PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21416940-4 2010 The urinary caffeine metabolites ratios are commonly used in the assessment of activities of drug metabolizing enzymes, mainly including CYP1A2, CYP2A6, N-acetyltransferase and xanthine oxidase. Caffeine 12-20 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 145-151 22850738-4 2013 Using caffeine as a probe, in vivo CYP2A6 activity was estimated by the 17U/17X urinary ratio. Caffeine 6-14 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 35-41 22849705-0 2012 Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers. Caffeine 49-57 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-19 22849705-1 2012 Phenotyping of cytochrome P450 2A6 (CYP2A6) was determined by assessing urinary caffeine metabolites in a Japanese population with a high frequency of CYP2A6 whole-gene deletion (CYP2A6*4). Caffeine 80-88 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 15-34 22849705-1 2012 Phenotyping of cytochrome P450 2A6 (CYP2A6) was determined by assessing urinary caffeine metabolites in a Japanese population with a high frequency of CYP2A6 whole-gene deletion (CYP2A6*4). Caffeine 80-88 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 36-42 22849705-3 2012 Low 17U/1X ratios were observed in accumulated overnight urine samples of subjects genotyped as CYP2A6*4/*4 after caffeine treatment. Caffeine 114-122 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 96-102 22849705-6 2012 The present results suggest that impaired CYP2A6 function associated with CYP2A6 *4/ *4 could be determined using the 17U/1X ratios in spot urine samples under normal dietary caffeine consumption in Japanese non-smokers, without the need for additional caffeine administration or prior abstention from caffeine. Caffeine 175-183 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 42-48 22849705-6 2012 The present results suggest that impaired CYP2A6 function associated with CYP2A6 *4/ *4 could be determined using the 17U/1X ratios in spot urine samples under normal dietary caffeine consumption in Japanese non-smokers, without the need for additional caffeine administration or prior abstention from caffeine. Caffeine 175-183 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 74-80 22849705-6 2012 The present results suggest that impaired CYP2A6 function associated with CYP2A6 *4/ *4 could be determined using the 17U/1X ratios in spot urine samples under normal dietary caffeine consumption in Japanese non-smokers, without the need for additional caffeine administration or prior abstention from caffeine. Caffeine 253-261 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 42-48 22849705-6 2012 The present results suggest that impaired CYP2A6 function associated with CYP2A6 *4/ *4 could be determined using the 17U/1X ratios in spot urine samples under normal dietary caffeine consumption in Japanese non-smokers, without the need for additional caffeine administration or prior abstention from caffeine. Caffeine 253-261 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 42-48 28253085-0 2017 Water pipe (Shisha, Hookah, Arghile) Smoking and Secondhand Tobacco Smoke Effects on CYP1A2 and CYP2A6 Phenotypes as Measured by Caffeine Urine Test. Caffeine 129-137 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 96-102 28253085-4 2017 In a sample of 99 healthy volunteers (28 water pipe smokers, 30 secondhand tobacco smoke exposed persons, and 41 controls), we systematically compared CYP1A2 and CYP2A6 enzyme activities in vivo using caffeine urine test. Caffeine 201-209 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 162-168 24380444-0 2014 High CYP2A6 enzyme activity as measured by a caffeine test and unique distribution of CYP2A6 variant alleles in Ethiopian population. Caffeine 45-53 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 5-11 20484172-8 2010 Urinary caffeine metabolite ratios were used as the indicators of the activities of CYP1A2, CYP2A6, NAT2, and XO. Caffeine 8-16 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 92-98 20155256-4 2010 In 100 of them, CYP2A6 and XO activities were determined by the urinary 17U/17X and 1U/(1U + 1X) ratios, respectively, after oral administration of 100 mg caffeine as a probe. Caffeine 155-163 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 16-22 19519341-7 2009 Caffeine has been used by different groups to evaluate the in vivo activity of CYP1A2, NAT2, XO and CYP2A6 in different populations and the effect of many factors on these activities. Caffeine 0-8 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 100-106 19519341-0 2009 Caffeine metabolic ratios for the in vivo evaluation of CYP1A2, N-acetyltransferase 2, xanthine oxidase and CYP2A6 enzymatic activities. Caffeine 0-8 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 108-114 19519341-2 2009 The caffeine metabolic ratio, in urine, plasma or saliva, has been used extensively as an index of CYP1A2, N-acetyltransferase 2 (NAT2), xanthine oxidase (XO) and CYP2A6 enzymatic activities. Caffeine 4-12 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 163-169 18715882-2 2008 In the metabolism of caffeine, the conversion of 1,7 dimethylxanthine (17X) to 1,7 dimethiylurate (17U) is catalyzed primarily by CYP2A6. Caffeine 21-29 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 130-136 18715882-3 2008 CYP2A6 phenotype was determined by the urinary ratio 17U:17X in the interval of 4-5 h after caffeine intake in 179 healthy white Spaniards (102 women and 76 men). Caffeine 92-100 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-6 15980104-0 2005 Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans. Caffeine 87-95 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-6 17344941-5 2007 Caffeine is a commonly used probe to assess the metabolic activities of CYP1A2, CYP2A6, N-acetyltransferase 2 (NAT2) and xanthine oxidase (XO). Caffeine 0-8 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 80-86 16759004-0 2006 [Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe]. Caffeine 78-86 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 51-57 15980104-1 2005 In a caffeine test previously performed with healthy Japanese volunteers, we found that the CYP1A2 index defined as urinary {5-acetylamino-6-amine-3-methyluracil (AAMU)+1-methylxanthine (1X)+1-methyluric acid (1 U)}/1,7-dimethyluric acid (17 U) was affected by the whole deleted allele of CYP2A6 (CYP2A6*4). Caffeine 5-13 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 289-295 15980104-1 2005 In a caffeine test previously performed with healthy Japanese volunteers, we found that the CYP1A2 index defined as urinary {5-acetylamino-6-amine-3-methyluracil (AAMU)+1-methylxanthine (1X)+1-methyluric acid (1 U)}/1,7-dimethyluric acid (17 U) was affected by the whole deleted allele of CYP2A6 (CYP2A6*4). Caffeine 5-13 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 297-305 4095132-1 1985 Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and metamizol (noramidopyrine methanesulfonate sodium) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB). Caffeine 0-8 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 76-81 12505289-6 2002 CYP2A6 converts the caffeine metabolite 1,7-dimethylxanthine (17X) to 1,7-dimethyluric acid (17U); we investigated CYP2A6 activity using the 17U/17X urinary metabolite ratio from case-control subjects who completed a caffeine phenotype assay. Caffeine 20-28 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-6 12505289-6 2002 CYP2A6 converts the caffeine metabolite 1,7-dimethylxanthine (17X) to 1,7-dimethyluric acid (17U); we investigated CYP2A6 activity using the 17U/17X urinary metabolite ratio from case-control subjects who completed a caffeine phenotype assay. Caffeine 20-28 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 115-121 12505289-6 2002 CYP2A6 converts the caffeine metabolite 1,7-dimethylxanthine (17X) to 1,7-dimethyluric acid (17U); we investigated CYP2A6 activity using the 17U/17X urinary metabolite ratio from case-control subjects who completed a caffeine phenotype assay. Caffeine 217-225 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-6 12189367-9 2002 CONCLUSIONS: Our results suggest that putative poor metabolizers of xanthine oxidase activities exist in a Japanese population and that a decreased 1,7-dimethyluric acid formation from caffeine in poor metabolizers of CYP2A6 appears to affect the metabolic ratio used for the assessment of CYP1A2 activity. Caffeine 185-193 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 218-224 11927498-0 2002 CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk. Caffeine 30-38 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-6 11927498-2 2002 CYP2A6 phenotype was determined using caffeine as a probe drug in individuals participating in a case-control study of colorectal cancer (127 cases and 333 controls matched on age, gender, race, and geographic region). Caffeine 38-46 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-6 11927498-3 2002 Conversion of the caffeine metabolite 1,7-dimethylxanthine (17X) to 1,7-dimethyl uric acid (17U) is catalyzed primarily by CYP2A6, and this activity can be assayed by comparison of urinary molar ratios of metabolites. Caffeine 18-26 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 123-129 11927498-10 2002 We found a strong relationship between CYP2A6 activity, measured by urinary caffeine metabolite ratio, and colorectal cancer risk. Caffeine 76-84 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 39-45 4095132-1 1985 Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and metamizol (noramidopyrine methanesulfonate sodium) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB). Caffeine 0-8 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 214-221 3991787-1 1985 Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and noramidopyrine-methanesulfonate sodium (metamizol, Analgin) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB). Caffeine 0-8 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 76-81 3991787-1 1985 Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and noramidopyrine-methanesulfonate sodium (metamizol, Analgin) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB). Caffeine 0-8 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 223-230 3991787-0 1985 [Determination of caffeine and metamizole elimination in men and women with and without hormonal contraceptives as an in vivo method for characterization of various cytochrome P-450 subspecies]. Caffeine 18-26 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 176-181 29971434-6 2018 We investigated potential effect modification by caffeine metabolism, defined by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism. Caffeine 49-57 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 152-158