PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21598306-5 2011 PKC activation increases ionomycin-induced histamine release in HMC-1(560) . Histamine 43-52 proline rich transmembrane protein 2 Homo sapiens 0-3 17615556-6 2008 Activation of PKC in combination with tyrosine kinase inhibition increases also histamine release in HMC-1(560, 816) cells. Histamine 80-89 proline rich transmembrane protein 2 Homo sapiens 14-17 12801607-6 2003 Following inhibition or downregulation of protein kinase C (PKC), the inhibitory effect of both histamine and thrombin on the endothelial response to EGF was prevented. Histamine 96-105 proline rich transmembrane protein 2 Homo sapiens 42-58 15599091-5 2004 Histamine-induced phosphorylation of H1R was partially inhibited by three protein kinase inhibitors including Ro-31-8220 for protein kinase C (PKC), KN-93 for calcium/calmodulin-dependent kinase II (CaMKII), and KT5823 for protein kinase G (PKG), while, M3-receptor-mediated phosphorylation of H1R was completely inhibited by Ro 31-8220. Histamine 0-9 proline rich transmembrane protein 2 Homo sapiens 125-141 15599091-5 2004 Histamine-induced phosphorylation of H1R was partially inhibited by three protein kinase inhibitors including Ro-31-8220 for protein kinase C (PKC), KN-93 for calcium/calmodulin-dependent kinase II (CaMKII), and KT5823 for protein kinase G (PKG), while, M3-receptor-mediated phosphorylation of H1R was completely inhibited by Ro 31-8220. Histamine 0-9 proline rich transmembrane protein 2 Homo sapiens 143-146 12801607-6 2003 Following inhibition or downregulation of protein kinase C (PKC), the inhibitory effect of both histamine and thrombin on the endothelial response to EGF was prevented. Histamine 96-105 proline rich transmembrane protein 2 Homo sapiens 60-63 7679016-1 1993 Protein kinase C (PKC) is suggested to be important for signal transduction of histamine-containing cells. Histamine 79-88 proline rich transmembrane protein 2 Homo sapiens 0-16 7526660-1 1994 Modulation of protein kinase C (PKC) activity in basophils (B) can influence IgE-mediated histamine release (HR). Histamine 90-99 proline rich transmembrane protein 2 Homo sapiens 14-30 7526660-1 1994 Modulation of protein kinase C (PKC) activity in basophils (B) can influence IgE-mediated histamine release (HR). Histamine 90-99 proline rich transmembrane protein 2 Homo sapiens 32-35 11071123-0 2000 Effects of protein kinase C and phospholipase C inhibitors on IgE-dependent and IgE-independent basophil histamine release. Histamine 105-114 proline rich transmembrane protein 2 Homo sapiens 11-27 11071123-3 2000 After incubation with PKC and PLC inhibitors, the stimuli were added and histamine release was measured by an automated fluorometric method. Histamine 73-82 proline rich transmembrane protein 2 Homo sapiens 22-25 11071123-8 2000 CONCLUSION: These results suggest that a prodegranulatory role of PKC in basophil histamine release induced by anti-IgE, FMLP, IL-3 and GM-CSF is unlikely; conversely, it is conceivable that PLC has a role in signal transduction and histamine release induced by the above stimuli. Histamine 82-91 proline rich transmembrane protein 2 Homo sapiens 66-69 7902747-3 1993 Noradrenaline-, ATP-, histamine- and glutamate-evoked [3H]-inositol phosphate accumulations were potentiated to varying degrees in PKC-depleted cultures whilst those evoked by carbachol and NaF were reduced and unchanged respectively. Histamine 22-31 proline rich transmembrane protein 2 Homo sapiens 131-134 7679016-1 1993 Protein kinase C (PKC) is suggested to be important for signal transduction of histamine-containing cells. Histamine 79-88 proline rich transmembrane protein 2 Homo sapiens 18-21 7679016-3 1993 Basophils were isolated from patients with severe AD (mean serum IgE level of 5,165 U/ml) and from healthy controls, and the effects of potent activators of PKC on histamine release were studied. Histamine 164-173 proline rich transmembrane protein 2 Homo sapiens 157-160 1422591-11 1992 Activation of protein kinase C (PKC) by phorbol-12-myristate-1 3-acetate was found to inhibit the histamine as well as ATP-induced Ca2" response in a dose-dependent manner.6. Histamine 98-107 proline rich transmembrane protein 2 Homo sapiens 14-30 1422591-14 1992 Based on our experimental data we suggest that short-term desensitization of the histamine H,receptor evolves from two different processes: a selective reduction of the histamine-induced Ca2+ release, mediated by a PKC-independent pathway, and a non-selective inhibition of the receptormediated Ca2+ influx activated by a PKC-dependent pathway. Histamine 81-90 proline rich transmembrane protein 2 Homo sapiens 215-218 1422591-11 1992 Activation of protein kinase C (PKC) by phorbol-12-myristate-1 3-acetate was found to inhibit the histamine as well as ATP-induced Ca2" response in a dose-dependent manner.6. Histamine 98-107 proline rich transmembrane protein 2 Homo sapiens 32-35 1422591-12 1992 In PKC downregulated cells the second phase of the histamine-induced Ca2+ response was significantly elevated, indicating the involvement of PKC in the negative feedback on the Ca2+ influx(control cells: second phase: 601 +/- 52 nM (n = 11); PKC downregulated cells: second phase:890 +/- 90nM, n = I0, P<0.05).7. Histamine 51-60 proline rich transmembrane protein 2 Homo sapiens 3-6 1422591-14 1992 Based on our experimental data we suggest that short-term desensitization of the histamine H,receptor evolves from two different processes: a selective reduction of the histamine-induced Ca2+ release, mediated by a PKC-independent pathway, and a non-selective inhibition of the receptormediated Ca2+ influx activated by a PKC-dependent pathway. Histamine 81-90 proline rich transmembrane protein 2 Homo sapiens 322-325 1422591-12 1992 In PKC downregulated cells the second phase of the histamine-induced Ca2+ response was significantly elevated, indicating the involvement of PKC in the negative feedback on the Ca2+ influx(control cells: second phase: 601 +/- 52 nM (n = 11); PKC downregulated cells: second phase:890 +/- 90nM, n = I0, P<0.05).7. Histamine 51-60 proline rich transmembrane protein 2 Homo sapiens 141-144 1422591-12 1992 In PKC downregulated cells the second phase of the histamine-induced Ca2+ response was significantly elevated, indicating the involvement of PKC in the negative feedback on the Ca2+ influx(control cells: second phase: 601 +/- 52 nM (n = 11); PKC downregulated cells: second phase:890 +/- 90nM, n = I0, P<0.05).7. Histamine 51-60 proline rich transmembrane protein 2 Homo sapiens 141-144 2465345-3 1989 Exposure to 0.1 microgram/ml anti-IgE resulted in an increase in total cellular PKC (169 +/- 23% of control, histamine release (HR) = 33 +/- 7%, n = 12) which could be accounted for solely by the increase in membrane-associated PKC. Histamine 109-118 proline rich transmembrane protein 2 Homo sapiens 80-83 2465345-5 1989 We found a good correlation between the increase in membrane-associated PKC and the eventual release of histamine (rs = 0.902). Histamine 104-113 proline rich transmembrane protein 2 Homo sapiens 72-75 2465345-6 1989 Donors whose basophils released less than 5% total histamine (n = 3, HR = 3 +/- 1%) showed a partial activation of PKC (173 +/- 18%) though much less than the remaining donors (increase in PKC = 346 +/- 59%, n = 9, HR = 43 +/- 7%). Histamine 51-60 proline rich transmembrane protein 2 Homo sapiens 115-118 3351335-6 1988 Stimulation with the H1-histamine agonist, thiazolylethylamine (TEA), of MNL from normal donors but not patients with AD, resulted in statistically significant increases in PK-C phosphorylation. Histamine 24-33 proline rich transmembrane protein 2 Homo sapiens 173-177 25682263-10 2016 In conclusion, both MAPK p44/p42 and PKC pathways appear to be involved in histamine-upregulated MMP-9 release via H1Rs in astrocytes. Histamine 75-84 proline rich transmembrane protein 2 Homo sapiens 37-40