PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3572250-1 1987 The relationship between the cholesterol 7 alpha-hydroxylase activity and the pool of free cholesterol in rat liver microsomes was studied under experimental conditions aimed to stimulate (biliary drainage, cholestyramine treatment, and lymphatic drainage) as well as inhibit (chenodeoxycholic acid treatment) bile acid synthesis. Cholestyramine Resin 207-221 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 29-60 3342051-4 1988 However, cholesterol 7 alpha-hydroxylase activity was stimulated by the treatment with cholestyramine in both obese and lean rats. Cholestyramine Resin 87-101 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 9-40 3342051-5 1988 Our results suggested that the diurnal regulation of cholesterol 7 alpha-hydroxylase activity is lost in obese rats but was present under cholestyramine treatment in the genetically obese strain of rats. Cholestyramine Resin 138-152 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 53-84 3431166-2 1987 Cholestyramine significantly enhanced the activities of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase both in young and adult rats; however, the absolute values were significantly higher in the former. Cholestyramine Resin 0-14 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 116-147 3367083-4 1988 1) The apparent degree of saturation of cholesterol 7 alpha-hydroxylase, as measured in vitro in rat liver microsomes, was found to be relatively high (70-90%) under most experimental conditions, including starvation, cholestyramine treatment, and cholesterol treatment. Cholestyramine Resin 218-232 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 40-71 2943275-3 1986 3-Hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase activity, determined as positive controls, were also found to be elevated by cholestyramine and additionally showed a diurnal variation. Cholestyramine Resin 161-175 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 52-83 7126254-3 1982 The enhancement of hepatic cholesterol 7 alpha-hydroxylase by SKF-525A or by cholestyramine is accompanied by homeostatic responses by the liver which include induction of low-density lipoprotein clearance and increased cholesterogenesis to attempt to replenish sterol pools. Cholestyramine Resin 77-91 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 27-58 6743385-2 1984 Feeding cholestyramine to weaned rats increased the bile acid pool and activity of cholesterol 7 alpha-hydroxylase as expected. Cholestyramine Resin 8-22 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 83-114 6743385-3 1984 Following adrenalectomy, cholestyramine still increased the activity of cholesterol 7 alpha-hydroxylase but the magnitude of increase was lower (P less than 0.01) than noted in intact rats. Cholestyramine Resin 25-39 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 72-103 446480-4 1979 The activity of cholesterol 7 alpha-hydroxylase from cells prepared from livers of rats fed the bile salt sequestering agent cholestyramine was 2--3 fold higher than the activity of this enzyme found in cells isolated from animals on a control diet. Cholestyramine Resin 125-139 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 16-47 446480-8 1979 The decrease in cholesterol 7 alpha-hydroxylase activity was observed whether cholestyramine was included in the diet or excluded from the diet of the animals used as sources of the liver cells. Cholestyramine Resin 78-92 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 16-47 568487-1 1978 The activities of hepatic microsomal 3-hydroxy-3-methylglutaryl CoA reductase and cholesterol 7alpha-hydroxylase were consistently higher (up to 3-fold) in female compared to male rats fed 2% cholestyramine for 8 h daily. Cholestyramine Resin 192-206 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 82-112 694973-3 1978 PCN significantly depressed the cholesterol-7alpha-hydroxylase activity in the livers of rats with elevated levels of the enzyme produced by cholestyramine feeding. Cholestyramine Resin 141-155 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 32-62 17107691-0 2007 Roles of nuclear receptors in the up-regulation of hepatic cholesterol 7alpha-hydroxylase by cholestyramine in rats. Cholestyramine Resin 93-107 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 59-89 17107691-1 2007 Nuclear receptors are involved in regulating the expression of cholesterol 7alpha-hydroxylase (CYP7A1), however, their roles in the up-regulation of CYP7A1 by cholestyramine (CSR) are still unclear. Cholestyramine Resin 159-173 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 63-93 17107691-1 2007 Nuclear receptors are involved in regulating the expression of cholesterol 7alpha-hydroxylase (CYP7A1), however, their roles in the up-regulation of CYP7A1 by cholestyramine (CSR) are still unclear. Cholestyramine Resin 159-173 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 95-101 17107691-1 2007 Nuclear receptors are involved in regulating the expression of cholesterol 7alpha-hydroxylase (CYP7A1), however, their roles in the up-regulation of CYP7A1 by cholestyramine (CSR) are still unclear. Cholestyramine Resin 159-173 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 149-155 17107691-1 2007 Nuclear receptors are involved in regulating the expression of cholesterol 7alpha-hydroxylase (CYP7A1), however, their roles in the up-regulation of CYP7A1 by cholestyramine (CSR) are still unclear. Cholestyramine Resin 175-178 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 149-155 17107691-4 2007 Cholestyramine raised hepatic levels of CYP7A1 mRNA and activity in both groups. Cholestyramine Resin 0-14 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 40-46 17107691-9 2007 These results suggest that cholestyramine up-regulates the expression of CYP7A1 independently via LXR- or FXR-mediated pathways in rats. Cholestyramine Resin 27-41 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 73-79 5084788-12 1972 Rats fed with cholestyramine had an elevated hepatic cholesterol 7alpha-hydroxylase activity, but neither the concentration of cytochrome P-450 nor the activity of the drug-hydroxylating enzyme, aminopyrine demethylase, was affected. Cholestyramine Resin 14-28 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 53-83 7751819-5 1995 The activity of cholesterol 7 alpha-hydroxylase increased about threefold in rats treated with cholestyramine when compared with controls. Cholestyramine Resin 95-109 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 16-47 8928794-3 1996 When compared with paired controls, sterol 27-hydroxylase and cholesterol 7 alpha-hydroxylase specific activities increased after CT administration by 188 +/- 20% (P < 0.05) and 415 +/- 36% (P < 0.01), respectively. Cholestyramine Resin 130-132 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 62-93 9698080-4 1998 Treatment of HSD rats with cholestyramine caused an increase in hepatic microsomal cholesterol 7alpha-hydroxylase activity of 3.3-fold compared with a 3.5-fold increase in SD rats with similar changes in apoprotein levels. Cholestyramine Resin 27-41 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 83-113 7544128-5 1995 Treatment of rats with cholestyramine increased CYP7 apoprotein in the morning (P < 0.005) and at night (P < 0.005), but diurnal variation was maintained. Cholestyramine Resin 23-37 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 48-52 7876920-0 1995 Cholesterol 7 alpha-hydroxylase activity is increased by dietary modification with psyllium hydrocolloid, pectin, cholesterol and cholestyramine in rats. Cholestyramine Resin 130-144 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 0-31 2154492-1 1990 Purification of cholesterol 7 alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7 alpha-hydroxylase by cholestyramine and circadian rhythm. Cholestyramine Resin 136-150 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 101-132 7846735-1 1994 The regulation of cholesterol 7 alpha-hydroxylase activity by estradiol and progesterone was investigated in liver microsomes isolated from rats fed standard diet, either ad libitum or fasted for 24 h, and diet containing the bile acid sequesterant cholestyramine. Cholestyramine Resin 249-263 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 18-49 7846735-5 1994 The administration of estradiol (50 micrograms) or progesterone (100 micrograms) for 21 days resulted in depressed cholesterol 7 alpha-hydroxylase activity in rats with high bile acid synthesis basal rate due to cholestyramine feeding. Cholestyramine Resin 212-226 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 115-146 8138269-8 1994 Cholestyramine led to a three-fold increase in cholesterol 7 alpha-hydroxylase specific activity, steady-state mRNA levels and gene transcriptional activity. Cholestyramine Resin 0-14 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 47-78 1694852-2 1990 Monospecific antibody against purified rat liver cholesterol 7 alpha-hydroxylase cytochrome P-450 was used to screen a lambda gt11 cDNA library constructed from immuno-enriched polysomal RNA of cholestyramine-treated female rat liver. Cholestyramine Resin 194-208 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 49-80 1694852-9 1990 Cholesterol 7 alpha-hydroxylase mRNAs were induced 2- to 3-fold in rat liver by cholestyramine treatment. Cholestyramine Resin 80-94 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 0-31 1694852-13 1990 These experiments suggest that the induction of cholesterol 7 alpha-hydroxylase activity by cholestyramine or cholesterol and inhibition of cholesterol 7 alpha-hydroxylase activity by bile acid feedback are results of the rapid turnover of cholesterol 7 alpha-hydroxylase enzyme and mRNA levels. Cholestyramine Resin 92-106 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 48-79 1512229-1 1992 In primary cultures of adult rat hepatocytes the level of cholesterol 7 alpha-hydroxylase steady-state mRNA markedly decreased by 72 h. However, the addition of L-thyroxine (T4) and dexamethasone synergistically returned cholesterol 7 alpha-hydroxylase steady-state mRNA levels near to that of cholestyramine-fed animals. Cholestyramine Resin 294-308 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 58-89 1512229-4 1992 The specific activities of cholesterol 7 alpha-hydroxylase in microsomes prepared from cultures treated with dexamethasone and T4 were 1.56 +/- 1.17 nmol/h/mg protein which is similar to that of intact liver (1.70 +/- 0.062 nmol/h/mg protein), but lower than cholestyramine-fed animals. Cholestyramine Resin 259-273 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 27-58 1431598-5 1992 Cholesterol 7 alpha-hydroxylase activity increased 4-fold with cholestyramine and 29% during cholesterol feeding, but decreased 64% with taurocholate. Cholestyramine Resin 63-77 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 0-31 1431598-6 1992 Cholesterol 7 alpha-hydroxylase mRNA levels rose 150% and 50% with cholestyramine and cholesterol feeding, respectively, but decreased 73% with taurocholate. Cholestyramine Resin 67-81 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 0-31 2018552-11 1991 In contrast, 7,8-benzoflavone inhibited cholesterol 7 alpha-hydroxylase and 7 alpha-hydroxycholesterol hydroxylase activities of microsomes from normal and cholestyramine-fed hamsters. Cholestyramine Resin 156-170 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 40-71 2018552-13 1991 These results suggest that hepatic cholesterol 7 alpha-hydroxylase and 7 alpha-hydroxycholesterol hydroxylase activities apparently involve multiple forms of cytochrome P450 in untreated and cholestyramine-treated hamsters. Cholestyramine Resin 191-205 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 35-66 2388097-6 1990 The activity of hepatic cholesterol 7 alpha-hydroxylase and fecal bile acid excretion at the end of the cholesterol challenge decreased in the cholestyramine-pretreated group, when compared to the normally weaned group. Cholestyramine Resin 143-157 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 24-55 2154492-2 1990 Two cholesterol 7 alpha-hydroxylase isozymes were purified from liver microsomes of cholestyramine-treated female rats by using anion exchange high performance liquid chromatography. Cholestyramine Resin 84-98 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 4-35 2154492-6 1990 Immunoblot of microsomal polypeptides indicated that microsomal cholesterol 7 alpha-hydroxylase enzyme levels were increased in parallel with cholesterol 7 alpha-hydroxylase activity upon the treatment of rats with diet supplemented with cholestyramine. Cholestyramine Resin 238-252 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 64-95 2154492-6 1990 Immunoblot of microsomal polypeptides indicated that microsomal cholesterol 7 alpha-hydroxylase enzyme levels were increased in parallel with cholesterol 7 alpha-hydroxylase activity upon the treatment of rats with diet supplemented with cholestyramine. Cholestyramine Resin 238-252 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 142-173 2154492-7 1990 Both cholesterol 7 alpha-hydroxylase activity and enzyme levels were drastically reduced immediately after the removal of cholestyramine from the diet. Cholestyramine Resin 122-136 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 5-36 2154492-12 1990 In genetically obese Zucker rats, cholesterol 7 alpha-hydroxylase activity and enzyme level did not respond to the change in the light cycle, however, were induced to the same levels as in the lean rats by cholestyramine treatment. Cholestyramine Resin 206-220 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 34-65