PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34435330-6	2021	These results indicate that tacrolimus impairs cognitive function via synaptic imbalance, and that these processes are associated with Klotho downregulation at synapses through tacrolimus-induced oxidative stress in the hippocampus.	Tacrolimus	177-187	klotho	Mus musculus	135-141	
34435330-0	2021	Tacrolimus Decreases Cognitive Function by Impairing Hippocampal Synaptic Balance: a Possible Role of Klotho.	Tacrolimus	0-10	klotho	Mus musculus	102-108	
34435330-4	2021	Furthermore, tacrolimus caused synaptic imbalance, as demonstrated by decreased excitatory synapses and increased inhibitory synapses, and downregulated Klotho in a dose-dependent manner; the downregulation of Klotho was localized to excitatory hippocampal synapses.	Tacrolimus	13-23	klotho	Mus musculus	153-159	
34435330-4	2021	Furthermore, tacrolimus caused synaptic imbalance, as demonstrated by decreased excitatory synapses and increased inhibitory synapses, and downregulated Klotho in a dose-dependent manner; the downregulation of Klotho was localized to excitatory hippocampal synapses.	Tacrolimus	13-23	klotho	Mus musculus	210-216	
34435330-6	2021	These results indicate that tacrolimus impairs cognitive function via synaptic imbalance, and that these processes are associated with Klotho downregulation at synapses through tacrolimus-induced oxidative stress in the hippocampus.	Tacrolimus	28-38	klotho	Mus musculus	135-141	
30307767-0	2019	Effect of Klotho on autophagy clearance in tacrolimus-induced renal injury.	Tacrolimus	43-53	klotho	Mus musculus	10-16	
30307767-1	2019	Recently, we showed that tacrolimus-induced renal injury was closely associated with impairment of autophagy clearance, and Klotho deficiency aggravated tacrolimus-induced renal injury.	Tacrolimus	153-163	klotho	Mus musculus	124-130	
30307767-2	2019	In this study, we evaluated the effect of Klotho treatment on autophagy clearance in tacrolimus-induced renal injury.	Tacrolimus	85-95	klotho	Mus musculus	42-48	
30307767-3	2019	We evaluated the effect of Klotho on tacrolimus-induced renal injury in an experimental mouse model and in vitro by treatment with tacrolimus and/or recombinant mouse Klotho.	Tacrolimus	37-47	klotho	Mus musculus	27-33	
30307767-8	2019	Collectively, our data suggest that Klotho improves autophagy clearance via activation of lysosomal function in tacrolimus-induced nephrotoxicity.-Lim, S. W., Shin, Y. J., Luo, K., Quan, Y., Ko, E. J., Chung, B. H., Yang, C. W. Effect of Klotho on autophagy clearance in tacrolimus-induced renal injury.	Tacrolimus	112-122	klotho	Mus musculus	36-42	
30307767-8	2019	Collectively, our data suggest that Klotho improves autophagy clearance via activation of lysosomal function in tacrolimus-induced nephrotoxicity.-Lim, S. W., Shin, Y. J., Luo, K., Quan, Y., Ko, E. J., Chung, B. H., Yang, C. W. Effect of Klotho on autophagy clearance in tacrolimus-induced renal injury.	Tacrolimus	271-281	klotho	Mus musculus	36-42	
31400753-0	2019	Ginseng increases Klotho expression by FoxO3-mediated manganese superoxide dismutase in a mouse model of tacrolimus-induced renal injury.	Tacrolimus	105-115	klotho	Mus musculus	18-24	
31400753-3	2019	Although tacrolimus treatment reduced Klotho level in the serum and kidney, ginseng treatment was found to reverse the levels.	Tacrolimus	9-19	klotho	Mus musculus	38-44	
31400753-5	2019	Effect of ginseng on Klotho-induced manganese superoxide dismutase signaling pathway during tacrolimus treatment in mice revealed that ginseng suppressed phosphatidylinositol 3-kinase/serine-threonine kinase Akt-mediated phosphorylation of forkhead box protein O3a and promoted the binding of forkhead box protein O3a to manganese superoxide dismutase promoter.	Tacrolimus	92-102	klotho	Mus musculus	21-27	
31400753-7	2019	These findings together suggested that ginseng attenuated tacrolimus-induced oxidative stress via signaling between Klotho and the phosphatidylinositol 3-kinase/serine-threonine kinase Akt/forkhead box protein O3a-related antioxidant pathway.	Tacrolimus	58-68	klotho	Mus musculus	116-122