PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10638913-4	2000	METHODS: Washed platelets were stimulated by thrombin after incubation with 0.5, 1.0, or 1.5 mM sevoflurane, halothane, or isoflurane.	Halothane	109-118	coagulation factor II, thrombin	Homo sapiens	45-53	
9710399-6	1998	RESULTS: Our results indicate that pretreating platelets with halothane leads to a partial impairment of the [Ca2+]i increase induced either by U46619, thrombin, or platelet-activating factor, but this had no significant effect on the [Ca2+]i response triggered by thapsigargin.	Halothane	62-71	coagulation factor II, thrombin	Homo sapiens	152-160	
8694388-2	1996	The current study aimed to clarify the inhibitory mechanisms of halothane on thrombin-induced human platelet aggregation by measuring (1) platelet-surface glycoprotein Ib expression, (2) the concentration of intracellular free Ca2+ ([Ca2+]i) measured simultaneously with aggregation, (3) the concentration of intracellular inositol 1,4,5-triphosphate, and (4) the concentration of intracellular cyclic 3",5"-adenosine monophosphate ([cAMP]i).	Halothane	64-73	coagulation factor II, thrombin	Homo sapiens	77-85	
8694388-8	1996	Halothane decreased the thrombin stimulated [Ca2+]i transient and inhibited platelet aggregation in a dose-dependent manner, both in the presence and in the absence of external Ca2+.	Halothane	0-9	coagulation factor II, thrombin	Homo sapiens	24-32	
8694388-10	1996	Halothane inhibited the increase in inositol 1,4,5-triphosphate induced by thrombin.	Halothane	0-9	coagulation factor II, thrombin	Homo sapiens	75-83	
8694388-12	1996	CONCLUSIONS: Halothane inhibits thrombin-induced human platelet aggregation by decreasing [Ca2+]i without inhibiting agonist-receptor binding; the inhibitory effect of halothane on [Ca2+]i might be mediated by a decrease in inositol 1,4,5 triphosphate and in part by an increase in [cAMP]i.	Halothane	13-22	coagulation factor II, thrombin	Homo sapiens	32-40	
8694388-12	1996	CONCLUSIONS: Halothane inhibits thrombin-induced human platelet aggregation by decreasing [Ca2+]i without inhibiting agonist-receptor binding; the inhibitory effect of halothane on [Ca2+]i might be mediated by a decrease in inositol 1,4,5 triphosphate and in part by an increase in [cAMP]i.	Halothane	168-177	coagulation factor II, thrombin	Homo sapiens	32-40