PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3044993-2 1988 To further test this hypothesis, we compared the time course of caffeine-induced increases in plasma renin activity with the time course of changes in plasma levels of adenosine in two models of renin-dependent renovascular hypertension. Caffeine 64-72 renin Rattus norvegicus 101-106 2677316-0 1989 Caffeine potentiates the renin response to furosemide in rats. Caffeine 0-8 renin Rattus norvegicus 25-30 2677316-10 1989 Caffeine and 1,3-dipropyl-8-(p-sulfophenyl)xanthine potentiated the increase in plasma renin activity produced by furosemide (to 120 +/- 15 and 147 +/- 21 ng Al/ml/hr, respectively), whereas having no significant effects on urinary volume, sodium excretion or blood pressure. Caffeine 0-8 renin Rattus norvegicus 87-92 3044993-6 1988 In 2K1C rats treated chronically with caffeine, plasma renin activity was markedly elevated during the first week after operation as compared to non-caffeine-treated 2K1C rats. Caffeine 38-46 renin Rattus norvegicus 55-60 3044993-6 1988 In 2K1C rats treated chronically with caffeine, plasma renin activity was markedly elevated during the first week after operation as compared to non-caffeine-treated 2K1C rats. Caffeine 149-157 renin Rattus norvegicus 55-60 3044993-7 1988 However, during the second and third weeks after clipping, caffeine had lesser effects on plasma renin activity. Caffeine 59-67 renin Rattus norvegicus 97-102 3044993-9 1988 Caffeine accelerated hypertension in 2K1C rats and rats with aortic ligation (renin-dependent renovascular hypertension), but it had no effect on plasma renin activity or blood pressure in one-kidney, one clip rats (renin-independent renovascular hypertension). Caffeine 0-8 renin Rattus norvegicus 78-83 10803761-10 2000 Seven days after both PAN injections, increased plasma renin activity was detected in animals that were consuming caffeine as compared with corresponding control groups (CAFF and CAFF + PAN vs CON and PAN, respectively). Caffeine 114-122 renin Rattus norvegicus 55-60 10803761-14 2000 In conclusion, this study indicates that caffeine adversely affects renal function in PAN-nephrotic rats, and that this effect may be due, in part, to increased activity of the renin angiotensin system. Caffeine 41-49 renin Rattus norvegicus 177-182 10069681-0 1999 Caffeine increases renal renin secretion in a rat model of genetic heart failure. Caffeine 0-8 renin Rattus norvegicus 25-30 10069669-1 1999 Our previous studies supported the hypothesis that prolonged administration of caffeine to animals with high-renin hypertension causes progressive deterioration of renal function. Caffeine 79-87 renin Rattus norvegicus 109-114 10069669-12 1999 These data support our hypothesis that prolonged consumption of caffeine has adverse effects on renal function, in high-renin hypertension. Caffeine 64-72 renin Rattus norvegicus 120-125 10069681-1 1999 In a previous study, we showed that caffeine (CAFF) increases basal renin secretion by blocking intrarenal adenosine receptors and, when sympathetic activity is increased, augments renin release in part by blockade of brain adenosine receptors, leading to increased central sympathetic tone. Caffeine 36-44 renin Rattus norvegicus 68-73 10069681-1 1999 In a previous study, we showed that caffeine (CAFF) increases basal renin secretion by blocking intrarenal adenosine receptors and, when sympathetic activity is increased, augments renin release in part by blockade of brain adenosine receptors, leading to increased central sympathetic tone. Caffeine 36-44 renin Rattus norvegicus 181-186 10069681-1 1999 In a previous study, we showed that caffeine (CAFF) increases basal renin secretion by blocking intrarenal adenosine receptors and, when sympathetic activity is increased, augments renin release in part by blockade of brain adenosine receptors, leading to increased central sympathetic tone. Caffeine 46-50 renin Rattus norvegicus 68-73 10069681-7 1999 CAFF increased plasma renin activity (PRA), norepinephrine (NE), and epinephrine (E) levels in all three strains [treatment effect, p<0.001, 2F analysis of variance (ANOVA)], and these effects were greater in hypertensive (SHRs and SHHF) animals as compared with normotensive WKY rats (p<0.015). Caffeine 0-4 renin Rattus norvegicus 22-27 10069681-9 1999 However, CAFF treatment significantly increased renal renin secretion (71.1+/-19.2 vs. 9.5+/-5.8 ng Ang I/h/min/kg for caffeine and control group, respectively; p<0.01). Caffeine 9-13 renin Rattus norvegicus 54-59 10069681-12 1999 Moreover, this study provides the first evidence that short-term caffeine consumption increases renal renin secretion in heart failure, an effect most likely due to the blockade of intrarenal adenosine receptors. Caffeine 65-73 renin Rattus norvegicus 102-107 8302420-5 1993 Caffeine exacerbated the development of 2K1C hypertension in association with a higher plasma renin concentration (PRC). Caffeine 0-8 renin Rattus norvegicus 94-99 8856488-0 1996 Central effects of caffeine on renal renin secretion and norepinephrine spillover. Caffeine 19-27 renin Rattus norvegicus 37-42 8856488-2 1996 The purpose of our study was to test the hypothesis that the adenosine receptor antagonist caffeine increases renin release in part by disabling the central nervous system (CNS) adenosine brake on renin release. Caffeine 91-99 renin Rattus norvegicus 110-115 8856488-2 1996 The purpose of our study was to test the hypothesis that the adenosine receptor antagonist caffeine increases renin release in part by disabling the central nervous system (CNS) adenosine brake on renin release. Caffeine 91-99 renin Rattus norvegicus 197-202 8445983-0 1993 Effect of caffeine treatment on plasma renin activity and angiotensin I concentrations in rats on a low sodium diet. Caffeine 10-18 renin Rattus norvegicus 39-44 8445983-4 1993 An earlier study partially addressed this question by showing that chronic blockade of adenosine receptors with caffeine exacerbated both the rise of plasma renin activity and the decline of renal function in 2-kidney-1-clip (2K1C) renovascular hypertensive rats. Caffeine 112-120 renin Rattus norvegicus 157-162 8445983-6 1993 The purpose of this study was to reexamine the effect of chronic caffeine consumption on plasma renin activity and angiotensin I levels in animals in another high-renin model, i.e., the low sodium diet. Caffeine 65-73 renin Rattus norvegicus 96-101 8234540-8 1993 Our data showed that the inhibitory effect of Ado on renin activity and blood pressure in salt restricted rats was attenuated by caffeine at the first week but not at six weeks after institution of the low sodium diet. Caffeine 129-137 renin Rattus norvegicus 53-58 8856488-15 1996 caffeine (10 micrograms/kg/min) on hydralazine-induced (1 and 10 mg/kg, administered intraperitoneally) changes in renal secretion of renin and renal NE spillover were investigated. Caffeine 0-8 renin Rattus norvegicus 134-139 8856488-19 1996 caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively). Caffeine 0-8 renin Rattus norvegicus 65-70 8856488-19 1996 caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively). Caffeine 0-8 renin Rattus norvegicus 186-191 8856488-19 1996 caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively). Caffeine 0-8 renin Rattus norvegicus 186-191 8856488-20 1996 The enhanced renin-secretion response to hydralazine in caffeine-treated rats was accompanied by augmented hydralazine-induced increase in renal NE spillover (p = 0.035). Caffeine 56-64 renin Rattus norvegicus 13-18 8856488-21 1996 These data strongly support the hypothesis of a CNS adenosine brake on renin release that is disabled by caffeine. Caffeine 105-113 renin Rattus norvegicus 71-76 8302420-9 1993 These results suggest that caffeine specifically exacerbates 2K1C hypertension through increasing renin release whereas it ameliorates DOCA-salt hypertension possibly through increasing renal excretion. Caffeine 27-35 renin Rattus norvegicus 98-103 1860718-7 1991 Six weeks of caffeine administration increased blood pressure, blood urea nitrogen, serum creatinine, plasma renin activity, and plasma irET-1 in the 2K1C rats but not in the sham-operated rats. Caffeine 13-21 renin Rattus norvegicus 109-114 2005584-11 1991 These data demonstrate that caffeine increases base-line renin release primarily by blocking peripheral (most likely renal), cell-surface adenosine receptors; however, caffeine potentiates vasodilator-induced renin secretion in part by blocking peripheral (most likely renal), cell-surface adenosine receptors and in part by additional central nervous system and/or intracellular mechanism(s) that involve the beta adrenergic system. Caffeine 168-176 renin Rattus norvegicus 209-214 2005584-0 1991 Caffeine potentiates vasodilator-induced renin release. Caffeine 0-8 renin Rattus norvegicus 41-46 2005584-2 1991 The clinical significance of this is that caffeine, a widely consumed adenosine receptor antagonist, could augment renin release responses to diseases such as renovascular hypertension, liver cirrhosis and heart failure and to therapeutic maneuvers such as salt restriction, diuretics and vasodilators. Caffeine 42-50 renin Rattus norvegicus 115-120 2005584-3 1991 Caffeine may be particularly troublesome in this regard because this methylxanthine has central nervous system effects and intracellular actions that also might contribute to the overall ability of caffeine to potentiate renin secretion. Caffeine 0-8 renin Rattus norvegicus 221-226 2005584-3 1991 Caffeine may be particularly troublesome in this regard because this methylxanthine has central nervous system effects and intracellular actions that also might contribute to the overall ability of caffeine to potentiate renin secretion. Caffeine 198-206 renin Rattus norvegicus 221-226 2005584-4 1991 The purpose of this study was to document the effects of caffeine on renin release responses to a vasodilator and to investigate what mechanisms were responsible for any augmentation of vasodilator-induced renin secretion. Caffeine 57-65 renin Rattus norvegicus 69-74 2005584-7 1991 Caffeine and DPSPX increased base-line plasma renin activity to a similar extent regardless of whether the animals were pretreated with propranolol. Caffeine 0-8 renin Rattus norvegicus 46-51 2005584-8 1991 In rats with an intact beta adrenergic system, caffeine, but not DPSPX, increased the renin release response to low-dose hydralazine (1 mg/kg). Caffeine 47-55 renin Rattus norvegicus 86-91 2005584-11 1991 These data demonstrate that caffeine increases base-line renin release primarily by blocking peripheral (most likely renal), cell-surface adenosine receptors; however, caffeine potentiates vasodilator-induced renin secretion in part by blocking peripheral (most likely renal), cell-surface adenosine receptors and in part by additional central nervous system and/or intracellular mechanism(s) that involve the beta adrenergic system. Caffeine 28-36 renin Rattus norvegicus 57-62