PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31711939-10 2019 We found that caffeine and anti-PD1 mAb combination therapy significantly increased intra-tumoral TNF-alpha and IFN-gamma levels. Caffeine 14-22 tumor necrosis factor Homo sapiens 98-107 33920292-4 2021 Carriers of the TNF-alpha SNP A allele appear to be more sensitive than homozygote G/G genotype to an attenuating effect of caffeine on PVT lapses during sleep deprivation only because they seem more degraded, but they do not perform better as a result. Caffeine 124-132 tumor necrosis factor Homo sapiens 16-25 31310752-11 2019 We found that TNF-alpha and IFN-gamma levels were significantly higher in caffeine-treated groups. Caffeine 74-82 tumor necrosis factor Homo sapiens 14-23 28330503-14 2017 Moreover, caffeine increased TNF-alpha mRNA in H441 cells (6.5 +- 2.2-fold, p < 0.05) which has been described as potent inhibitor of CTGF expression. Caffeine 10-18 tumor necrosis factor Homo sapiens 29-38 29678503-5 2018 TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee. Caffeine 51-59 tumor necrosis factor Homo sapiens 0-3 29678503-5 2018 TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee. Caffeine 121-129 tumor necrosis factor Homo sapiens 0-3 29678503-6 2018 Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment. Caffeine 129-137 tumor necrosis factor Homo sapiens 61-64 27008631-6 2016 Additionally, diabetes duration modified both of the positive associations of tumor necrosis factor-alpha levels (both interactions p<=0.01) with mean glycemic control during the previous 10 years (significant only in women with longer durations) and current daily caffeine intake (significant only in women with shorter durations). Caffeine 268-276 tumor necrosis factor Homo sapiens 78-105 26982450-1 2016 BACKGROUND: Serum caffeine concentrations >20 mug/ml (100 mumol/l) in infants treated for apnea of prematurity increases TNF-alpha and decreases IL-10, changes that perhaps are linked to comorbidities. Caffeine 18-26 tumor necrosis factor Homo sapiens 124-133 26982450-5 2016 RESULTS: Caffeine at <=100 mumol/l decreased TNF-alpha levels (~25%, P = 0.01) and cAMP. Caffeine 9-17 tumor necrosis factor Homo sapiens 48-57 26982450-8 2016 Caffeine further decreased TNF-alpha following A3R and PDE blockades. Caffeine 0-8 tumor necrosis factor Homo sapiens 27-36 22437887-8 2012 Luciferase reporter assay revealed a caffeine dependent activation of the TF promoter, and RT-PCR revealed a dose dependent increase in TF mRNA levels when stimulated with caffeine in the presence of TNF-alpha. Caffeine 172-180 tumor necrosis factor Homo sapiens 200-209 24761282-3 2013 It has been reported that chronic caffeine use suppresses the production of proinflammatory cytokine TNF-alpha (tumor necrosis factor Alpha) and alters adenosine receptor expression in human neutrophils, indicating that caffeine may attenuate vascular injury-induced inflammation and subsequent neointimal hyperplasia. Caffeine 34-42 tumor necrosis factor Homo sapiens 101-110 24761282-3 2013 It has been reported that chronic caffeine use suppresses the production of proinflammatory cytokine TNF-alpha (tumor necrosis factor Alpha) and alters adenosine receptor expression in human neutrophils, indicating that caffeine may attenuate vascular injury-induced inflammation and subsequent neointimal hyperplasia. Caffeine 34-42 tumor necrosis factor Homo sapiens 112-139 24761282-3 2013 It has been reported that chronic caffeine use suppresses the production of proinflammatory cytokine TNF-alpha (tumor necrosis factor Alpha) and alters adenosine receptor expression in human neutrophils, indicating that caffeine may attenuate vascular injury-induced inflammation and subsequent neointimal hyperplasia. Caffeine 220-228 tumor necrosis factor Homo sapiens 101-110 23415910-8 2013 DISCUSSION: These findings suggest that caffeine-free decaffeinated coffee may prevent memory impairment in human through the inhibition of NF-kappaB activation and subsequent TNF-alpha production. Caffeine 40-48 tumor necrosis factor Homo sapiens 176-185 22437887-4 2012 Caffeine concentration-dependently enhanced TF protein expression and surface activity in human endothelial cells stimulated by tumour necrosis factor (TNF)-alpha or thrombin. Caffeine 0-8 tumor necrosis factor Homo sapiens 128-162 22437887-9 2012 In conclusion, caffeine enhances TNF-alpha-induced endothelial TF protein expression as well as surface activity by inhibition of PI3K signalling. Caffeine 15-23 tumor necrosis factor Homo sapiens 33-42 19047957-0 2009 Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptors. Caffeine 0-8 tumor necrosis factor Homo sapiens 19-28 21119886-6 2010 Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1alpha/VEGF/IL-8 along with NO, TNF-alpha, IL1, and GHRH, among others. Caffeine 40-48 tumor necrosis factor Homo sapiens 170-179 19047957-6 2009 Only caffeine (50 microM) and DPCPX (10 nM) decreased tumor necrosis factor-alpha (TNF-alpha) release from LPS activated-CBM by 20 and 25% (p = 0.01) and TNF-alpha gene expression by 30 and 50%, respectively, in conjunction with a > or =2-fold increase in cAMP (p < 0.05). Caffeine 5-13 tumor necrosis factor Homo sapiens 54-81 19047957-6 2009 Only caffeine (50 microM) and DPCPX (10 nM) decreased tumor necrosis factor-alpha (TNF-alpha) release from LPS activated-CBM by 20 and 25% (p = 0.01) and TNF-alpha gene expression by 30 and 50%, respectively, in conjunction with a > or =2-fold increase in cAMP (p < 0.05). Caffeine 5-13 tumor necrosis factor Homo sapiens 83-92 19047957-6 2009 Only caffeine (50 microM) and DPCPX (10 nM) decreased tumor necrosis factor-alpha (TNF-alpha) release from LPS activated-CBM by 20 and 25% (p = 0.01) and TNF-alpha gene expression by 30 and 50%, respectively, in conjunction with a > or =2-fold increase in cAMP (p < 0.05). Caffeine 5-13 tumor necrosis factor Homo sapiens 154-163 19047957-9 2009 Our findings also suggest that caffeine, via A1R blockade, increases cAMP production and inhibits pretranscriptional TNF-alpha production by CBM. Caffeine 31-39 tumor necrosis factor Homo sapiens 117-126 16540173-4 2006 For instance studies indicate that caffeine and its major metabolite paraxanthine suppress neutrophil and monocyte chemotaxis, and also suppress production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha from human blood. Caffeine 35-43 tumor necrosis factor Homo sapiens 189-223 18457008-0 2007 Caffeine reduces TNFalpha up-regulation in human adipose tissue primary culture. Caffeine 0-8 tumor necrosis factor Homo sapiens 17-25 18457008-3 2007 Since xanthine family compounds such as caffeine were shown to decrease inflammatory production by human blood cells, we investigated the possible effect of caffeine on Tumor Necrosis Factor alpha (TNFalpha) and Interleukin-6 (IL-6) expression by human adipose tissue primary culture. Caffeine 157-165 tumor necrosis factor Homo sapiens 169-196 18457008-3 2007 Since xanthine family compounds such as caffeine were shown to decrease inflammatory production by human blood cells, we investigated the possible effect of caffeine on Tumor Necrosis Factor alpha (TNFalpha) and Interleukin-6 (IL-6) expression by human adipose tissue primary culture. Caffeine 157-165 tumor necrosis factor Homo sapiens 198-206 18457008-11 2007 Thus, caffeine, by decreasing TNFalpha expression, could improve adipose tissue inflammation during obesity. Caffeine 6-14 tumor necrosis factor Homo sapiens 30-38 34371919-6 2021 We showed that although TNF-alpha secretion was downregulated in both LPS-activated MPhi subtypes by caffeine, the secretion of IL-8, IL-6, and IL-1beta as well as the expression of Nod-like receptors was enhanced in M-MPhis, while it did not change in GM-MPhis. Caffeine 101-109 tumor necrosis factor Homo sapiens 24-33 15313438-0 2004 Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway. Caffeine 0-8 tumor necrosis factor Homo sapiens 20-29 15313438-8 2004 Moreover, the effect of caffeine on TNF-alpha production was abolished by pretreatment with the protein kinase A inhibitor Rp-8-Br-cAMPS (10(-4) and 10(-5)M). Caffeine 24-32 tumor necrosis factor Homo sapiens 36-45 15313438-9 2004 To conclude, this study demonstrates that concentrations of caffeine that are relevant to human consumption consistently suppress production of the proinflammatory cytokine TNF-alpha in human blood and that this effect is mediated by the cyclic AMP/protein kinase A pathway. Caffeine 60-68 tumor necrosis factor Homo sapiens 173-182