PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7538218-1 1995 We investigated the inhibitory action of FK506 (0.0005-5 micrograms/ml) on the metabolism of arachidonate 5-lipoxygenase in rat basophilic leukemia-1 cells. Tacrolimus 41-46 arachidonate 5-lipoxygenase Rattus norvegicus 93-120 7538218-8 1995 These results indicate that FK506 inhibits the production of peptide LTs, LTB4 and 5-HETE by inhibiting 5-lipoxygenase activity in intact cells. Tacrolimus 28-33 arachidonate 5-lipoxygenase Rattus norvegicus 104-118