PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33336605-10 2021 A final concentration of 9 microg/mL of azithromycin was sufficient to decrease IL-6, IL-8 mRNA, and extracellular IL-8 levels. Azithromycin 40-52 C-X-C motif chemokine ligand 8 Homo sapiens 115-119 33937285-5 2021 Among such class of drugs, azithromycin is described as azalide and is well-known for its ability to decrease the production of pro-inflammatory cytokines, including matrix metalloproteinases, tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. Azithromycin 27-39 C-X-C motif chemokine ligand 8 Homo sapiens 246-250 33336605-10 2021 A final concentration of 9 microg/mL of azithromycin was sufficient to decrease IL-6, IL-8 mRNA, and extracellular IL-8 levels. Azithromycin 40-52 C-X-C motif chemokine ligand 8 Homo sapiens 86-90 33336605-11 2021 Conclusion: Pretreatment with azithromycin decreased the expression of IL-6 and IL-8 mRNA and the release of IL-8 in bronchial epithelial cells exposed to cigarette smoke. Azithromycin 30-42 C-X-C motif chemokine ligand 8 Homo sapiens 80-84 33336605-11 2021 Conclusion: Pretreatment with azithromycin decreased the expression of IL-6 and IL-8 mRNA and the release of IL-8 in bronchial epithelial cells exposed to cigarette smoke. Azithromycin 30-42 C-X-C motif chemokine ligand 8 Homo sapiens 109-113 33396644-7 2020 In response to LPS stimulation, the gene expression levels of IL-6 and IL-8 in hGFs increased due to AZM in a concentration-dependent manner, and phosphorylation of nuclear factor kappa B (NF-kappaB) was also promoted. Azithromycin 101-104 C-X-C motif chemokine ligand 8 Homo sapiens 71-75 32725797-0 2021 Azithromycin and ciprofloxacin inhibit interleukin-8 secretion without disrupting human sinonasal epithelial integrity in vitro. Azithromycin 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 39-52 33396644-10 2020 Thus, AZM may increase the expression of IL-6 and IL-8 under LPS stimulation to modify the inflammatory response and increase the expression of MMP-1 to promote connective tissue remodeling. Azithromycin 6-9 C-X-C motif chemokine ligand 8 Homo sapiens 50-54 32920000-6 2020 Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases. Azithromycin 33-45 C-X-C motif chemokine ligand 8 Homo sapiens 83-88 30686699-9 2019 Patients treated with azithromycin demonstrated less airway inflammation, with lower bronchoalveolar lavage (BAL) neutrophilia and BAL interleukin-8 protein levels at Day 30 (p = 0.09 and p = 0.04, respectively) and Day 90 (p = 0.002 and p = 0.08, respectively) after LTx. Azithromycin 22-34 C-X-C motif chemokine ligand 8 Homo sapiens 135-148 32894857-9 2020 Five days after the last dose, serum IL-2 and IL-8 levels dropped significantly in the azithromycin group. Azithromycin 87-99 C-X-C motif chemokine ligand 8 Homo sapiens 46-50 32534189-4 2020 In vitro studies have demonstrated the capacity of azithromycin in reducing production of pro-inflammatory cytokines such as IL-8, IL-6, TNF alpha, reduce oxidative stress, and modulate T-helper functions. Azithromycin 51-63 C-X-C motif chemokine ligand 8 Homo sapiens 125-129 32589092-5 2020 Moreover, AZM can inhibit the ability of TNF-alpha-to induce interleukin (IL)-8 production. Azithromycin 10-13 C-X-C motif chemokine ligand 8 Homo sapiens 61-79 32589092-6 2020 This review focuses on the effects on AZM that may be beneficial in inhibiting MUC5AC, matrix metalloprotease-9 and IL-8 production in airway epithelial cells. Azithromycin 38-41 C-X-C motif chemokine ligand 8 Homo sapiens 116-120 19788749-9 2009 IL-8 release in TNF-alpha stimulated hu-BEC decreased by 16 +/- 8% (p < 0.05) with AZM (1.5 mg/l). Azithromycin 86-89 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 28535933-11 2017 Additional ex vivo studies confirmed reduced induction of IL-6 (P = 0.017) and CXCL8/IL-8 (P = 0.005) with azithromycin. Azithromycin 107-119 C-X-C motif chemokine ligand 8 Homo sapiens 79-84 28535933-11 2017 Additional ex vivo studies confirmed reduced induction of IL-6 (P = 0.017) and CXCL8/IL-8 (P = 0.005) with azithromycin. Azithromycin 107-119 C-X-C motif chemokine ligand 8 Homo sapiens 85-89 26252749-8 2015 At specific times during healing, the azithromycin group exhibited significantly lower levels of interleukin (IL)-6 and IL-8 in GCF than the amoxicillin group and exhibited significantly lower levels of granulocyte colony stimulating factor, IL-8, macrophage inflammatory protein-1beta, and interferon-gamma-inducible protein-10 in PICF. Azithromycin 38-50 C-X-C motif chemokine ligand 8 Homo sapiens 120-124 26252749-8 2015 At specific times during healing, the azithromycin group exhibited significantly lower levels of interleukin (IL)-6 and IL-8 in GCF than the amoxicillin group and exhibited significantly lower levels of granulocyte colony stimulating factor, IL-8, macrophage inflammatory protein-1beta, and interferon-gamma-inducible protein-10 in PICF. Azithromycin 38-50 C-X-C motif chemokine ligand 8 Homo sapiens 242-246 25458910-0 2015 Randomized trial to evaluate azithromycin"s effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. Azithromycin 29-41 C-X-C motif chemokine ligand 8 Homo sapiens 78-82 25458910-3 2015 OBJECTIVES: We sought to investigate whether azithromycin treatment during RSV bronchiolitis reduces serum and nasal lavage IL-8 levels and the occurrence of postbronchiolitis recurrent wheezing. Azithromycin 45-57 C-X-C motif chemokine ligand 8 Homo sapiens 124-128 25458910-7 2015 RESULTS: Compared with placebo, azithromycin treatment did not reduce serum IL-8 levels at day 8 (P = .6) but resulted in a greater decrease in nasal lavage fluid IL-8 levels by day 15 (P = .03). Azithromycin 32-44 C-X-C motif chemokine ligand 8 Homo sapiens 163-167 25458910-10 2015 CONCLUSION: In this proof-of-concept study azithromycin treatment during RSV bronchiolitis reduced upper airway IL-8 levels, prolonged the time to the third wheezing episode, and reduced overall respiratory morbidity over the subsequent year. Azithromycin 43-55 C-X-C motif chemokine ligand 8 Homo sapiens 112-116 24716633-0 2014 Increased IL-8 production in human bronchial epithelial cells after exposure to azithromycin-pretreated Pseudomonas aeruginosa in vitro. Azithromycin 80-92 C-X-C motif chemokine ligand 8 Homo sapiens 10-14 24716633-4 2014 The results showed that AZM-pretreated P. aeruginosa (PAO1 and six different clinical isolates) significantly stimulated HBE cells to release IL-8, a crucial pro-inflammatory cytokine. Azithromycin 24-27 C-X-C motif chemokine ligand 8 Homo sapiens 142-146 24716633-6 2014 Our results suggest that AZM-pretreated P. aeruginosa could indirectly exacerbate pro-inflammation by inducing IL-8 production in HBEs. Azithromycin 25-28 C-X-C motif chemokine ligand 8 Homo sapiens 111-115 23199585-7 2013 CAM and AZM induced a dose-dependent suppression of spontaneous TNF-alpha, sTNFR2, IL-6, IL-8 and CCL18 production (p<0.05). Azithromycin 8-11 C-X-C motif chemokine ligand 8 Homo sapiens 89-93 23199585-9 2013 CAM and AZM significantly and dose-dependently attenuated the LPS-stimulated production of sTNFR1, sTNFR2, IL-8 and CCL18 (p<0.05). Azithromycin 8-11 C-X-C motif chemokine ligand 8 Homo sapiens 107-111 21417583-4 2011 Therefore, we investigated the effects of AZM on IL-8 production in an oral epithelial cell line. Azithromycin 42-45 C-X-C motif chemokine ligand 8 Homo sapiens 49-53 21417583-8 2011 RESULTS: IL-8 mRNA expression, IL-8 production, and NF-kappaB activation in LPS-stimulated KB cells were inhibited by the addition of AZM. Azithromycin 134-137 C-X-C motif chemokine ligand 8 Homo sapiens 9-13 21417583-8 2011 RESULTS: IL-8 mRNA expression, IL-8 production, and NF-kappaB activation in LPS-stimulated KB cells were inhibited by the addition of AZM. Azithromycin 134-137 C-X-C motif chemokine ligand 8 Homo sapiens 31-35 21417583-10 2011 CONCLUSIONS: This study suggests that AZM inhibits LPS-induced IL-8 production in an oral epithelial cell line, in part caused by the suppression of Rac1 and NF-kappaB activation. Azithromycin 38-41 C-X-C motif chemokine ligand 8 Homo sapiens 63-67 24806810-5 2015 RESULTS: P. gingivalis LPS induced cytokine/chemokine (IL-6, IL-8, MCP-1, and GRO) protein production in HGFs, and this effect was suppressed by azithromycin at all concentrations tested. Azithromycin 145-157 C-X-C motif chemokine ligand 8 Homo sapiens 61-65 25148049-4 2014 This study tested the hypothesis that azithromycin treatment, as an add-on to standard medication, would significantly reduce airway neutrophil and neutrophils chemokine (CXCL8) levels, as well as bacterial load. Azithromycin 38-50 C-X-C motif chemokine ligand 8 Homo sapiens 171-176 25148049-12 2014 Azithromycin treatment resulted in a non-significant reduction in sputum neutrophil proportion, CXCL8 levels and bacterial load. Azithromycin 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 96-101 25148049-15 2014 CONCLUSIONS: In stable COPD with neutrophilic bronchitis, add-on azithromycin therapy showed a trend to reduced severe exacerbations sputum neutrophils, CXCL8 levels and bacterial load. Azithromycin 65-77 C-X-C motif chemokine ligand 8 Homo sapiens 153-158 21848430-8 2012 We observed inhibition of cytokines (interleukin [IL]-1beta (beta), IL-6, IL-8, IL-10, and tumor necrosis factor-alpha) in the presence of azithromycin in EB-stimulated cells from both fertile and infertile women with primary and recurrent C. trachomatis infection. Azithromycin 139-151 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 19661014-0 2009 Macrolide antibiotics like azithromycin increase lipopolysaccharide-induced IL-8 production by human gingival fibroblasts. Azithromycin 27-39 C-X-C motif chemokine ligand 8 Homo sapiens 76-80 10853849-6 2000 There were significant (p<0.05) pre- to post-exposure increases in total cells, neutrophils, IL-6 and IL-8 in both the azithromycin and placebo arms. Azithromycin 122-134 C-X-C motif chemokine ligand 8 Homo sapiens 105-109 19503797-8 2009 AZT pretreatment prevented the up-regulation of some genes, such as MUC5AC and MMP9, triggered by the inflammatory stimulus, but the up-regulation of other inflammatory genes, e.g., cytokines and chemokines, such as interleukin-8, was not affected. Azithromycin 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 216-229 19503797-10 2009 Notably, secreted IL-8 protein levels did not reflect mRNA levels, and were, in fact, higher after AZT pretreatment in cultures exposed to the inflammatory stimulus, suggesting that AZT can affect inflammatory pathways other than by altering gene expression. Azithromycin 99-102 C-X-C motif chemokine ligand 8 Homo sapiens 18-22 19503797-10 2009 Notably, secreted IL-8 protein levels did not reflect mRNA levels, and were, in fact, higher after AZT pretreatment in cultures exposed to the inflammatory stimulus, suggesting that AZT can affect inflammatory pathways other than by altering gene expression. Azithromycin 182-185 C-X-C motif chemokine ligand 8 Homo sapiens 18-22 16741151-0 2006 Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. Azithromycin 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 45-58 16741151-4 2006 HYPOTHESES: (1) Azithromycin reduces airway neutrophilia and interleukin (IL)-8 and (2) airway neutrophilia predicts the improvement in FEV(1). Azithromycin 16-28 C-X-C motif chemokine ligand 8 Homo sapiens 61-79 16741151-11 2006 CONCLUSION: Azithromycin significantly reduces airway neutrophilia and IL-8 mRNA in patients with BOS. Azithromycin 12-24 C-X-C motif chemokine ligand 8 Homo sapiens 71-75 16085674-5 2006 AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P < 0.001). Azithromycin 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 19-23 16085674-5 2006 AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P < 0.001). Azithromycin 153-156 C-X-C motif chemokine ligand 8 Homo sapiens 19-23 16085674-5 2006 AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P < 0.001). Azithromycin 153-156 C-X-C motif chemokine ligand 8 Homo sapiens 184-188 16085674-5 2006 AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P < 0.001). Azithromycin 153-156 C-X-C motif chemokine ligand 8 Homo sapiens 184-188 19661014-7 2009 AZM increased PgLPS-induced IL-8 production dose-dependently, while AZM did not alter IL-6 and PGE2 productions. Azithromycin 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 28-32 19661014-11 2009 However, the use of the inhibitors of cell signaling pathway failed to reveal the mechanism that AZM enhanced PgLPS-induced IL-8 production. Azithromycin 97-100 C-X-C motif chemokine ligand 8 Homo sapiens 124-128 19661014-13 2009 Because AZM increased LPS-induced IL-8 production by HGFs, the possibility is considered that neutrophils may be migrated to periodontal tissue and phagocytize the periodontopathic bacteria more efficiently. Azithromycin 8-11 C-X-C motif chemokine ligand 8 Homo sapiens 34-38 18971093-9 2008 Azithromycin caused a significant decrease in the LPS-stimulated IL-8 and GM-CSF release. Azithromycin 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 65-69 18487355-14 2008 Whereas clarithromycin, azithromycin, and moxifloxacin individually were able to inhibit TNF-alpha-induction of IL-8, each failed to inhibit MMF-induction of IL-8. Azithromycin 24-36 C-X-C motif chemokine ligand 8 Homo sapiens 112-116 17667842-3 2007 We studied the effect of azithromycin (AZM) on the suppression of NF-kappaB activation and the synthesis of pro-inflammatory cytokines IL-6 and IL-8 by TA cells obtained from premature infants. Azithromycin 25-37 C-X-C motif chemokine ligand 8 Homo sapiens 144-148 17667842-3 2007 We studied the effect of azithromycin (AZM) on the suppression of NF-kappaB activation and the synthesis of pro-inflammatory cytokines IL-6 and IL-8 by TA cells obtained from premature infants. Azithromycin 39-42 C-X-C motif chemokine ligand 8 Homo sapiens 144-148 17667842-8 2007 AZM significantly reduced the IL-6 and IL-8 production to the levels similar to control. Azithromycin 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 39-43 17061983-7 2007 IL17-induced IL8 production was decreased by both erythromycin and azithromycin. Azithromycin 67-79 C-X-C motif chemokine ligand 8 Homo sapiens 13-16 17061983-8 2007 In nonstimulated condition, IL8 production only increased at the highest dose of azithromycin. Azithromycin 81-93 C-X-C motif chemokine ligand 8 Homo sapiens 28-31 17045242-3 2006 AZM reduced about 40% of IL-8 mRNA and protein expression (n=9, p=0.02, and n=4, p=0.00011) in CF cells reaching the levels of non-CF cells. Azithromycin 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 25-29 11389120-1 2001 We investigated the effects of azithromycin and clarithromycin, two antibiotics that possess a broad spectrum of antimicrobial activity (including antimycobacterial activity), on interleukin-8 (IL-8) release from human whole blood leucocytes and lung macrophages. Azithromycin 31-43 C-X-C motif chemokine ligand 8 Homo sapiens 179-192 11389120-1 2001 We investigated the effects of azithromycin and clarithromycin, two antibiotics that possess a broad spectrum of antimicrobial activity (including antimycobacterial activity), on interleukin-8 (IL-8) release from human whole blood leucocytes and lung macrophages. Azithromycin 31-43 C-X-C motif chemokine ligand 8 Homo sapiens 194-198 11389120-3 2001 Incubation of alveolar macrophages with different concentrations of azithromycin or clarithromycin modified IL-8 production: it increased at a drug concentration of 4 mg/L and decreased at concentration of 400 mg/L. Azithromycin 68-80 C-X-C motif chemokine ligand 8 Homo sapiens 108-112 11389120-4 2001 Our findings suggest that azithromycin and clarithromycin may alter IL-8 production, thus enhancing the clinical effectiveness of these antibiotics. Azithromycin 26-38 C-X-C motif chemokine ligand 8 Homo sapiens 68-72 34310083-11 2021 Azithromycin concentration was positively correlated with IL-8 (r = 0.38, p = 0.03), IL1a (r = 0.39, p = 0.03), and IL-1b (r = 0.36, p = 0.04) in amniotic fluid. Azithromycin 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 58-62 34414894-8 2021 The combination of azithromycin and budesonide had a more pronounced inhibitory effect on the production of IL-4 and CXCL8 by NK and NKT-like cells than the effect of these drugs alone. Azithromycin 19-31 C-X-C motif chemokine ligand 8 Homo sapiens 117-122 35072213-6 2022 RESULTS: Azithromycin decreased the secretion of interleukin (IL) 4, IL-5, IL-13, and IL-17A from PBMCs, as well as the production of IL-4 and IL-8 by CD4+ and CD8+ T cells. Azithromycin 9-21 C-X-C motif chemokine ligand 8 Homo sapiens 143-147 35072213-7 2022 The combination of azithromycin and budesonide suppressed inflammatory response by inhibition of IL-4, IL-5, IL-8, IL-13, IL-17A, IL-33, thymic stromal lymphopoietin (TSLP), macrophage migration inhibitory factor (MIF) release from PBMCs and by reduction of the percentage of IL-4-, IL-8-, interferon gamma- and tumor necrosis factor a-expressing CD4+ and CD8+ T cells. Azithromycin 19-31 C-X-C motif chemokine ligand 8 Homo sapiens 109-113 34414894-7 2021 Azithromycin suppressed production of IL-4 and CXCL8 by NK and NKT-like cells, and theophylline inhibited IL-4 synthesis by these lymphocytes. Azithromycin 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 47-52 34602387-5 2021 The mRNA expression of TNF-alpha, IL-8 and IL-1beta in the azithromycin group was lower than that in the control group (P<0.05). Azithromycin 59-71 C-X-C motif chemokine ligand 8 Homo sapiens 34-38 35072213-8 2022 The inhibitory effect of azithromycin combined with budesonide on IL-4, IL-5, IL-8, IL-17A, TSLP production by PBMCs, as well as IL-4 and IL-8 production by T helper cells and cytotoxic T lymphocytes was significantly greater than the effect of budesonide alone. Azithromycin 25-37 C-X-C motif chemokine ligand 8 Homo sapiens 78-82 35072213-8 2022 The inhibitory effect of azithromycin combined with budesonide on IL-4, IL-5, IL-8, IL-17A, TSLP production by PBMCs, as well as IL-4 and IL-8 production by T helper cells and cytotoxic T lymphocytes was significantly greater than the effect of budesonide alone. Azithromycin 25-37 C-X-C motif chemokine ligand 8 Homo sapiens 138-142