PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16501051-3 2006 In this study, we demonstrate that CGS-21680 (a selective agonist of the adenosine A2A receptor) and histamine also potently inhibit PAF biosynthesis in agonist [formyl Met-Leu-Phe (fMLP)]- and thapsigargin-activated human PMN. Histamine 101-110 formyl peptide receptor 1 Homo sapiens 182-186 21945198-9 2012 RESULTS: Stimulation with anti-IgE, allergen, fMLP and PMA+-ionomycin induces a rapid release of histamine that can be analyzed flow cytometrically. Histamine 97-106 formyl peptide receptor 1 Homo sapiens 46-50 18556460-6 2008 The experiments also show that fMLP-primed PMNs increase the CD54 expression by coincubated ECs, and the expression of CD203c and the release of histamine by coincubated MCs. Histamine 145-154 formyl peptide receptor 1 Homo sapiens 31-35 16399248-11 2006 RESULTS: Histamine 10(-4) M (2C) and histamine 10(-32) M (16C) were capable of inhibiting both IgE-dependent (anti-IgE) and IgE-independent (fMLP) basophil activation. Histamine 9-18 formyl peptide receptor 1 Homo sapiens 141-145 16399248-11 2006 RESULTS: Histamine 10(-4) M (2C) and histamine 10(-32) M (16C) were capable of inhibiting both IgE-dependent (anti-IgE) and IgE-independent (fMLP) basophil activation. Histamine 37-46 formyl peptide receptor 1 Homo sapiens 141-145 14744809-5 2004 We report here that histamine inhibits thapsigargin- and ligand (PAF and fMLP)-induced leukotriene (LT) biosynthesis in human PMN in a dose-dependent manner. Histamine 20-29 formyl peptide receptor 1 Homo sapiens 73-77 12695031-3 2003 Moreover, histamine release from basophils activated with non-immunological stimuli (FMLP and A23187) is inhibited by 8-MOP, alone or in combination with UVA. Histamine 10-19 formyl peptide receptor 1 Homo sapiens 85-89 12540020-7 2002 In isolated neutrophils both histamine and Dithiaden inhibited OZ- and A23187-stimulated CL dose-dependently, with potentiation observed after stimulation with PMA and fMLP. Histamine 29-38 formyl peptide receptor 1 Homo sapiens 168-172 12540020-10 2002 Simultaneous application of Dithiaden and histamine abolished the effect of Dithiaden on fMLP-stimulated CL. Histamine 42-51 formyl peptide receptor 1 Homo sapiens 89-93 12540020-13 2002 Histamine administered simultaneously abolished the effect of Dithiaden on fMLP-stimulated PMN-leukocytes. Histamine 0-9 formyl peptide receptor 1 Homo sapiens 75-79 12370393-8 2002 However, low concentrations of peptides 2019 and 2021 (10(-8)-10(-6) M) inhibited histamine release from basophils challenged with FMLP but not the secretion caused by anti-IgE and gp120. Histamine 82-91 formyl peptide receptor 1 Homo sapiens 131-135 11071123-5 2000 FMLP-induced histamine release in a physiological Na+-containing medium was not significantly modified by staurosporine, although it was reduced by high concentrations of chelerythrine. Histamine 13-22 formyl peptide receptor 1 Homo sapiens 0-4 10979966-1 2000 Cross-linking of IgE or a bacterial product (f-Met-Leu-Phe; FMLP) induces the release of leukotriene C4 (LTC4) and histamine in human basophils. Histamine 115-124 formyl peptide receptor 1 Homo sapiens 60-64 11071123-7 2000 U73122 exerted a significant and dose-dependent inhibitory effect on basophil histamine release induced by anti-IgE, FMLP, IL-3 and GM-CSF. Histamine 78-87 formyl peptide receptor 1 Homo sapiens 117-121 10201947-1 1999 Human basophils secrete histamine and leukotriene C4 (LTC4) in response to various stimuli, such as Ag and the bacterial product, FMLP. Histamine 24-33 formyl peptide receptor 1 Homo sapiens 130-134 10201947-5 1999 Following FMLP stimulation, histamine release preceded phosphorylation of ERKs, whereas phosphorylation of cytosolic phospholipase A2 (cPLA2), and arachidonic acid (AA) and LTC4 release followed phosphorylation of ERKs. Histamine 28-37 formyl peptide receptor 1 Homo sapiens 10-14 9930595-11 1998 Active treatment exerted an inhibitory effect also on basophil histamine release induced by fMLP and Ca2+ ionophore A23187. Histamine 63-72 formyl peptide receptor 1 Homo sapiens 92-96 9802375-3 1998 METHODS: Basophil histamine release to the anti-Fc(epsilon)RI mAb 22E7, anti-IgE, and formyl-methionyl-leucyl-phenylalanine (fMLP); basophil numbers; and total cellular histamine were measured in 26 patients with CIU and 18 healthy control subjects. Histamine 18-27 formyl peptide receptor 1 Homo sapiens 125-129 9360750-4 1997 A trend toward higher fMLP-induced histamine release was found in allergic adult subjects. Histamine 35-44 formyl peptide receptor 1 Homo sapiens 22-26 9676763-3 1998 The priming effect of IL-3 on anti-IgE and fMLP induced histamine release was evaluated. Histamine 56-65 formyl peptide receptor 1 Homo sapiens 43-47 9676763-5 1998 RESULTS: No significant difference was found between patients with SSc (n = 12) and control subjects (n = 16) regarding spontaneous IL-3 and fMLP induced histamine release. Histamine 154-163 formyl peptide receptor 1 Homo sapiens 141-145 9676763-8 1998 IL-3 enhanced anti-IgE and fMLP induced histamine release in a dose dependent fashion. Histamine 40-49 formyl peptide receptor 1 Homo sapiens 27-31 9676763-10 1998 In contrast, no difference was found between the 2 populations regarding the enhancement of fMLP induced histamine release by IL-3. Histamine 105-114 formyl peptide receptor 1 Homo sapiens 92-96 9360750-9 1997 In conclusion, IL-3 primes cord-blood as well as adult blood basophils for a consecutive anti-IgE- or fMLP-induced histamine release and its activity is not limited by the low density of membrane IgE in cord-blood basophils. Histamine 115-124 formyl peptide receptor 1 Homo sapiens 102-106 8943842-7 1996 Similarly, the fraction of histamine-loaded cytoplasmic vesicles after FMLP stimulation significantly exceeded the fraction in unstimulated cells, a process that persisted for 10 minutes after FMLP stimulation and was associated with the morphologic continuum of PMD-->anaphylactic degranulation (characterized by extrusion of granules)-->recovery, a process largely complete in the 10-minute samples. Histamine 27-36 formyl peptide receptor 1 Homo sapiens 71-75 8943842-7 1996 Similarly, the fraction of histamine-loaded cytoplasmic vesicles after FMLP stimulation significantly exceeded the fraction in unstimulated cells, a process that persisted for 10 minutes after FMLP stimulation and was associated with the morphologic continuum of PMD-->anaphylactic degranulation (characterized by extrusion of granules)-->recovery, a process largely complete in the 10-minute samples. Histamine 27-36 formyl peptide receptor 1 Homo sapiens 193-197 8943842-10 1996 Vesicular transport of histamine was also significant in the more complex stimulated secretory and recovery model produced by exposure of human basophils to the bacterial peptide FMLP. Histamine 23-32 formyl peptide receptor 1 Homo sapiens 179-183 8902469-4 1996 Na+ removal from extracellular medium and its isosmotic substitution with choline chloride or with N-methyl-D-glucamine led to a significant increase of anti-IgE-, FMLP- and IL-3-induced histamine release in normal subjects, but not in allergic patients. Histamine 187-196 formyl peptide receptor 1 Homo sapiens 164-168 8902469-5 1996 The increase in Na+ concentration in the extra-cellular medium was accompanied by a dose-dependent decrease of anti-IgE- and FMLP-induced histamine release in normal subjects, but not in allergic patients. Histamine 138-147 formyl peptide receptor 1 Homo sapiens 125-129 8874655-3 1996 A trend toward higher histamine release after challenge with anti-IgE, FMLP, and IL-3 was found in atopic subjects. Histamine 22-31 formyl peptide receptor 1 Homo sapiens 71-75 8874655-4 1996 Preincubation of basophils with IL-3 resulted in a dose-dependent increase of anti-IgE- and FMLP-induced histamine release, with a more marked effect in nonatopic than in atopic subjects. Histamine 105-114 formyl peptide receptor 1 Homo sapiens 92-96 8874655-6 1996 The enhancement of FMLP-induced histamine release by IL-3 was 10.3 +/- 3.9% in atopic patients and 29 +/- 2.4% in nonatopic subjects (P < 0.01). Histamine 32-41 formyl peptide receptor 1 Homo sapiens 19-23 8874655-7 1996 In atopic subjects, a negative correlation was found between anti-IgE- or FMLP-induced histamine release and net enhancement by IL-3 (r = -0.45, P < 0.02; r = -0.48, P < 0.01, respectively). Histamine 87-96 formyl peptide receptor 1 Homo sapiens 74-78 8603541-5 1996 Na+ removal from the extracellular medium and its isosmotic replacement with choline chloride led to a significant increase of anti-IgE-and fMLP-induced histamine release in normal subjects, but not in SSc patients. Histamine 153-162 formyl peptide receptor 1 Homo sapiens 140-144 8765829-5 1996 Inhibition of histamine release from basophils challenged with FMLP was extremely rapid and was abolished by washing the cells (three times) before challenge. Histamine 14-23 formyl peptide receptor 1 Homo sapiens 63-67 8765829-8 1996 CsH competitively inhibited the effect of FMLP on histamine release from basophils. Histamine 50-59 formyl peptide receptor 1 Homo sapiens 42-46 8603541-8 1996 Na+ exerted a dose-dependent inhibitory effect on anti-IgE- and fMLP-induced histamine release in normal subjects, but not in SSc patients. Histamine 77-86 formyl peptide receptor 1 Homo sapiens 64-68 7579464-0 1995 Histamine distribution in human basophil secretory granules undergoing FMLP-stimulated secretion and recovery. Histamine 0-9 formyl peptide receptor 1 Homo sapiens 71-75 7579464-1 1995 We examined subcellular histamine localizations in purified human basophils that were stimulated to degranulate with FMLP using an ultrastructural enzyme-affinity technique. Histamine 24-33 formyl peptide receptor 1 Homo sapiens 117-121 7541309-6 1995 The concentrations inhibiting 50% of histamine release were 30 microM (anti-IgE), 27 microM (FMLP) and 19 microM (Ca2+ ionophore A23187). Histamine 37-46 formyl peptide receptor 1 Homo sapiens 93-97 7533185-10 1995 Heart mast cells released histamine in response to immunologic (anti-IgE, anti-Fc epsilon RI, and C5a) and nonimmunologic stimuli (recombinant human stem cell factor, A23187, and compound 48/80) but did not respond to substance P, FMLP, 12-O-tetradecanoylphorbol-13-acetate, or acetylcholine. Histamine 26-35 formyl peptide receptor 1 Homo sapiens 231-235 7552580-4 1995 The effect of histamine on formyl-methionyl-leucyl-phenylalanine (fmlp) stimulated cells is examined. Histamine 14-23 formyl peptide receptor 1 Homo sapiens 66-70 7552580-6 1995 It is found that 10(-3) M histamine can inhibit the fmlp induced superoxide anion radical production. Histamine 26-35 formyl peptide receptor 1 Homo sapiens 52-56 7532302-6 1994 The Na+/H+ exchanger monensin, in the concentration range of 10(-8)-10(-4) M, exerted a dose-dependent inhibitory effect on anti-IgE-, FMLP- and PMA-induced histamine release, but not on A23187-induced histamine release. Histamine 202-211 formyl peptide receptor 1 Homo sapiens 135-139 7524750-11 1994 Cross linking of either IgE receptor or SCF receptor (c-kit) on CMC resulted in histamine secretion (non-specific release: < 6% of total histamine, alpha IgE induced: 12% to 52%; SCF-induced release: 9% to 18%), whereas neither substance P (a skin MC agonist) nor the basophil agonist FMLP showed an effect on CMC. Histamine 80-89 formyl peptide receptor 1 Homo sapiens 288-292 7532302-3 1994 The effects of Na+ and Ca2+ ions on histamine release from human basophils stimulated by anti-IgE, N-formyl-methionyl-leucyl-phenylalanine (FMLP), 4 beta-phorbol 12-myristate 13-acetate (PMA) and Ca2+ ionophore A23187 were evaluated. Histamine 36-45 formyl peptide receptor 1 Homo sapiens 140-144 7532302-6 1994 The Na+/H+ exchanger monensin, in the concentration range of 10(-8)-10(-4) M, exerted a dose-dependent inhibitory effect on anti-IgE-, FMLP- and PMA-induced histamine release, but not on A23187-induced histamine release. Histamine 157-166 formyl peptide receptor 1 Homo sapiens 135-139 8086832-2 1994 An ultrastructural enzyme-affinity method to detect histamine, employing diamine oxidase coupled to gold, was used to localize this proinflammatory mediator in human basophils stimulated to release histamine by FMLP. Histamine 52-61 formyl peptide receptor 1 Homo sapiens 211-215 8086832-2 1994 An ultrastructural enzyme-affinity method to detect histamine, employing diamine oxidase coupled to gold, was used to localize this proinflammatory mediator in human basophils stimulated to release histamine by FMLP. Histamine 198-207 formyl peptide receptor 1 Homo sapiens 211-215 7532302-8 1994 Removal of extracellular Na+ lowered the requirement of extracellular Ca2+ for anti-IgE, FMLP- and PMA-induced histamine release. Histamine 111-120 formyl peptide receptor 1 Homo sapiens 89-93 8245711-3 1993 Histamine, in contrast, was found to inhibit dose-dependently the rise in [Ca2+]i induced by two neutrophil receptor agonists, N-formylmethionyl-leucylphenylalanine (fMLP) and serum-opsonized zymosan particles. Histamine 0-9 formyl peptide receptor 1 Homo sapiens 166-170 7693814-9 1993 A rapid and significant reduction of histamine release induced by anti-IgE, FMLP, and A23187 paralleled a sharp increase of CsA plasma levels, which peaked at 5 h and lasted approximately 13 h. This study indicates that oral administration of CsA in normal subjects causes a rapid and significant inhibition of histamine release from basophils. Histamine 37-46 formyl peptide receptor 1 Homo sapiens 76-80 1378073-6 1992 In the same group of donors, MCAF/MCP-1, goat anti-human IgE (anti-IgE; 1 microgram/ml), and FMLP (10(-5) M) released 41.1 +/- 2.9%, 40.5 +/- 4.6%, and 44 +/- 3.1% histamine, respectively. Histamine 164-173 formyl peptide receptor 1 Homo sapiens 93-97 7505057-4 1993 When stimulated with anti-IgE or fMLP, histamine release from purified basophils was similar to that from mixed leukocytes. Histamine 39-48 formyl peptide receptor 1 Homo sapiens 33-37 7684660-5 1993 IL-3, IL-5, IL-6, and GM-CSF enhanced significantly anti-IgE- and FMLP-induced histamine release. Histamine 79-88 formyl peptide receptor 1 Homo sapiens 66-70 1375615-8 1992 The kinetics and the dose response of histamine release after the addition of anti-IgE or FMLP was also unchanged. Histamine 38-47 formyl peptide receptor 1 Homo sapiens 90-94 1716839-1 1991 Histamine release (HR) after stimulation with anti-IgE, concanavalin A (ConA) and Formyl-Met-Leu-Phe (FMLP) from 97 cord blood samples was compared to results obtained in identically treated blood samples from adults. Histamine 0-9 formyl peptide receptor 1 Homo sapiens 82-100 1716285-9 1991 In contrast, histamine release by anti-IgE and FMLP was not affected by IL-8. Histamine 13-22 formyl peptide receptor 1 Homo sapiens 47-51 1645357-10 1991 Histamine also diminished the FMLP-stimulated production of respiratory burst oxidants from cells in suspension or cells allowed to adhere to fibrinogen substrates. Histamine 0-9 formyl peptide receptor 1 Homo sapiens 30-34 1706397-2 1991 Treatment with polyclonal anti-IgE, FMLP, or the calcium ionophore A23187 induced histamine release, along with rapid and sustained unimodal increases in basophil CD11b mean fluorescence intensity. Histamine 82-91 formyl peptide receptor 1 Homo sapiens 36-40 1718902-3 1991 Anti-IgE and fMLP released 24.5 +/- 5.4% and 14.5 +/- 4.5% histamine from the cells, respectively. Histamine 59-68 formyl peptide receptor 1 Homo sapiens 13-17 1718902-5 1991 In contrast to anti-IgE stimulation, fMLP induced rapid actin polymerization with a peak response at 30 s in correlation with kinetics of histamine release. Histamine 138-147 formyl peptide receptor 1 Homo sapiens 37-41 1695458-3 1990 A variability in the extent of histamine release upon stimulation by either anti-IgE or FMLP was found between donors. Histamine 31-40 formyl peptide receptor 1 Homo sapiens 88-92 2327557-4 1990 However BaPA ranging from 0.001 to 0.5 U/ml enhanced histamine release from basophils stimulated with anti-IgE, calcium ionophore A23187 or FMLP in a dose-dependent manner. Histamine 53-62 formyl peptide receptor 1 Homo sapiens 140-144 1695458-4 1990 Non-responders for FMLP showed high histamine release for anti-IgE, and vice versa. Histamine 36-45 formyl peptide receptor 1 Homo sapiens 19-23 1689975-4 1990 We found that BAL fluids from 12 to 17 volunteers contained a dialyzable (molecular weight cutoff 3500) factor that inhibited basophil histamine release by HRF, anti-IgE, concanavalin A, and N-formyl-methionyl-leucyl-phenylalanine (FMLP). Histamine 135-144 formyl peptide receptor 1 Homo sapiens 232-236 1713571-0 1990 Differential effect of hypertonicity on FMLP-, anti-IgE- and Ca2+ ionophore A23187-induced histamine release from human basophil leukocytes. Histamine 91-100 formyl peptide receptor 1 Homo sapiens 40-44 1713571-2 1990 High extracellular Na+ and K+ concentrations were shown to reduce N-formyl-methionyl-leucyl-phenyl-alanine- (FMLP), but not anti-IgE- or Ca2+ ionophore A23187-induced histamine release. Histamine 167-176 formyl peptide receptor 1 Homo sapiens 109-113 1713571-5 1990 When leukocytes were suspended in isotonic choline chloride solutions (choline is a nonpermeant monovalent cation), an enhancement of anti-IgE- and FMLP-induced histamine release was observed. Histamine 161-170 formyl peptide receptor 1 Homo sapiens 148-152 1713571-8 1990 Thus, the reduction of FMLP-evoked histamine secretion from human basophils seems to be due to hypertonicity and not to the type of monovalent cation, either permeant or nonpermeant, contained in extracellular milieu. Histamine 35-44 formyl peptide receptor 1 Homo sapiens 23-27 1713571-9 1990 The different effects of a hypertonic solution on anti-IgE and FMLP-induced histamine release are probably related to the different cell activation pathways triggered by the two stimuli. Histamine 76-85 formyl peptide receptor 1 Homo sapiens 63-67 2448594-4 1987 The suppression of histamine release was also demonstrated when the leukocytes, preincubated with fosfomycin, were challenged with either Ca ionophore A 23187 or a synthetic peptide, formyl-methionyl-leucyl-phenylalanine (FMLP). Histamine 19-28 formyl peptide receptor 1 Homo sapiens 222-226 2460553-4 1988 Enhancement of histamine release by both factors was not necessarily IgE mediated, because they also amplified histamine release upon stimulation with FMLP and ionophore A23187. Histamine 15-24 formyl peptide receptor 1 Homo sapiens 151-155 2460553-4 1988 Enhancement of histamine release by both factors was not necessarily IgE mediated, because they also amplified histamine release upon stimulation with FMLP and ionophore A23187. Histamine 111-120 formyl peptide receptor 1 Homo sapiens 151-155 2452580-2 1988 A novel and potent inhibitor of PKC, K-252a, inhibited the release of histamine induced by anti-IgE in a dose-dependent manner with ID50 (the dose required for 50% inhibition of histamine release) of 2.2 x 10(-8) M. Histamine release stimulated with 12-0-tetradecanoyl-phorbol-13-acetate(TPA) was also suppressed by K-252a with maximal inhibition of 48.0 +/- 9.3% at 10(-7) M. In contrast, K-252a did not inhibit the release of histamine in response to FMLP and ionophore A23187. Histamine 70-79 formyl peptide receptor 1 Homo sapiens 453-457 2409774-1 1985 Histamine inhibits superoxide anion (O-2) production from human neutrophils stimulated by N-formylmethionyl-leucyl-phenylalanine (FMLP). Histamine 0-9 formyl peptide receptor 1 Homo sapiens 130-134 2425573-0 1986 FMLP-activated neutrophils evoke histamine release from mast cells. Histamine 33-42 formyl peptide receptor 1 Homo sapiens 0-4 2425573-1 1986 Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. Histamine 121-130 formyl peptide receptor 1 Homo sapiens 108-112 2409774-5 1985 Exposure of non-sensitized rat mast cells to FMLP-stimulated human neutrophils causes histamine release. Histamine 86-95 formyl peptide receptor 1 Homo sapiens 45-49 2409021-1 1985 We report differential effects of various compounds on inhibition of histamine release from washed leukocytes stimulated through IgE (using antigen or anti-IgE antibody) or N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) receptors. Histamine 69-78 formyl peptide receptor 1 Homo sapiens 220-224 2409021-4 1985 When FMLP was used to stimulate histamine release the order of potency (IC50) changed: meclofenamate = FPL 55712 = proxicromil less than CI-922 less than NDGA = BW755c less than indomethacin less than isamoxole = phenidone. Histamine 32-41 formyl peptide receptor 1 Homo sapiens 5-9 2409021-5 1985 The inhibition of FMLP-induced histamine release by FPL 55712, meclofenamate and indomethacin in the absence of inhibition (or even enhancement) of histamine release by the IgE mechanism suggests that different pathways of activation and/or control are critical in the release process when different stimuli are used to activate basophils. Histamine 31-40 formyl peptide receptor 1 Homo sapiens 18-22