PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10089133-5	1999	In contrast, cicaprost reduced the secretion of TNF-alpha but led to a slight enhancement of IL-10 release from PBMCs.	cicaprost	13-22	tumor necrosis factor	Homo sapiens	48-57	
10089133-6	1999	When LPS-activated PBMCs were incubated in the presence of cicaprost and IL-4 or IL-13 there was a selective, synergistic inhibition of the TNF-alpha release which was not observed for IL-10.	cicaprost	59-68	tumor necrosis factor	Homo sapiens	140-149	
9409229-5	1997	Cicaprost as well as forskolin significantly inhibited TNF-alpha- and IL-1 beta-induced cell surface expression of ICAM-1 and VCAM-1.	cicaprost	0-9	tumor necrosis factor	Homo sapiens	55-64	
9469479-9	1998	In the same samples, the LPS-stimulated production of TNF was markedly attenuated by rolipram or cicaprost.	cicaprost	97-106	tumor necrosis factor	Homo sapiens	54-57	
9469479-12	1998	Taken together, rolipram and cicaprost exert a dual regulatory function by enhancing IL-10 formation and attenuating TNF synthesis.	cicaprost	29-38	tumor necrosis factor	Homo sapiens	117-120	
9409229-6	1997	Semiquantitative rt-PCR measurements showed a marked decrease of TNF-alpha- and IL-1 beta-induced mRNA levels of both adhesion molecules after preincubation with cicaprost.	cicaprost	162-171	tumor necrosis factor	Homo sapiens	65-74	
8901027-0	1996	Cicaprost and the type IV phosphodiesterase inhibitor, rolipram, synergize in suppression of tumor necrosis factor-alpha synthesis.	cicaprost	0-9	tumor necrosis factor	Homo sapiens	93-120	
9298541-6	1997	Exposure of human monocytes to LPS (3 ng ml-1, approximately EC84) resulted in a time-dependent elaboration to TNF alpha which was suppressed in cells pretreated with prostaglandin E1 (PGe1), PGE2 and cicaprost.	cicaprost	201-210	tumor necrosis factor	Homo sapiens	111-120	
9063693-6	1997	First, we confirmed the TNF-suppressing effect of interleukin-10, rolipram and cicaprost alone and determined the IC50 for these substances.	cicaprost	79-88	tumor necrosis factor	Homo sapiens	24-27	
8901027-2	1996	We now showed the synergistic suppressive effect of the specific type IV phosphodiesterase inhibitor, rolipram, and of the stable prostacyclin analogue, cicaprost, on TNF synthesis.	cicaprost	153-162	tumor necrosis factor	Homo sapiens	167-170	
8901027-4	1996	Lipopolysaccharide-induced TNF synthesis by mononuclear cells decreased from 3.4 ng/ml to 1.5 ng/ml in the presence of 100 nM rolipram and to 0.7 ng/ml in the presence of 10 nM cicaprost.	cicaprost	177-186	tumor necrosis factor	Homo sapiens	27-30	
7525928-5	1994	The analogs were more potent inhibitors of tumor necrosis factor-alpha synthesis (50% inhibition at 334 +/- 40 pM cicaprost or 846 +/- 182 pM iloprost) and extraordinarily potent when combined with a phosphodiesterase inhibitor (50% inhibition at 101 +/- 31 pM iloprost in the presence of 20 microM isobutylmethylxanthine).	cicaprost	114-123	tumor necrosis factor	Homo sapiens	43-70	
7525928-7	1994	Cicaprost inhibited lipopolysaccharide-induced increases in mRNA levels for TF, tumor necrosis factor-alpha and interleukin-1 beta; differential potency was again observed.	cicaprost	0-9	tumor necrosis factor	Homo sapiens	76-107	
7507098-3	1993	Our results show, that the stable analogs of PGI2, iloprost and cicaprost, markedly suppress TNF-alpha synthesis in LPS-stimulated MNC without effect on IL-1 beta production.	cicaprost	64-73	tumor necrosis factor	Homo sapiens	93-102	
7507098-7	1993	Suppression of TNF-alpha synthesis by cicaprost and PGE2 is probably mediated by an increased intracellular cAMP formation.	cicaprost	38-47	tumor necrosis factor	Homo sapiens	15-24