PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2672065-4	1989	Surprisingly, our female subjects evidenced a small drop in SBP (1 mm Hg) and a decline in HR (5 bpm), and, as expected, they demonstrated a rise in DBP of 6 mm Hg in response to caffeine.	Caffeine	179-187	D-box binding PAR bZIP transcription factor	Homo sapiens	149-152	
2672065-7	1989	Previous evidence of significantly greater DBP pressor effects when caffeine is consumed under stressful conditions was confirmed.	Caffeine	68-76	D-box binding PAR bZIP transcription factor	Homo sapiens	43-46	
10904026-4	2000	Caffeine raised both systolic and diastolic BP (SBP and DBP, respectively; P<0.0001 for both) in all groups.	Caffeine	0-8	D-box binding PAR bZIP transcription factor	Homo sapiens	56-59	
29522901-7	2018	Furthermore, the results indicated that the habitual heavy caffeine consumers AC individuals had increased basal-DBP when compared to the AA ones.	Caffeine	59-67	D-box binding PAR bZIP transcription factor	Homo sapiens	113-116	
29562659-8	2018	RESULTS: In the above experiment, having consumed three portions of ED (240 mg of caffeine), the participants presented a significant increase in DBP (p = 0.003), by over 8%, which coincided with a lack of any significant impact on SBP (p = 0.809).	Caffeine	82-90	D-box binding PAR bZIP transcription factor	Homo sapiens	146-149	
24950113-4	2014	Caffeine increased (p < 0.05) pre-exercise DBP and MAP.	Caffeine	0-8	D-box binding PAR bZIP transcription factor	Homo sapiens	46-49	
24950113-6	2014	Notwithstanding, the mean values for SBP, DBP and MAP during the 9 h of post-exercise monitoring were increased (p < 0.05) for the caffeine.	Caffeine	134-142	D-box binding PAR bZIP transcription factor	Homo sapiens	42-45	
22298600-9	2012	Daytime DBP (77.0 vs 72.0 mm Hg, p = 0.04) also was significantly higher with the energy drink versus caffeine supplementation.	Caffeine	102-110	D-box binding PAR bZIP transcription factor	Homo sapiens	8-11	
19767812-5	2009	Results showed that, following caffeine ingestion: (i) both systolic and diastolic blood pressure (SBP and DBP, respectively) increased significantly (p < 0.05) in the older women (SBP, 128.4 +/- 14.2 vs. 132.1 +/- 13.0 mm Hg (3%); DBP, 80.2 +/- 6.9 vs. 83.4 +/- 7.5 mm Hg (4%), whereas only DBP increased in the younger women (67.1 +/- 4.7 vs. 69.9 +/- 5.4 mm Hg (4.2%); p < 0.05); (ii) heart rate decreased significantly (Y, 59.2 +/- 8.7 to 53.9 +/- 10.6 beats.min-1 (p < 0.05); O, 61.9 +/- 9.2 to 59.2 +/- 8.4 beats.min-1 (p < 0.05)) in both groups; and (iii) self-reported feelings of tension and vigor increased and feelings of fatigue decreased (p < 0.05) in younger women, whereas depression decreased (p < or = 0.05) in older women.	Caffeine	31-39	D-box binding PAR bZIP transcription factor	Homo sapiens	107-110	
19767812-5	2009	Results showed that, following caffeine ingestion: (i) both systolic and diastolic blood pressure (SBP and DBP, respectively) increased significantly (p < 0.05) in the older women (SBP, 128.4 +/- 14.2 vs. 132.1 +/- 13.0 mm Hg (3%); DBP, 80.2 +/- 6.9 vs. 83.4 +/- 7.5 mm Hg (4%), whereas only DBP increased in the younger women (67.1 +/- 4.7 vs. 69.9 +/- 5.4 mm Hg (4.2%); p < 0.05); (ii) heart rate decreased significantly (Y, 59.2 +/- 8.7 to 53.9 +/- 10.6 beats.min-1 (p < 0.05); O, 61.9 +/- 9.2 to 59.2 +/- 8.4 beats.min-1 (p < 0.05)) in both groups; and (iii) self-reported feelings of tension and vigor increased and feelings of fatigue decreased (p < 0.05) in younger women, whereas depression decreased (p < or = 0.05) in older women.	Caffeine	31-39	D-box binding PAR bZIP transcription factor	Homo sapiens	235-238	
19767812-5	2009	Results showed that, following caffeine ingestion: (i) both systolic and diastolic blood pressure (SBP and DBP, respectively) increased significantly (p < 0.05) in the older women (SBP, 128.4 +/- 14.2 vs. 132.1 +/- 13.0 mm Hg (3%); DBP, 80.2 +/- 6.9 vs. 83.4 +/- 7.5 mm Hg (4%), whereas only DBP increased in the younger women (67.1 +/- 4.7 vs. 69.9 +/- 5.4 mm Hg (4.2%); p < 0.05); (ii) heart rate decreased significantly (Y, 59.2 +/- 8.7 to 53.9 +/- 10.6 beats.min-1 (p < 0.05); O, 61.9 +/- 9.2 to 59.2 +/- 8.4 beats.min-1 (p < 0.05)) in both groups; and (iii) self-reported feelings of tension and vigor increased and feelings of fatigue decreased (p < 0.05) in younger women, whereas depression decreased (p < or = 0.05) in older women.	Caffeine	31-39	D-box binding PAR bZIP transcription factor	Homo sapiens	235-238	
19767812-6	2009	Self-reported level of physical activity was inversely related to change in DBP following caffeine ingestion in younger women.	Caffeine	90-98	D-box binding PAR bZIP transcription factor	Homo sapiens	76-79	
10904026-7	2000	The potential clinical relevance of caffeine-induced BP changes is seen in the BPs that reached the hypertensive range (SBP >/=140 mm Hg or DBP >/=90 mm Hg) after caffeine.	Caffeine	36-44	D-box binding PAR bZIP transcription factor	Homo sapiens	143-146	
10904026-5	2000	However, an ANCOVA revealed that the strongest response to caffeine was observed among diagnosed men, followed by the stage 1 and high-normal groups and then by the normal and optimal groups (SBP F(4),(175)=5.06, P<0.0001; DBP F(4,175)=3.02, P<0.02).	Caffeine	59-67	D-box binding PAR bZIP transcription factor	Homo sapiens	226-229	
9399380-5	1997	Caffeine in the beverage rapidly augmented skin conductance responses but, in contrast to the effect of hot water, reduced the skin temperature response and increased SBP (+2.8 mmHg) and DBP (+2.1 mmHg) 30-60 min post-consumption.	Caffeine	0-8	D-box binding PAR bZIP transcription factor	Homo sapiens	187-190