PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34056932-7 2021 Caffeine injection also increased locomotor activity and c-Fos expression in the medial septum-vertical limb of the diagonal band of Broca (MS-VDB), one of the arousal regions of the basal forebrain. Caffeine 0-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 57-62 34056932-9 2021 In addition, MAI treatment at HT7, compared with treatment at a location not corresponding to any traditional acupuncture point, reduced the caffeine-induced increase in c-Fos expression. Caffeine 141-149 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 170-175 33420284-7 2021 Caffeine administered both IV and ICV increased neuronal activity, as measured by c-Fos-immunoreactivity within subregions of the hypothalamic area, previously implicated in regulating BAT thermogenesis. Caffeine 0-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 82-87 28320839-10 2017 Caffeine treatment in midnight triggered c-Fos expression in dorsal SCN. Caffeine 0-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 41-46 31539618-8 2019 In all regions of SSCx, Rt, VB, CM and LGN, GAERS caffeine group had lower c-Fos protein expression comparing to the GAERS control group (p < 0.05). Caffeine 50-58 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 75-80 31539618-9 2019 Wistar caffeine rats had lower expression of c-Fos protein comparing to the Wistar control group only in SSCx. Caffeine 7-15 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 45-50 31539618-11 2019 In conclusion differential effects of caffeine in the seizure modulation may involve c-Fos protein activity-dependent protection mechanisms. Caffeine 38-46 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 85-90 28320839-11 2017 Both sleep deprivation and caffeine treatment potentiated light-induced c-Fos expression in calbindin-containing cells of the ventral SCN in early and late night. Caffeine 27-35 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 72-77 25323389-8 2014 Expression levels of c-Fos and NGF in all central micturition areas were significantly increased following the administration of caffeine. Caffeine 129-137 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 21-26 26874560-14 2016 Adolescent caffeine consumption increased basal c-fos mRNA in the paraventricular nucleus of the hypothalamus. Caffeine 11-19 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 48-53 25323389-9 2014 The effects on contraction pressure and time were the most potent and expression levels of c-Fos and NGF were greatest at the lowest dose of caffeine. Caffeine 141-149 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 91-96 24907695-10 2014 Acute, but not chronic, caffeine exposure elevated c-Fos expression in the NAc. Caffeine 24-32 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 51-56 25031227-9 2014 Immunostaining showed a significantly elevated number of c-Fos-labeled histamine neurons in caffeine-treated rats compared with saline-treated animals. Caffeine 92-100 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 57-62 18706486-10 2008 The abolition of Fos protein expression evoked by hypoxia suggested that caffeine exposure may decrease the activity of O2-sensing peripheral chemoreceptor pathway. Caffeine 73-81 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 17-20 22771386-8 2012 An increase in c-Fos-positive labeled cells was found in the caffeine-treated group at P5-P6 within the same areas described above, with the most clear-cut increase seen in the arcuate nucleus. Caffeine 61-69 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 15-20 19864960-0 2009 Caffeine elicits c-Fos expression in horizontal diagonal band cholinergic neurons. Caffeine 0-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 17-22 19864960-5 2009 Caffeine significantly increased c-Fos expression in cholinergic neurons of the horizontal limb of the diagonal band of Broca but not other basal forebrain regions such as the medial septum or substantia innominata. Caffeine 0-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 33-38 21967278-8 2012 Co-administration of caffeine with MDMA increased p-CREB, p-DARPP-32 and c-fos expression when compared with either treatment alone. Caffeine 21-29 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 73-78 14521986-0 2003 Stimulant doses of caffeine induce c-FOS activation in orexin/hypocretin-containing neurons in rat. Caffeine 19-27 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 35-40 16917819-0 2006 Differential c-Fos immunoreactivity in arousal-promoting cell groups following systemic administration of caffeine in rats. Caffeine 106-114 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 13-18 16917819-2 2006 By using c-Fos immunohistochemistry as a marker of neuronal activation, we recently showed that stimulant doses of caffeine activate arousal-promoting hypothalamic orexin (hypocretin) neurons. Caffeine 115-123 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 9-14 16917819-6 2006 The three doses of caffeine induced distinct dose-related patterns of c-Fos immunoreactivity in several arousal-promoting areas, including orexin neurons and adjacent neurons containing neither orexin nor melanin-concentrating hormone; tuberomammillary histaminergic neurons; locus coeruleus noradrenergic neurons; noncholinergic basal forebrain neurons that do not contain parvalbumin; and nondopaminergic neurons in the ventral tegmental area. Caffeine 19-27 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 70-75 16917819-9 2006 These results indicate that motor-stimulatory doses of caffeine induce a remarkably restricted pattern of c-Fos expression in the arousal-promoting system and suggest that this specific neuronal activation may be involved in the behavioral arousal by caffeine. Caffeine 55-63 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 106-111 16917819-9 2006 These results indicate that motor-stimulatory doses of caffeine induce a remarkably restricted pattern of c-Fos expression in the arousal-promoting system and suggest that this specific neuronal activation may be involved in the behavioral arousal by caffeine. Caffeine 251-259 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 106-111 14521986-7 2003 Compared with saline, all doses of caffeine increased the number of cells immunoreactive for both orexin and c-Fos. Caffeine 35-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 109-114 14521986-10 2003 In contrast, caffeine significantly increased the number of non-orexin-immunoreactive neurons expressing c-Fos only in the dorsomedial nucleus. Caffeine 13-21 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 105-110 12538785-6 2003 In addition, the hypoxic respiratory depression is clearly emphasized after in utero exposure to caffeine and coincides with an increased Fos expression in the area postrema and nucleus raphe obscurus, two structures in which it is not increased in the absence of caffeine. Caffeine 264-272 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 138-141 10891619-9 2000 In summary, each of the anxiogenic drugs tested (FG-7142, yohimbine, m-chlorophenyl piperazine, caffeine and BOC-CCK(4)) increased Fos expression in a restricted number of hindbrain regions, including the periaqueductal gray and locus coeruleus. Caffeine 96-104 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 131-134 11760011-2 2001 Other treatments that induce c-fos expression in the fetal SCN include caffeine and nicotine. Caffeine 71-79 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 29-34 9681931-5 1998 Similar region-specific effects of caffeine were observed on c-fos mRNA induced by the selective dopamine D2 antagonist raclopride (0.5 mg kg(-1)). Caffeine 35-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 61-66 9802702-0 1998 Immunohistochemical localization of caffeine-induced c-Fos protein expression in the rat brain. Caffeine 36-44 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 53-58 9802702-8 1998 In contrast, caffeine at 75 mg/kg induced a significant increase compared with the saline condition in the number of Fos-immunoreactive neurons in the majority of structures examined. Caffeine 13-21 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 117-120 9681931-0 1998 Regional differences in the ability of caffeine to affect haloperidol-induced striatal c-fos mRNA expression in the rat. Caffeine 39-47 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 87-92 9681931-1 1998 By using in situ hybridisation we examined the acute effects of caffeine on haloperidol-induced c-fos mRNA in rat striatum. Caffeine 64-72 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 96-101 9681931-6 1998 Both haloperidol and raclopride counteracted caffeine-induced c-fos mRNA expression in somatosensory cortex. Caffeine 45-53 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 62-67 9681931-8 1998 The present data show that caffeine modulates c-fos mRNA induced by dopamine D2 receptor antagonism differentially in sensorimotor and limbic-related areas of striatum. Caffeine 27-35 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 46-51 9364486-2 1997 A significant induction of c-fos mRNA, but not of any of the other IEGs, was found 2, 4 and 8 hr after a single injection of 50 mg/kg caffeine. Caffeine 134-142 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 27-32 9421173-0 1997 Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum. Caffeine 46-54 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 17-22 9421173-6 1997 The antisense blockade of c-fos reduced the effect of caffeine on the expression of mRNAs for preprotachykinin A and neurotensin/neuromedin N in the ventrolateral caudate-putamen. Caffeine 54-62 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 26-31 9421173-8 1997 Thus caffeine induction of striatal preprotachykinin A mRNA and neurotensin/neuromedin N mRNA, but not of preproenkephalin mRNA or prodynorphin mRNA, may at least in part be mediated by a pathway involving Fos protein. Caffeine 5-13 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 206-209 9364486-4 1997 The ability of caffeine to increase pallidal c-fos mRNA expression was mimicked by the dopamine D2/3 receptor agonist quinpirole (1 or 3 mg/kg), whereas the dopamine D2/3 receptor antagonist raclopride (2 mg/kg) was ineffective. Caffeine 15-23 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 45-50 9364486-6 1997 The caffeine-induced c-fos mRNA expression was not counteracted by concomitant treatment with raclopride. Caffeine 4-12 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 21-26 9364486-9 1997 The fact that pallidal c-fos mRNA expression decreased upon repeated administration of caffeine may be related to the development of tolerance to locomotion stimulation that occurs following chronic caffeine ingestion. Caffeine 87-95 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 23-28 9364486-9 1997 The fact that pallidal c-fos mRNA expression decreased upon repeated administration of caffeine may be related to the development of tolerance to locomotion stimulation that occurs following chronic caffeine ingestion. Caffeine 199-207 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 23-28 8128903-0 1993 Caffeine-induced expression of the proto-oncogene c-fos in rat striatum is increased after dopamine denervation. Caffeine 0-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 35-55 8717354-0 1996 Caffeine-induced expression of c-fos mRNA and NGFI-A mRNA in caudate putamen and in nucleus accumbens are differentially affected by the N-methyl-D-aspartate receptor antagonist MK-801. Caffeine 0-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 31-36 8717354-6 1996 The two NMDA receptor antagonists significantly reduced the caffeine-induced expression of both c-fos mRNA and NGFI-A mRNA in the medial part of the caudate putamen. Caffeine 60-68 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 96-101 8717354-10 1996 These findings suggest that glutamatergic transmission via NMDA receptors contributes to the induction of c-fos mRNA and NGFI-A mRNA by caffeine in striatum. Caffeine 136-144 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 106-111 7572198-1 1995 It has previously been shown that caffeine, in a dose-dependent manner, increases the expression of the protooncogene c-fos in the rat brain, predominantly in the caudate-putamen and tuberculum olfactorium. Caffeine 34-42 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 118-123 7572198-5 1995 Thus, c-fos is induced in rat striatum following administration of caffeine and other xanthines that (provided they enter the brain) block adenosine receptors, suggesting an involvement of central adenosine receptors. Caffeine 67-75 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 6-11 7751931-1 1995 The effect of a single injection of caffeine on the expression of c-fos, c-jun, junB, and junD, on activator protein 1 (AP-1) and on the levels of preproenkephalin mRNA in rat striatum was studied. Caffeine 36-44 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 66-71 7751931-4 1995 By using in situ hybridization of adjacent sections we found a rapid, transient, and dose-dependent increase of c-fos, c-jun, and junB by caffeine in striatum, especially in the lateral part. Caffeine 138-146 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 112-117 7751931-12 1995 The data show that a single dose of caffeine induces a temporally and spatially characteristic pattern of c-fos, c-jun, and junB induction, followed by changes in AP-1 and preproenkephalin mRNA. Caffeine 36-44 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 106-111 7520134-0 1994 Differences in the regional and cellular localization of c-fos messenger RNA induced by amphetamine, cocaine and caffeine in the rat. Caffeine 113-121 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 57-62 7520134-17 1994 With caffeine treatment, about 73% of neuron-like cells were c-fos labelled in the lateral striatum, but labelling was much less pronounced in the medial part or in the accumbens. Caffeine 5-13 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 61-66 7748323-1 1993 The expression of c-fos mRNA in rat brain was induced by intraperitoneal (ip) administration of N-methyl-D-aspartate (NMDA) and kainic acid, agonists of different classes of glutamate receptors and by caffeine, an antagonist of adenosine receptors. Caffeine 201-209 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 18-23 1328519-1 1992 The expression of c-fos mRNA in rat brain was induced by intraperitoneal administration of pentylenetetrazole (PTZ) and picrotoxin, which act on the picrotoxin binding site of the gamma-aminobutyric acid-benzodiazepine (GABA-BZ) receptor complex, by N-methyl-D-aspartate (NMDA) and kainic acid, agonists of different classes of glutamate receptors and by caffeine, an antagonist of adenosine receptors. Caffeine 355-363 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 18-23