PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23333628-9 2013 Quercetin also inhibited histamine- or PMA-induced phosphorylation of Tyr(311) of PKCdelta and translocation of PKCdelta to the Golgi. Histamine 25-34 protein kinase C delta Homo sapiens 82-90 31949043-8 2020 Of note, blockade of protein kinase Cdelta or PI3K-Akt signaling abolished histamine-mediated HYBID stimulation and HAS2 suppression, respectively. Histamine 75-84 protein kinase C delta Homo sapiens 21-42 23333628-3 2013 Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously. Histamine 31-40 protein kinase C delta Homo sapiens 155-176 23333628-3 2013 Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously. Histamine 31-40 protein kinase C delta Homo sapiens 178-186 23333628-9 2013 Quercetin also inhibited histamine- or PMA-induced phosphorylation of Tyr(311) of PKCdelta and translocation of PKCdelta to the Golgi. Histamine 25-34 protein kinase C delta Homo sapiens 112-120 21730054-8 2011 Histamine or PMA stimulation resulted in PKCdelta phosphorylation at Tyr(311) and Thr(505). Histamine 0-9 protein kinase C delta Homo sapiens 41-49 21730054-11 2011 Histamine or PMA caused translocation PKCdelta from the cytosol to the Golgi. Histamine 0-9 protein kinase C delta Homo sapiens 38-46 21730054-16 2011 These results suggest the involvement of the PKCdelta/ERK/poly(ADP-ribose) polymerase-1 signaling pathway in histamine- or PMA-induced up-regulation of H1R gene expression in HeLa cells. Histamine 109-118 protein kinase C delta Homo sapiens 45-53 12801607-11 2003 Overall, this study demonstrated that the G-protein activators thrombin and histamine inhibited both EGF- and S1P-mediated Akt phosphorylation in HUVEC by activation of PKCdelta, while the inhibitory effects of LPC were independent of PKCdelta. Histamine 76-85 protein kinase C delta Homo sapiens 169-177 12946446-9 2003 And, the protein kinase C (PKC)-delta inhibitor, rottlerin (5 microM) significantly blocked the apoptotic effect of histamine, though the cleavage of PKC-delta in 20 h cultured neutrophils was increased by histamine. Histamine 116-125 protein kinase C delta Homo sapiens 9-37 12946446-9 2003 And, the protein kinase C (PKC)-delta inhibitor, rottlerin (5 microM) significantly blocked the apoptotic effect of histamine, though the cleavage of PKC-delta in 20 h cultured neutrophils was increased by histamine. Histamine 206-215 protein kinase C delta Homo sapiens 9-37 12946446-9 2003 And, the protein kinase C (PKC)-delta inhibitor, rottlerin (5 microM) significantly blocked the apoptotic effect of histamine, though the cleavage of PKC-delta in 20 h cultured neutrophils was increased by histamine. Histamine 206-215 protein kinase C delta Homo sapiens 150-159 12946446-11 2003 These results suggest that high concentrations of histamine in local inflammatory and allergic lesions induce neutrophil apoptosis, and that this histamine-induced apoptosis is mediated by caspase activation and PKC-delta signaling. Histamine 50-59 protein kinase C delta Homo sapiens 212-221 12946446-11 2003 These results suggest that high concentrations of histamine in local inflammatory and allergic lesions induce neutrophil apoptosis, and that this histamine-induced apoptosis is mediated by caspase activation and PKC-delta signaling. Histamine 146-155 protein kinase C delta Homo sapiens 212-221 18682391-5 2008 Histamine also rapidly and transiently activates protein kinase C-delta (PKCdelta), extracellular signal-regulated kinase (ERK)1/2, p38 kinase, and c-Jun N-terminal kinase (JNK) prior to Egr-1 induction. Histamine 0-9 protein kinase C delta Homo sapiens 73-81 18682391-6 2008 Using specific pharmacological inhibitors and small interfering RNA technology, we determined that PKCdelta and ERK, but not p38 and JNK, mediate histamine-induced Egr-1 expression. Histamine 146-155 protein kinase C delta Homo sapiens 99-107 18682391-8 2008 The present study reveals the following regulatory mechanism: histamine up-regulates Egr-1 expression in primary HAECs via the H1 receptor and the PKCdelta-dependent ERK activation pathway. Histamine 62-71 protein kinase C delta Homo sapiens 147-155 16823786-7 2006 Activation of PKC with PMA enhances histamine release in response to NH(4)Cl and ionomycin. Histamine 36-45 protein kinase C delta Homo sapiens 14-17 12801607-11 2003 Overall, this study demonstrated that the G-protein activators thrombin and histamine inhibited both EGF- and S1P-mediated Akt phosphorylation in HUVEC by activation of PKCdelta, while the inhibitory effects of LPC were independent of PKCdelta. Histamine 76-85 protein kinase C delta Homo sapiens 235-243 11466390-7 2001 Both effects of histamine were selectively inhibited probably by the delta isoform of PKC in HL-60 cells. Histamine 16-25 protein kinase C delta Homo sapiens 86-89 34698097-2 2021 Protein kinase Cdelta (PKCdelta) signaling is involved in histamine-induced upregulation of H1R gene expression in HeLa cells. Histamine 58-67 protein kinase C delta Homo sapiens 0-21 34698097-2 2021 Protein kinase Cdelta (PKCdelta) signaling is involved in histamine-induced upregulation of H1R gene expression in HeLa cells. Histamine 58-67 protein kinase C delta Homo sapiens 23-31