PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19034627-4 2009 RESULTS: In human primary hepatocytes, real-time PCR analysis showed induction of CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2 by EGb 761, ginkgolide A (GA) and ginkgolide B (GB), but not by bilobalide (BB) or the flavonoids (quercetin, kaempferol and tamarixetin) of GBE. ginkgolide A 133-145 ATP binding cassette subfamily C member 2 Homo sapiens 116-120 1954303-0 1991 Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine. Physostigmine 100-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 1954303-2 1991 Acetylcholinesterase activity was most effectively inhibited in all tissues by physostigmine, followed by tacrine and galanthamine. Physostigmine 79-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1954303-5 1991 While physostigmine and tacrine acted equally on acetylcholinesterase from different sources, galanthamine was 10-fold less potent in inhibiting the enzyme activity from human brain that from human erythrocytes. Physostigmine 6-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 1907148-7 1991 The rate of recovery of red cell AChE and plasma ChE activities, following incubation of whole blood with physostigmine (1 x 10(-7) M), was in the order human greater than rhesus monkey greater than marmoset greater than guinea-pig. Physostigmine 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 1676644-0 1991 Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects. Physostigmine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 1676644-3 1991 Plasma physostigmine concentrations correlated with percentage of AChE inhibition across time by dose and across all doses and subjects tested. Physostigmine 7-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 1676644-4 1991 These data should be helpful to physicians in adjusting physostigmine dosing, enabling them to use the relatively simple and widely available AChE assay to approximate plasma physostigmine concentrations. Physostigmine 56-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 1676644-4 1991 These data should be helpful to physicians in adjusting physostigmine dosing, enabling them to use the relatively simple and widely available AChE assay to approximate plasma physostigmine concentrations. Physostigmine 175-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 1825627-11 1991 If the effects of the nondepolarizing neuromuscular blocking agents must be reversed more rapidly, acetylcholinesterase-inhibiting agents such as physostigmine, neostigmine, pyridostigmine, and edrophonium can be used. Physostigmine 146-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 2294657-0 1990 Effects of tacrine, aminopyridines, and physostigmine on acetylcholinesterase, acetylcholine release, and potassium currents. Physostigmine 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 2326327-4 1990 Intraventricular administration of the acetylcholinesterase inhibitor, physostigmine (10 micrograms bilaterally), activated lordosis of short duration in ovariectomized hamsters primed only with estrogen. Physostigmine 71-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 33478277-2 2021 In the present study, we used three docking-based virtual screening approaches to screen both ZINC15 and MolPort databases for synthetic analogs of physostigmine and donepezil, two highly potent AChE inhibitors. Physostigmine 148-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 3185960-3 1988 IC50 values (the concentration required to reduce enzyme activity by 50%) for the inhibition of total tissue AChE were 7.9 x 10(-7) M and 4.5 x 10(-8) M for THA and physostigmine, respectively, and similar values were also obtained for individual molecular forms of AChE (monomer G1, dimer G2 and tetramer G4) separated by sucrose density gradient centrifugation. Physostigmine 165-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 3694255-3 1987 The effects of acetylcholine (ACh), the muscarinic antagonist scopolamine (Sco), the nicotinic antagonist dihydro-beta-erythroidine (DBE), and the acetylcholinesterase inhibitor physostigmine (Phy) on maintained and light-evoked ganglion cell discharge was examined using iontophoresis techniques. Physostigmine 178-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 3685073-3 1987 A rate-decreasing dose of physostigmine, an acetylcholinesterase inhibitor, was studied in combination with the range of atropine doses. Physostigmine 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 3575379-1 1987 A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer"s disease. Physostigmine 25-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 4077467-2 1985 The inhibition of eel acetylcholinesterase by physostigmine at 20 degrees and 25 degrees C have been investigated. Physostigmine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 6661467-4 1983 Greater than 90% of AChE activity in CSF could be inhibited by 10(-3) M eserine. Physostigmine 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 6289994-3 1982 Exposure to the acetylcholinesterase (AChe) inhibitor physostigmine (1 microM) resulted in a 50% increase in electrically evoked [3H]dopamine release. Physostigmine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6289994-3 1982 Exposure to the acetylcholinesterase (AChe) inhibitor physostigmine (1 microM) resulted in a 50% increase in electrically evoked [3H]dopamine release. Physostigmine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 7096782-0 1982 [Effect of intraperitoneal physostigmine administration on the multiple forms of acetylcholinesterase in different brain structures]. Physostigmine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 7092918-0 1982 Reversible inhibition of acetylcholinesterase by eseroline, an opioid agonist structurally related to physostigmine (eserine) and morphine. Physostigmine 102-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 7217205-10 1981 As in the normal SCG, physostigmine-resistant staining, caused by noncholinesterase enzymes plus the possible presence of very low concentrations of AChE or BuChE, was noted at external mitochondrial membranes, elements of the endoplasmic reticulum of neurites and Schwann cells, and also in lysosomes. Physostigmine 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 1151640-1 1975 NMR was used to study the binding of acetylcholine, atropine, and physostigmine to acetylcholinesterase. Physostigmine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 1151640-4 1975 The dissociation constant, KD and the linewidth of the acetylcholinesterase-inhibitor complex, increment v bound, for atropine and physostigmine can be estimated from the linewidth changes of the N-methyl and phenyl group resonances of atropine and from the N-methyl and C-methyl group resonances of physostigmine resulting from association with the enzyme. Physostigmine 131-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 1151640-4 1975 The dissociation constant, KD and the linewidth of the acetylcholinesterase-inhibitor complex, increment v bound, for atropine and physostigmine can be estimated from the linewidth changes of the N-methyl and phenyl group resonances of atropine and from the N-methyl and C-methyl group resonances of physostigmine resulting from association with the enzyme. Physostigmine 300-313 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 5873635-0 1965 [Acetylcholinesterase and the bioelectrical activity of the brain under the action of eserine and galanthamine in animals with premesencephalic section of the brain]. Physostigmine 86-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-21 14099400-0 1963 [ON THE INHIBITION OF THE HISTOCHEMICAL ACETYLCHOLINESTERASE REACTION ON MOTOR END-PLATES BY INJECTIONS OF NEOSTIGMINE AND PHYSOSTIGMINE]. Physostigmine 123-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 33357230-7 2020 Inhibition of this cancer-cell-intrinsic AChE via pyridostigmine and physostigmine, or administration of acetylcholine (ACh), diminished PCa cell viability and invasion in vitro and in vivo via suppression of pERK signaling, and reduced tumor-associated macrophage (TAM) infiltration and serum pro-inflammatory cytokine levels. Physostigmine 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 31398669-12 2019 Physostigmine inhibited AChE activity with a sigmoidal concentration-response effect. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 31517530-2 2019 The structural properties and binding interactions of the AD drug physostigmine (-)-phy, and its analogues (-)-hex and (-)-phe and (+)-phe, were examined, as well as their impact on the conformational changes of two different AD target enzymes AChE and BChE. Physostigmine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 244-248 28373858-3 2017 To determine if enhancing central cholinergic activity with the centrally acting acetylcholinesterase inhibitor, physostigmine would increase CBF when upright compared to the peripherally acting acetylcholinesterase inhibitor, neostigmine, or saline. Physostigmine 113-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Physostigmine 239-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Physostigmine 248-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26200465-1 2015 BACKGROUND: Physostigmine, a centrally acting acetylcholinesterase inhibitor, is most commonly used by anesthesiologists in the postanesthetic setting to reverse confusion caused by central anticholinergic medication effects. Physostigmine 12-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 25446352-3 2015 Using the pyrithiamine-induced thiamine deficiency (PTD) rat model of human Wernicke-Korsakoff syndrome, we tested the hypothesis that co-infusion of the acetylcholinesterase inhibitor physostigmine across the PFC and HPC would recover spatial alternation performance in PTD rats. Physostigmine 185-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-174 23747570-4 2013 Furthermore, elevating extracellular ACh with the acetylcholinesterase inhibitor physostigmine had a larger effect on depolarizing versus hyperpolarizing responses. Physostigmine 81-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 23975732-6 2013 infusion of saline and the other during an infusion of the acetylcholinesterase inhibitor physostigmine. Physostigmine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. Physostigmine 51-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. Physostigmine 51-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 22200647-4 2012 MATERIALS AND METHODS: AChE activity was evaluated utilizing reaction with Ellman"s reagent with physostigmine as a control. Physostigmine 97-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 22461927-5 2012 DISCUSSION: Atropine causes anticholinergic toxicity; physostigmine reverses this by inhibiting acetylcholinesterase. Physostigmine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 21414391-0 2011 In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species. Physostigmine 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 21402092-0 2011 Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro. Physostigmine 34-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 21402092-5 2011 The present study was performed to investigate a possible pre- and post-treatment effect of physostigmine on soman-inhibited human AChE given at different time intervals before or after perfusion with soman by using a well-established dynamically working in vitro model for real-time analysis of erythrocyte and muscle AChE. Physostigmine 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 21402092-6 2011 The major findings were that prophylactic physostigmine prevented complete inhibition of AChE by soman and resulted in partial spontaneous recovery of the enzyme by de-carbamylation. Physostigmine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 21402092-7 2011 Physostigmine given as post-treatment resulted in a time-dependent reduction of the protection from soman inhibition and recovery of AChE. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137