PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22394379-8	2012	These results establish the presence of two distinct bupropion binding sites within the Torpedo nAChR transmembrane domain: a high affinity site at the middle (M2-9) of the ion channel and a second site near the extracellular end of alphaM1 within a previously described halothane (general anesthetic) binding pocket.	Halothane	271-280	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	96-101	
20661501-5	2010	At the majority of binding sites in alpha4beta2 nAChR, halothane replaced the slow-exchanging water molecules and caused a regional water population decrease.	Halothane	55-64	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	48-53	
20014754-0	2010	Higher susceptibility to halothane modulation in open- than in closed-channel alpha4beta2 nAChR revealed by molecular dynamics simulations.	Halothane	25-34	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	90-95	
20014754-12	2010	The study concludes that sensitivity and global dynamics responsiveness of alpha4beta2 nAChR to halothane are conformation dependent.	Halothane	96-105	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	87-92	
19697903-3	2009	Using our published open-channel structure model of alpha4beta2 nAChR, we identified and evaluated six amphiphilic interaction sites for the volatile anesthetic halothane via flexible ligand docking and subsequent 20-ns molecular dynamics simulations.	Halothane	161-170	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	64-69	
15618790-13	2005	CONCLUSIONS: Isoflurane, sevoflurane, and halothane potently blocked the alpha4beta2 nAChR.	Halothane	42-51	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	85-90	
14621991-0	2003	Identification of nicotinic acetylcholine receptor amino acids photolabeled by the volatile anesthetic halothane.	Halothane	103-112	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	18-50	
14621991-1	2003	To identify inhalational anesthetic binding domains in a ligand-gated ion channel, we photolabeled nicotinic acetylcholine receptor (nAChR)-rich membranes from Torpedo electric organ with [(14)C]halothane and determined by Edman degradation some of the photolabeled amino acids in nAChR subunit fragments isolated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and high-performance liquid chromatography.	Halothane	195-204	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	99-131	
14621991-9	2003	Halothane photolabeling of deltaTyr-228 provides initial evidence that halothane and isoflurane bind within this pocket with occupancy or access increased in the nAChR desensitized state compared to the closed channel state.	Halothane	0-9	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	162-167	
14621991-9	2003	Halothane photolabeling of deltaTyr-228 provides initial evidence that halothane and isoflurane bind within this pocket with occupancy or access increased in the nAChR desensitized state compared to the closed channel state.	Halothane	71-80	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	162-167	
8610122-1	1996	To determine inhalational anesthetic binding domains on a ligand-gated ion channel, I used halothane direct photoaffinity labeling of the nicotinic acetylcholine receptor (nAChR) in native Torpedo membranes.	Halothane	91-100	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	138-170	
8610122-1	1996	To determine inhalational anesthetic binding domains on a ligand-gated ion channel, I used halothane direct photoaffinity labeling of the nicotinic acetylcholine receptor (nAChR) in native Torpedo membranes.	Halothane	91-100	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	172-177	
8610122-2	1996	[14C]Halothane photoaffinity labeling of both the native Torpedo membranes and the isolated nAChR was saturable, with Kd values within the clinically relevant range.	Halothane	5-14	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	92-97	
8610122-6	1996	Unlabeled halothane reduced labeling more than did isoflurane, suggesting differences in the binding domains for inhalational anesthetics in the nAChR.	Halothane	10-19	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	145-150	
8610122-7	1996	These data suggest multiple similar binding domains for halothane in the transmembrane region of the nAChR.	Halothane	56-65	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	101-106