PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18523135-1 2008 The plant-derived acetylcholinesterase inhibitor physostigmine has previously been shown to act on the nicotinic acetylcholine receptor (nAChR) causing either direct activation or potentiation of currents elicited by low concentrations of nicotinic agonists, or, at higher concentrations, channel block. Physostigmine 49-62 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 103-135 18523135-2 2008 We examined mouse adult-type muscle nAChR activation by physostigmine and found that channel activation by physostigmine exhibits many characteristics common with channel activity elicited by nicotinic agonists. Physostigmine 107-120 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 36-41 18523135-10 2008 These observations indicate that physostigmine is able to activate muscle nAChR by interacting with a site other than the nicotinic ligand binding site. Physostigmine 33-46 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 74-79 18523135-1 2008 The plant-derived acetylcholinesterase inhibitor physostigmine has previously been shown to act on the nicotinic acetylcholine receptor (nAChR) causing either direct activation or potentiation of currents elicited by low concentrations of nicotinic agonists, or, at higher concentrations, channel block. Physostigmine 49-62 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 137-142 18523135-2 2008 We examined mouse adult-type muscle nAChR activation by physostigmine and found that channel activation by physostigmine exhibits many characteristics common with channel activity elicited by nicotinic agonists. Physostigmine 56-69 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 36-41 9863767-10 1998 Only in locust cells physostigmine induced a non-desensitizing inward current, that appeared to originate from nAChR activation. Physostigmine 21-34 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 111-116 20654340-3 1997 The nitromethylene heterocyclic insecticide WL145004 and physostigmine selectively agonize the insect type nAChR. Physostigmine 57-70 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 107-112