PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28654087-0 2017 Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice. Caffeine 0-8 adenosine A1 receptor Mus musculus 31-34 31707092-6 2020 Caffeine increased A1R in the striatum of bulbectomized mice and in SHAM-water group caffeine increased A2AR in the striatum and decreased SNAP-25 in the frontal cortex. Caffeine 0-8 adenosine A1 receptor Mus musculus 19-22 31646844-9 2019 On the other hand, the hypnotic effect of 3 mg/kg of luteolin was almost completely blocked by caffeine, an antagonist for both adenosine A1 and A2A receptor (A1R and A2AR), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), an A1R antagonist, and SCH-58261, an A2AR antagonist. Caffeine 95-103 adenosine A1 receptor Mus musculus 145-162 31646844-9 2019 On the other hand, the hypnotic effect of 3 mg/kg of luteolin was almost completely blocked by caffeine, an antagonist for both adenosine A1 and A2A receptor (A1R and A2AR), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), an A1R antagonist, and SCH-58261, an A2AR antagonist. Caffeine 95-103 adenosine A1 receptor Mus musculus 159-162 29882086-8 2018 Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day. Caffeine 31-39 adenosine A1 receptor Mus musculus 143-149 29882086-8 2018 Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day. Caffeine 91-99 adenosine A1 receptor Mus musculus 143-149 29882086-8 2018 Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day. Caffeine 91-99 adenosine A1 receptor Mus musculus 143-149 29882086-10 2018 Adora1, Slc6a15, and Comt may be involved in the antidepressant-like effect observed after joint administration of caffeine and mianserin or agomelatine, following chronic treatment with caffeine. Caffeine 115-123 adenosine A1 receptor Mus musculus 0-6 29882086-10 2018 Adora1, Slc6a15, and Comt may be involved in the antidepressant-like effect observed after joint administration of caffeine and mianserin or agomelatine, following chronic treatment with caffeine. Caffeine 187-195 adenosine A1 receptor Mus musculus 0-6 29107002-6 2017 Caffeine withdrawal caused a decrease in Adora1 mRNA level in the cerebral cortex (Cx). Caffeine 0-8 adenosine A1 receptor Mus musculus 41-47 29107002-7 2017 Administration of escitalopram or fluoxetine followed by caffeine withdrawal caused an increase in this gene expression, whereas administration of escitalopram, but not fluoxetine, on day 15th together with caffeine caused a decrease in Adora1 mRNA level in the Cx. Caffeine 207-215 adenosine A1 receptor Mus musculus 237-243 28654087-1 2017 Caffeine, an antagonist of the adenosine receptor A1R, is used as a dietary supplement to reduce body weight, although the underlying mechanism is unclear. Caffeine 0-8 adenosine A1 receptor Mus musculus 50-53 26764541-8 2015 Up-regulation of adenosine A1 receptor expression might contribute to the favorable effects of chronic caffeine consumption. Caffeine 103-111 adenosine A1 receptor Mus musculus 17-38 26560700-7 2015 Importantly, caffeine-cocaine combination potentiated the cocaine-induced germ cell loss, and induced pro-apoptotic BAX protein expression and diminished adenosine receptor A1 mRNA levels. Caffeine 13-21 adenosine A1 receptor Mus musculus 154-175 15081797-2 2004 We wanted to elucidate the role of the adenosine A(1) receptor (A1R) in mediating the locomotor effects of increasing doses of caffeine using wild-type mice (A1R(WT)), mice heterozygous for (A1R(HET)), and mice lacking the adenosine A(1) receptor (A1R(KO)). Caffeine 127-135 adenosine A1 receptor Mus musculus 64-67 24475304-4 2014 Pregnant A1AR knockout mice were treated with caffeine (20 mg/kg) or vehicle (0.09% NaCl) i.p. Caffeine 46-54 adenosine A1 receptor Mus musculus 9-13 24475304-8 2014 A1AR+/+ offspring treated in utero with caffeine were 10% heavier than vehicle controls. Caffeine 40-48 adenosine A1 receptor Mus musculus 0-4 24475304-11 2014 Using DNA methylation arrays, we identified altered DNA methylation patterns in A1AR+/+ caffeine treated hearts, including 7719 differentially methylated regions (DMRs) within the genome and an overall decrease in DNA methylation of 26%. Caffeine 88-96 adenosine A1 receptor Mus musculus 80-84 22164264-14 2011 CONCLUSIONS/SIGNIFICANCE: These data show that caffeine alters embryonic cardiac function and disrupts the normal cardiac response to hypoxia through blockade of A1AR action. Caffeine 47-55 adenosine A1 receptor Mus musculus 162-166 15081797-2 2004 We wanted to elucidate the role of the adenosine A(1) receptor (A1R) in mediating the locomotor effects of increasing doses of caffeine using wild-type mice (A1R(WT)), mice heterozygous for (A1R(HET)), and mice lacking the adenosine A(1) receptor (A1R(KO)). Caffeine 127-135 adenosine A1 receptor Mus musculus 39-62 22085758-11 2012 Caffeine reversal of acetaminophen results from actions in the spinal cord, as intrathecal DPCPX 10 nmol inhibited antinociception by systemic acetaminophen; this was also observed in +/+ but not in -/- adenosine A(1) receptor mice. Caffeine 0-8 adenosine A1 receptor Mus musculus 203-226 18562097-6 2008 Intraplantar administration of caffeine also reversed the effect of intraplantar amitriptyline in A1R +/+, but not in -/- or +/- mice. Caffeine 31-39 adenosine A1 receptor Mus musculus 98-101 15081797-3 2004 Caffeine had the typical biphasic dose-effect relationship in all three genotypes, but the stimulatory action of caffeine was facilitated in the A1R(KO) mice. Caffeine 113-121 adenosine A1 receptor Mus musculus 145-148 15081797-6 2004 As expected, the A1R is not crucial for the stimulatory effect of caffeine, but seems to modulate the effect of caffeine exerted via A2AR blockade. Caffeine 112-120 adenosine A1 receptor Mus musculus 17-20 14960625-8 2004 Caffeine treatment augmented A1AR expression on microglia, with ensuing reduction of EAE severity, which was further enhanced by concomitant treatment with the A1AR agonist, adenosine amine congener. Caffeine 0-8 adenosine A1 receptor Mus musculus 29-33 14960625-8 2004 Caffeine treatment augmented A1AR expression on microglia, with ensuing reduction of EAE severity, which was further enhanced by concomitant treatment with the A1AR agonist, adenosine amine congener. Caffeine 0-8 adenosine A1 receptor Mus musculus 160-164 11470917-1 2001 Caffeine is believed to act by blocking adenosine A(1) and A(2A) receptors (A(1)R, A(2A)R), indicating that some A(1) receptors are tonically activated. Caffeine 0-8 adenosine A1 receptor Mus musculus 76-81