Rattus norvegicus 88-95 18684975-2 2008 Herein we demonstrate that the CNI cyclosporin A and tacrolimus (FK506), independent of TGFbeta synthesis, rapidly activate TGFbeta/Smad signaling in cultured mesangial cells and in whole kidney samples from CNI-treated rats. Tacrolimus 53-63 transforming growth factor, beta 1 Rattus norvegicus 124-131 18684975-2 2008 Herein we demonstrate that the CNI cyclosporin A and tacrolimus (FK506), independent of TGFbeta synthesis, rapidly activate TGFbeta/Smad signaling in cultured mesangial cells and in whole kidney samples from CNI-treated rats. Tacrolimus 65-70 transforming growth factor, beta 1 Rattus norvegicus 124-131 16980029-14 2006 RESULTS: CsA and FK506 stimulated gene expression and protein production of TGF-beta1, smad2, and smad3, but inhibited expression of smad7 both in VSMC and in the transplanted kidney. Tacrolimus 17-22 transforming growth factor, beta 1 Rattus norvegicus 76-85 16980036-0 2006 Comparison of expression of TGF-beta1, its receptors TGFbeta1R-I and TGFbeta1R-II in rat kidneys during chronic nephropathy induced by cyclosporine and tacrolimus. Tacrolimus 152-162 transforming growth factor, beta 1 Rattus norvegicus 28-37 16980036-8 2006 The results of immunohistochemistry and in situ hybridization showed that the expression of renal TGFbeta1, TR I, TR-II proteins and TR and TR II mRNA in the FK506 group were lower than those in the CsA groups. Tacrolimus 158-163 transforming growth factor, beta 1 Rattus norvegicus 98-106 16549155-0 2006 Transforming growth factor-beta1, vascular endothelial growth factor, and bone morphogenic protein-7 expression in tacrolimus-induced nephrotoxicity in rats. Tacrolimus 115-125 transforming growth factor, beta 1 Rattus norvegicus 0-32 15854665-5 2005 RESULTS: Tacrolimus reduced TGF-beta mRNA expression below control levels and treatment with pirfenidone at all doses did not alter this effect. Tacrolimus 9-19 transforming growth factor, beta 1 Rattus norvegicus 28-36 15808571-10 2005 Tacrolimus alone decreased TGF-beta and TIMP-1 expression, suggesting some antifibrotic action; addition of pirfenidone had no further effect. Tacrolimus 0-10 transforming growth factor, beta 1 Rattus norvegicus 27-35