PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2906082-4 1985 The studies described herein extend these findings to the conjunctiva, where the relatively selective beta 2-adrenoceptor agonists salbutamol and terbutaline reduced the microvascular permeability response to histamine. Histamine 209-218 adrenoceptor beta 2 Homo sapiens 102-121 2990269-8 1985 Beta 2-adrenoceptor responsiveness of the airways after inhaled adenosine and histamine was further studied in 12 asthmatic subjects by observing the antibronchoconstrictor effect of inhaled isoproterenol. Histamine 78-87 adrenoceptor beta 2 Homo sapiens 0-19 6205605-0 1984 Sustained inhibition of antigen-induced histamine release from human lung by the beta 2-adrenoceptor agonist terbutaline. Histamine 40-49 adrenoceptor beta 2 Homo sapiens 81-100 6205605-1 1984 Antigen-induced histamine release from passively sensitized human lung tissue was inhibited in the presence of the beta 2-adrenoceptor agonist, terbutaline. Histamine 16-25 adrenoceptor beta 2 Homo sapiens 115-134 17196553-0 2007 Histamine augments beta2-adrenoceptor-induced cyclic AMP accumulation in human prostate cancer cells DU-145 independently of known histamine receptors. Histamine 0-9 adrenoceptor beta 2 Homo sapiens 19-37 32932742-4 2020 Therefore, we created a model of the histamine-H2R-Gs complex based on the structure of the ternary complex of the beta2-adrenoceptor and investigated the conformational stability of this active GPCR conformation. Histamine 37-46 adrenoceptor beta 2 Homo sapiens 115-133 20423350-5 2010 KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected. Histamine 197-206 adrenoceptor beta 2 Homo sapiens 33-53 26608913-6 2016 Constitutive HLMC histamine release was increased in HLMC-HASMC coculture and this was enhanced by beta2-AR agonists. Histamine 18-27 adrenoceptor beta 2 Homo sapiens 99-107 25538773-1 2014 BACKGROUND: The beta2-adrenoceptor agonist, isoprenaline, is an effective inhibitor of histamine release from human lung mast cells (HLMC). Histamine 87-96 adrenoceptor beta 2 Homo sapiens 16-34 17196553-6 2007 While not having effect of its own on basal [3H]-cAMP accumulation, histamine significantly augmented the beta2-adrenoceptor-induced response (overall effect 152+/-6% of isoproterenol alone) with EC50 1.35 microM (pEC50 5.87+/-0.06). Histamine 68-77 adrenoceptor beta 2 Homo sapiens 106-124 17196553-8 2007 Taken together, our results show that in DU-145 cells histamine augments beta2-adrenoceptor-induced cAMP independently of the activation of known histamine receptors. Histamine 54-63 adrenoceptor beta 2 Homo sapiens 73-91 9535032-2 1998 The long-acting beta2-adrenoceptor agonist, salmeterol (10(-9)-10(-5) M), inhibited the IgE-mediated release of histamine from human lung mast cells (HLMC) in a dose-dependent fashion. Histamine 112-121 adrenoceptor beta 2 Homo sapiens 16-34 16412418-5 2006 1 microM beta2-adrenoceptor agonist treatment for 24 h did not alter sodium fluoride Inositol Phosphate (IP) responses, however augmented histamine IP responses (P<0.05). Histamine 138-147 adrenoceptor beta 2 Homo sapiens 9-27 15756641-4 2005 beta2AR activation by epinephrine, norepinephrine, and salbutamol suppressed the IgE receptor-dependent release of histamine, lipid mediators, and TNF-alpha, and inhibited SCF-dependent MC proliferation and migration. Histamine 115-124 adrenoceptor beta 2 Homo sapiens 0-7 15467193-11 2004 Furthermore, the beta2-adrenoceptor desensitization causes differential attenuating effects on the inhibition of histamine, PGD2, and LT release, suggesting that downstream events involved in each inhibitory pathway have different sensitivity to receptor desensitization. Histamine 113-122 adrenoceptor beta 2 Homo sapiens 17-35 14662724-2 2004 The long-acting beta(2)-adrenoceptor agonist formoterol (10(-10)-10(-6) m) inhibited the IgE-dependent release of histamine from human lung mast cells in a concentration-dependent manner. Histamine 114-123 adrenoceptor beta 2 Homo sapiens 16-36 14662724-4 2004 By contrast, the long-acting beta(2)-adrenoceptor agonist salmeterol (10(-10)-10(-6) m) was about two-thirds less efficacious than either formoterol or isoprenaline as an inhibitor of histamine release. Histamine 184-193 adrenoceptor beta 2 Homo sapiens 29-49 14662724-11 2004 The desensitisation induced by long-term treatments with salmeterol and formoterol was specific for beta(2)-adrenoceptor-mediated inhibition of histamine release as the inhibitory effects of alternative cAMP-elevating compounds, prostaglandin E(2), a receptor-mediated activator of adenylate cyclase, and forskolin, a direct activator of adenylate cyclase, were unaffected by desensitising treatments. Histamine 144-153 adrenoceptor beta 2 Homo sapiens 100-120 16895550-15 2006 The selective beta2-adrenoceptor antagonist ICI 118 551 (108 mol/L) strongly reversed the concentration-dependent suppression of histamine release by isoprenaline and salbutamol; however, the selective beta1-adrenoceptor antagonist atenolol (106 mol/L) did not have any effect. Histamine 129-138 adrenoceptor beta 2 Homo sapiens 14-32 12569076-2 2003 2 The non-selective beta-adrenoceptor agonist, isoprenaline, and the selective beta(2)-adrenoceptor agonists, salbutamol and terbutaline, inhibited the IgE-mediated release of histamine from HLMC. Histamine 176-185 adrenoceptor beta 2 Homo sapiens 79-99 9535032-10 1998 The beta-adrenoceptor antagonist, propranolol (1 microM), and the selective beta2-adrenoceptor antagonist, ICI 118,551 (0.1 microM), both caused rightward shifts in the dose-response curve for the inhibition of histamine release by isoprenaline. Histamine 211-220 adrenoceptor beta 2 Homo sapiens 76-94 1356984-2 1992 Key areas of homology in the structures of the histamine H2 and beta 2 adrenergic receptor suggested specific transmembrane amino acids that might be important for binding of histamine. Histamine 47-56 adrenoceptor beta 2 Homo sapiens 64-90 7780648-10 1995 Histamine response curves were shifted to the right immediately after pretreatment of tissues with the beta 2-adrenoceptor agonists (10 microM; 20 min), but maximal contractions were not affected. Histamine 0-9 adrenoceptor beta 2 Homo sapiens 103-122 2182697-3 1990 Thus, this dose of beta 2-adrenoceptor agonist displaced the concentration-response curves for methacholine, histamine, and AMP to the right in a parallel fashion by 8.8 (0.6 to 29.3)-, 10.3 (1.4 to 33)-, and 26.6 (1.5 to 76.6)-fold, respectively, the difference between the results for AMP and those for histamine and methacholine being statistically significant (p less than 0.01). Histamine 109-118 adrenoceptor beta 2 Homo sapiens 19-38 2182697-3 1990 Thus, this dose of beta 2-adrenoceptor agonist displaced the concentration-response curves for methacholine, histamine, and AMP to the right in a parallel fashion by 8.8 (0.6 to 29.3)-, 10.3 (1.4 to 33)-, and 26.6 (1.5 to 76.6)-fold, respectively, the difference between the results for AMP and those for histamine and methacholine being statistically significant (p less than 0.01). Histamine 305-314 adrenoceptor beta 2 Homo sapiens 19-38