PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26838733-3	2016	Electrophysiological experiments revealed that tacrolimus (10 micromol/L) increased the large-conductance Ca(2+)-activated K(+) currents (BKCa) in rat aortic vascular smooth muscle cells (AVSMCs), which could be blocked by ryanodine (10 micromol/L).	Tacrolimus	47-57	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	138-142	
26838733-5	2016	In conclusion, tacrolimus could indirectly activate BKCa currents by increasing Ca(2+) sparks released from ryanodine receptors, which inhibited the NE- or KCl-induced contraction in rat aorta.	Tacrolimus	15-25	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	52-56