PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29790105-6 2018 Furthermore, it led to a decreased expression of ATG-3 after 24 h and an increased expression of p62/ SQSTM1 after 1 h and 24 h. Administration of physostigmine significantly increased autophagy related markers and restored the autophagic flux after surgery stress, detected by increased degradation of p62/ SQSTM1 in the hippocampus after 1 h and 24 h. Furthermore, physostigmine reduced activated microglia and apoptosis relevant proteins and elevated the increased expression of TGF-beta1 and MFG-E8 after surgery stress. Physostigmine 147-160 milk fat globule EGF and factor V/VIII domain containing Rattus norvegicus 496-502