PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29247050-13	2018	We conclude that the binding of halothane to RyR1 alters the voltage dependence of Ca2+ release in MH-susceptible muscle fibers such that the resting membrane potential becomes a decisive factor for the efficiency of the drug to trigger Ca2+ release.	Halothane	32-41	ryanodine receptor 1, skeletal muscle	Mus musculus	45-49	
32764093-9	2020	CAF +- HAL are studied on RYR1 single-channel currents and HET myotubes to define molecular mechanisms of gene-by-environment synergism.	Halothane	7-10	ryanodine receptor 1, skeletal muscle	Mus musculus	26-30	
32764093-11	2020	Central and peripheral nervous systems mediate adverse responses to HAL in a HET model of MH susceptibility exposed to dietary CAF, a modifiable lifestyle factor that may mitigate risks of acute and chronic diseases associated with RYR1 mutations.	Halothane	68-71	ryanodine receptor 1, skeletal muscle	Mus musculus	232-236	
32795494-0	2020	Pharmacological evidence for the involvement of ryanodine receptors in halothane-induced liver injury in mice.	Halothane	71-80	ryanodine receptor 1, skeletal muscle	Mus musculus	48-67	
32665491-7	2020	Furthermore, local pretreatment with SAR7334 partially decreased the elevation of intracellular resting calcium that is seen in RYR1-p.G2435R muscles during exposure to halothane.	Halothane	169-178	ryanodine receptor 1, skeletal muscle	Mus musculus	128-132	
23159934-5	2013	[Ca(2+)]i and [Na(+)]i are persistently elevated in vivo and further increased by halothane in MH-RyR1(R163C/WT) muscle.	Halothane	82-91	ryanodine receptor 1, skeletal muscle	Mus musculus	98-102