PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24789201-3	2014	Upon activation by phenobarbital (PB) or the PB-like inducer 1,4-bis[2-(3,5-dichloropyridyloxy)]-benzene (TCPOBOP), CAR translocates into the nucleus.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	61-104	nuclear receptor subfamily 1 group I member 3	Homo sapiens	116-119	
27530964-7	2016	Hepatocytes from all three species demonstrated CAR activation in response to the CAR agonists TCPOBOP, CITCO, and phenobarbital based on increased gene expression for Cyp2b isoforms.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	95-102	nuclear receptor subfamily 1 group I member 3	Homo sapiens	48-51	
27530964-7	2016	Hepatocytes from all three species demonstrated CAR activation in response to the CAR agonists TCPOBOP, CITCO, and phenobarbital based on increased gene expression for Cyp2b isoforms.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	95-102	nuclear receptor subfamily 1 group I member 3	Homo sapiens	82-85	
21557330-2	2012	Huh7 cells over-expressing CAR were either treated with dimethyl sulfoxide, the CAR activator TCPOBOP (1,4-bis[2-(3,5-dichloropyridyloxy)]benzene; androstenol, 16,(5alpha)-androsten-3alpha-OL), or repressor androstenol; these treatments were then followed by adriamycin treatment to damage DNA.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	94-101	nuclear receptor subfamily 1 group I member 3	Homo sapiens	80-83	
21220114-1	2011	The constitutive androstane receptor (CAR) transactivation can occur in the absence of exogenous ligand and this activity is enhanced by agonists TCPOBOP and meclizine.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	146-153	nuclear receptor subfamily 1 group I member 3	Homo sapiens	4-36	
21220114-1	2011	The constitutive androstane receptor (CAR) transactivation can occur in the absence of exogenous ligand and this activity is enhanced by agonists TCPOBOP and meclizine.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	146-153	nuclear receptor subfamily 1 group I member 3	Homo sapiens	38-41	
16929008-9	2006	As for exogenous chemicals, the seal CAR was transactivated by a human CAR agonist, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime), but not by a mouse CAR agonist, (1,4-bis[2-(3,5-dichloropyridyloxy)]benzene).	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	208-250	nuclear receptor subfamily 1 group I member 3	Homo sapiens	37-40	
16929008-9	2006	As for exogenous chemicals, the seal CAR was transactivated by a human CAR agonist, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime), but not by a mouse CAR agonist, (1,4-bis[2-(3,5-dichloropyridyloxy)]benzene).	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	208-250	nuclear receptor subfamily 1 group I member 3	Homo sapiens	71-74	
16623664-2	2006	In this up-regulation, CAR acts as both a transcription factor and a co-regulator, directly binding to and enhancing PBREM upon activation by xenobiotics such as TCPOBOP {1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene} and indirectly associating with the OARE in response to OA [Swales, Kakizaki, Yamamoto, Inoue, Kobayashi and Negishi (2005) J. Biol.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	162-169	nuclear receptor subfamily 1 group I member 3	Homo sapiens	23-26	
16623664-2	2006	In this up-regulation, CAR acts as both a transcription factor and a co-regulator, directly binding to and enhancing PBREM upon activation by xenobiotics such as TCPOBOP {1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene} and indirectly associating with the OARE in response to OA [Swales, Kakizaki, Yamamoto, Inoue, Kobayashi and Negishi (2005) J. Biol.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	171-214	nuclear receptor subfamily 1 group I member 3	Homo sapiens	23-26	
23340159-7	2013	We demonstrate that activation of porcine CAR by the human CAR (hCAR) ligand CITCO (6-(4-chlorophenyl)-imidazo[2,1-b]thiazole-5-carbaldehyde) leads to an up-regulation of both transporters, whereas the mouse-specific CAR ligand TCPOBOP (1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene) had no effect on transporter expression.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	228-235	nuclear receptor subfamily 1 group I member 3	Homo sapiens	42-45	
23340159-7	2013	We demonstrate that activation of porcine CAR by the human CAR (hCAR) ligand CITCO (6-(4-chlorophenyl)-imidazo[2,1-b]thiazole-5-carbaldehyde) leads to an up-regulation of both transporters, whereas the mouse-specific CAR ligand TCPOBOP (1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene) had no effect on transporter expression.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	228-235	nuclear receptor subfamily 1 group I member 3	Homo sapiens	59-62	
23340159-7	2013	We demonstrate that activation of porcine CAR by the human CAR (hCAR) ligand CITCO (6-(4-chlorophenyl)-imidazo[2,1-b]thiazole-5-carbaldehyde) leads to an up-regulation of both transporters, whereas the mouse-specific CAR ligand TCPOBOP (1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene) had no effect on transporter expression.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	228-235	nuclear receptor subfamily 1 group I member 3	Homo sapiens	59-62	
23340159-7	2013	We demonstrate that activation of porcine CAR by the human CAR (hCAR) ligand CITCO (6-(4-chlorophenyl)-imidazo[2,1-b]thiazole-5-carbaldehyde) leads to an up-regulation of both transporters, whereas the mouse-specific CAR ligand TCPOBOP (1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene) had no effect on transporter expression.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	237-280	nuclear receptor subfamily 1 group I member 3	Homo sapiens	42-45	
23340159-7	2013	We demonstrate that activation of porcine CAR by the human CAR (hCAR) ligand CITCO (6-(4-chlorophenyl)-imidazo[2,1-b]thiazole-5-carbaldehyde) leads to an up-regulation of both transporters, whereas the mouse-specific CAR ligand TCPOBOP (1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene) had no effect on transporter expression.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	237-280	nuclear receptor subfamily 1 group I member 3	Homo sapiens	59-62	
23340159-7	2013	We demonstrate that activation of porcine CAR by the human CAR (hCAR) ligand CITCO (6-(4-chlorophenyl)-imidazo[2,1-b]thiazole-5-carbaldehyde) leads to an up-regulation of both transporters, whereas the mouse-specific CAR ligand TCPOBOP (1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene) had no effect on transporter expression.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	237-280	nuclear receptor subfamily 1 group I member 3	Homo sapiens	59-62	
18798339-1	2008	UNLABELLED: In the adult liver, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), an agonist of the constitutive androstane receptor (CAR, NR1I3), produces rapid hepatomegaly in the absence of injury.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	32-74	nuclear receptor subfamily 1 group I member 3	Homo sapiens	104-136	
18798339-1	2008	UNLABELLED: In the adult liver, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), an agonist of the constitutive androstane receptor (CAR, NR1I3), produces rapid hepatomegaly in the absence of injury.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	32-74	nuclear receptor subfamily 1 group I member 3	Homo sapiens	138-141	
18798339-1	2008	UNLABELLED: In the adult liver, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), an agonist of the constitutive androstane receptor (CAR, NR1I3), produces rapid hepatomegaly in the absence of injury.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	32-74	nuclear receptor subfamily 1 group I member 3	Homo sapiens	143-148	
18798339-1	2008	UNLABELLED: In the adult liver, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), an agonist of the constitutive androstane receptor (CAR, NR1I3), produces rapid hepatomegaly in the absence of injury.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	76-83	nuclear receptor subfamily 1 group I member 3	Homo sapiens	104-136	
18798339-1	2008	UNLABELLED: In the adult liver, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), an agonist of the constitutive androstane receptor (CAR, NR1I3), produces rapid hepatomegaly in the absence of injury.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	76-83	nuclear receptor subfamily 1 group I member 3	Homo sapiens	138-141	
18798339-1	2008	UNLABELLED: In the adult liver, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), an agonist of the constitutive androstane receptor (CAR, NR1I3), produces rapid hepatomegaly in the absence of injury.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	76-83	nuclear receptor subfamily 1 group I member 3	Homo sapiens	143-148	
18362160-2	2008	Overexpression of GADD45B augmented CAR-mediated induction of the human CYP2B gene by the CAR activator 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and coactivated CAR-dependent transcription of the NR1-luciferase reporter gene.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	104-146	nuclear receptor subfamily 1 group I member 3	Homo sapiens	36-39	
18362160-2	2008	Overexpression of GADD45B augmented CAR-mediated induction of the human CYP2B gene by the CAR activator 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and coactivated CAR-dependent transcription of the NR1-luciferase reporter gene.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	104-146	nuclear receptor subfamily 1 group I member 3	Homo sapiens	90-93	
18362160-2	2008	Overexpression of GADD45B augmented CAR-mediated induction of the human CYP2B gene by the CAR activator 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and coactivated CAR-dependent transcription of the NR1-luciferase reporter gene.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	104-146	nuclear receptor subfamily 1 group I member 3	Homo sapiens	90-93	
18362160-2	2008	Overexpression of GADD45B augmented CAR-mediated induction of the human CYP2B gene by the CAR activator 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and coactivated CAR-dependent transcription of the NR1-luciferase reporter gene.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	148-155	nuclear receptor subfamily 1 group I member 3	Homo sapiens	36-39	
18362160-2	2008	Overexpression of GADD45B augmented CAR-mediated induction of the human CYP2B gene by the CAR activator 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and coactivated CAR-dependent transcription of the NR1-luciferase reporter gene.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	148-155	nuclear receptor subfamily 1 group I member 3	Homo sapiens	90-93	
18362160-2	2008	Overexpression of GADD45B augmented CAR-mediated induction of the human CYP2B gene by the CAR activator 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and coactivated CAR-dependent transcription of the NR1-luciferase reporter gene.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	148-155	nuclear receptor subfamily 1 group I member 3	Homo sapiens	90-93	
16101572-3	2005	CAR is highly expressed in the liver and the small intestine, two key tissues expressing xenobiotic metabolizing enzymes, and mediates the induction of their expression by the widely used antiepileptic drug, phenobarbital (PB) and the potent synthetic inducer 1, 4-bis-(2-(3, 5, -dichloropyridyloxy)) benzene (TCPOBOP).	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	260-308	nuclear receptor subfamily 1 group I member 3	Homo sapiens	0-3	
16101572-3	2005	CAR is highly expressed in the liver and the small intestine, two key tissues expressing xenobiotic metabolizing enzymes, and mediates the induction of their expression by the widely used antiepileptic drug, phenobarbital (PB) and the potent synthetic inducer 1, 4-bis-(2-(3, 5, -dichloropyridyloxy)) benzene (TCPOBOP).	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	310-317	nuclear receptor subfamily 1 group I member 3	Homo sapiens	0-3	
15764585-6	2005	Secondly, CAR specifically interacted with the first LXXLL motif of ASC-2, and these interactions were stimulated by CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and repressed by CAR inverse agonist androstanol, suggesting that this motif may mediate the interactions of ASC-2 and CAR in vivo.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	129-171	nuclear receptor subfamily 1 group I member 3	Homo sapiens	10-13	
15764585-6	2005	Secondly, CAR specifically interacted with the first LXXLL motif of ASC-2, and these interactions were stimulated by CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and repressed by CAR inverse agonist androstanol, suggesting that this motif may mediate the interactions of ASC-2 and CAR in vivo.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	129-171	nuclear receptor subfamily 1 group I member 3	Homo sapiens	117-120	
15764585-6	2005	Secondly, CAR specifically interacted with the first LXXLL motif of ASC-2, and these interactions were stimulated by CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and repressed by CAR inverse agonist androstanol, suggesting that this motif may mediate the interactions of ASC-2 and CAR in vivo.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	129-171	nuclear receptor subfamily 1 group I member 3	Homo sapiens	117-120	
15764585-6	2005	Secondly, CAR specifically interacted with the first LXXLL motif of ASC-2, and these interactions were stimulated by CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and repressed by CAR inverse agonist androstanol, suggesting that this motif may mediate the interactions of ASC-2 and CAR in vivo.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	129-171	nuclear receptor subfamily 1 group I member 3	Homo sapiens	117-120