PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19926639-0 2010 Oral administration of caffeine during voluntary exercise markedly decreases tissue fat and stimulates apoptosis and cyclin B1 in UVB-treated skin of hairless p53-knockout mice. Caffeine 23-31 transformation related protein 53, pseudogene Mus musculus 159-162 23785666-6 2013 Caffeine administration enhances UVB-induced apoptosis by p53-dependent and p53-independent mechanisms. Caffeine 0-8 transformation related protein 53, pseudogene Mus musculus 58-61 23785666-6 2013 Caffeine administration enhances UVB-induced apoptosis by p53-dependent and p53-independent mechanisms. Caffeine 0-8 transformation related protein 53, pseudogene Mus musculus 76-79 23785666-7 2013 Exploration of the p53-independent effect indicated that caffeine administration enhanced UVB-induced apoptosis by inhibiting the UVB-induced increase in ATR-mediated formation of phospho-Chk1 (Ser345) and abolishing the UVB-induced decrease in cyclin B1 which resulted in caffeine-induced premature and lethal mitosis in mouse skin. Caffeine 57-65 transformation related protein 53, pseudogene Mus musculus 19-22 19926639-3 2010 Western blot analysis indicated that treatment of p53(-/-) mice with caffeine together with exercise increased the level of cyclin B1 significantly more than in p53(+/+) mice. Caffeine 69-77 transformation related protein 53, pseudogene Mus musculus 50-53 19926639-3 2010 Western blot analysis indicated that treatment of p53(-/-) mice with caffeine together with exercise increased the level of cyclin B1 significantly more than in p53(+/+) mice. Caffeine 69-77 transformation related protein 53, pseudogene Mus musculus 161-164 19926639-4 2010 p53(-/-) mice, but not p53(+/+) mice, treated with caffeine during exercise exhibited a dramatic decrease in the level of survivin. Caffeine 51-59 transformation related protein 53, pseudogene Mus musculus 0-3 18179623-4 2008 Oral or topical administration of caffeine enhanced the removal of patches of epidermal cells with a mutant form of p53 protein that appeared early during the course of UVB-induced carcinogenesis, and oral administration of caffeine altered the profile of p53 mutations in the patches. Caffeine 34-42 transformation related protein 53, pseudogene Mus musculus 116-119 18381462-10 2008 The ability of caffeine to promote the deletion of p53(-/-) keratinocytes may be relevant to its inhibitory effect on UVB-induced skin cancer. Caffeine 15-23 transformation related protein 53, pseudogene Mus musculus 51-54 20151649-10 2010 When mouse lung fibroblasts were treated with caffeine, an ATM kinase inhibitor, the levels of p53, phosphorylated p53(Ser18), and cell death induced by gallic acid were significantly attenuated. Caffeine 46-54 transformation related protein 53, pseudogene Mus musculus 95-98 20151649-10 2010 When mouse lung fibroblasts were treated with caffeine, an ATM kinase inhibitor, the levels of p53, phosphorylated p53(Ser18), and cell death induced by gallic acid were significantly attenuated. Caffeine 46-54 transformation related protein 53, pseudogene Mus musculus 115-118 18179623-4 2008 Oral or topical administration of caffeine enhanced the removal of patches of epidermal cells with a mutant form of p53 protein that appeared early during the course of UVB-induced carcinogenesis, and oral administration of caffeine altered the profile of p53 mutations in the patches. Caffeine 34-42 transformation related protein 53, pseudogene Mus musculus 256-259 18179623-4 2008 Oral or topical administration of caffeine enhanced the removal of patches of epidermal cells with a mutant form of p53 protein that appeared early during the course of UVB-induced carcinogenesis, and oral administration of caffeine altered the profile of p53 mutations in the patches. Caffeine 224-232 transformation related protein 53, pseudogene Mus musculus 116-119 18179623-4 2008 Oral or topical administration of caffeine enhanced the removal of patches of epidermal cells with a mutant form of p53 protein that appeared early during the course of UVB-induced carcinogenesis, and oral administration of caffeine altered the profile of p53 mutations in the patches. Caffeine 224-232 transformation related protein 53, pseudogene Mus musculus 256-259 15256477-0 2004 Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice. Caffeine 45-53 transformation related protein 53, pseudogene Mus musculus 99-102 17664435-3 2007 Although orally administrated caffeine (0.1 mg/ml in the drinking water) or voluntary exercise for 2 weeks caused only a small nonsignificant stimulation of UVB-induced increase in the percentage of phospho-p53 (Ser-15)-positive cells in the epidermis (27 or 18%, respectively), the combination of the two treatments enhanced the UVB-induced increase in phospho-p53 (Ser-15)-positive cells by 99%. Caffeine 30-38 transformation related protein 53, pseudogene Mus musculus 207-210 17664435-3 2007 Although orally administrated caffeine (0.1 mg/ml in the drinking water) or voluntary exercise for 2 weeks caused only a small nonsignificant stimulation of UVB-induced increase in the percentage of phospho-p53 (Ser-15)-positive cells in the epidermis (27 or 18%, respectively), the combination of the two treatments enhanced the UVB-induced increase in phospho-p53 (Ser-15)-positive cells by 99%. Caffeine 30-38 transformation related protein 53, pseudogene Mus musculus 362-365 15817611-0 2005 Administration of green tea or caffeine enhances the disappearance of UVB-induced patches of mutant p53 positive epidermal cells in SKH-1 mice. Caffeine 31-39 transformation related protein 53, pseudogene Mus musculus 100-103 15817611-7 2005 Oral administration of green tea (6 mg tea solids/ml) or caffeine (0.4 mg/ml) as the sole source of drinking fluid during irradiation with UVB, twice a week for 20 weeks, inhibited UVB-induced formation of mutant p53 positive patches by approximately 40%. Caffeine 57-65 transformation related protein 53, pseudogene Mus musculus 213-216 15817611-8 2005 Oral administration of green tea (6 mg tea solids/ml) as the sole source of drinking fluid or topical applications of caffeine (6.2 micromol) once a day 5 days a week starting immediately after discontinuation of UVB treatment enhanced the rate and extent of disappearance of the mutant p53-positive patches. Caffeine 118-126 transformation related protein 53, pseudogene Mus musculus 287-290 15735681-4 2005 The results indicate that ATM kinase is likely to be indispensable for the p53-dependent S-phase checkpoint since the suppression was abrogated by inhibitors such as caffeine and wortmannin. Caffeine 166-174 transformation related protein 53, pseudogene Mus musculus 75-78 15975959-0 2005 Effect of administration of caffeine or green tea on the mutation profile in the p53 gene in early mutant p53-positive patches of epidermal cells induced by chronic UVB-irradiation of hairless SKH-1 mice. Caffeine 28-36 transformation related protein 53, pseudogene Mus musculus 81-84 15975959-0 2005 Effect of administration of caffeine or green tea on the mutation profile in the p53 gene in early mutant p53-positive patches of epidermal cells induced by chronic UVB-irradiation of hairless SKH-1 mice. Caffeine 28-36 transformation related protein 53, pseudogene Mus musculus 106-109 15975959-3 2005 Sequencing analysis of the p53 gene (exons 3 to 9) detected 88, 82 or 39 point mutations in 67, 70 or 29 patches from water, caffeine or tea treated mice, respectively. Caffeine 125-133 transformation related protein 53, pseudogene Mus musculus 27-30 15975959-10 2005 In summary, oral treatment of mice with caffeine or green tea during chronic UVB irradiation changed the mutation profile of the p53 gene in early mutant p53 positive epidermal patches, and topical applications of caffeine after discontinuation of chronic UVB irradiation specifically eliminated patches harboring homozygous p53 mutations. Caffeine 40-48 transformation related protein 53, pseudogene Mus musculus 129-132 15975959-10 2005 In summary, oral treatment of mice with caffeine or green tea during chronic UVB irradiation changed the mutation profile of the p53 gene in early mutant p53 positive epidermal patches, and topical applications of caffeine after discontinuation of chronic UVB irradiation specifically eliminated patches harboring homozygous p53 mutations. Caffeine 40-48 transformation related protein 53, pseudogene Mus musculus 154-157 15975959-10 2005 In summary, oral treatment of mice with caffeine or green tea during chronic UVB irradiation changed the mutation profile of the p53 gene in early mutant p53 positive epidermal patches, and topical applications of caffeine after discontinuation of chronic UVB irradiation specifically eliminated patches harboring homozygous p53 mutations. Caffeine 40-48 transformation related protein 53, pseudogene Mus musculus 154-157 15256477-3 2004 Topical applications of caffeine immediately after UVB irradiation in female p53(+/+) or p53(-/-) mice enhanced the UVB-induced increase in apoptotic sunburn cells 6 h later by 127% and 563%, respectively. Caffeine 24-32 transformation related protein 53, pseudogene Mus musculus 77-80 15256477-3 2004 Topical applications of caffeine immediately after UVB irradiation in female p53(+/+) or p53(-/-) mice enhanced the UVB-induced increase in apoptotic sunburn cells 6 h later by 127% and 563%, respectively. Caffeine 24-32 transformation related protein 53, pseudogene Mus musculus 89-92 15256477-7 2004 The results indicate that UVB-induced increases in apoptosis in the epidermis of wild-type mice are predominantly (but not entirely) by p53- and Bax-dependent pathways and that topical application of caffeine can enhance UVB-induced increases in apoptosis by p53- and Bax-independent pathways. Caffeine 200-208 transformation related protein 53, pseudogene Mus musculus 136-139 15256477-7 2004 The results indicate that UVB-induced increases in apoptosis in the epidermis of wild-type mice are predominantly (but not entirely) by p53- and Bax-dependent pathways and that topical application of caffeine can enhance UVB-induced increases in apoptosis by p53- and Bax-independent pathways. Caffeine 200-208 transformation related protein 53, pseudogene Mus musculus 259-262 12101227-6 2002 Additionally, E2F1-mediated apoptosis is abolished in the presence of caffeine, an inhibitor of phosphatidylinositol 3-kinase-related kinases that phosphorylate p53. Caffeine 70-78 transformation related protein 53, pseudogene Mus musculus 161-164 12907610-0 2003 Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways. Caffeine 26-34 transformation related protein 53, pseudogene Mus musculus 54-57 12907610-6 2003 Induction of apoptosis by caffeine appeared to be p53-dependent because cells lacking p53 (p53(-/-)) showed no signs of apoptosis after treatment with caffeine. Caffeine 26-34 transformation related protein 53, pseudogene Mus musculus 50-53 12907610-7 2003 Immunoprecipitation assays and Western blot analysis showed that caffeine induced phosphorylation of p53 at Ser(15) in JB6 Cl41 cells. Caffeine 65-73 transformation related protein 53, pseudogene Mus musculus 101-104 12907610-8 2003 The same low concentration of caffeine that was effective for inducing phosphorylation of p53 was also shown to increase p53 activation. Caffeine 30-38 transformation related protein 53, pseudogene Mus musculus 90-93 12907610-8 2003 The same low concentration of caffeine that was effective for inducing phosphorylation of p53 was also shown to increase p53 activation. Caffeine 30-38 transformation related protein 53, pseudogene Mus musculus 121-124 12356735-7 2002 Caffeine further reduced p53 accumulation, suggesting the existence of an ATM/ATR-dependent but Chk2-independent pathway for p53 stabilization. Caffeine 0-8 transformation related protein 53, pseudogene Mus musculus 25-28 12356735-7 2002 Caffeine further reduced p53 accumulation, suggesting the existence of an ATM/ATR-dependent but Chk2-independent pathway for p53 stabilization. Caffeine 0-8 transformation related protein 53, pseudogene Mus musculus 125-128 12392153-1 2002 In an earlier study, we showed that oral administration of green tea or caffeine to SKH-1 mice for 2 weeks prior to a single application of UVB enhanced UVB-induced increases in the number of p53-positive cells, p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells in the epidermis. Caffeine 72-80 transformation related protein 53, pseudogene Mus musculus 192-195 12392153-5 2002 Topical application of caffeine had only a small stimulatory effect on UVB-induced increases in the level of wild-type p53 protein and these changes were not related temporally to caffeine-induced increases in apoptotic cells. Caffeine 23-31 transformation related protein 53, pseudogene Mus musculus 119-122 10987287-3 2000 The stimulatory effect of green tea and caffeine on UV-induced increases in the number of p53-positive cells, p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells may play a role in the inhibitory effects of tea and caffeine on UV-induced carcinogenesis. Caffeine 40-48 transformation related protein 53, pseudogene Mus musculus 90-93 11502601-7 2001 Caffeine (2 mM) greatly reduces the p53 level and Ser(15) phosphorylation, followed by a remarkable increase of DNA replication rate, by failure of hypertonicity to inhibit it, and by reduction of cell number during hypertonicity. Caffeine 0-8 transformation related protein 53, pseudogene Mus musculus 36-39 10987287-0 2000 Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice. Caffeine 58-66 transformation related protein 53, pseudogene Mus musculus 129-132 11210826-0 2000 The effect of caffeine on p53-dependent radioresponses in undifferentiated mouse embryonal carcinoma cells after X-ray and UV-irradiations. Caffeine 14-22 transformation related protein 53, pseudogene Mus musculus 26-29 11210826-10 2000 Therefore, the effects of caffeine on the p53-dependent radioresponses were found to be agent specific: suppression for the X-ray induced and augmentation for the UV induced. Caffeine 26-34 transformation related protein 53, pseudogene Mus musculus 42-45 34979447-7 2021 Caffeine potentiated dacarbazine-induced cytotoxic effects by increasing dacarbazine biotransformation, apoptosis, DNA damage, and malondialdehyde levels; also, caffeine reduced Ki67 and ERK1/2 nuclear labeling and increased p53 labeling in B16F10 cells. Caffeine 0-8 transformation related protein 53, pseudogene Mus musculus 225-228 34979447-7 2021 Caffeine potentiated dacarbazine-induced cytotoxic effects by increasing dacarbazine biotransformation, apoptosis, DNA damage, and malondialdehyde levels; also, caffeine reduced Ki67 and ERK1/2 nuclear labeling and increased p53 labeling in B16F10 cells. Caffeine 161-169 transformation related protein 53, pseudogene Mus musculus 225-228