PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26608913-6	2016	Constitutive HLMC histamine release was increased in HLMC-HASMC coculture and this was enhanced by beta2-AR agonists.	Histamine	18-27	adrenoceptor beta 2	Homo sapiens	99-107	
15467193-11	2004	Furthermore, the beta2-adrenoceptor desensitization causes differential attenuating effects on the inhibition of histamine, PGD2, and LT release, suggesting that downstream events involved in each inhibitory pathway have different sensitivity to receptor desensitization.	Histamine	113-122	adrenoceptor beta 2	Homo sapiens	17-35	
25538773-1	2014	BACKGROUND: The beta2-adrenoceptor agonist, isoprenaline, is an effective inhibitor of histamine release from human lung mast cells (HLMC).	Histamine	87-96	adrenoceptor beta 2	Homo sapiens	16-34	
16412418-5	2006	1 microM beta2-adrenoceptor agonist treatment for 24 h did not alter sodium fluoride Inositol Phosphate (IP) responses, however augmented histamine IP responses (P<0.05).	Histamine	138-147	adrenoceptor beta 2	Homo sapiens	9-27	
15756641-4	2005	beta2AR activation by epinephrine, norepinephrine, and salbutamol suppressed the IgE receptor-dependent release of histamine, lipid mediators, and TNF-alpha, and inhibited SCF-dependent MC proliferation and migration.	Histamine	115-124	adrenoceptor beta 2	Homo sapiens	0-7	
20423350-5	2010	KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected.	Histamine	197-206	adrenoceptor beta 2	Homo sapiens	33-53	
17196553-0	2007	Histamine augments beta2-adrenoceptor-induced cyclic AMP accumulation in human prostate cancer cells DU-145 independently of known histamine receptors.	Histamine	0-9	adrenoceptor beta 2	Homo sapiens	19-37	
17196553-6	2007	While not having effect of its own on basal [3H]-cAMP accumulation, histamine significantly augmented the beta2-adrenoceptor-induced response (overall effect 152+/-6% of isoproterenol alone) with EC50 1.35 microM (pEC50 5.87+/-0.06).	Histamine	68-77	adrenoceptor beta 2	Homo sapiens	106-124	
17196553-8	2007	Taken together, our results show that in DU-145 cells histamine augments beta2-adrenoceptor-induced cAMP independently of the activation of known histamine receptors.	Histamine	54-63	adrenoceptor beta 2	Homo sapiens	73-91	
16895550-15	2006	The selective beta2-adrenoceptor antagonist ICI 118 551 (108 mol/L) strongly reversed the concentration-dependent suppression of histamine release by isoprenaline and salbutamol; however, the selective beta1-adrenoceptor antagonist atenolol (106 mol/L) did not have any effect.	Histamine	129-138	adrenoceptor beta 2	Homo sapiens	14-32	
9535032-2	1998	The long-acting beta2-adrenoceptor agonist, salmeterol (10(-9)-10(-5) M), inhibited the IgE-mediated release of histamine from human lung mast cells (HLMC) in a dose-dependent fashion.	Histamine	112-121	adrenoceptor beta 2	Homo sapiens	16-34	
14662724-2	2004	The long-acting beta(2)-adrenoceptor agonist formoterol (10(-10)-10(-6) m) inhibited the IgE-dependent release of histamine from human lung mast cells in a concentration-dependent manner.	Histamine	114-123	adrenoceptor beta 2	Homo sapiens	16-36	
14662724-4	2004	By contrast, the long-acting beta(2)-adrenoceptor agonist salmeterol (10(-10)-10(-6) m) was about two-thirds less efficacious than either formoterol or isoprenaline as an inhibitor of histamine release.	Histamine	184-193	adrenoceptor beta 2	Homo sapiens	29-49	
14662724-11	2004	The desensitisation induced by long-term treatments with salmeterol and formoterol was specific for beta(2)-adrenoceptor-mediated inhibition of histamine release as the inhibitory effects of alternative cAMP-elevating compounds, prostaglandin E(2), a receptor-mediated activator of adenylate cyclase, and forskolin, a direct activator of adenylate cyclase, were unaffected by desensitising treatments.	Histamine	144-153	adrenoceptor beta 2	Homo sapiens	100-120	
12569076-2	2003	2 The non-selective beta-adrenoceptor agonist, isoprenaline, and the selective beta(2)-adrenoceptor agonists, salbutamol and terbutaline, inhibited the IgE-mediated release of histamine from HLMC.	Histamine	176-185	adrenoceptor beta 2	Homo sapiens	79-99	
9535032-10	1998	The beta-adrenoceptor antagonist, propranolol (1 microM), and the selective beta2-adrenoceptor antagonist, ICI 118,551 (0.1 microM), both caused rightward shifts in the dose-response curve for the inhibition of histamine release by isoprenaline.	Histamine	211-220	adrenoceptor beta 2	Homo sapiens	76-94	
7780648-10	1995	Histamine response curves were shifted to the right immediately after pretreatment of tissues with the beta 2-adrenoceptor agonists (10 microM; 20 min), but maximal contractions were not affected.	Histamine	0-9	adrenoceptor beta 2	Homo sapiens	103-122	
1356984-2	1992	Key areas of homology in the structures of the histamine H2 and beta 2 adrenergic receptor suggested specific transmembrane amino acids that might be important for binding of histamine.	Histamine	47-56	adrenoceptor beta 2	Homo sapiens	64-90	
2182697-3	1990	Thus, this dose of beta 2-adrenoceptor agonist displaced the concentration-response curves for methacholine, histamine, and AMP to the right in a parallel fashion by 8.8 (0.6 to 29.3)-, 10.3 (1.4 to 33)-, and 26.6 (1.5 to 76.6)-fold, respectively, the difference between the results for AMP and those for histamine and methacholine being statistically significant (p less than 0.01).	Histamine	109-118	adrenoceptor beta 2	Homo sapiens	19-38	
2182697-3	1990	Thus, this dose of beta 2-adrenoceptor agonist displaced the concentration-response curves for methacholine, histamine, and AMP to the right in a parallel fashion by 8.8 (0.6 to 29.3)-, 10.3 (1.4 to 33)-, and 26.6 (1.5 to 76.6)-fold, respectively, the difference between the results for AMP and those for histamine and methacholine being statistically significant (p less than 0.01).	Histamine	305-314	adrenoceptor beta 2	Homo sapiens	19-38	
2990269-8	1985	Beta 2-adrenoceptor responsiveness of the airways after inhaled adenosine and histamine was further studied in 12 asthmatic subjects by observing the antibronchoconstrictor effect of inhaled isoproterenol.	Histamine	78-87	adrenoceptor beta 2	Homo sapiens	0-19	
2906082-4	1985	The studies described herein extend these findings to the conjunctiva, where the relatively selective beta 2-adrenoceptor agonists salbutamol and terbutaline reduced the microvascular permeability response to histamine.	Histamine	209-218	adrenoceptor beta 2	Homo sapiens	102-121	
6205605-0	1984	Sustained inhibition of antigen-induced histamine release from human lung by the beta 2-adrenoceptor agonist terbutaline.	Histamine	40-49	adrenoceptor beta 2	Homo sapiens	81-100	
6205605-1	1984	Antigen-induced histamine release from passively sensitized human lung tissue was inhibited in the presence of the beta 2-adrenoceptor agonist, terbutaline.	Histamine	16-25	adrenoceptor beta 2	Homo sapiens	115-134	
32932742-4	2020	Therefore, we created a model of the histamine-H2R-Gs complex based on the structure of the ternary complex of the beta2-adrenoceptor and investigated the conformational stability of this active GPCR conformation.	Histamine	37-46	adrenoceptor beta 2	Homo sapiens	115-133