PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11342615-7	2001	In addition, histamine induces a potent production of IL-6, IL-8, monocyte chemoattractant protein 1, and macrophage-inflammatory protein 1alpha by immature DC and also up-regulates IL-1beta, RANTES, and macrophage-inflammatory protein 1beta but not TNF-alpha and IL-12 mRNA expression.	Histamine	13-22	C-C motif chemokine ligand 2	Homo sapiens	66-100	
27170049-10	2016	Orbital fibroblasts expressed HRH1 and loratadine and SC-514 both blocked histamine-induced IL-6, IL-8 and CCL2 production by orbital fibroblasts.	Histamine	74-83	C-C motif chemokine ligand 2	Homo sapiens	107-111	
26038194-7	2015	Chemokines, RANTES/CCL5, MCP-1/CCL2, and related molecules, constitute the C-C class of chemokine supergene family, play a role in regulating T helper-cell cytokine production and MC trafficking, and are involved in histamine and serotonin generation and MC functions.	Histamine	216-225	C-C motif chemokine ligand 2	Homo sapiens	25-31	
26038194-7	2015	Chemokines, RANTES/CCL5, MCP-1/CCL2, and related molecules, constitute the C-C class of chemokine supergene family, play a role in regulating T helper-cell cytokine production and MC trafficking, and are involved in histamine and serotonin generation and MC functions.	Histamine	216-225	C-C motif chemokine ligand 2	Homo sapiens	31-35	
19958313-7	2010	Stimulation with histamine or a H(4)R agonist downregulated the chemokine (C-C motif) ligand 2 (CCL2) in human monocyte-derived LC and primary LC.	Histamine	17-26	C-C motif chemokine ligand 2	Homo sapiens	64-94	
19958313-7	2010	Stimulation with histamine or a H(4)R agonist downregulated the chemokine (C-C motif) ligand 2 (CCL2) in human monocyte-derived LC and primary LC.	Histamine	17-26	C-C motif chemokine ligand 2	Homo sapiens	96-100	
19655299-7	2010	Addition of ROC at different concentrations together with IFN-gamma and histamine induced a dose-dependent inhibition of ICAM-1 expression and MCP-1 and IL-8 release.	Histamine	72-81	C-C motif chemokine ligand 2	Homo sapiens	143-148	
18239617-5	2008	Functionally, histamine and H(4)R agonists clobenpropit and 4-methylhistamine downregulated the production of the Th2-linked chemokine CCL2 and the Th1 cytokine IL-12 on Mo-IDEC, whereas agonists for the other histamine receptors did not.	Histamine	14-23	C-C motif chemokine ligand 2	Homo sapiens	135-139	
17507084-0	2007	Histamine downregulates monocyte CCL2 production through the histamine H4 receptor.	Histamine	0-9	C-C motif chemokine ligand 2	Homo sapiens	33-37	
16220783-4	2005	RESULTS: Compared with the control group of dermal fibroblast (DF) cells and HaCaT cells, MCP-1 mRNA was significantly upregulated by histamine (10 micromol x L(-1)) and IFN-gamma (20 ng x mL(-1)).	Histamine	134-143	C-C motif chemokine ligand 2	Homo sapiens	90-95	
16220783-7	2005	The enhancing effects of histamine and IFN-gamma on MCP-1 protein production were significantly inhibited by cetirizine (1 and 10 micromol x L(-1)) in DF and HaCaT cells.	Histamine	25-34	C-C motif chemokine ligand 2	Homo sapiens	52-57	
15189499-2	2004	As monocytic migration is a key event of atherogenesis, we investigated whether histamine induces monocytic expression of monocyte chemoattractant protein (MCP)-1 and its receptors CCR2-A and -B, and also endothelial expression of ICAM-1 and VCAM-1.	Histamine	80-89	C-C motif chemokine ligand 2	Homo sapiens	122-162	
15189499-4	2004	Histamine stimulated monocytes, but not macrophages, to express MCP-1 and CCR2-A and -B.	Histamine	0-9	C-C motif chemokine ligand 2	Homo sapiens	64-69	
15189499-5	2004	The expression of MCP-1 was inhibited by histamine H2 blocker.	Histamine	41-50	C-C motif chemokine ligand 2	Homo sapiens	18-23	
31548589-6	2019	Evaluation of the effect of histamine on LPS-induced CCL2 secretion showed an inhibitory effect in the majority of adults, whereas this effect was detectable in all NBs.	Histamine	28-37	C-C motif chemokine ligand 2	Homo sapiens	53-57	
31548589-7	2019	Histamine receptor (HR) blockage revealed partial involvement of H1R, H2R and H4R in LPS-induced CCL2 inhibition in MNCs from both NBs and adults.	Histamine	0-9	C-C motif chemokine ligand 2	Homo sapiens	97-101	
31548589-11	2019	The immunomodulatory role of histamine on CCL2 and CXCL8 was detected at the transcript and protein levels.	Histamine	29-38	C-C motif chemokine ligand 2	Homo sapiens	42-46	
27170049-9	2016	Histamine stimulated the production of IL-6, IL-8 and CCL2 by orbital fibroblasts, while it had no effect on the production of CCL5, CCL7, CXCL10, CXCL11 and hyaluronan.	Histamine	0-9	C-C motif chemokine ligand 2	Homo sapiens	54-58	
17460445-10	2007	RESULTS: The release of RANTES and MCP-1 was significantly upregulated by histamine compared with the control group.	Histamine	74-83	C-C motif chemokine ligand 2	Homo sapiens	35-40	
15189499-8	2004	These results indicate that histamine and IL-4, which are both synthesized in the arterial intima, chronically participates in the pathogenesis of atherosclerosis via the enhanced expression of monocytic MCP-1, CCR2 and endothelial adhesion molecules.	Histamine	28-37	C-C motif chemokine ligand 2	Homo sapiens	204-209	
12851645-3	2003	Mechanisms by which CCL2 may be acting include recruitment of regulatory and effector leukocytes; stimulation of histamine or leukotriene release from mast cells or basophils; induction of fibroblast production of transforming growth factor-beta (TGF-beta) and procollagen; and enhancement of Th2 polarization.	Histamine	113-122	C-C motif chemokine ligand 2	Homo sapiens	20-24	
9489430-0	1997	[The effect of heparin on release of histamine from basophils under the influence of MCAF/MCP-I in patients with bronchial asthma].	Histamine	37-46	C-C motif chemokine ligand 2	Homo sapiens	85-89	
9687567-8	1998	Of the mRNAs tested, only those encoding monocyte chemotactic protein-1 (approximately 2-fold over basal) and interleukin-8 (approximately 6-fold over basal) are induced by histamine; both of these responses are suppressed by CsA and FK506.	Histamine	173-182	C-C motif chemokine ligand 2	Homo sapiens	41-71	
9865755-11	1998	CONCLUSIONS: These results suggest that MCAF/MCP-1, which is produced constantly by monocytes and macrophages and is stored in human nasal mucosa, possibly participates in the protracted histamine release from basophils and in the pathogenesis of perennial allergic rhinitis.	Histamine	187-196	C-C motif chemokine ligand 2	Homo sapiens	40-44	
9865755-11	1998	CONCLUSIONS: These results suggest that MCAF/MCP-1, which is produced constantly by monocytes and macrophages and is stored in human nasal mucosa, possibly participates in the protracted histamine release from basophils and in the pathogenesis of perennial allergic rhinitis.	Histamine	187-196	C-C motif chemokine ligand 2	Homo sapiens	45-50	
9489430-11	1997	We observed that incubation of basophils with heparin inhibits histamine release as shown in the table: [table: see text] Preincubation of anti-IgE or MCAF/MCP-I with heparin did not induce any changes in histamine release.	Histamine	63-72	C-C motif chemokine ligand 2	Homo sapiens	151-155	
8550082-11	1995	Our report describes additional biological activities for MCP-1, suggesting for the first time that this human monocyte chemoattractant plays a fundamental role in histamine and serotonin release and cell aggregation in rat peritoneal mast cells.	Histamine	164-173	C-C motif chemokine ligand 2	Homo sapiens	58-63	
8753839-0	1996	Pharmacologic study of basophil histamine release induced by monocyte chemotactic protein-1 with kinase inhibitors.	Histamine	32-41	C-C motif chemokine ligand 2	Homo sapiens	61-91	
8753839-2	1996	In this study, we examined the effect of a panel of kinase inhibitors on MCP-1-induced histamine release from human basophils to characterize the signaling pathway used by this chemokine.	Histamine	87-96	C-C motif chemokine ligand 2	Homo sapiens	73-78	
8753839-3	1996	Genistein (3 micrograms/ml), an inhibitor of tyrosine kinase, inhibited MCP-1-induced histamine release by 44%.	Histamine	86-95	C-C motif chemokine ligand 2	Homo sapiens	72-77	
8753839-5	1996	It blocked MCP-1-induced histamine release with an IC50 of 3.3 x 10(-8) M indicating a role of PI-3 kinase in this reaction.	Histamine	25-34	C-C motif chemokine ligand 2	Homo sapiens	11-16	
8753839-6	1996	KT5926, an inhibitor of myosin light chain kinase, also inhibited histamine release in response to MCP-1 with an IC50 of 10(-6) M. Staurosporine, a potent inhibitor of protein kinase C, although being not specific, augmented MCP-1-induced histamine release by 31.9% at 10(-6) M. These results indicate the possible involvement of a series of kinases, including PI-3 kinase, in the signal transduction pathway used by MCP-1.	Histamine	66-75	C-C motif chemokine ligand 2	Homo sapiens	99-104	
8939160-8	1996	RESULTS: Replacing IgE- on basophils with IgE+ serum decreased the correlation between monocyte chemotactic protein-1 and histamine release (rho = 0.80, n = 280 vs p = 0.12, n = 18; p for difference between p values; < 0.05).	Histamine	122-131	C-C motif chemokine ligand 2	Homo sapiens	87-117	
8753839-6	1996	KT5926, an inhibitor of myosin light chain kinase, also inhibited histamine release in response to MCP-1 with an IC50 of 10(-6) M. Staurosporine, a potent inhibitor of protein kinase C, although being not specific, augmented MCP-1-induced histamine release by 31.9% at 10(-6) M. These results indicate the possible involvement of a series of kinases, including PI-3 kinase, in the signal transduction pathway used by MCP-1.	Histamine	239-248	C-C motif chemokine ligand 2	Homo sapiens	99-104	
8877158-8	1996	About 90-95% of the total histamine containing capability was attributable to MCP-1/MCAF.	Histamine	26-35	C-C motif chemokine ligand 2	Homo sapiens	78-83	
8877158-8	1996	About 90-95% of the total histamine containing capability was attributable to MCP-1/MCAF.	Histamine	26-35	C-C motif chemokine ligand 2	Homo sapiens	84-88	
7531729-1	1995	Monocyte chemotactic and activating factor (MCAF) is the most potent cytokine that activates basophils to release histamine.	Histamine	114-123	C-C motif chemokine ligand 2	Homo sapiens	0-42	
7540203-9	1995	These results suggested that MCAF is one of the important mediators causing histamine release in the late phase reaction and in protracted inflammation of the nasal mucosa.	Histamine	76-85	C-C motif chemokine ligand 2	Homo sapiens	29-33	
8568122-2	1996	IL-8 inhibits MCAF-induced histamine release from basophils.	Histamine	27-36	C-C motif chemokine ligand 2	Homo sapiens	14-18	
8568122-10	1996	We also found a correlation between the level of MCAF/MCP-1 and IL-8 and the level of histamine or IL-8 and ECP.	Histamine	86-95	C-C motif chemokine ligand 2	Homo sapiens	49-53	
8568122-10	1996	We also found a correlation between the level of MCAF/MCP-1 and IL-8 and the level of histamine or IL-8 and ECP.	Histamine	86-95	C-C motif chemokine ligand 2	Homo sapiens	54-59	
7531729-1	1995	Monocyte chemotactic and activating factor (MCAF) is the most potent cytokine that activates basophils to release histamine.	Histamine	114-123	C-C motif chemokine ligand 2	Homo sapiens	44-48	
7531729-3	1995	Simultaneous addition of MCAF and any of the chemokines studied evoked an augmented response as measured by histamine release, whereas preincubation of leukocytes or purified basophils (80%) with these chemokines decreased MCAF-induced histamine release in a dose-dependent manner.	Histamine	108-117	C-C motif chemokine ligand 2	Homo sapiens	25-29	
7531729-3	1995	Simultaneous addition of MCAF and any of the chemokines studied evoked an augmented response as measured by histamine release, whereas preincubation of leukocytes or purified basophils (80%) with these chemokines decreased MCAF-induced histamine release in a dose-dependent manner.	Histamine	236-245	C-C motif chemokine ligand 2	Homo sapiens	25-29	
7531729-10	1995	We have therefore characterized RANTES, MIP-1 alpha, MIP-1 beta, CTAP III, PF4, IL-8, and IP-10 as inhibitors of MCAF-induced histamine release.	Histamine	126-135	C-C motif chemokine ligand 2	Homo sapiens	113-117	
7680615-2	1993	We have studied the effects of four CC-chemokines and show that MCP-1, RANTES (regulated on activation, normal T expressed and secreted) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are potent basophil agonists inducing a rapid change of cytosolic free calcium ([Ca2+]i), the release of histamine and sulfido-leukotrienes, and chemotaxis.	Histamine	300-309	C-C motif chemokine ligand 2	Homo sapiens	64-69	
1382479-0	1992	Interleukin-8 and RANTES inhibit basophil histamine release induced with monocyte chemotactic and activating factor/monocyte chemoattractant peptide-1 and histamine releasing factor.	Histamine	42-51	C-C motif chemokine ligand 2	Homo sapiens	73-115	
1382479-1	1992	The objective of this study was to investigate the effect of interleukin-8 (IL-8) and RANTES on basophil histamine release induced with monocyte chemoattractant peptide-1 (MCP-1) and crude histamine releasing factor (HRF).	Histamine	105-114	C-C motif chemokine ligand 2	Homo sapiens	136-170	
1382479-1	1992	The objective of this study was to investigate the effect of interleukin-8 (IL-8) and RANTES on basophil histamine release induced with monocyte chemoattractant peptide-1 (MCP-1) and crude histamine releasing factor (HRF).	Histamine	105-114	C-C motif chemokine ligand 2	Homo sapiens	172-177	
1370686-1	1992	Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE.	Histamine	83-92	C-C motif chemokine ligand 2	Homo sapiens	12-50	
1371775-2	1992	In our pursuit of cytokines affecting basophil function, we studied the effect of MCAF on histamine secretion from basophils.	Histamine	90-99	C-C motif chemokine ligand 2	Homo sapiens	82-86	
1371775-4	1992	MCAF caused dose-dependent release of histamine at concentrations of 10(-8) and 10(-7) M, and the mean release was 31.25 +/- 2.9% at the highest concentration.	Histamine	38-47	C-C motif chemokine ligand 2	Homo sapiens	0-4	
1371775-6	1992	All 20 subjects responded to MCAF with significant histamine release.	Histamine	51-60	C-C motif chemokine ligand 2	Homo sapiens	29-33	
1371775-8	1992	The histamine release was significantly correlated between MCAF and HRF (P less than 0.01), but not between MCAF and anti-IgE (P greater than 0.05).	Histamine	4-13	C-C motif chemokine ligand 2	Homo sapiens	59-63	
1371775-9	1992	The histamine release by MCAF was complete within the first 3 min.	Histamine	4-13	C-C motif chemokine ligand 2	Homo sapiens	25-29	
1378073-4	1992	In this manuscript, we show that it is capable of inducing histamine release from human basophils at concentrations as low as 10(-10) M and compare its activity with that of monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 (MCAF/MCP-1), another intercrine/chemokine.	Histamine	59-68	C-C motif chemokine ligand 2	Homo sapiens	253-257	
1378073-4	1992	In this manuscript, we show that it is capable of inducing histamine release from human basophils at concentrations as low as 10(-10) M and compare its activity with that of monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 (MCAF/MCP-1), another intercrine/chemokine.	Histamine	59-68	C-C motif chemokine ligand 2	Homo sapiens	258-263	
1378073-7	1992	The percent histamine release by RANTES in atopic vs nonatopics was 30.3 +/- 6.7 and 16.5 +/- 2.4, respectively (p less than 0.05), and histamine release by RANTES correlated significantly with histamine release by MCAF (r = 0.69; p less than 0.001) but not with histamine release by anti-IgE (r = 0.29; p greater than 0.05).	Histamine	136-145	C-C motif chemokine ligand 2	Homo sapiens	215-219	
1378073-7	1992	The percent histamine release by RANTES in atopic vs nonatopics was 30.3 +/- 6.7 and 16.5 +/- 2.4, respectively (p less than 0.05), and histamine release by RANTES correlated significantly with histamine release by MCAF (r = 0.69; p less than 0.001) but not with histamine release by anti-IgE (r = 0.29; p greater than 0.05).	Histamine	136-145	C-C motif chemokine ligand 2	Homo sapiens	215-219	
1378073-7	1992	The percent histamine release by RANTES in atopic vs nonatopics was 30.3 +/- 6.7 and 16.5 +/- 2.4, respectively (p less than 0.05), and histamine release by RANTES correlated significantly with histamine release by MCAF (r = 0.69; p less than 0.001) but not with histamine release by anti-IgE (r = 0.29; p greater than 0.05).	Histamine	136-145	C-C motif chemokine ligand 2	Homo sapiens	215-219	
1378073-8	1992	Histamine release by RANTES and MCAF/MCP-1 was extremely rapid, reaching a maximum within 1 min.	Histamine	0-9	C-C motif chemokine ligand 2	Homo sapiens	32-36	
1378073-8	1992	Histamine release by RANTES and MCAF/MCP-1 was extremely rapid, reaching a maximum within 1 min.	Histamine	0-9	C-C motif chemokine ligand 2	Homo sapiens	37-42	
1370686-1	1992	Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE.	Histamine	83-92	C-C motif chemokine ligand 2	Homo sapiens	52-56	
1370686-1	1992	Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE.	Histamine	218-227	C-C motif chemokine ligand 2	Homo sapiens	12-50	
1370686-1	1992	Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE.	Histamine	218-227	C-C motif chemokine ligand 2	Homo sapiens	52-56	
1370686-1	1992	Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE.	Histamine	291-300	C-C motif chemokine ligand 2	Homo sapiens	12-50	
1370686-1	1992	Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE.	Histamine	291-300	C-C motif chemokine ligand 2	Homo sapiens	52-56	
1370686-2	1992	MCAF led to peak histamine release within 1 min.	Histamine	17-26	C-C motif chemokine ligand 2	Homo sapiens	0-4	
1370686-4	1992	The percentage histamine release by MCAF was, however, less than that seen with anti-IgE or FMLP, but this was attributable to a lesser percent release in nonatopic subjects; atopic subjects responded similarly to all three agonists.	Histamine	15-24	C-C motif chemokine ligand 2	Homo sapiens	36-40	
1370686-6	1992	At a suboptimal concentration (2.5 x 10(-9) M), MCAF was unable to prime the basophil to histamine release by other secretagogues.	Histamine	89-98	C-C motif chemokine ligand 2	Homo sapiens	48-52	
35411649-9	2022	C-C motif chemokine ligand (CCL) 2 and CCL22 were co-expressed with histamine H1 and H2 receptors.	Histamine	68-77	C-C motif chemokine ligand 2	Homo sapiens	0-34