PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33552855-3	2021	This CID tool, evolved from an anti-caffeine nanobody via cell-based high-throughput screening, permits caffeine-inducible gating of calcium channels, tumor killing via necroptosis, growth factors-independent activation of tyrosine receptor kinase signaling, and enhancement of nanobody-mediated antigen recognition for the severe acute respiratory distress coronavirus 2 (SARS-CoV-2) spike protein.	Caffeine	36-44	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	385-390	
33552855-3	2021	This CID tool, evolved from an anti-caffeine nanobody via cell-based high-throughput screening, permits caffeine-inducible gating of calcium channels, tumor killing via necroptosis, growth factors-independent activation of tyrosine receptor kinase signaling, and enhancement of nanobody-mediated antigen recognition for the severe acute respiratory distress coronavirus 2 (SARS-CoV-2) spike protein.	Caffeine	104-112	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	385-390	
35281252-1	2022	The aim of the present study was to test the binding affinity of methylxanthines (caffeine/theine, methylxanthine, theobromine, theophylline and xanthine) to three potential target proteins namely Spike protein (6LZG), main protease (6LU7) and nucleocapsid protein N-terminal RNA binding domain (6M3M) of SARS-CoV-2.	Caffeine	91-97	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	197-202	
33080900-0	2020	In silico Investigation on the Inhibiting Role of Nicotine/Caffeine by Blocking the S Protein of SARS-CoV-2 Versus ACE2 Receptor.	Caffeine	59-67	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	84-85	
33080900-2	2020	The simulations reveal the efficient blocking of ACE2 by caffeine and nicotine in the exposure to the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).	Caffeine	57-65	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	102-107	
33080900-2	2020	The simulations reveal the efficient blocking of ACE2 by caffeine and nicotine in the exposure to the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).	Caffeine	57-65	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	109-110	
33080900-3	2020	We have selected the two most important active sites of ACE2-S protein, i.e., 6LZG and 6VW1, which are critically responsible in the interaction of S protein to the receptor and thus, we investigated their interaction with nicotine and caffeine through MD simulations.	Caffeine	236-244	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	61-62	
33080900-5	2020	Our results reveal that caffeine or nicotine in a specific molar ratio to 6LZG shows a very strong interaction and indicate that caffeine is more efficient in the interaction with 6LZG and further blocking of this site against S protein binding.	Caffeine	24-32	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	227-228	
33080900-5	2020	Our results reveal that caffeine or nicotine in a specific molar ratio to 6LZG shows a very strong interaction and indicate that caffeine is more efficient in the interaction with 6LZG and further blocking of this site against S protein binding.	Caffeine	129-137	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	227-228